1. Early impairment of insulin secretion in rats after surgical trauma
- Author
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Lisa Strömmer, Malin Wickbom, Johan Permert, Claes-Göran Östenson, Urban Arnelo, Feng Wang, and Margery K. Herrington
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,In Vitro Techniques ,Arginine ,Islets of Langerhans ,chemistry.chemical_compound ,Endocrinology ,Insulin resistance ,Corticosterone ,Internal medicine ,Insulin Secretion ,Intestine, Small ,Animals ,Insulin ,Medicine ,Glucose homeostasis ,Rats, Wistar ,Digestive System Surgical Procedures ,Pancreatic hormone ,Glucose tolerance test ,medicine.diagnostic_test ,business.industry ,Pancreatic islets ,General Medicine ,Glucose Tolerance Test ,medicine.disease ,Pathophysiology ,Rats ,medicine.anatomical_structure ,chemistry ,business - Abstract
OBJECTIVE: Hyperglycaemia associated with insulin resistance is common after trauma and surgical procedures. Both reduced insulin sensitivity and altered insulin secretion may contribute to the impaired glucose homeostasis. We have demonstrated that skeletal muscle insulin resistance is present 2 h after small intestinal resection in rats. In this study, the aim was to investigate insulin secretion in the same experimental model. DESIGN: Small intestinal resection (5 cm) was performed in adult rats. The control animals underwent anaesthesia only. METHODS: The intravenous glucose tolerance test (IVGTT), the hyperglycaemic clamp and in vitro studies in isolated pancreatic islets were performed after surgery. Concentrations of blood glucose, plasma insulin, corticosterone and interleukin-6 (IL-6) were determined 0-5 h postoperatively. RESULTS: The insulin response in the IVGTT was attenuated 2 h (P
- Published
- 2002