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12 results on '"Valente, Elena"'

3. Persistent Non-Suicidal Self-Injury and Suicidality in Referred Adolescents: A Longitudinal Study Exploring the Role of Cyclothymic Temperament

Author

Masi, Gabriele, primary, Pisano, Simone, additional, Sesso, Gianluca, additional, Mazzullo, Cristina, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Narzisi, Antonio, additional, Placini, Francesca, additional, Valente, Elena, additional, Viglione, Valentina, additional, and Milone, Annarita, additional

Published
2023
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5. Early Sensory Profile in Autism Spectrum Disorders Predicts Emotional and Behavioral Issues

Author

Fabbri-Destro, Maddalena, primary, Maugeri, Federica, additional, Ianni, Carolina, additional, Corsini, Sofia, additional, Di Stefano, Erica, additional, Scatigna, Stefano, additional, Crifaci, Giulia, additional, Bruzzi, Gianina, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Prato, Adriana, additional, Muccio, Rosy, additional, Valente, Elena, additional, Pelagatti, Susanna, additional, Pecchini, Edoardo, additional, Zulli, Filippo, additional, Rizzo, Renata, additional, Milone, Annarita, additional, Viglione, Valentina, additional, Barone, Rita, additional, Masi, Gabriele, additional, and Narzisi, Antonio, additional

Published
2022
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6. Sensory Profiles in School-Aged Children with Autism Spectrum Disorder: A Descriptive Study Using the Sensory Processing Measure-2 (SPM-2)

Author

Narzisi, Antonio, primary, Fabbri-Destro, Maddalena, additional, Crifaci, Giulia, additional, Scatigna, Stefano, additional, Maugeri, Federica, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Prato, Adriana, additional, Muccio, Rosy, additional, Valente, Elena, additional, Viglione, Valentina, additional, Pecchini, Edoardo, additional, Pelagatti, Susanna, additional, Rizzo, Renata, additional, Milone, Annarita, additional, Barone, Rita, additional, and Masi, Gabriele, additional

Published
2022
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8. Could You Give Me the Blue Brick? LEGO®-Based Therapy as a Social Development Program for Children with Autism Spectrum Disorder: A Systematic Review

Author

Narzisi, Antonio, primary, Sesso, Gianluca, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Muccio, Rosy, additional, Valente, Elena, additional, Viglione, Valentina, additional, Villafranca, Arianna, additional, Milone, Annarita, additional, and Masi, Gabriele, additional

Published
2021
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9. Autism Spectrum Disorder and Disruptive Behavior Disorders Comorbidities Delineate Clinical Phenotypes in Attention-Deficit Hyperactivity Disorder: Novel Insights from the Assessment of Psychopathological and Neuropsychological Profiles

Author

Sesso, Gianluca, primary, Cristofani, Chiara, additional, Berloffa, Stefano, additional, Cristofani, Paola, additional, Fantozzi, Pamela, additional, Inguaggiato, Emanuela, additional, Narzisi, Antonio, additional, Pfanner, Chiara, additional, Ricci, Federica, additional, Tacchi, Annalisa, additional, Valente, Elena, additional, Viglione, Valentina, additional, Milone, Annarita, additional, and Masi, Gabriele, additional

Published
2020
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10. The Role of Executive Functions in the Development of Empathy and Its Association with Externalizing Behaviors in Children with Neurodevelopmental Disorders and Other Psychiatric Comorbidities

Author

Cristofani, Chiara, primary, Sesso, Gianluca, additional, Cristofani, Paola, additional, Fantozzi, Pamela, additional, Inguaggiato, Emanuela, additional, Muratori, Pietro, additional, Narzisi, Antonio, additional, Pfanner, Chiara, additional, Pisano, Simone, additional, Polidori, Lisa, additional, Ruglioni, Laura, additional, Valente, Elena, additional, Masi, Gabriele, additional, and Milone, Annarita, additional

Published
2020
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11. The Role of Executive Functions in the Development of Empathy and Its Association with Externalizing Behaviors in Children with Neurodevelopmental Disorders and Other Psychiatric Comorbidities

Author

Antonio Narzisi, Pietro Muratori, Chiara Pfanner, Laura Ruglioni, Emanuela Inguaggiato, Gianluca Sesso, Gabriele Masi, Annarita Milone, Simone Pisano, Paola Cristofani, Pamela Fantozzi, Elena Valente, Lisa Polidori, Chiara Cristofani, Cristofani, Chiara, Sesso, Gianluca, Cristofani, Paola, Fantozzi, Pamela, Inguaggiato, Emanuela, Muratori, Pietro, Narzisi, Antonio, Pfanner, Chiara, Pisano, Simone, Polidori, Lisa, Ruglioni, Laura, Valente, Elena, Masi, Gabriele, and Milone, Annarita

Subjects
medicine.medical_treatment, media_common.quotation_subject, autism spectrum disorder, Empathy, Article, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, Social cognition, medicine, 0501 psychology and cognitive sciences, empathy, attention deficit and hyperactivity disorder, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, media_common, General Neuroscience, 05 social sciences, executive functions, medicine.disease, Executive functions, Cognitive behavioral therapy, Behavior Rating Inventory of Executive Function, Prosocial behavior, disruptive behavior disorders, Autism spectrum disorder, Autism, Psychology, disruptive behavior disorder, 030217 neurology & neurosurgery, 050104 developmental & child psychology, Clinical psychology
Abstract

Executive functions have been previously shown to correlate with empathic attitudes and prosocial behaviors. People with higher levels of executive functions, as a whole, may better regulate their emotions and reduce perceived distress during the empathetic processes. Our goal was to explore the relationship between empathy and executive functioning in a sample of children and adolescents diagnosed with Attention Deficit and Hyperactivity Disorder alone or associated with comorbid Disruptive Behavior Disorders and/or Autism Spectrum Disorder. We also aimed to examine the role of empathic dimensions and executive skills in regulating externalizing behaviors. The 151 participants with ADHD were assigned to four groups according to their psychiatric comorbidity (either &ldquo, pure&rdquo, or with ASD and/or ODD/CD) and assessed by means of either parent- or self-reported questionnaires, namely the BRIEF&minus, 2, the BES, and the IRI. No questionnaire was found to discriminate between the four groups. Affective Empathy was found to positively correlate with Emotional and Behavioral Regulation competences. Furthermore, Aggressiveness and Oppositional Defiant Problems were positively associated with Executive Emotional and Behavioral Regulation competences. On the other hand, Rule-Breaking Behaviors and Conduct Problems were negatively associated with Affective Empathy and with Behavioral skills. Our study provides an additional contribution for a better understanding of the complex relationship between empathic competence and executive functions, showing that executive functioning and empathic attitudes interact with each other to regulate aggressive behaviors. This study further corroborates developmental models of empathy and their clinical implications, for which externalizing behaviors could be attenuated by enhancing executive functioning skills.

Published
2020

12. Micromolar Dihydroartemisinin Concentrations Elicit Lipoperoxidation in Plasmodium falciparum -Infected Erythrocytes.

Author

Skorokhod O, Valente E, Mandili G, Ulliers D, and Schwarzer E

Abstract

Malaria is still the most important parasitic infectious disease. Numerous substances are known to have antimalarial activity; among them, artemisinin is the most widely used one, and artemisinin-based combination therapy (ACT) is recommended for the treatment of Plasmodium falciparum (P.f.) malaria. Antitumor, immunomodulatory, and other therapeutic applications of artemisinin are under extensive study. Several different mechanisms of action were proposed for dihydroartemisinin (DHA), the active metabolite of artemisinin, such as eliciting oxidative stress in target cells. The goal of this study is to monitor the generation of reactive oxygen species (ROS) and lipid peroxidation product 4-hydroxynonenal (4-HNE) by DHA in P.f. -infected human erythrocytes. Checking ROS and 4-HNE-protein adducts kinetics along the maturation of the parasite, we detected the highest level of 4-HNE in ring forms of P.f. due to DHA treatment. Low micromolar concentrations of DHA quickly induced levels of 4-HNE-adducts which are supposed to be damaging. Mass spectrometry identified the P.f. protein cysteine proteinase falcipain-1 as being heavily modified by 4-HNE, and plausibly, 4-HNE conjugation with vital P.f. proteins might contribute to DHA-elicited parasite death. In conclusion, significant 4-HNE accumulation was detectable after DHA treatment, though, at concentrations well above pharmacologically effective ranges in malaria treatment, but at concentrations described for antitumor activity. Thus, lipid peroxidation with consequent 4-HNE conjugation of functionally relevant proteins might be considered as a uniform mechanism for how DHA potentiates antimalarials' action in ACT and controls the progression of tumors.

Published
2023
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