Search

Your search keyword '"Adams, Emily R"' showing total 16 results
Start Over Author "Adams, Emily R" Publisher public library of science (plos)
16 results on '"Adams, Emily R"'

3. Diagnostic performance of GENEDIA W and ActiveXpress+ COVID-19 antigens tests among symptomatic individuals in Peru and The United Kingdom

Author

Palomino-Padilla, Sandra, Finch, Lorna, de Vos, Margaretha, Savage, Helen Rose, Villa-Castillo, Luz, Hayward, Gail, Cook, Eloïse, Escadafal, Camille, Body, Richard, Adams, Emily R., Ugarte-Gil, Cesar, and Cubas Atienzar, Ana Isabel

Subjects
COVID-19 Testing, Multidisciplinary, Peru, Humans, Prospective Studies, COVID-19, SARS-CoV-2, United Kingdom
Abstract

Objectives In order to generate independent performance data regarding accuracy of COVID-19 antigen-based rapid diagnostic tests (Ag-RDTs), prospective diagnostic evaluation studies across multiple sites are required to evaluate their performance in different clinical settings. This report describes the clinical evaluation the GENEDIA W COVID-19 Ag Device (Green Cross Medical Science Corp., Chungbuk, Korea) and the ActiveXpress+ COVID-19 Complete Testing Kit (Edinburgh Genetics Ltd, UK), in two testing sites Peru and the United Kingdom. Methods Nasopharyngeal swabs collected from 456 symptomatic patients at primary points of care in Lima, Peru and 610 symptomatic participants at a COVID-19 Drive-Through testing site in Liverpool, England were analyzed by Ag-RDT and compared to RT-PCR. Analytical evaluation of both Ag-RDTs was assessed using serial dilutions of direct culture supernatant of a clinical SARS-CoV-2 isolate from the B.1.1.7 lineage. Results For GENEDIA brand, the values of overall sensitivity and specificity were 60.4% [95% CI 52.4–67.9%], and 99.2% [95% CI 97.6–99.7%] respectively; and for Active Xpress+ the overall values of sensitivity and specificity were 66.2% [95% CI 54.0–76.5%], and 99.6% [95% CI 97.9–99.9%] respectively. The analytical limit of detection was determined at 5.0 x 102 pfu/ml what equals to approximately 1.0 x 104 gcn/ml for both Ag-RDTs. The UK cohort had lower median Ct values compared to that of Peru during both evaluations. When split by Ct, both Ag-RDTs had optimum sensitivities at Ct Conclusions Whilst the overall clinical sensitivity of the Genedia did not meet WHO minimum performance requirements for rapid immunoassays in either cohort, the ActiveXpress+ did so for the small UK cohort. This study illustrates comparative performance of Ag-RDTs across two global settings and considers the different approaches in evaluation methods.

Published
2023

4. Longitudinal profile of antibody response to SARS-CoV-2 in patients with COVID-19 in a setting from Sub–Saharan Africa: A prospective longitudinal study

Author

Gebrecherkos, Teklay, primary, Kiros, Yazezew Kebede, additional, Challa, Feyissa, additional, Abdella, Saro, additional, Gebreegzabher, Atsbeha, additional, Leta, Dereje, additional, Desta, Abraham, additional, Hailu, Ataklti, additional, Tasew, Geremew, additional, Abdulkader, Mahmud, additional, Tessema, Masresha, additional, Tollera, Getachew, additional, Kifle, Tsigereda, additional, Arefaine, Zekarias Gessesse, additional, Schallig, Henk HDF, additional, Adams, Emily R., additional, Urban, Britta C., additional, de Wit, Tobias F. Rinke, additional, and Wolday, Dawit, additional

Published
2022
Full Text
View/download PDF

5. Prevalence of neutralising antibodies against SARS-CoV-2 in acute infection and convalescence: A systematic review and meta-analysis

Author

Savage, Helen R., primary, Santos, Victor S., additional, Edwards, Thomas, additional, Giorgi, Emanuele, additional, Krishna, Sanjeev, additional, Planche, Timothy D., additional, Staines, Henry M., additional, Fitchett, Joseph R. A., additional, Kirwan, Daniela E., additional, Cubas Atienzar, Ana I., additional, Clark, David J., additional, Adams, Emily R., additional, and Cuevas, Luis E., additional

Published
2021
Full Text
View/download PDF

7. Epidemiology of dengue fever in Guatemala

Author

Castillo Signor, Leticia del Carmen, primary, Edwards, Thomas, additional, Escobar, Luis E., additional, Mencos, Yolanda, additional, Matope, Agnes, additional, Castaneda-Guzman, Mariana, additional, Adams, Emily R., additional, and Cuevas, Luis E., additional

Published
2020
Full Text
View/download PDF

8. Assessing expanded community wide treatment for schistosomiasis: Baseline infection status and self-reported risk factors in three communities from the Greater Accra region, Ghana

Author

Cunningham, Lucas J., primary, Campbell, Suzy J., additional, Armoo, Samuel, additional, Koukounari, Artemis, additional, Watson, Victoria, additional, Selormey, Pamela, additional, Stothard, J. Russell, additional, Idun, Bright, additional, Asiedu, Manfred, additional, Ashong, Yvonne, additional, Adams, Emily R., additional, and Osei-Atweneboana, Mike Yaw, additional

Published
2020
Full Text
View/download PDF

9. Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates

Author

Bailey, Freddie, primary, Mondragon-Shem, Karina, additional, Haines, Lee Rafuse, additional, Olabi, Amina, additional, Alorfi, Ahmed, additional, Ruiz-Postigo, José Antonio, additional, Alvar, Jorge, additional, Hotez, Peter, additional, Adams, Emily R., additional, Vélez, Iván D., additional, Al-Salem, Waleed, additional, Eaton, Julian, additional, Acosta-Serrano, Álvaro, additional, and Molyneux, David H., additional

Published
2019
Full Text
View/download PDF

11. Expanding molecular diagnostics of helminthiasis: Piloting use of the GPLN platform for surveillance of soil transmitted helminthiasis and schistosomiasis in Ghana

Author

Cunningham, Lucas J., primary, Odoom, John, additional, Pratt, Deborah, additional, Boatemaa, Linda, additional, Asante-Ntim, Nana, additional, Attiku, Keren, additional, Banahene, Bismarck, additional, Osei-Atweneboana, Mike, additional, Verweij, Jaco J., additional, Molyneux, David, additional, Stothard, Russell J., additional, and Adams, Emily R., additional

Published
2018
Full Text
View/download PDF

13. Parasitological Confirmation and Analysis of Leishmania Diversity in Asymptomatic and Subclinical Infection following Resolution of Cutaneous Leishmaniasis

Author

Rosales-Chilama, Mariana, primary, Gongora, Rafael E., additional, Valderrama, Liliana, additional, Jojoa, Jimena, additional, Alexander, Neal, additional, Rubiano, Luisa C., additional, Cossio, Alexandra, additional, Adams, Emily R., additional, Saravia, Nancy G., additional, and Gomez, María Adelaida, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results