1. HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration
- Author
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Shoko Fujino, Toshihiko Oda, Utako Shirono, Midori Yamamoto, Yasuo Kurimoto, Masashi Fujihara, Satoshi Sugiyama, Hirokazu Sakaguchi, Tadao Maeda, Ayumi Hono, Seiji Takagi, Kazuichi Maruyama, Masataka Igeta, Mitsuhiro Matsuzaki, Kyoko Iseki, Misato Tozaki, Chikako Hara, Naoshi Koide, Hiromi Dohi, Kohji Nishida, Motoki Terada, Yumiko Shibata, Mitsuhiro Nishida, Masaki Nomura, Naoko Hayashi, Michiko Mandai, Yasuhiko Hirami, Takashi Daimon, Kota Totani, Noriko Sakai, Masayo Takahashi, Naoki Amano, and Sunao Sugita
- Subjects
medicine.medical_specialty ,retina ,macular degeneration ,lcsh:Medicine ,Human leukocyte antigen ,Article ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Endophthalmitis ,Ophthalmology ,medicine ,030304 developmental biology ,0303 health sciences ,Retina ,Retinal pigment epithelium ,immune reactions ,business.industry ,lcsh:R ,General Medicine ,Macular degeneration ,medicine.disease ,eye diseases ,Transplantation ,HLA ,iPS cells ,medicine.anatomical_structure ,surgical procedures, operative ,sense organs ,Epiretinal membrane ,business ,030217 neurology & neurosurgery ,transplantation - Abstract
Immune attacks are key issues for cell transplantation. To assess the safety and the immune reactions after iPS cells-derived retinal pigment epithelium (iPS-RPE) transplantation, we transplanted HLA homozygote iPS-RPE cells established at an iPS bank in HLA-matched patients with exudative age-related macular degeneration. In addition, local steroids without immunosuppressive medications were administered. We monitored immune rejections by routine ocular examinations as well as by lymphocytes-graft cells immune reaction (LGIR) tests using graft RPE and the patient&rsquo, s blood cells. In all five of the cases that underwent iPS-RPE transplantation, the presence of graft cells was indicated by clumps or an area of increased pigmentation at 6 months, which became stable with no further abnormal growth in the graft during the 1-year observation period. Adverse events observed included corneal erosion, epiretinal membrane, retinal edema due to epiretinal membrane, elevated intraocular pressure, endophthalmitis, and mild immune rejection in the eye. In the one case exhibiting positive LGIR tests along with a slight fluid recurrence, we administrated local steroid therapy that subsequently resolved the suspected immune attacks. Although the cell delivery strategy must be further optimized, the present results suggest that it is possible to achieve stable survival and safety of iPS-RPE cell transplantation for a year.
- Published
- 2020
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