1. The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus
- Author
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Thomas H. Hauser, Ernest V. Gervino, Alessandro Doria, Diego Bailetti, Vincenzo Trischitta, Christine Mendonca, Laura Pucci, Olga Lamacchia, Sabrina Prudente, Salvatore De Cosmo, Giuseppe Penno, Luana Mercuri, Hetal Shah, Mauro Cignarelli, and Daniela Lucchesi
- Subjects
Male ,medicine.medical_specialty ,gene polymorphism ,albuminuria ,coronary artery disease ,glomerular filtration rate ,Albuminuria ,Chromosomes, Human, Pair 9 ,Coronary Artery Disease ,Diabetes Mellitus, Type 2 ,Diabetic Angiopathies ,Female ,Glomerular Filtration Rate ,Humans ,Kidney ,Polymorphism, Single Nucleotide ,Nephrology ,Transplantation ,Renal function ,Gastroenterology ,Chromosomes ,CLINICAL SCIENCE ,chemistry.chemical_compound ,Internal medicine ,Diabetes mellitus ,medicine ,Diabetes Mellitus ,Polymorphism ,Creatinine ,business.industry ,Type 2 Diabetes Mellitus ,Odds ratio ,Single Nucleotide ,medicine.disease ,Confidence interval ,Endocrinology ,chemistry ,Gene polymorphism ,medicine.symptom ,business ,Type 2 ,Human ,Pair 9 - Abstract
Background. We investigated whether the coronary artery disease (CAD) locus on chromosome 9p21 (as represented by single nucleotide polymorphism rs2383206) is associated with low estimated glomerular filtration rate (eGFR) or increased urinary albumin excretion in patients with Type 2 diabetes mellitus (T2DM). Methods. Four samples, including a total of 3167 patients, were studied. The presence of low eGFR (
- Published
- 2012