6 results on '"Schuster, Johannes"'
Search Results
2. Endovascular brachytherapy using liquid Beta-emitting rhenium-188 for the treatment of long-segment femoropopliteal in-stent stenosis.
- Author
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Werner M, Scheinert D, Henn M, Scheinert S, Bräunlich S, Bausback Y, Friedenberger J, Schuster J, Hertting K, Piorkowski M, Rosner C, Schmidt A, Ulrich M, and Gutberlet M
- Subjects
- Adult, Aged, Aged, 80 and over, Amputation, Surgical, Angioplasty, Balloon adverse effects, Arterial Occlusive Diseases diagnosis, Arterial Occlusive Diseases physiopathology, Arterial Occlusive Diseases radiotherapy, Brachytherapy adverse effects, Chi-Square Distribution, Constriction, Pathologic, Disease-Free Survival, Female, Germany, Humans, Kaplan-Meier Estimate, Limb Salvage, Male, Middle Aged, Predictive Value of Tests, Radiography, Radioisotopes adverse effects, Recurrence, Retrospective Studies, Rhenium adverse effects, Risk Assessment, Risk Factors, Thrombosis etiology, Time Factors, Treatment Outcome, Ultrasonography, Doppler, Duplex, Vascular Patency, Angioplasty, Balloon instrumentation, Arterial Occlusive Diseases therapy, Brachytherapy methods, Femoral Artery diagnostic imaging, Femoral Artery physiopathology, Popliteal Artery diagnostic imaging, Popliteal Artery physiopathology, Radioisotopes therapeutic use, Rhenium therapeutic use, Stents
- Abstract
Purpose: To evaluate the efficacy and safety of endovascular brachytherapy with liquid beta-emitting rhenium-188 (Re-188) in patients with long-segment in-stent stenosis in the femoropopliteal segment., Methods: From July 2009 to April 2011, 90 consecutive patients (59 men; mean age 68.3±10.3 years, range 43-86) with symptomatic in-stent stenosis/occlusion (24.6-cm mean lesion length) of the femoropopliteal segment underwent angioplasty and subsequent endovascular brachytherapy. The liquid beta-emitting Re-188 was applied to the target lesion within an angioplasty balloon using a dose of 13 Gy at a depth of 2 mm into the vessel wall. Clinical and angiographic follow-up data were collected up to 2 years. The main study endpoints were the 6- and 12-month primary patency rates defined as <50% in-stent stenosis as detected by duplex ultrasound. Clinical endpoints were the cumulative rates of death, amputation, and bypass surgery, as well as improvement in the Rutherford category and the ankle-brachial index. Results were correlated with patient and lesion characteristics., Results: Primary technical success was achieved in all patients, with 1 early stent thrombosis, but no other complications related to the irradiation. Eighty-eight patients reached the 6-month and 82 the 12-month examinations; the primary patency was 95.2% and 79.8%, respectively. In-stent stenosis occurred in 9 patients, while 10 patients had reocclusion of the treated segment. During follow-up, there were 2 late acute thrombotic occlusions, both after discontinuation of clopidogrel. The clinical status improved in 67.0% and 62.2% of the patients after 6 and 12 months, respectively. No patient, lesion, or procedure variables were predictive of restenosis after EVBT., Conclusion: EVBT with liquid beta-emitting Re-188 was safe and effective in preventing restenosis in long-segment femoropopliteal ISS.
- Published
- 2012
- Full Text
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3. Sirolimus-eluting stents for the treatment of infrapopliteal arteries in chronic limb ischemia: long-term clinical and angiographic follow-up.
- Author
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Werner M, Schmidt A, Freyer M, Bausback Y, Bräunlich S, Friedenberger J, Schuster J, Botsios S, Scheinert D, and Ulrich M
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- Aged, Aged, 80 and over, Amputation, Surgical, Angioplasty, Balloon adverse effects, Angioplasty, Balloon mortality, Atherosclerosis complications, Atherosclerosis diagnostic imaging, Atherosclerosis mortality, Atherosclerosis physiopathology, Chi-Square Distribution, Chronic Disease, Constriction, Pathologic, Female, Germany, Humans, Ischemia diagnostic imaging, Ischemia etiology, Ischemia mortality, Ischemia physiopathology, Kaplan-Meier Estimate, Male, Middle Aged, Proportional Hazards Models, Prosthesis Design, Radiography, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Vascular Patency, Vascular Surgical Procedures, Angioplasty, Balloon instrumentation, Atherosclerosis therapy, Cardiovascular Agents administration & dosage, Drug-Eluting Stents, Ischemia therapy, Lower Extremity blood supply, Popliteal Artery diagnostic imaging, Popliteal Artery physiopathology, Sirolimus administration & dosage
- Abstract
Purpose: To present the 5-year angiographic and clinical results of a retrospective registry assessing the performance of sirolimus-eluting stents (SES) in the treatment of infrapopliteal atherosclerotic disease., Methods: From 2004 to 2009, 158 patients (95 men; mean age 71.9 years) with chronic lower limb ischemia (Rutherford categories 3-6) underwent primary SES placement in focal infrapopliteal lesions. The angiographic endpoint was patency, defined as freedom from in-stent stenosis (ISS) >50%. Clinical endpoints were death, amputation, and bypass surgery. Results were correlated with patient and lesion characteristics and cumulative outcomes were assessed with Kaplan-Meier analysis., Results: Technical success was achieved in all cases. The primary patency rates were 97.0% after 6 months, 87.0% after 12 months, and 83.8% at 60 months. In-stent stenosis was predominantly observed in the first year after stent placement. Female gender was associated with a higher rate of ISS. During clinical follow-up of 144 (91%) patients over a mean 31.1±20.3 months, there were 27 (18.8%) deaths, 4 (2.8%) amputations, and no bypass surgery. Clinical status improved in 92% of the patients with critical limb ischemia (CLI) and 77% of the patients suffering from claudication (p=0.022)., Conclusion: Treatment of focal infrapopliteal lesions with SES showed encouraging long-term angiographic results in this registry. Clinical improvement was evident, but more pronounced in CLI patients than in patients suffering from claudication. Further studies are needed to evaluate the potential clinical benefit of SES as compared to balloon angioplasty or bare metal stents in the treatment of infrapopliteal lesions.
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- 2012
- Full Text
- View/download PDF
4. Retrograde recanalization technique for use after failed antegrade angioplasty in chronic femoral artery occlusions.
- Author
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Schmidt A, Bausback Y, Piorkowski M, Werner M, Bräunlich S, Ulrich M, Varcoe R, Friedenberger J, Schuster J, Botsios S, and Scheinert D
- Subjects
- Aged, Aged, 80 and over, Arterial Occlusive Diseases diagnostic imaging, Chronic Disease, Constriction, Pathologic, Female, Humans, Male, Middle Aged, New South Wales, Patient Positioning, Punctures, Radiography, Retrospective Studies, Stents, Supine Position, Treatment Failure, Angioplasty adverse effects, Angioplasty, Balloon adverse effects, Angioplasty, Balloon instrumentation, Arterial Occlusive Diseases therapy, Catheterization, Peripheral adverse effects, Femoral Artery diagnostic imaging
- Abstract
Purpose: To describe a technique to approach chronic total occlusions (CTOs) of the superficial femoral artery (SFA) after failed antegrade recanalization as an alternative to a conventional transpopliteal approach., Methods: A retrospective analysis was undertaken of 50 patients (37 men; mean age 71 years) who underwent retrograde recanalization via a distal SFA access after failed antegrade recanalization of SFA CTOs that were not beyond the adductor canal. Antegrade recanalization failed due to flush SFA occlusion, occluded stents, wire perforation, and re-entry failure. Retrograde SFA access required introduction of a 7- to 15-cm, 21-G needle distal to the occlusion. A 0.018-inch guidewire was inserted through the needle followed by a 4- or 6-F, 10-cm sheath or dedicated support catheter only. All retrograde SFA punctures were performed with the patient in the supine position. Once retrograde passage of the occlusion was successful, oftentimes requiring a "double-balloon" technique to disrupt the dissection membrane with abutting balloons delivered from both access sites, balloon angioplasty and/or stenting could be performed from either direction., Results: Retrograde puncture of the distal SFA was successful in all cases. Retrograde recanalization involved insertion of a 6-F sheath in 3 (6%) cases, a 4-F sheath in 32 (64%), and a sheathless approach in 15 (30%). The "double-balloon" technique was necessary to achieve guidewire passage in 12 cases. Recanalization was successful in 48 (96%) cases. Hemostasis time at the distal puncture site was 9.2 minutes (range 3-30). Perioperative complications included 4 pseudoaneurysms (2 groins, 2 distal), 1 peripheral embolization, and 1 small arteriovenous fistula at the distal puncture site., Conclusion: For failure of antegrade recanalization of SFA occlusions, the retrograde SFA puncture distal to the adductor canal with the patient remaining supine is a safe and successful technique that represents a convenient alternative to the conventional transpopliteal approach.
- Published
- 2012
- Full Text
- View/download PDF
5. Outback catheter for femoropopliteal occlusions: immediate and long-term results.
- Author
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Bausback Y, Botsios S, Flux J, Werner M, Schuster J, Aithal J, Varcoe R, Bräunlich S, Ulrich M, Scheinert D, and Schmidt A
- Subjects
- Aged, Aged, 80 and over, Amputation, Surgical, Angioplasty, Balloon adverse effects, Ankle Brachial Index, Arterial Occlusive Diseases complications, Arterial Occlusive Diseases diagnosis, Constriction, Pathologic, Equipment Design, Female, Germany, Humans, Intermittent Claudication diagnosis, Intermittent Claudication etiology, Ischemia diagnosis, Ischemia etiology, Kaplan-Meier Estimate, Male, Middle Aged, Recurrence, Retrospective Studies, Stents, Time Factors, Treatment Outcome, Ultrasonography, Doppler, Color, Vascular Patency, Angioplasty, Balloon instrumentation, Arterial Occlusive Diseases therapy, Catheters, Femoral Artery diagnostic imaging, Femoral Artery physiopathology, Intermittent Claudication therapy, Ischemia therapy, Popliteal Artery diagnostic imaging, Popliteal Artery physiopathology
- Abstract
Purpose: To report a retrospective, single-center study that evaluates technical and clinical outcomes from subintimal recanalization of femoropopliteal chronic total occlusions (CTO) facilitated by the Outback re-entry catheter., Methods: The Outback catheter was required to complete recanalization of femoropopliteal CTOs (mean lesion length 195 ± 91 mm) in 118 limbs of 113 patients (77 men; mean age 70 ± 10 years). In 80/118 (67.8%) limbs, treatment was performed for claudication and in the remaining 38 (32.2%) for critical limb ischemia (CLI). Technical and procedural success, clinical outcome, and cumulative patency rates in follow-up were evaluated., Results: Re-entry was accomplished in 108/118 limbs (91.5%) with recanalization completed in 107/118 (90.7%). Of these, only 61/107 (57%) arteries were left with a residual stenosis <30%. Complications included minor bleeding of the target vessel (5/118, 4.2%) and minor hematoma/pseudoaneurysm at the access site (6/118, 5.1%). Acute reocclusion developed in 2/118 cases (1.7%) without major complication. After 12 months, primary patency was 56.7%, assisted primary patency 83.1%, and secondary patency 89.1%. Primary patency was significantly reduced in limbs with residual stenosis. Over a median 15-month follow-up (range 2-32), 4 major and 2 minor amputations were performed in patients with CLI., Conclusion: The Outback catheter is a reliable tool to recanalize challenging chronic femoropopliteal occlusions after failed guidewire re-entry. Restenosis rates are high, which may be due to the severity and extent of disease in these patients, who are particularly challenging.
- Published
- 2011
- Full Text
- View/download PDF
6. Drug-eluting stents for the treatment of vertebral artery origin stenosis.
- Author
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Werner M, Bräunlich S, Ulrich M, Bausback Y, Schuster J, Lukhaup A, Botsios S, Scheinert D, and Schmidt A
- Subjects
- Aged, Cohort Studies, Female, Graft Occlusion, Vascular diagnosis, Graft Occlusion, Vascular epidemiology, Graft Occlusion, Vascular prevention & control, Humans, Male, Paclitaxel administration & dosage, Retrospective Studies, Stroke diagnosis, Stroke epidemiology, Stroke prevention & control, Treatment Outcome, Tubulin Modulators administration & dosage, Vertebrobasilar Insufficiency complications, Vertebrobasilar Insufficiency diagnosis, Angioplasty, Drug-Eluting Stents, Vertebrobasilar Insufficiency therapy
- Abstract
Purpose: To present our experience with the use of drug-eluting stents (DES) in patients with symptomatic vertebral artery ostium stenosis (VAOS)., Methods: Between 2003 and 2008, 28 consecutive patients (17 men; mean age 66 years) with symptomatic extracranial vertebral artery stenosis were treated with a paclitaxel-eluting stent. All patients were prospectively scheduled for serial clinical, duplex, and angiographic follow-up to identify restenosis., Results: After stent implantation, the mean stenosis was reduced from 68% to 9%. There were no periprocedural neurological complications. After a mean follow-up of 16 months (range 5-41), no strokes, worsening of symptoms, or deaths occurred. Angiographic restenosis >50% was seen in 6 (21.4%) patients. Restenosis occurred significantly more often in patients with an ipsilateral subclavian artery stenosis (p = 0.01). Radiography during follow-up angiography revealed stent fracture in 1 patient and stent compression/kinking in 11 (39%) of the patients. Stent compression and recoil, not intimal hyperplasia, were the major contributing factors to restenosis., Conclusion: Compared to the restenosis rate of bare metal stents reported in the literature, DES seems to be superior for the treatment of VAOS. However, stent compression and recoil are relevant problems contributing to restenosis. Further improvement of the materials for the interventional treatment of VAOS seems necessary.
- Published
- 2010
- Full Text
- View/download PDF
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