1. Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
- Author
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Yueru Chen, Honglei Zhou, Ying An, Xue Liu, Lu Wang, Qing Liu, De-Gang Kong, Fulin Wang, Wei Zhao, Fu-Jie Cai, Jin-Li Tian, Yi Wu, and Xiao-Hui Sun
- Subjects
Phytochemistry ,Pharmaceutical Science ,Organic chemistry ,Review ,Analytical Chemistry ,Cynanchum wilfordii (Maxim.) Hemsl ,QD241-441 ,Drug Discovery ,Species identification ,caudatin ,Physical and Theoretical Chemistry ,Cynanchum auriculatum Royle ex Wight ,cynandione A ,Cynanchum auriculatum ,biology ,Traditional medicine ,Cynanchum bungei Decne ,Cynanchum bungei ,biology.organism_classification ,Terpenoid ,Chemistry (miscellaneous) ,Cynanchum wilfordii ,Molecular mechanism ,Molecular Medicine ,Clinical safety - Abstract
Cynanchum auriculatum Royle ex Wight. (CA), Cynanchum bungei Decne. (CB) and Cynanchum wilfordii (Maxim.) Hemsl. (CW) are three close species belonging to the Asclepiadaceous family, and their dry roots as the bioactive part have been revealed to exhibit anti-tumor, neuroprotection, organ protection, reducing liver lipid and blood lipid, immunomodulatory, anti-inflammatory, and other activities. Until 2021, phytochemistry investigations have uncovered 232 compounds isolated from three species, which could be classified into C21-steroids, acetophenones, terpenoids, and alkaloids. In this review, the morphology characteristics, species identification, and the relationship of botany, extraction, and the separation of chemical constituents, along with the molecular mechanism and pharmacokinetics of bioactive constituents of three species, are summarized for the first time, and their phytochemistry, pharmacology, and clinical safety are also updated. Moreover, the direction and limitation of current research on three species is also discussed.
- Published
- 2021