185 results on '"Spring, David R."'
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2. Site-selective peptide functionalisation mediated via vinyl-triazine linchpins.
3. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
4. A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction.
5. Chapter 2. The Application of Diversity-oriented Synthesis in Chemical Biology
6. Disulfide re-bridging reagents for single-payload antibody-drug conjugates.
7. Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy.
8. Identification of macrocyclic peptides which activate bacterial cylindrical proteases.
9. Peroxide-cleavable linkers for antibody–drug conjugates.
10. Non-internalising antibody–drug conjugates.
11. Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
12. All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
13. Development of small cyclic peptides targeting the CK2α/β interface.
14. Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability.
15. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction† †Electronic supplementary information (ESI) available: Computational methods and structure files, chemical synthesis, fluorescence polarization assays, crystallographic data. See DOI: 10.1039/c7cc05379g
16. Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes† †Electronic supplementary information (ESI) available: Synthetic protocols, 1H/13C NMR and HR mass spectra are provided. CCDC 1443618–1443620 and 1534812–1534815. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00964j Click here for additional data file. Click here for additional data file
17. Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst† †Dedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k Click here for additional data file
18. Stereocontrolled semi-syntheses of deguelin and tephrosin† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra. See DOI: 10.1039/c6ob02659a Click here for additional data file
19. Rapid and robust cysteine bioconjugation with vinylheteroarenes.
20. The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.
21. Chemical probes targeting the kinase CK2: a journey outside the catalytic box.
22. The role of chemical synthesis in developing RiPP antibiotics.
23. A dual-enzyme cleavable linker for antibody–drug conjugates.
24. Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs).
25. Site-selective modification strategies in antibody–drug conjugates.
26. Photocatalytic methods for amino acid modification.
27. Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck–Suzuki reaction† †Electronic supplementary information (ESI) available: Full experimental details, 1H and 13C NMR spectra and X-ray crystallographic data for compound 4d. CCDC 936207. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02547d Click here for additional data file. Click here for additional data file
28. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.
29. C(sp3)–H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection.
30. Efficient and selective antibody modification with functionalised divinyltriazines.
31. An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds.
32. General dual functionalisation of biomacromolecules via a cysteine bridging strategy.
33. Sulfatase-cleavable linkers for antibody-drug conjugates.
34. Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery.
35. Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.
36. Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.
37. Cleavable linkers in antibody–drug conjugates.
38. Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.
39. Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
40. Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction.
41. A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates.
42. Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking.
43. Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol.
44. Stapled peptides as a new technology to investigate protein–protein interactions in human platelets.
45. Second-generation CK2α inhibitors targeting the αD pocket.
46. Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1–42).
47. Specific inhibition of CK2α from an anchor outside the active site.
48. A new Pseudomonas quinolone signal (PQS) binding partner: MexG.
49. A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds.
50. Peptide stapling techniques based on different macrocyclisation chemistries.
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