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Start Over Author "Ning, Juan" Publisher royal society of chemistry

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1. A DNA–Au nanomachine activated by dual types of biomarkers for multi-site imaging and gene silencing.

Author

Zhou, Yanmei, Li, Zhaoge, Wu, Tian, Ning, Juan, Hu, Guizhen, and Nie, Yamin

Subjects
*GENE silencing, *GENE therapy, *DNA adducts, *GOLD clusters
Abstract

A programmed DNA–Au nanomachine has been constructed to achieve in situ imaging of transmembrane glycoprotein MUC1 and cytoplasmic miRNA-21 and trigger gene silencing therapy. The results of MCF-7 cell-specific imaging and apoptosis experiments demonstrate that the nanomachine provides a valuable nanotheranostic platform for accurate multi-site imaging and intracellular gene silencing. [ABSTRACT FROM AUTHOR]

Published
2022
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