Search

Your search keyword '"Geneve Awong"' showing total 4 results
Start Over Author "Geneve Awong" Publisher nature portfolio
4 results on '"Geneve Awong"'

1. Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia

Author

Domenico Lo Tartaro, Anita Neroni, Annamaria Paolini, Rebecca Borella, Marco Mattioli, Lucia Fidanza, Andrew Quong, Carlene Petes, Geneve Awong, Samuel Douglas, Dongxia Lin, Jordan Nieto, Licia Gozzi, Erica Franceschini, Stefano Busani, Milena Nasi, Anna Vittoria Mattioli, Tommaso Trenti, Marianna Meschiari, Giovanni Guaraldi, Massimo Girardis, Cristina Mussini, Lara Gibellini, Andrea Cossarizza, and Sara De Biasi

Subjects
Biology (General), QH301-705.5
Abstract

Patients over the age of 70 show inflammaging and a weaker anti-viral response to SARS-CoV-2, pointing at the immunological changes associated with COVID-19 severity and outcome for aged patients.

Published
2022
Full Text
View/download PDF

2. Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection

Author

Sara De Biasi, Domenico Lo Tartaro, Lara Gibellini, Annamaria Paolini, Andrew Quong, Carlene Petes, Geneve Awong, Samuel Douglas, Dongxia Lin, Jordan Nieto, Francesco Maria Galassi, Rebecca Borella, Lucia Fidanza, Marco Mattioli, Chiara Leone, Isabella Neri, Marianna Meschiari, Luca Cicchetti, Anna Iannone, Tommaso Trenti, Mario Sarti, Massimo Girardis, Giovanni Guaraldi, Cristina Mussini, Fabio Facchinetti, and Andrea Cossarizza

Subjects
Science
Abstract

SARS-CoV-2 infection of expecting mothers has been reported. Here the authors profile the peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection to find grossly normal immune cell composition but heterogenous induction of pro-inflammatory cytokines, thereby implicating possible therapeutic targets for virus-induced damages during pregnancy.

Published
2021
Full Text
View/download PDF

3. Author Correction: Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection

Author

Sara De Biasi, Domenico Lo Tartaro, Lara Gibellini, Annamaria Paolini, Andrew Quong, Carlene Petes, Geneve Awong, Samuel Douglas, Dongxia Lin, Jordan Nieto, Francesco Maria Galassi, Rebecca Borella, Lucia Fidanza, Marco Mattioli, Chiara Leone, Isabella Neri, Marianna Meschiari, Luca Cicchetti, Anna Iannone, Tommaso Trenti, Mario Sarti, Massimo Girardis, Giovanni Guaraldi, Cristina Mussini, Fabio Facchinetti, and Andrea Cossarizza

Subjects
Science
Published
2021
Full Text
View/download PDF

4. Author Correction: Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection

Author

Marianna Meschiari, Carlene Petes, Cristina Mussini, Sara De Biasi, Jordan Nieto, Francesco M. Galassi, Geneve Awong, Andrew A. Quong, Dongxia Lin, Luca Cicchetti, Fabio Facchinetti, Tommaso Trenti, Lucia Fidanza, Domenico Lo Tartaro, Mario Sarti, Rebecca Borella, Samuel Douglas, Anna Iannone, Chiara Leone, Marco Mattioli, Lara Gibellini, Annamaria Paolini, Giovanni Guaraldi, Isabella Neri, Andrea Cossarizza, and Massimo Girardis

Subjects
Adult, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Adolescent, Neutrophils, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Science, General Physics and Astronomy, Translational immunology, Inflammation, Endogeny, Viral infection, Asymptomatic, General Biochemistry, Genetics and Molecular Biology, Young Adult, Pregnancy, Medicine, Humans, Pregnancy Complications, Infectious, Author Correction, Asymptomatic Infections, Multidisciplinary, business.industry, SARS-CoV-2, COVID-19, General Chemistry, Middle Aged, Virology, Cross-Sectional Studies, Case-Control Studies, Cytokines, Female, medicine.symptom, business, Biomarkers
Abstract

SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results