1. Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae
- Author
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Rainer Kalscheuer, Peter Proksch, BO Umeokoli, Zhen Liu, Kun Zou, Dieter Meier, Werner E. G. Müller, Xiaoqin Yu, and Zhiyong Guo
- Subjects
Models, Molecular ,Magnetic Resonance Spectroscopy ,Stereochemistry ,Pharmaceutical Science ,010402 general chemistry ,01 natural sciences ,Article ,Polyketide ,polyketide ,Drug Discovery ,medicine ,Endophytes ,Cytotoxicity ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,IC50 ,lcsh:QH301-705.5 ,endophytic fungus ,biology ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Absolute configuration ,Fungi ,biology.organism_classification ,0104 chemical sciences ,Acinetobacter baumannii ,Pseudopestalotiopsis theae ,lcsh:Biology (General) ,Polyketides ,Fermentation ,Colistin ,cytotoxicity ,Rhizophoraceae ,Antibacterial activity ,Two-dimensional nuclear magnetic resonance spectroscopy ,medicine.drug - Abstract
Chemical investigation of secondary metabolites from the endophytic fungus Pseudopestalotiopsis theae led to the isolation of eighteen new polyketide derivatives, pestalotheols I&ndash, Q (1&ndash, 9) and cytosporins O&ndash, W (15&ndash, 23), together with eight known analogs (10&ndash, 14 and 24&ndash, 26). The structures of the new compounds were elucidated by HRMS and 1D and 2D NMR data, as well as by comparison with literature data. Modified Mosher&rsquo, s method was applied to determine the absolute configuration of some compounds. Compound 23 showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with an IC50 value of 3.0 &mu, M. Furthermore, compounds 22 and 23 showed moderate antibacterial activity against drug-resistant Acinetobacter baumannii (ATCC BAA-1605) in combination with sublethal colistin concentrations.
- Published
- 2020