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3 results on '"Darius Pranys"'

1. Multiorgan Toxicity from Dual Checkpoint Inhibitor Therapy, Resulting in a Complete Response—A Case Report

Author

Skaistė Astašauskaitė, Rita Kupčinskaitė-Noreikienė, Inga Zaborienė, Rūta Vaičiūnienė, Tomas Vanagas, Darius Pranys, Lina Poškienė, and Elona Juozaitytė

Subjects
immune checkpoint inhibitors, immune checkpoint inhibitor-induced colitis, immune-mediated nephritis, immune checkpoint inhibitor-induced hepatitis, clear cell renal carcinoma, complete response, Medicine (General), R5-920
Abstract

Immunotherapy treatment with checkpoint inhibitors (ICIs) has led to a breakthrough in the treatment of oncological diseases. Despite its clinical effectiveness, this treatment differs from others, such as cytotoxic chemotherapy, in that it causes immune-related adverse events. This type of toxicity can affect any organ or organ system of the body. We present a literature review and a rare clinical case from our clinical practice, in which a patient with metastatic clear cell renal carcinoma was treated with a single dose of dual checkpoint blockade (cytotoxic T-lymphocyte-4 (CTLA-4) and programmed death-1 (PD-1)) and simultaneously diagnosed with colitis, hepatitis, and nephritis. After early immunosuppressive treatment with the glucocorticoids, complete organ function recovery was achieved. The follow-up revealed a sustained complete response lasting more than a year.

Published
2024
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2. Distribution of CD4+ and CD8+ T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking

Author

Jurgita Jackutė, Marius Žemaitis, Darius Pranys, Brigita Šitkauskienė, Skaidrius Miliauskas, Vytis Bajoriūnas, and Raimundas Sakalauskas

Subjects
Non-small cell lung cancer, Chronic obstructive pulmonary disease, CD4+ T cells, CD8+ T cells, Smoking, Medicine (General), R5-920
Abstract

Background and objective: The immune system plays an important role in non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the infiltration patterns of CD4+ and CD8+ T cells in NSCLC and to analyze their relation to COPD, smoking status and other clinicopathologic variables. Materials and methods: Lung tissue specimens from 50 patients who underwent surgery for NSCLC (stages I–III) and 10 control group subjects were analyzed immunohistochemically. Results: NSCLC patients had a greater number of CD4+ and CD8+ T cells infiltrating the lung tissue than the control group (P = 0.001) with predominant infiltration in the tumor stroma. We found a significant association between the number of total and tumor stroma-infiltrating CD4+ and CD8+ T cells, and smoking status (P

Published
2015
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3. Diagnostic Yield of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Cytological Smears and Cell Blocks: A Single-Institution Experience

Author

Raimundas Sakalauskas, Greta Musteikienė, Darius Pranys, Skaidrius Miliauskas, and Marius Žemaitis

Subjects
Adult, Male, endobronchial ultrasound (EBUS), medicine.medical_specialty, Lung Neoplasms, lung cancer, sarcoidosis, cytology, cell blocks, 030204 cardiovascular system & hematology, Sensitivity and Specificity, Lung neoplasms, diagnostic imaging, Endoscopic ultrasound-guided fine needle aspiration, Endosonography, methods, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Sarcoidosis, Pulmonary, Predictive Value of Tests, Cytology, Bronchoscopy, medicine, Humans, Endobronchial ultrasound, 616.24-006.6 [udc], Lung cancer, Endoscopic Ultrasound-Guided Fine Needle Aspiration, Lymphatic Diseases, Cell block, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Ultrasound, Mediastinum, Histology, General Medicine, Middle Aged, medicine.disease, 030228 respiratory system, Female, Lymph Nodes, Sarcoidosis, Radiology, business, Airway
Abstract

Background and Objective: Endobronchial ultrasound (EBUS) is a minimally invasive endobronchial technique, which uses ultrasound along with a bronchoscope to visualize the airway wall and structures that are adjacent to it. Indications for endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are samplings of mediastinal, hilar lymph nodes, and tumors adjacent to airway walls. EBUS-TBNA has been used in our clinic since 2009. The aim of the study is to evaluate the sensitivity, specificity, positive and negative predictive value, and diagnostic accuracy of cytological and histological specimens, and the safety of EBUS-TBNA in an unselected patient population that has been referred to our hospital. Materials and Methods: We have retrospectively analyzed the medical documentation of 215 patients who had EBUS-TBNA performed in our clinic from April 2009 to February 2014. Results: There were 215 patients who underwent EBUS-TBNA. A total of 296 lymph nodes were sampled. EBUS-TBNA was diagnostic in 176 (81.9%) cases of cytological, 147 (68.4%) cases of histological, and 191 (88.9%) cases of the combined evaluation. In the lung cancer patients, EBUS-TBNA cytology had a sensitivity of 72.9% and histology of 72.9%, and in the sarcoidosis group, it had a cytology of 55.8% and histology of 64.5%. As all positive cytology and histology specimens were assumed to be true positive, specificity and positive predictive value (PPV) were 100%. The sensitivity and diagnostic accuracy was significantly higher when cytology and histology specimens were combined, compared with cytology or histology results evaluated separately (p < 0.05) (for lung cancer 84.1% and for sarcoidosis 78.8%). The sensitivity and diagnostic accuracy of EBUS-TBNA procedures increased significantly over time, with increased experience. There were no complications with EBUS-TBNA in our clinical practice. Conclusions: EBUS-TBNA had a high diagnostic yield and was safe in the diagnosis of lung cancer and sarcoidosis. It was most informative when cytology and histology were combined. The informative value of EBUS-TBNA histology increased with our experience.

Published
2018
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