1. Human placental perfusion measured using dynamic contrast enhancement MRI.
- Author
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Deloison, Benjamin, Arthuis, Chloé, Benchimol, Gabriel, Balvay, Daniel, Bussieres, Laurence, Millischer, Anne-Elodie, Grévent, David, Butor, Cécile, Chalouhi, Gihad, Mahallati, Houman, Hélénon, Olivier, Tavitian, Bertrand, Clement, Olivier, Ville, Yves, Siauve, Nathalie, and Salomon, Laurent Julien
- Subjects
PLACENTA ,MAGNETIC resonance imaging ,PERFUSION ,ABORTION ,BLOOD flow ,GESTATIONAL age - Abstract
Objectives: To evaluate the feasibility of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and measure values of in vivo placental perfusion in women. Methods: This study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enhanced dynamic MRI was performed two days before termination of pregnancies at 16 to 34 weeks gestational age (GA). Quantitative analysis was performed using one-compartment intravascular modeling. DCE perfusion parameters were analyzed across GA and were compared in IUGR and AGA fetuses. Results: 134 patients were enrolled. After quality control check, 62 DCE MRI were analyzed including 48 and 14 pregnancies with normal and abnormal karyotypes, respectively. Mean placental blood flow was 129±61 mL/min/100ml in cases with normal karyotypes. Fetuses affected by IUGR (n = 13) showed significantly lower total placental blood flow values than AGA fetuses (n = 35) (F
total = 122±88 mL/min versus 259±34 mL/min, p = 0.002). DCE perfusion parameters showed a linear correlation with GA. Conclusions: Measuring placental perfusion in vivo is possible using DCE MRI. Although this study has many limitations it gives us the first DCE MRI values that provide a potential standard for future research into placental perfusion methods and suggests that placental functional parameters are altered in IUGR pregnancies. [ABSTRACT FROM AUTHOR]- Published
- 2021
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