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1. A Novel, High-sensitivity, Bacteriophage-based Assay Identifies Low-level Mycobacterium tuberculosis Bacteremia in Immunocompetent Patients With Active and Incipient Tuberculosis.

Author

Verma R, Swift BMC, Handley-Hartill W, Lee JK, Woltmann G, Rees CED, and Haldar P

Subjects
Animals, Humans, Bacteremia diagnosis, Bacteriophages, Mycobacterium tuberculosis, Tuberculosis, Tuberculosis, Pulmonary diagnosis
Abstract

The haematogenous dissemination of Mycobacterium tuberculosis (Mtb) is critical to the pathogenesis of progressive tuberculous infections in animal models. Using a novel, phage-based blood assay, we report the first concordant evidence in well-characterized, immunocompetent human cohorts, demonstrating associations of Mtb bacteremia with progressive phenotypes of latent infection and active pulmonary tuberculosis., (© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)

Published
2020
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