1. Down's syndrome and Alzheimer's disease: towards secondary prevention.
- Author
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Ness S, Rafii M, Aisen P, Krams M, Silverman W, and Manji H
- Subjects
- Alzheimer Disease etiology, Alzheimer Disease genetics, Amyloid beta-Peptides adverse effects, Amyloid beta-Peptides genetics, Apolipoprotein E4 adverse effects, Apolipoprotein E4 genetics, Down Syndrome etiology, Down Syndrome genetics, Genetic Markers genetics, Genotype, Humans, Alzheimer Disease prevention & control, Down Syndrome prevention & control, Secondary Prevention methods
- Abstract
A public-private partnership to establish biomarkers of dementia in Down's syndrome could aid the development of preventive therapies for the dementia associated with both Down's syndrome and Alzheimer's disease, based on the apparent common pathogenic role of amyloid precursor protein in the two conditions.
- Published
- 2012
- Full Text
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