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Gold surfaces were molecularly tailored with a saccharide binding motif capable of covalently adhering cells. This facilitated communication via the macrophage membrane with implications for understanding mammalian cell signalling., The fabrication of a molecularly tailored surface functionalised with a saccharide binding motif, a phenyl boronic acid derivative is reported. The functionalised surface facilitated the transfer of electrons, via unique electronic interactions mediated by the presence of the boronic acid, from a macrophage cell line. This is the first example of eukaryotic cellular-electrical communication mediated by the binding of cells via their cell–surface saccharide units.