1. Role of TNF-α Gene Variation in Idiopathic Childhood Ischemic Stroke: A Case-Control Study.
- Author
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Kai-Li Shi, Bing He, Jian-Jun Wang, and Li-Ping Zou
- Subjects
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CHILDREN'S health , *GENETIC research , *ETIOLOGY of diseases , *CEREBROVASCULAR disease in children , *TUMOR necrosis factors , *IMMUNOGENETICS , *GENETIC polymorphisms , *PATHOGENIC microorganisms , *THERAPEUTICS - Abstract
Etiology of the idiopathic childhood stroke remains unknown. In previous studies, the immunologic process may be involved in the idiopathic stroke. Tumor necrosis factor- alpha (TNF-α), an important immune mediator, may contribute to the initiation and progression in the stroke. The main purpose of this study was to investigate correlation of TNF-α genetic variation and idiopathic childhood ischemic stroke. Using the direct DNA sequencing method, polymorphisms in the TNF-α promoter region were genotyped in 67 Chinese patients with idiopathic childhood stroke and 70 controls. Among totally 7 single nucleotide polymorphisms identified in the TNF-α promoter region, the variant of the -863C/A is associated with increased risk of idiopathic childhood ischemic stroke in our study group. TNF-α molecule may have genetically as well as functionally an important role in the pathogenesis of idiopathic childhood ischemic stroke in the Chinese population. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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