1. COVID-19 infection and renal injury: where is the place for acute interstitial nephritis disease?
- Author
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León-Román, Juan, Agraz, Irene, Vergara, Ander, Ramos, Natalia, Toapanta, Nestor, García-Carro, Clara, Gabaldón, Alejandra, Bury, Roxana, Bermejo, Sheila, Bestard, Oriol, and Soler, María José
- Subjects
COVID-19 ,INTERSTITIAL nephritis ,SARS-CoV-2 ,COVID-19 pandemic ,ACUTE kidney failure ,VIRAL tropism - Abstract
Novel coronavirus disease infection (coronavirus disease 2019, COVID-19) was declared a global pandemic in March 2020 and since then has become a major public health problem. The prevalence of COVID-19 infection and acute kidney injury (AKI) is variable depending on several factors such as race/ethnicity and severity of illness. The pathophysiology of renal involvement in COVID-19 infection is not entirely clear, but it could be in part explained by the viral tropism in the kidney parenchyma. AKI in COVID-19 infection can be either by direct invasion of the virus or as a consequence of immunologic response. Diverse studies have focused on the effect of COVID-19 on glomerulonephritis (GN) patients or the 'novo' GN; however, the effect of COVID-19 in acute tubulointerstitial nephritis (ATIN) has been scarcely studied. In this article, we present five cases with different spectrums of COVID-19 infection and ATIN that may suggest that recent diagnosis of ATIN is accompanied by a worse clinical prognosis in comparison with long-term diagnosed ATIN. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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