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Researchers at the University of Guadalajara conducted a study on the impact of tourism on the quality of life in the Magic Town of San Sebastian Del Oeste, Jalisco, Mexico. The research found that while tourism has provided economic benefits and improved public services for the local population, it is not a comprehensive solution for all aspects of quality of life. The study used a qualitative-phenomenological methodology, including interviews with local inhabitants, to assess the effects of tourism on their quality of life. This research was supported by financial assistance from the Universidad de Guadalajara and provides valuable insights into the complex relationship between tourism and quality of life in the region. [Extracted from the article]

Researchers at the Mexican Institute of Social Security conducted a study on Neuromyelitis Optica Spectrum Disorder (NMOSD) in Western Mexico, focusing on its incidence, prevalence, and clinical characteristics. The study included 58 patients with NMOSD, predominantly women, with an incidence of 0.71/100,000 and a prevalence of 1.09/100,000. The research highlighted the importance of identifying and understanding NMOSD in the population treated for demyelinating diseases in the region. [Extracted from the article]

Researchers at the University of Guadalajara in Mexico conducted a study to investigate the association between type 2 diabetes mellitus (T2DM) in adulthood, cesarean section delivery, and incomplete full breastfeeding (FBF) in individuals from the metropolitan area of Guadalajara. The study found that the combination of cesarean section delivery and limited exposure to FBF in the first six months of life may increase the risk of obesity and diabetes mellitus. The research concluded that prioritizing the limitation of nonmedically justified cesarean section deliveries is crucial to mitigate the risk of obesity and T2DM in adulthood. [Extracted from the article]

Researchers from the University of Guadalajara in Jalisco, Mexico, have conducted a review on central nervous system tumors (CNSTs), focusing on the evaluation of DNA ploidy and the DNA index by flow cytometry. The study highlights the importance of tumor biology in accurate diagnosis and treatment of CNSTs, which are classified according to the World Health Organization's schema. The research found that DNA ploidy assessment via flow cytometry could predict CNST behavior, but standardization of protocols and alignment with WHO classification are crucial for integrating ploidy analysis into routine assessment. This peer-reviewed study provides valuable insights into potential prognostic markers for CNSTs. [Extracted from the article]

Researchers from the National Technological Institute of Mexico have conducted a study on the preparation and characterization of nanocapsules using the acid fraction of potato protein through electrospraying. The study aimed to evaluate the properties of the acid fraction of potato protein in forming capsules independently and with adjuvants. The research found that the inclusion of adjuvants enhanced the stability of the electrospraying process, resulting in capsules with photoprotective properties and encapsulation efficiency values exceeding 50%. The study concluded that the acid fraction of potato protein could be used as an encapsulating medium for food and pharmaceutical compounds in the electrospraying process. [Extracted from the article]

A recent study conducted in Jalisco, Mexico, examined the effectiveness of sleep deprivation EEG in diagnosing epilepsy. The study included 460 patients with suspected epilepsy who underwent either sleep deprivation EEG or routine EEG. The results showed no significant difference in the yield of epilepsy diagnosis between the two groups, indicating the need for further research to clarify the role of sleep deprivation in epilepsy diagnosis. The study's findings have been peer-reviewed and published in Clinical EEG and Neuroscience. [Extracted from the article]

Researchers from the University of Guadalajara conducted a study to evaluate the effects of propolis and metformin on glycemic control in patients with type 2 diabetes mellitus. The study involved a double-blind, randomized, placebo-controlled clinical trial with 36 patients. Results showed that both propolis and metformin groups experienced significant reductions in fasting plasma glucose and 2-hour postload glucose levels, as well as improvements in insulin sensitivity. The research concluded that propolis and metformin were effective in reducing glucose levels and improving insulin sensitivity compared to a placebo. [Extracted from the article]

A study conducted by researchers at the University of Guadalajara in Mexico focused on the distribution of the genetic variant rs10974944 in Mexican populations, specifically Mestizos and Native Americans. The variant is associated with a higher risk of myeloproliferative neoplasms (MPNs). While the allele distribution was found to be homogeneous among Mexican and worldwide control populations, genetic clustering of worldwide patients supported the claimed association with MPNs. The research was funded by the Mexican government and the University of Guadalajara, and has been peer-reviewed. [Extracted from the article]

Researchers from the University of Guadalajara in Mexico have conducted a network pharmacology study to explore the potential of Resveratrol as an antidiabetic agent for Type 2 diabetes. They identified common disease-compound targets and analyzed the genes using various databases and software. The study found that Resveratrol influences insulin receptors, endoplasmic reticulum functions, and oxidoreductase activity, and is involved in the estrogen and HIF-1 pathways. Ten hub genes were identified, and molecular docking and dynamic simulations showed a stable interaction of Resveratrol with certain proteins. The researchers suggest that further experimental studies are needed to corroborate these findings. [Extracted from the article]

A report from the University of Guadalajara discusses the impact of chronic fluoride exposure on dental health and growth in male Wistar rats at different developmental stages. The study found that prolonged exposure to fluoride can have adverse effects on different tissues, and it can cross the placental barrier and be present in breast milk, leading to prenatal exposure. The research showed that high concentrations of fluoride had negative effects on adult individuals, including reproductive and developmental effects. The study also highlighted that the effects of chronic fluoride exposure vary depending on the developmental stage of the individual at the time of exposure. [Extracted from the article]

A study conducted at the University of Guadalajara in Mexico examined the role of the leptin/ghrelin axis and antibodies reactive to both hormones in relation to metabolic syndrome (MetS) and its components in Mexican children. The study found that children with two or three components of MetS had significantly higher levels of glucose, insulin, leptin, HOMA-IR, and plasma atherogenic index compared to children with none or one component. The study also observed higher ratios of leptin/ghrelin and anti-leptin/anti-ghrelin immune complexes in the MetS 2-3 group, suggesting affinity changes in these antibodies that may lead to alterations in hormone function. This research provides insights into the role of leptin and ghrelin in insulin sensitivity and metabolic regulation in children with MetS. [Extracted from the article]

A study conducted by researchers at the University of Guadalajara in Jalisco, Mexico, explores the role of coloration in amphibians and its implications for adaptation, reproduction, speciation, crypsis, and thermoregulation. The study focuses on the Blunt-headed Salamander (Ambystoma amblycephalum) in west-central Mexico and reports the discovery of a neotenic individual with abnormal coloration. The individual exhibited a gradual change in coloration over a period of 220 days, which the researchers attribute to piebaldism, a coloration anomaly that may be epigenetically controlled. The research was supported by the Consejo Nacional de Ciencia y Tecnologia (CONACyT) and has been peer-reviewed. [Extracted from the article]

A report from the University of Guadalajara in Mexico discusses a study that aimed to determine the correlation between personal, academic, and psychological factors with academic achievement and intelligence in university students. The study included 439 health sciences students, with 67.7% of them being women. The findings showed that there were no differences in grade point average (GPA) between sexes, but women had a higher correlation between intelligence and GPA compared to men. Additionally, studying strategies had a higher association with GPA in men than in women. Women also showed higher levels of diseases, somatization, anxiety, depression, and academic stress, which correlated with intelligence scores only in women. [Extracted from the article]

A recent study conducted at the Monterrey Institute of Technology and Higher Education in Jalisco, Mexico, analyzed the proximate composition, bioactive compounds, antimicrobial activity, and fermentability of strawberry, raspberry, blueberry, and blackberry by-products. The researchers found that blackberry by-products showed the highest pathogen inhibition, while lacticaseibacillus rhamnosus GG and lentilactobacillus kefiri BIOTEC014 were successful in media with strawberry or blueberry by-products as a carbon source. The study concluded that berry by-products have the potential to be valuable functional ingredients for food and pharmaceutical applications. For more information, readers can refer to the journal article "Characterization of Berry By-products As Fermentable Substrates: Proximate and Phenolic Composition, Antimicrobial Activity, and Probiotic Growth Dynamics" published in LWT. [Extracted from the article]

A study conducted by the Monterrey Institute of Technology and Higher Education in Jalisco, Mexico, explores the treatment options for type 1 and some type 2 diabetes patients. The study discusses cell-based therapies as a potential alternative to the current standard of exogenous insulin application. The researchers highlight the advantages and disadvantages of these methods and address the challenges of donor shortage and the need for immunosuppressive therapies. This research provides valuable insights into current and future translatable therapies for diabetes. [Extracted from the article]

New research conducted at the University of Guadalajara in Mexico explores the association between certain genetic polymorphisms and lepromatous leprosy (LL) in Western Mexican patients. The study compares the frequencies of specific polymorphisms in genes related to tumor necrosis factor-alpha (TNF alpha) and TNF receptors 1 and 2 (TNFR1 and TNFR2) in LL patients and healthy subjects. The researchers found an association between a specific genotype and the risk of lepromatous leprosy, suggesting that this genotype could potentially serve as a marker for identifying high-risk populations. However, further studies with larger sample sizes and diverse ethnic populations are needed to confirm these findings. [Extracted from the article]

A recent report from researchers at the Mexican Social Security Institute in Jalisco, Mexico, discusses the findings of a study on Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) in dialysis patients. The study aimed to determine the frequency of different CKD-MBD phenotypes and their associated factors. The most common phenotype observed was high parathyroid hormone (PTH), low vitamin D, and high on-target phosphorus. Patients with this phenotype were more likely to use peritoneal dialysis, had higher lipid levels, and lower potassium levels. The study found that peritoneal dialysis use, total cholesterol, and serum creatinine were significantly associated with these phenotypes. [Extracted from the article]

A report from the University of Guadalajara in Mexico discusses the findings of a study on reducing the presence of Listeria monocytogenes on Hass avocados. The study found that wet steam treatment for 60 seconds effectively reduced the number of attached cells of both Listeria monocytogenes and Salmonella on the avocados. The research suggests that avocados and their products have been linked to outbreaks of illness caused by these pathogens, and that steam treatment could be an effective method for reducing their presence. [Extracted from the article]

A report from the Monterrey Institute of Technology and Higher Education in Mexico discusses the potential of using Chlorella vulgaris, a type of algae, to bioremediate the wastewater generated by the food and beverage industries in Mexico. The study found that Chlorella vulgaris was able to grow in the wastewater and effectively reduce pollutants, including nitrogen, phosphates, and COD. Additionally, the algae produced valuable compounds such as pigments, phenolic compounds, and proteins. The researchers concluded that this approach could offer a practical solution for addressing environmental challenges in the food and beverage industries within a circular economy framework. [Extracted from the article]

A report from the University of Guadalajara in Mexico discusses the use of bacteriophages, specifically the PHA46 cocktail, as a biocontrol agent against Salmonella enterica. The study aimed to characterize the phages in the cocktail and evaluate their efficacy in reducing the adherence and internalization of Salmonella into cherry tomatoes. The results showed that the PHA46 cocktail was effective in reducing the adherence and internalization of Salmonella strains into cherry tomatoes, without harming the nematode used in the experiments. The researchers concluded that the PHA46 cocktail could be a potential biocontrol agent against Salmonella enterica. [Extracted from the article]

A recent study conducted by the University of Guadalajara in Mexico examined the relationship between lipid profiles, anthropometric indicators, and appetite-regulating hormones in infants based on their type of feeding. The study included 145 mother-infant dyads, with 64 receiving full breastfeeding, 47 receiving partial breastfeeding, and 34 receiving human milk substitutes. The researchers found significant differences in triglycerides and LDL cholesterol based on the type of feeding. They concluded that there is a relationship between growth, energy reserve, lipid profile, and modulation of appetite-regulating hormones according to the type of feeding received. [Extracted from the article]

A recent study conducted in Oaxaca, Mexico, found a high prevalence of familial hypercholesterolemia (FH) due to a specific genetic variant. The researchers performed population screening in 11 communities and identified 205 individuals with suggestive FH. Two pathogenic variants in the LDLR gene were detected in 149 individuals, and cascade screening of their relatives identified 15 more individuals with the variant. The study concluded that a founder effect and inbreeding may be responsible for the high percentage of patients with this variant. The frequency of FH in this study was the highest reported worldwide. [Extracted from the article]

A recent study conducted in Jalisco, Mexico, explored the association between genetic variants and the prognosis of acute lymphoblastic leukemia (ALL) in children. The researchers found that elevated levels of fetal hemoglobin (HbF) were linked to a poorer prognosis in ALL patients. They also identified specific genetic variants, such as HBG2 rs7482144 and HBS1L-MYB rs9399137, that were associated with high HbF concentration and unfavorable prognosis. On the other hand, the variant BCL11A rs4671393 showed a protective role. These findings contribute to our understanding of the genetic factors influencing ALL and may have implications for future treatment strategies. [Extracted from the article]

A recent study conducted by researchers from the University of Guadalajara in Mexico explored the electroencephalographic (EEG) activity in the brains of primiparous breastfeeding mothers during direct breastfeeding and breast milk expression. The study found that mothers reported higher valence and arousal, as well as a pleasant state, during direct breastfeeding compared to breast milk expression. EEG activity in the prefrontal and parietal cortices was also found to be different between the two conditions, suggesting that direct breastfeeding may involve a state of focused attention and integration of emotional and cognitive processes. This research provides valuable insights into the mother-baby interaction during breastfeeding. [Extracted from the article]

A study conducted by researchers from the University of Guadalajara in Mexico aimed to validate and assess the reliability of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) in a Mexican population with multiple sclerosis (MS). The study involved 100 healthy controls and 100 MS patients, who completed three tests of the BICAMS. The results showed that the MS group performed significantly worse than the healthy controls on all three neuropsychological tests. The researchers concluded that the BICAMS can provide valuable information on cognitive impairment in MS patients, which can be used for cognitive rehabilitation. [Extracted from the article]

A recent study conducted in Jalisco, Mexico, explored the development of a functional beverage using tamarind and partially-hydrolyzed agave syrup. The researchers found that this beverage was associated with decreased blood cholesterol and triglyceride concentrations in healthy mice, as well as lower lipid concentrations and evidence of protein oxidation in the liver. The study concluded that the tamarind-based beverage with partially-hydrolyzed agave syrup was stable and had beneficial metabolic properties. This research has been peer-reviewed and provides valuable insights into the potential for developing healthier beverages. [Extracted from the article]

This article discusses a research study conducted by the University of Guadalajara in Jalisco, Mexico, on the use of 4-aminopyridine (4-AP) as a model for generalized seizures. 4-AP is a drug that enhances synaptic transmission and blocks K+ channels, leading to depolarization and the release of neurotransmitters like glutamate. The study focuses on the effectiveness of 4-AP as a seizure model for testing antiseizure drugs in both in vitro and in vivo studies. The research has been peer-reviewed and published in Acta Neurobiologiae Experimentalis. [Extracted from the article]

A recent study conducted by researchers from the University of Guadalajara in Mexico has found that certain strains of Lactobacillus bacteria and their extracts have the potential to counteract the genotoxicity and oxidative stress caused by acrylamide, a compound found in many thermally processed food products. The researchers used Lactobacillus caseiShirota and Lactobacillus reuteriNRRL B-14171 strains, which were cultured and subjected to mechanical and enzymatic treatments to obtain intra and extracellular extracts. The study found that both strains and their extracts demonstrated the ability to reduce lipid peroxidation and genotoxicity caused by acrylamide. These findings suggest that the use of Lactobacillus extracts could be a viable alternative for reducing the harmful effects of acrylamide without the need for live bacteria. [Extracted from the article]

A recent study conducted by researchers at the University of Guadalajara in Jalisco, Mexico, explored the role of the transcription factor Nrf2 in persistent periapical lesions (PPL). PPL are caused by bacterial infection and result in bone degradation and tooth loss. The study found that patients with PPL exhibited alterations in antioxidants controlled by Nrf2, which are related to the destruction of bone tissue. These findings contribute to a better understanding of the pathogenesis of PPL and may have implications for future treatment strategies. [Extracted from the article]

Researchers at the University of Guadalajara in Mexico have conducted a study on the phytoestrogenic effects of hibiscus sabdariffa, a plant known for its high anthocyanin content. The study focused on the impact of hibiscus sabdariffa on estrogen receptors in ovariectomized Wistar rats, which experience a rapid decline in ovarian hormone production. The researchers found that hibiscus sabdariffa extract and estradiol affected the expression of estrogen receptors differently, suggesting that hibiscus sabdariffa could be a potential alternative to hormone replacement therapy. Further research is needed to explore the use of hibiscus sabdariffa as a nutrition-based alternative to hormone replacement therapy. [Extracted from the article]

A recent study conducted by researchers at the University of Guadalajara in Mexico explored the food web of lizard species on Maria Cleofas Island in the Gulf of California. The researchers found that the lizards had a wide variety of arthropods in their stomach contents, regardless of their foraging strategy and habitat use. They also observed differences in prey groups among lizard species, highlighting the broader niche of some species and the narrowest niche of others. This study expands our understanding of trophic relationships in island ecosystems and has important implications for ecological studies. [Extracted from the article]

A study conducted by researchers at the University of Guadalajara in Jalisco, Mexico, aimed to understand how the maternal liver responds during early and late pregnancy to a low protein/high carbohydrate diet (LPHCD). The study found that pregnant rats on a control diet showed histological modifications in the liver during late pregnancy, while those on the LPHCD showed similar modifications but at early pregnancy. However, no functional hepatic alterations were detected in either group, indicating that no evident pathological condition was present. Further research is needed to explore the biochemical mechanisms underlying these histological modifications. [Extracted from the article]

A recent study conducted in Jalisco, Mexico, examined the association between certain genetic variants and colorectal cancer (CRC) in Mexican patients. The study focused on three variants in microRNAs (miR-27a, miR-196a2, and miR-146a) and their impact on CRC susceptibility and clinicopathological features. The researchers found that the rs895819 variant in miR-27a and the rs11614913 variant in miR-196a2 were associated with an increased risk of CRC. However, the rs2910164 variant in miR-146a did not show any significant risk associations. These findings highlight the potential impact of these genetic variants on CRC development. [Extracted from the article]

A new report from researchers at the Mexican Social Security Institute in Jalisco, Mexico, presents fresh data on stroke. The study involved treating rats with cerebrolysin, environmental enrichment, or both after inducing stroke. The researchers found that motor and cognitive performance improved in the treated groups, and the size of the infarct zone was smaller compared to the control group. The study suggests that combining cerebrolysin administration with environmental enrichment could be a promising approach for treating the motor and cognitive symptoms of stroke. [Extracted from the article]

A study conducted by researchers at the University of Guadalajara in Mexico has analyzed the epidemiology and burden of type 2 diabetes (T2D) in Mexico from 1990 to 2021. The study found that the prevalence of T2D increased by 25% during this period, with a higher incidence among those under 45 years old and a decrease in mortality among women. The rate of disability-adjusted life years (DALY) also increased in all states, with T2D causing the loss of 3.1 million DALYs in 2021. The study highlights the urgent need for comprehensive policies to reduce the burden of T2D in Mexico through standardized guidelines and improved medical care accessibility. [Extracted from the article]

A recent study conducted by the University of Guadalajara in Mexico has reported the presence of three molecular transcripts in a pediatric patient diagnosed with acute promyelocytic leukemia (APL). This finding is significant as it is the first case to exhibit all three PML/RARA transcripts (bcr1, bcr2, and bcr3). The study utilized various molecular techniques to confirm the presence of these transcripts and also identified upregulated genes that may serve as potential diagnostic biomarkers. The research suggests a possible signaling pathway involving the PML/RARA oncoprotein in APL. [Extracted from the article]

A recent study conducted by researchers from the University of Guadalajara in Mexico examined the effects of maternal consumption of toxic substances during breastfeeding on the abundance of lactic acid bacteria in breast milk. The study involved interviews with 254 breastfeeding women and the collection of milk samples for analysis. The findings revealed a significant decline in lactic acid bacteria when breast milk was exposed to substances such as cocaine, cannabis, crystal, and morphine. However, the study also concluded that the nutritional quality of breast milk was not significantly impacted by the use of toxic substances. [Extracted from the article]

A case report from Jalisco, Mexico discusses the treatment of metastatic iridociliary ring melanoma with pembrolizumab, an immune checkpoint inhibitor. The patient, a 54-year-old Hispanic woman, experienced progressive vision loss due to the melanoma. The research highlights the limited treatment options for metastatic uveal melanoma and the potential of novel therapies like pembrolizumab. This information may be useful for individuals researching melanoma treatments and advancements in oncology. [Extracted from the article]

A case report from Jalisco, Mexico discusses the treatment of metastatic iridociliary ring melanoma with pembrolizumab, an immune checkpoint inhibitor. The report highlights the rarity of this type of melanoma and the varying clinical manifestations it can present. The researchers emphasize the limited treatment options for metastatic uveal melanoma and the ongoing study of novel therapies using immune checkpoint inhibitors. The case presented involves a 54-year-old Hispanic woman with progressive vision loss who was successfully treated with pembrolizumab. [Extracted from the article]

A study conducted by researchers at the University of Guadalajara in Mexico examined the effects of high fluoride levels in water on non-verbal intelligence in young adults. The study included participants from different cities in Mexico with varying fluoride concentrations in their water. The researchers found an inverse relationship between the concentration of fluoride in urine and IQ scores, with higher fluoride levels associated with lower IQ scores. This study suggests a potential link between fluoride exposure and cognitive function in adults. [Extracted from the article]

A study conducted at the University of Guadalajara in Mexico has provided new information about oral cancer. The researchers focused on the role of oxidative stress and DNA damage in the development of oral squamous cell carcinoma. They found that 8-hydroxy-2-deoxyguanosine (8-OHdG), a free radical, was expressed in the cytoplasm of most tumor cells. Tumors larger than 4 cm showed a higher frequency of cytoplasmic expression of 8-OHdG, and the presence of 8-OHdG in the nucleus was associated with a higher risk of death. This research contributes to our understanding of the mechanisms underlying oral cancer and may have implications for treatment and prognosis. [Extracted from the article]

A study conducted by the Mexican Social Security Institute in Jalisco, Mexico, has found that beta-caryophyllene (BCP) has neuroprotective effects on dopaminergic neurons in a model of hemiparkinsonism. BCP, which activates the type 2 cannabinoid receptor, demonstrated antioxidant and anti-inflammatory properties, leading to improvements in motor dysfunction and inhibition of the NLRP3 inflammasome. The study suggests that BCP has the potential to mitigate motor deficits and reduce neuroinflammation in Parkinson's disease. The research was supported by the Consejo Nacional de Humanidades, Ciencias y Tecnologias (CONAHCYT) and has been peer-reviewed. [Extracted from the article]

New research from Jalisco, Mexico explores the proteome and immunogenicity differences between the BCG Pasteur ATCC 35734 strain and its derivative, the vaccine candidate BCGDBCG1419c, during planktonic growth in different media. The study found that both the presence or absence of the BCG1419c gene and the culture medium affected the proteome produced in vitro, potentially leading to changes in the capacity to induce immune responses. The research suggests that modifications in the antigenic repertoire of the BCG vaccine may arise from in vitro growth conditions, which could contribute to the variable efficacy of the vaccine in preventing tuberculosis. [Extracted from the article]

Researchers from the University of Guadalajara in Mexico have developed a low-cost pupillometer, a device that measures the response of the pupil to LED flash stimuli. This non-invasive technique can be used to analyze the photomotor reflex and diagnose mental, ocular, and other health conditions. The researchers implemented an experimental prototype that includes a web camera and a lighting system to capture pupillary images and induce stimuli. They also developed a robust algorithm to estimate pupil diameters and analyze pupillary behavior. This research provides a new tool for medical diagnosis and expands access to specialized equipment. [Extracted from the article]

A recent study conducted by researchers from the University of Guadalajara in Mexico has found that beta-caryophyllene, a natural sesquiterpene and dietary cannabinoid, may have potential benefits for individuals with obesity. The study used a diet-induced obesity mouse model and found that treatment with beta-caryophyllene improved various metabolic parameters, including body weight, glucose levels, insulin tolerance, and triglyceride levels. Additionally, beta-caryophyllene was found to modulate immune response factors. The research suggests that chronic supplementation with beta-caryophyllene may improve metabolic and immunological processes in obese individuals. [Extracted from the article]