Search

Your search keyword '"Aldoshin SM"' showing total 8 results
Start Over Author "Aldoshin SM" Publisher pleiades publishing
8 results on '"Aldoshin SM"'

1. Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro.

Author

Faingold II, Kotelnikova RA, Smolina AV, Poletaeva DA, Soldatova YV, Pokidova OV, Sadkov AP, Sanina NA, and Aldoshin SM

Subjects
Animals, Mice, Monoamine Oxidase metabolism, Brain enzymology, Electron Transport Complex IV antagonists & inhibitors, Electron Transport Complex IV metabolism, Iron chemistry, Iron pharmacology, Mitochondria enzymology, Mitochondrial Proteins antagonists & inhibitors, Mitochondrial Proteins metabolism, Monoamine Oxidase Inhibitors chemical synthesis, Monoamine Oxidase Inhibitors chemistry, Monoamine Oxidase Inhibitors pharmacology, Nitrogen Oxides chemical synthesis, Nitrogen Oxides chemistry, Nitrogen Oxides pharmacology, Thiosulfates chemical synthesis, Thiosulfates chemistry, Thiosulfates pharmacology
Abstract

The antioxidant and antiradical properties of the tetra nitrosyl iron complex with thiosulfate ligands (TNIC) were studied in vitro in mouse brain homogenates. It was found for the first time that TNIC is an effective antioxidant. The effect of TNIC on the catalytic activity of mitochondrial enzymes cytochrome c oxidase and monoamine oxidase A was studied. It was shown for the first time that TNIC is an inhibitor of the catalytic activity of cytochrome c oxidase and monoamine oxidase A in animal brain mitochondria in vitro.

Published
2019
Full Text
View/download PDF

2. Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets.

Author

Soldatova YV, Kotelnikova RA, Zhilenkov AV, Faingold II, Troshin PA, Kozlova MA, Areshidze DA, and Aldoshin SM

Subjects
Aldehyde Reductase metabolism, Animals, Drug Evaluation, Preclinical, L-Iditol 2-Dehydrogenase metabolism, Mice, Aldehyde Reductase chemistry, Diabetes Mellitus, Experimental drug therapy, Diabetes Mellitus, Type 2 drug therapy, Hypoglycemic Agents chemistry, L-Iditol 2-Dehydrogenase chemistry
Abstract

It was shown for the first time that pentaamino acid derivative of fullerene C 60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.

Published
2019
Full Text
View/download PDF

3. Anticancer Activity of Dinitrosyl Iron Complex (NO Donor) on the Multiple Myeloma Cells.

Author

Akentieva NP, Sanina NA, Prichodchenko TR, Gizatullin AR, Shkondina NI, Shushanov SS, Stupina TS, and Aldoshin SM

Subjects
Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Humans, Reactive Oxygen Species metabolism, Antineoplastic Agents pharmacology, Iron pharmacology, Multiple Myeloma pathology, Nitrogen Oxides pharmacology
Abstract

The results of the study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donors) on the viability of multiple myeloma cells are presented. It was shown that DNIC7 decreased cell viability and inhibited the proliferation of multiple myeloma cells, i.e., exhibits cytotoxic properties. Fluorescent analysis showed that the DNIC7 compound decreases the level of intracellular glutathione and increases the level of reactive oxygen species in multiple myeloma cells. It is assumed that DNIC7 has a therapeutic potential for the treatment of cancer.

Published
2019
Full Text
View/download PDF

4. Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts.

Author

Gizatullin AR, Akentieva NP, Sanina NA, Shmatko NY, Goryachev NS, Shkondina NI, Prichodchenko TR, Zhelev N, and Aldoshin SM

Subjects
Cardiovascular Diseases drug therapy, Cardiovascular Diseases metabolism, Cardiovascular Diseases pathology, Cell Survival drug effects, Fibroblasts pathology, Humans, Lung pathology, Fibroblasts metabolism, Iron pharmacology, Lung metabolism, Membrane Potential, Mitochondrial drug effects, Nitric Oxide Donors pharmacology, Nitrogen Oxides pharmacology
Abstract

The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

Published
2018
Full Text
View/download PDF

5. The inhibitory effect of dinitrosyl iron complexes (NO donors) on myeloperoxidase activity.

Author

Akentieva NP, Sanina NA, Gizatullin AR, Shmatko NY, Goryachev NS, Shkondina NI, Prikhodchenko TR, and Aldoshin SM

Subjects
Animals, Cell Adhesion drug effects, Cells, Cultured, Enzyme Activation drug effects, Myocytes, Cardiac enzymology, Rats, Iron pharmacology, Myocytes, Cardiac drug effects, Nitrogen Oxides pharmacology, Peroxidase antagonists & inhibitors, Peroxidase metabolism
Abstract

The effect of synthetic analogues of dinitrosyl mononuclear iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the activity of myeloperoxidase (MPO) was studied, and their efficiency was evaluated. It was shown that the enzyme MPO is the molecular target of DNICs. It was found that six DNICs inhibited the activity of MPO and one compound potentiated it. The evaluation of their efficiency showed that two DNICs effectively inhibited the activity of MPO by 50% at IC 50 = 2 × 10 -4 M and IC 50 = 5 × 10 -7 M.

Published
2017
Full Text
View/download PDF

6. Reversible NO-catalyzed destruction of the Fe-S cluster of the FNR[4Fe-4S]²+ transcription factor: a way to regulate the aidB gene activity in Escherichia coli cells cultured under anaerobic conditions.

Author

Vasilieva SV, Strel'tsova DA, Moshkovskaya EY, Vanin AF, Mikoyan VD, Sanina NA, and Aldoshin SM

Subjects
Anaerobiosis genetics, Catalysis, Dithiothreitol pharmacology, Escherichia coli drug effects, Escherichia coli growth & development, Iron metabolism, Sulfur metabolism, Transcription Factors chemistry, Transcription Factors metabolism, Escherichia coli genetics, Escherichia coli metabolism, Escherichia coli Proteins chemistry, Escherichia coli Proteins genetics, Escherichia coli Proteins metabolism, Gene Expression Regulation, Bacterial drug effects, Iron-Sulfur Proteins chemistry, Iron-Sulfur Proteins metabolism, Nitric Oxide metabolism
Published
2010
Full Text
View/download PDF

7. Fnr[4Fe-4S](2+) protein regulates the aidB gene expression in Escherichia coli cultured under anaerobic conditions.

Author

Vasilieva SV, Streltsova DA, Moshkovskaya EY, Sanina NA, and Aldoshin SM

Subjects
Anaerobiosis physiology, Computer Simulation, Escherichia coli metabolism, Escherichia coli Proteins metabolism, Gene Expression Regulation, Bacterial physiology, Iron-Sulfur Proteins metabolism, Models, Biological, Oxygen metabolism, Signal Transduction physiology
Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results