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The rise of radical right-wing leaders, parties, movements, and ideas have transformed not only domestic political landscapes but also the direction and dynamics of international relations. Yet for all their emphasis on nationalist identity, on “America First” and “Taking Back Control,” there is an unmistakable international dimension to contemporary nationalist, populist movements. Yet these movements are also often transnationally linked. We argue that a constitutive part of this globality is the New Right's (NR) own distinctive international political sociology (IPS). Key thinkers of the contemporary NR have, over several decades, theorized and strategically mobilized globalized economic dislocation and cultural resentment, developing a coherent sociological critique of globalization. Drawing on the oft-neglected tradition of elite managerialism, NR ideologues have borrowed freely from Lenin and Schmitt on the power of enmity, as well as from Gramsci and the Frankfurt School on counterhegemonic strategies. Against the temptation to dismiss right-wing ideas as “merely” populist and by implication as lacking in ideological and theoretical foundations, we are faced with the much more challenging task of engaging a position that has already developed its own international political sociology and incorporated it into its political strategies.

Background and aimsPituitary apoplexy (PA) is a rare neurosurgical emergency, associated with deficiency of one or more pituitary hormones. Few studies have explored the relative outcomes associated with conservative and neurosurgical intervention.MethodsA retrospective evaluation of all patients with PA reviewed at Morriston Hospital was undertaken and diagnosis was obtained from Morriston database (Leicester Clinical Workstation database) between 1998 and 2019 from clinic letters and discharge summaries.ResultsThirty-nine patients with PA were identified with a mean age of 74.5 years and 20 (51.3%) patients were women. Patients were followed up for a mean±SD 68.1±61.7 months. Twenty-three (59.0%) patients had a known pituitary adenoma. Commoner clinical presentations of PA were ophthalmoplegia or visual field loss. Following PA, 34 (87.2%) patients were noted to have a non-functioning pituitary adenoma (either pre-existing or new), while 5 (12.8%) patients had a pre-existing functional macroadenoma. Neurosurgical intervention was taken in 15 (38.5%) patients of which 3 (20.0%) patients also received radiotherapy, 2 (13.3%) patients had radiotherapy alone and the remainder managed conservatively. External ophthalmoplegia recovered in all cases. Visual loss remained in all cases. One (2.6%) patient with chromophobe adenoma had a significant second episode of PA requiring repeat surgery.ConclusionPA often occurs in patients with undiagnosed adenoma. Hypopituitarism commonly occurred following conservative or surgical treatment. External ophthalmoplegia resolved in all cases, however, visual loss did not recover. Pituitary tumour recurrence and further PA episodes are rare.

Many readers of International Affairs will be familiar with Tarak Barkawi’s frequent skewering of IR theories and debates, from his demolition of liberal peace and so-called “schools” of critical security studies to his elevation of empire and critical war studies. In each intervention, Barkawi engaged directly with core IR debates and ruthlessly exposed their flawed premises, establishing a new agenda for research in the process. In doing so, he has shaped at least two generations of IR scholarship. The influence of Soldiers of empire could be of a totally different order. It will come less from the book’s main arguments than the quality of the scholarship and style of intellectual engagement. This book, Soldiers of empire, delivers on something far more urgent than a new agenda for research. It is a yardstick for those in our field interested in producing scholarship that is critical, but also of real substance and originality. That is, work that is historically rich, theoretically engaged, well-written, multi-and inter-disciplinary, and pays no heed whatsoever to the debilitating distinctions between IR subfields. However, as one would expect of a book of real substance, there are problems that will limit its intellectual reach. In this review forum, I focus on two.

Edwardsiella andrillae is a sea anemone (Cnidaria: Anthozoa: Actiniaria) only known to live embedded in the ice at the seawater interface on the underside of the Ross Ice Shelf, Antarctica. Although the anatomy and morphological characteristics of E. andrillae have been described, the adaptations of this species to the under-ice ecosystem have yet to be examined. One feature that may be important to the physiology and ecology of E. andrillae is its microbiome, which may play a role in health and survival, as has been deduced in other metazoans, including anthozoans. Here we describe the microbiome of five specimens of E. andrillae, compare the diversity we recovered to that known for temperate anemones and another Antarctic cnidarian, and consider the phylogenetic and functional implications of microbial diversity for these animals. The E. andrillae microbiome was relatively low in diversity, with seven phyla detected, yet included substantial phylogenetic novelty. Among the five anemones investigated, the distribution of microbial taxa varied; this trait appears to be shared by many anthozoans. Most importantly, specimens either appeared to be dominated by Proteobacteria-affiliated members or by deeply branching Tenericute sequences. There were few closely related sequence types that were common to temperate and Antarctic sea anemone microbiomes, the exception being an Acinetobacter-related representative. Similar observations were made between microbes associated with E. andrillae and an Antarctic soft coral; however, there were several closely-related, low abundance Gammaproteobacteria in both Antarctic microbiomes, particularly from the soft coral, that are also commonly detected in Southern Ocean seawater. Although this preliminary study leaves open many questions concerning microbiome diversity and its role in host ecology, we identify major lineages of microbes (e.g., diverse deep-branching Alphaproteobacteria, Epsilonproteobacteria, and divergent Tenericutes affiliates) that may play critical roles, and we highlight the current understanding and the need for future studies of sea anemone-microbiome relationships.

Objectives Primary mucinous adenocarcinoma of the skin is a rare clinical entity derived primarily from sweat glands with reported sites mainly arising from the head and neck region. Difficulty then arises with distinguishing between these primary neoplasms and those with similar morphology in the breast and/or gastrointestinal tract. Presentation of Case We report a case of an 85-year-old female with a past medical history of endometrial cancer presenting to clinic with a slow-growing right temporal lesion that was excised and diagnosed as primary mucinous adenocarcinoma. Further clinical workup and imaging revealed an oral lesion diagnosed as squamous cell carcinoma after excision along with an enhancing right breast mass with biopsy and excision showing an invasive ductal carcinoma with papillary and micropapillary features. This unusual presentation of more than two malignancies provides a challenge to differentiate between primary versus metastatic disease, especially with a rare malignancy that is present. Discussion A review of the literature on primary mucinous adenocarcinoma of the skin is presented, discussing epidemiology, clinical presentation, morphology, and immunohistochemistry sets historically studied to aid in diagnosis, with our case relying on morphology to finalize our diagnosis. Conclusion This unusual case highlights the difficulty in differentiating between primary versus metastatic mucinous adenocarcinoma yet highlights the value of morphology to aid in arriving at a diagnosis to help guide correct clinical treatment and follow-up.

The identification of genetic variants responsible for behavioral variation is an enduring goal in biology, with wide-scale ramifications, ranging from medical research to evolutionary theory on personality syndromes. Here, we use for the first time a large-scale genetical genomics analysis in the brains of chickens to identify genes affecting anxiety as measured by an open field test. We combine quantitative trait locus (QTL) analysis in 572 individuals and expression QTL (eQTL) analysis in 129 individuals from an advanced intercross between domestic chickens and Red Junglefowl. We identify 10 putative quantitative trait genes affecting anxiety behavior. These genes were tested for an association in the mouse Heterogeneous Stock anxiety (open field) data set and human GWAS data sets for bipolar disorder, major depressive disorder, and schizophrenia. Although comparisons between species are complex, associations were observed for four of the candidate genes in mice and three of the candidate genes in humans. Using a multimodel approach we have therefore identified a number of putative quantitative trait genes affecting anxiety behavior, principally in chickens but also with some potentially translational effects as well. This study demonstrates that chickens are an excellent model organism for the genetic dissection of behavior.

In Drosophila, the monoamine octopamine, through mechanisms that are not completely understood, regulates both aggression and mating behavior. Interestingly, our study demonstrates that the Drosophila obesity-linked homologs Transcription factor AP-2 (TfAP-2; TFAP2B in humans) and Tiwaz (Twz; KCTD15 in humans) interact to modify male behavior by controlling the expression of Tyramine β-hydroxylase and Vesicular monanime transporter, genes necessary for octopamine production and secretion. Furthermore, we reveal that octopamine in turn regulates aggression through the Drosophila cholecystokinin satiation hormone homolog Drosulfakinin (Dsk). Finally, we establish that TfAP-2 is expressed in octopaminergic neurons known to control aggressive behavior and that TfAP-2 requires functional Twz for its activity. We conclude that genetically manipulating the obesity-linked homologs TfAP-2 and Twz is sufficient to affect octopamine signaling, which in turn modulates Drosophila male behavior through the regulation of the satiation hormone Dsk.

Jennifer M. Bean (ed.), Flickers of Desire: Movie Stars of the 1910s (Star Decades Series). New Brunswick, NJ: Rutgers University Press, 2011, 297 pp. Mark Lynn Anderson, Twilight of the Idols: Hollywood and the Human Sciences in 1920s America. Berkeley, CA: University of California Press, 2011, 223 pp.

Seasonal influenza causes excess morbidity and mortality at the extremes of age: It disproportionately affects the very young and the very old, typically resulting in "U"-shaped age-distributed curves. By means of a well-established public health department surveillance system using positive influenza tests submitted from sentinel sites, the authors generated annual influenza-specific morbidity curves over a 10-year period (1998-2008) for St. Louis County, Missouri. The authors detected an unusually high incidence of cases of medically attended test-positive influenza, particularly in young adults, during the 2007-2008 season, resulting in an unexpected "W"-shaped age-distributed morbidity curve that was distinctly unique in comparison with the prior 9 influenza seasons. Public health influenza surveillance programs are useful tools for detecting emerging epidemiologic trends that may have clinical importance.

Drusen are small focal extracellular deposits underneath the retina, visible ophthalmoscopically as yellow dots. The more hard drusen there are, the greater the risk of developing soft drusen and retinal pigmentary changes, which in turn increase the risk of developing advanced age-related macular degeneration. Much remains to be discovered about drusen. For the patient with drusen, basic advice on diet and smoking and maintenance of a high level of vigilance for visual changes is appropriate management. © The Author 2009. Published by Oxford University Press [on behalf of the British Geriatrics Society]. All rights reserved.

To date, most discussion of security privatization in international politics has been focused on the role of private military companies and mercenaries. This article seeks to shift the focus away from the battlefields and toward the less spectacular privatization and globalization of commercial private security. Drawing on Saskia Sassen’s notion of state ‘‘disassembly,’’ we situate the growth of private security within broader shifts in global governance. Pointing to the weakness of seeing the rise of private security as an erosion of state power and authority, we show instead a re-articulation of the public ⁄private and global ⁄local distinctions and relationships into what we term ‘‘global security assemblages.’’ Analyzing the role of private security in two such assemblages in Sierra Leone and Nigeria, we show how a range of different security agents and normativities interact, cooperate and compete, to produce new institutions, practices and forms of security governance. Global security assemblages thus mark important developments in the relationship between security and the sovereign state, structures of political power and authority, and the operations of global capital. Spurred by the apparent return of mercenary activities in Africa at the end of the Cold War, and given further impetus and urgency by the substantial involvement of private military contractors in Afghanistan and Iraq, the privatization of security has become one of the most controversial issues in contemporary international politics. Once obscure companies such as Blackwater, Triple Canopy, and Erinys have joined with tales of ‘‘neo-mercenaries’’ like Executive Outcomes in Sierra Leone and Simon Mann’s attempted coup in Equatorial Guinea in 2004, to become the focus of widespread journalistic coverage, increasingly sophisticated scholarly analysis, as well as popular books, entertainment and Hollywood films. Yet the privatization of security and its consequences go well beyond the activities of the private soldier. Away from the battlefields, in the day-to-day activities of ordinary life, private security has also become ubiquitous. Less spectacular than the ‘‘return of the dogs of war,’’ commercial private security activities, ranging from manned guarding and alarm installation, to risk analysis and surveillance, have expanded at a phenomenal rate. Worldwide, the commercial private security market is now valued at $165 billion, and its growth is forecast to continue at an annual rate of 8% for the foreseeable future (Securitas 2007). Indeed, what was once described as a ‘‘quiet revolution’’ in security provision has become global in scope (Shearing and Stenning 1981).

A response to Sosa's criticisms of Sellars's account of the relation between knowledge and experience, noting that Sellars excludes merely animal knowledge, and hopes to bypass epistemology by an adequate philosophy of mind and language.

Aims To determine the effects on homocysteine levels of two doses of folic acid compared to placebo, where the high dose is typical of that provided by pharmacological intervention and the low dose approximates that provided by dietary supplementation. Methods and results The PACIFIC study was a double-blind, placebo-controlled, factorial randomized trial. Seven hundred and twenty-three individuals with a history of myocardial infarction or unstable angina were recruited from 28 clinical cardiology centres in Australia and New Zealand and randomized to folic acid 2.0 mg daily, folic acid 0.2 mg daily or placebo. The primary outcome, homocysteine, was measured using a fluorescence polarization immunoassay. Compared to placebo, 2.0 mg folic acid reduced homo-cysteine by 1.8 micromol x 1(-1) [95% confidence interval (CI) 1.3-2.3] and 0.2 mg reduced homocysteine by 1.2 micromol x 1(-1) [95% CI 0.8-1.7). The higher dose reduced homocysteine significantly more than the lower dose (P=001). Conclusions Both doses of folic acid reduced homocysteine, but the effects of the 2.0 mg dose were about one third greater than the 0.2 mg dose. Fortification of foods with folic acid should result in population-wide lower levels of homocysteine but high-dose pharmacological supplementation would produce greater reductions for high-risk individuals.

We performed a prospective, community-based evaluation of molecular typing of Mycobacterium tuberculosis isolates as a method for tuberculosis (TB) control. We performed restriction fragment-length polymorphism (RFLP) analysis of the insertion sequences IS6110 and pTBN12 for isolates recovered from 61 of 62 patients with culture-positive TB in St. Louis during 12 months. Twenty-four (39%) of the 61 patients were infected with an isolate with an RFLP pattern that was shared with >/=1 other isolate, and 11 (46%) also had epidemiologic links with patients in their cluster of cases. One case each of laboratory cross-contamination and occupational transmission were discovered. The patients in clusters were more likely to be younger, black, United States-born, to have substance abuse problems, and to live in poorer areas. A predictive algorithm for molecular identification of clusters had a sensitivity and a specificity of 75%. This study allowed the TB-control program in St. Louis to be redirected toward the affected subpopulations.

Economic orthodoxy has but a minimal interest in methodology. Heterodoxy is suspicious of dialectics. As exemplified recently in a book by John Rosenthal, even Marxism likes to eschew the notion of any more than a residual Hegelian influence in Marx and Marxist discourse. Bouncing off Rosenthal's argument, this paper argues for the legitimacy of a pragmatic post-Hegelian method for critical political economy. Copyright 2001 by Oxford University Press.

During 1994-1996, Shigella sonnei outbreaks occurred in 8 North American traditionally observant Jewish communities. These communities remain relatively separate from neighboring populations while maintaining close contact by travel with coreligionists in other cities. Epidemiologic investigations suggested community-to-community transmission via travel. Outbreak-related and control isolates of S. sonnei from each city were subtyped by pulsed-field gel electrophoresis (PFGE) to confirm an epidemiologic linkage between outbreaks. Forty-three (94%) of 46 outbreak-related isolates had closely related PFGE patterns, constituting a single subtype; 33 (94%) of 35 control isolates demonstrated unrelated PFGE patterns. Several patterns differing by < or = 3 bands were identified within the outbreak subtype; one of these accounted for 65% of outbreak isolates. Hence, a single subtype of S. sonnei caused an international outbreak involving 8 traditionally observant Jewish communities, but not neighboring populations, over a 2-year period, suggesting sustained propagation of the epidemic strain between communities.

Reinstating the dialectic in Marx's account of capitalism is argued to be the best way of maintaining its coherence after the Sraffian critique. The key to this involves purging any reliance upon any autonomous labor-value substructure underlying prices and money. It is shown that adopting this approach opens up rich possibilities for interpretation of contemporary developments such as the increasing dominance of the monetary and financial sectors, and the two decades of liberalization of labor markets. The paper focuses on the appropriate conceptualization of money and labor-power, arguing against the modern classical approach of W. Dixon and G. Kay (1995). Copyright 1998 by Oxford University Press.

Background Echinocandins are an important class of antifungal agents in the treatment of invasive candidiasis. However, little is known about the metabolomic effects of echinocandins on Candida . We therefore performed LC-high-resolution MS (LC-HRMS)-based metabolomics profiling of the response of Candida albicans cells to increasing concentrations of micafungin to determine the metabolic response of Candida to micafungin subinhibitory injury. Methods Isolates of C. albicans were cultured on nitrocellulose filters to mid-logarithmic phase of growth and micafungin (0-0.25 mg/L) was added. At mid-logarithmic phase, replicates were metabolically quenched. Intracellular metabolites were analysed by LC-HRMS. Changes in pool sizes of individual metabolites were analysed by Student's t -test adjusted for multiple hypothesis testing by Benjamini-Hochberg correction. Metabolites were ascribed by the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways database. Results Among 3446 detected metabolites, 204 were identified by comparison against pure standard or comparison against a library of mass-retention-time pairs. Fifty had significantly altered abundances in response to increasing micafungin concentrations. Pool sizes of amino acids, nucleic acids and polyamine metabolism were significantly increased at subinhibitory concentrations, while exposure to inhibitory concentrations resulted in a precipitous decrease consistent with fungicidal activity. Conclusions Micafungin induces a re-routing of metabolic pathways inhibiting protein synthesis and cell replication. These results shed light on new mechanisms of action of echinocandins.

This study identified malingering strategies of test performance and investigated their presence in the responses to computer-mediated versions of Rey's Dot-Counting and 15-Items tests, a forced-choice symptom validity procedure and the Memory Assessment Scales (MAS). Sixty volunteer subjects were randomly assigned to control (n = 30) or malingering (n = 30) groups. The control subjects were instructed to perform their best and the malingerers were instructed to fake a poor performance on the tests. As expected, malingering subjects scored significantly worse than control subjects on virtually all tests. Malingerers had slower response times on most tests. They also performed worse on recognition tasks in contrast to performance on recall tasks. Their response style was characterized by intentional wrong and random responding on recognition tasks. Malingerers did not show the expected worse-than-chance responding on the forced-choice symptom validity procedure. Current tests of symptom validity may not have sufficient sensitivity to detect milder forms of malingering.

Compared ratings of everyday cognitive functioning made by parents of leukemic children to ratings made by parents of normal control and learning disabled (LD) children. The leukemic children had been randomly assigned to one of two CNS prophylaxis treatments, one including cranial irradiation and intrathecal methotrexate and another including only intrathecal methotrexate and intermediate dose infusions of methotrexate. Leukemic children were rated significantly worse than controls in areas related to schooling and academic skills. The type of CNS prophylaxis was not discriminated by parent ratings. LD children were rated as significantly worse than either of the two groups in all areas of cognitive functioning. Leukemic and LD children were both rated as having poor academic skills. Leukemic children missed significantly more school than control and LD children, and their poor ratings on academic skills were partially attributed to academic deprivation. These results suggest that studies should control for academic deprivation when evaluating the neuropsychological outcome of CNS prophylactic treatment and that reintegration and normalization programs should be designed to address the intellectual problems resulting from missed academic experiences.

By adopting a monetary approach with no reference to any substratum of value substance preexisting monetary exchange, the key to capitalism's form-determined interconnectedness is revealed. The concrete existence of the value-form is in money--in a ll its contingent physical manifestations. Valorization is founded in t he peculiarities of the wage relation, such that labor-power is not a commodity but a universal capacity created outside the capitalist labor-process and, therefore, potentially the sole necessary factor of valorization. This potential is grounded in successful entrepreneuri al behavior, ensuring that value-added is not exhausted by labor costs. Copyright 1992 by Oxford University Press.

The field of security studies has been the subject of considerable debate in recent years. Attempts to broaden and deepen the scope of the field beyond its traditional focus on states and military conflict have raised fundamental theoretical and practical issues. Yet, adherents to the prevailing neorealist approach to security studies have often reacted to these challenges in ways that preclude a recognition of the issues raised by alternative understandings. An examination of the debates over "rethinking security" in particular reveals an unfortunate tendency to foreclose debate between scholars taking critical and neorealist approaches. Coming to terms more fully with the foundations of these debates allows both a better view of the positions within the field and a clearer assessment of their relevance for understanding the dynamics of contemporary security.

Pyruvate dehydrogenase complex is associated with intact chloroplasts and mitochondria of 9-day-old Pisum sativum L. seedlings. The ratio of the mitochondrial complex to the chloroplast complex activities is about 3 to 1. Maximal rates observed for chloroplast pyruvate dehydrogenase complex activity ranged from 6 to 9 micromoles of NADH produced per milligram of chlorophyll per hour. Osmotic rupture of pea chloroplasts released 88% of the complex activity, indicating that chloroplast pyruvate dehydrogenase complex is a stromal complex. The pH optimum for chloroplast pyruvate dehydrogenase complex was between 7.8 and 8.2, whereas the mitochondrial pyruvate dehydrogenase complex had a pH optimum between 7.3 and 7.7. Chloroplast pyruvate dehydrogenase complex activity was specific for pyruvate, dependent upon coenzyme A and NAD and partially dependent upon Mg(2+) and thiamine pyrophosphate.Chloroplast-associated pyruvate dehydrogenase complex provides a direct link between pyruvate metabolism and chloroplast fatty acid biosynthesis by providing the substrate, acetyl-CoA, necessary for membrane development in young plants.

The observations made by family members of cognitive impairment and decline serve an important role in the description of dementia-related illnesses such as Alzheimer's disease. A common clinical practice is to interview the family and informally gather information about the severity and history of intellectual impairment such as memory disorder and aphasia. The present study introduces a method to formalize this information gathering using an inventory that allows a family member to rate the presence and severity of the everyday manifestations of dementia. Results of initial psychometric studies of the rating scale indicate that a family member can make reliable judgments of everyday cognitive impairment. Observer ratings such as these should significantly enhance diagnostic efforts when they are used in conjunction with neuropsychological tests and in cases in which the demented person cannot participate in a full neuropsychological evaluation.

The metabolic fate of l-[4- 14 C]ascorbic acid has been examined in the grape ( Vitis labrusca L.) and lemon geranium ( Pelargonium crispum L. L9Her. cv. Prince Rupert) under conditions comparable to data from l-[1- 14 C]ascorbic acid and l-[6- 14 C]ascorbic acid experiments. In detached grape leaves and immature berries, l-[4- 14 C]ascorbic acid and l-[1- 14 C]ascorbic acid were equivalent precursors to carboxyl labeled (+)-tartaric acid. In geranium apices, l-[4- 14 C]ascorbic acid yielded internal labeled (+)-tartaric acid while l-[6- 14 C]ascorbic acid gave an equivalent conversion to carboxyl labeled (+)-tartaric acid. These findings clearly show that two distinct processes for the synthesis of (+)-tartaric acid from l-ascorbic acid exist in plants identified as (+)-tartaric acid accumulators. In grape leaves and immature berries, (+)-tartaric acid synthesis proceeds via preservation of a four-carbon fragment derived from carbons 1 through 4 of l-ascorbic acid while carbons 3 through 6 yield (+)-tartaric acid in geranium apices.