26 results on '"Lucidi, Gian Andrea"'
Search Results
2. Clinical Outcomes of Medial Meniscal Allograft Transplantation With or Without High Tibial Osteotomy: A Case-Control Study Up to 8 Years of Follow-up.
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Grassi, Alberto, Lucidi, Gian Andrea, Di Paolo, Stefano, Altovino, Emanuele, Agostinone, Piero, Dal Fabbro, Giacomo, Romandini, Iacopo, Filardo, Giuseppe, and Zaffagnini, Stefano
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MENISCUS surgery , *MENISCUS (Anatomy) , *QUESTIONNAIRES , *HOMOGRAFTS , *TREATMENT effectiveness , *DESCRIPTIVE statistics , *OSTEOTOMY , *LONGITUDINAL method , *KAPLAN-Meier estimator , *CASE-control method , *REOPERATION , *DATA analysis software , *TREATMENT failure - Abstract
Background: Satisfactory clinical results of meniscal allograft transplantation (MAT) have been reported in recent years. However, it remains unclear whether the clinical outcomes of MAT when combined with an osteotomy are inferior to those of isolated MAT. Purpose: To compare the survival rates and clinical outcomes of patients who received isolated medial MAT with those of patients undergoing medial MAT combined with high tibial osteotomy (HTO). Study Design: Cohort study; Level of evidence, 3. Methods: A total of 55 patients underwent arthroscopic medial MAT using the soft tissue technique and HTO (mean age, 41.3 ± 10.4 years; 9 female); after fuzzy case-control matching on demographics, 55 controls who underwent isolated medial MAT were also included. Survival analyses were performed using the Kaplan-Meier method with surgical failure, clinical failure (Lysholm score, <65), and reoperation as endpoints. Subjective clinical scores were collected preoperatively and at the final follow-up. Results: The mean follow-up time was 5.4 years, up to 8 years. All outcomes significantly improved at the last follow-up (P <.001). No differences were identified between MAT and MAT + HTO groups preoperatively and at the last follow-up (P >.05). At the final follow-up, 8 of 55 (14.5%) of the MAT + HTO patients and 9 of 55 (16.4%) of the MAT patients had a Lysholm score <65 (P =.885). Overall, 90% of the patients declared they would repeat the surgery regardless of the combined procedure. Surgical failure was identified in 6 of 110 (5.5%) patients: 5 of 55 (9.1%) in the MAT + HTO group and 1 of 55 (1.8%) in the MAT group (P =.093). Clinical failure was identified in 19 of 110 (17.3%) patients: 11 of 55 (20%) in the MAT + HTO group and 8 of 55 (14.5%) in the MAT group (P =.447). A significantly lower survivorship from surgical failure was identified in the MAT + HTO group (hazard ratio, 5.1; P =.049), while no differences in survivorship from reoperation and clinical failure were identified (P >.05). Conclusion: Patients undergoing medial MAT + HTO showed similar clinical results to patients undergoing isolated medial MAT at midterm follow-up, and thus a surgically addressed malalignment does not represent a contraindication for medial MAT. However, the need for a concomitant HTO is associated with a slightly higher failure rate over time. [ABSTRACT FROM AUTHOR]
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- 2024
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3. A Lateral Extra-articular Procedure Reduces the Failure Rate of Revision Anterior Cruciate Ligament Reconstruction Surgery Without Increasing Complications: A Systematic Review and Meta-analysis.
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Grassi, Alberto, Olivieri Huerta, Rodrigo A., Lucidi, Gian Andrea, Agostinone, Piero, Dal Fabbro, Giacomo, Pagano, Anna, Tischer, Thomas, and Zaffagnini, Stefano
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PREVENTION of surgical complications ,RISK assessment ,CONTINUING education units ,ANTERIOR cruciate ligament surgery ,ARTICULAR ligaments ,SURGERY ,PATIENTS ,META-analysis ,DESCRIPTIVE statistics ,SYSTEMATIC reviews ,KNEE joint ,MEDLINE ,SURGICAL complications ,REOPERATION ,MEDICAL databases ,TREATMENT failure ,ADVERSE health care events ,COMPARATIVE studies ,ONLINE information services ,DATA analysis software ,CONFIDENCE intervals ,EVALUATION ,DISEASE risk factors - Abstract
Background: Lateral extra-articular procedures are becoming increasingly popular in association with anterior cruciate ligament (ACL) reconstruction, especially in patients with persistent rotatory instability and in a high-risk population. However, few studies have investigated the outcomes of the lateral extra-articular procedure as an associated procedure in an ACL revision (R-ACLR) setting and its benefit with respect to isolated intra-articular reconstruction. Hypothesis: Lateral extra-articular procedures reduce the failure rate of revision ACL reconstruction (R-ACLR). Purpose: To compare subjective outcomes, knee stability, and failure and complication rates between patients who underwent ACL revision with and without an associated lateral extra-articular procedure. Study Design: Systematic review and meta-analysis; Level of evidence, 3. Methods: A systematic search of the PubMed, Cochrane, and OVID databases was performed on September 2022 in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Eligible studies were trials directly comparing patients who had isolated ACL revision with patients who had ACL revision associated with lateral extra-articular procedures at a minimum follow-up of 2 years. A meta-analysis was performed, and bias and the quality of the evidence were rated according to the Newcastle-Ottawa Scale. The meta-analysis was conducted according to the PRISMA guidelines. Results: Eight studies were included: a total of 334 patients were treated with isolated revision (isolated (R-ACLR)) and 342 treated with combined revision and a lateral extra-articular procedure (combined (R-ACLR)). For the failure rate, the meta-analysis showed a significantly decreased relative risk reduction of 54% (P =.004) in patients with combined (R-ACLR) with respect to isolated R-ACL, whereas no difference in complication rate was observed. The combined (R-ACLR) group demonstrated a decreased risk ratio of 50% (P =.002) for having a positive pivot-shift test result and a relative risk reduction of 68% (P =.003) for having a grade 2-3 pivot shift when compared with the isolated (R-ACLR) group. Finally, no significant differences were observed among the lateral extra-articular procedures. Conclusion: The addition of a lateral extra-articular procedure to revision ACL significantly reduced the failure rate and postoperative pivot shift without increasing the complication rate. Anterolateral ligament reconstruction and a lateral extra-articular procedure with iliotibial band were effective in improving the outcomes of revision ACL reconstruction. Further high-level studies could help to clarify which subgroup of patients could particularly benefit from an anterolateral procedure in the context of ACL revision. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Predictors of the Ten-Year Patient-Reported Outcome Measures After Collagen Meniscus Implant (CMI) for Partial Meniscus Deficiency.
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Lucidi, Gian Andrea, Zaffagnini, Stefano, Agostinone, Piero, Dal Fabbro, Giacomo, Pizza, Nicola, Di Paolo, Stefano, and Grassi, Alberto
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- 2023
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5. Medial Meniscal Posterior Horn Suturing Influences Tibial Internal-External Rotation in ACL-Reconstructed Knees.
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Grassi, Alberto, Agostinone, Piero, Paolo, Stefano Di, Lucidi, Gian Andrea, Pinelli, Erika, Marchiori, Gregorio, Bontempi, Marco, Bragonzoni, Laura, and Zaffagnini, Stefano
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- 2023
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6. Combined Anterior Cruciate Ligament Reconstruction and Lateral Extra-Articular Tenodesis: The "Over-the-Top" Technique.
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Zaffagnini, Stefano, Grassi, Alberto, Lucidi, Gian Andrea, Dal Fabbro, Giacomo, and Ambrosini, Luca
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ANTERIOR cruciate ligament surgery ,TENODESIS ,AUTOGRAFTS ,SPORTS medicine ,PATIENT reported outcome measures - Abstract
Background: The anterior cruciate ligament (ACL) is a primary restraint to anteroposterior as well as rotatory knee laxity. In case of concomitant lesion of menisci or other ligamentous structures, further dynamic instability is encountered. A lateral extra-articular tenodesis (LET) augmentation has been proposed by the Authors to treat or prevent residual laxity. Indications: ACL reconstruction is recommended in young athletes involved in pivoting sports, non-contact pivoting injuries, high-grade pivot shift, deep notch sign and double bone bruise, meniscal loss, and revision of previous bone-patellar tendon-bone autograft. Technique Description: A 2 to 3 cm oblique incision is made over the pes anserinus. Gracilis and semitendinosus tendons are harvested with their attachment preserved and sutured together. Tibial tunnel is reamed after positioning of a guide pin. A wire-loop passer is directed from the tibial tunnel to the anteromedial portal. A 2 to 3 cm longitudinal incision is made superior-laterally, the ileotibial band is divided and retracted anteriorly. A suture-loop is retrieved from the lateral incision through the anteromedial portal with a curved Kelly clamp. The suture is placed into the wire-loop and retrieved with it from the tibial tunnel. The graft is retrieved from the lateral incision, tensioned with the knee at 70° to 90° of flexion and foot in neutral rotation and secured with 2 staples to the femur. A 1-cm skin incision is performed just below the Gerdy tubercle. The graft is retrieved from this incision below the fascia with a small Kelly clamp, tensioned and secured with a staple. The iliotibial tract defect is closed. Results: At long-term follow-up, a revision rate of 3% has been reported, while patient-reported outcome measures (PROMs) were excellent. At very-long-term follow-up, most patients were still involved in sports with a very low rate of positive Lachman and pivot shift tests. No overconstraint and lateral osteoarthritis were encountered. Medial osteoarthritis was related only to medial meniscectomy. Discussion/Conclusion: The ACL reconstruction plus LET over-the-top technique is a safe and reliable surgery with a low rate of reoperations and peri-operative complications at very-long-term follow-up. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication. Graphical Abstract This is a visual representation of the abstract. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Biomechanical Analysis of Tibial Motion and ACL Graft Forces After ACLR With and Without LET at Varying Tibial Slopes: Letter to the Editor.
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Winkler, Philipp W., Kayaalp, M. Enes, Runer, Armin, Zsidai, Bálint, Lucidi, Gian Andrea, Debski, Richard E., Samuelsson, Kristian, and Musahl, Volker
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ANTERIOR cruciate ligament transplantation ,BIOMECHANICS ,MATERIALS testing ,TENODESIS ,ANTERIOR cruciate ligament injuries ,ANTERIOR cruciate ligament surgery ,COMPLICATIONS of prosthesis ,TREATMENT effectiveness ,TIBIA ,ANTERIOR cruciate ligament ,BONE grafting ,EVALUATION - Abstract
The article presents a commentary on the paper "Biomechanical Analysis of Tibial Motion and ACL Graft Forces After ACLR With and Without LET at Varying Tibial Slopes," by S. L. Pearce, A. R. Bryniarski and J. R. Brown. Topics covered include the concerns over the methodology of the study, the decision to standardize each slope to 5 degrees and the lack of report on posterior tibial slope, knee kinematics and anterior cruciate ligament (ACL).
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- 2024
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8. Survivorship and Reoperation of 324 Consecutive Isolated or Combined Arthroscopic Meniscal Allograft Transplants Using Soft Tissue Fixation.
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Grassi, Alberto, Di Paolo, Stefano, Coco, Vito, Romandini, Iacopo, Filardo, Giuseppe, Lucidi, Gian Andrea, Marcacci, Maurilio, and Zaffagnini, Stefano
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MENISCUS surgery ,STATISTICS ,HOMOGRAFTS ,CONFIDENCE intervals ,ARTHROSCOPY ,SURGERY ,PATIENTS ,HEALTH outcome assessment ,SPORTS medicine ,TREATMENT failure ,TREATMENT effectiveness ,COMPARATIVE studies ,T-test (Statistics) ,REOPERATION ,CASE studies ,KAPLAN-Meier estimator ,DESCRIPTIVE statistics ,ODDS ratio ,DATA analysis software ,DATA analysis ,SOFT tissue injuries ,LONGITUDINAL method - Abstract
Background: Meniscal allograft transplant (MAT) is an effective treatment for relieving symptoms and improving knee function in patients who experience symptomatic unicompartmental knee pain after a previous meniscectomy. However, the literature contains a paucity of studies assessing the survival rate and prognostic factors of soft tissue MAT. Purpose: To report the survivorship of a large, single-center cohort of consecutive patients treated with arthroscopic MAT using soft tissue technique and to investigate variables that could potentially influence failures and outcomes. Study design: Case series; Level of evidence, 4. Methods: Consecutive MAT procedures totaling 364 performed in a single institution between June 2004 and April 2019 were screened and assessed for eligibility. Subjective clinical scores (Lysholm score, Tegner activity scale, and visual analog score) were collected preoperatively and at 2, 5, 7, and 10 years of follow-up. Two survival analyses were performed using Kaplan-Meier curves, with surgical failure (defined as any graft revision) and clinical failure (defined as a Lysholm score <65 points) used as endpoints. Univariate analyses were performed using reoperations, surgical failure, clinical failure, and different demographic and surgical characteristics as endpoints. Results: A total of 324 consecutive patients were evaluated at a mean follow-up 5.7 ± 3.0 years. Of these, 189 (58%) underwent an associated surgical procedure. A total of 22 patients (6.8%) were considered to have experienced surgical failure, and no predictors of surgical failure were identified based on the relevant variables. When all patients were considered, a significant improvement in all of the patient-reported outcome measures was present between the preoperative assessment and the last follow-up (P <.001), with no significant decrease over time. Moreover, 70 (21.6%) patients were considered to have experienced clinical failure; the need for concurrent cartilage procedures (odds ratio, 0.16; P =.001) and anterior cruciate ligament (ACL) reconstruction (odds ratio, 0.40; P =.059) were predictors of failure. Finally, a lower survival rate was reported in female patients compared with male patients (49% vs 69%, respectively; P =.007) and in patients who required cartilage surgery (P =.014). In particular, patients who required cartilage surgery showed nearly half the survival rate compared with those with required no cartilage procedures at 10-year follow-up (36.4% vs 71%, respectively; P =.029). Conclusion: Female sex and the need to combine MAT with a cartilage procedure or ACL reconstruction could result in an increased rate of clinical failure at midterm follow-up. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Risk Factors Affecting the Survival Rate of Collagen Meniscal Implant for Partial Meniscal Deficiency: An Analysis of 156 Consecutive Cases at a Mean 10 Years of Follow-up.
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Lucidi, Gian Andrea, Grassi, Alberto, Agostinone, Piero, Di Paolo, Stefano, Dal Fabbro, Giacomo, D'Alberton, Chiara, Pizza, Nicola, and Zaffagnini, Stefano
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MENISCUS surgery , *COLLAGEN , *PROSTHETICS , *PATIENT aftercare , *HOMOGRAFTS , *CONFIDENCE intervals , *ARTIFICIAL implants , *CASE-control method , *ACQUISITION of data , *MENISCECTOMY , *TREATMENT effectiveness , *TREATMENT failure , *SURVIVAL rate , *T-test (Statistics) , *MEDICAL records , *CHI-squared test , *KAPLAN-Meier estimator , *DESCRIPTIVE statistics , *DATA analysis software , *LOGISTIC regression analysis , *MENISCUS injuries , *LONGITUDINAL method ,SURGICAL complication risk factors - Abstract
Background: Collagen meniscal implant (CMI) is a biologic scaffold that can be used to replace meniscus host tissue after partial meniscectomy. The short-term results of this procedure have already been described; however, little is known about risk factors for failure. Purpose: To determine the factors that predict failure of meniscal scaffold implantation in a large series of patients treated at a single institution and to better define the indications for surgery. Study Design: Case-control study; Level of evidence, 3. Methods: The analysis included 186 consecutive patients with a minimum 5-year follow-up who underwent CMI scaffold implantation or combined procedures. Patients' characteristics and details of the surgery were obtained via chart review. Patients with a Lysholm score <65 were considered to have experienced clinical failure. Surgical failure was defined as partial or total scaffold removal. Results: The final analysis included 156 patients (84%) at a mean follow-up of 10.9 ± 4.3 years. The patients' mean age at surgery was 42.0 ± 11.1 years, and the survival rate was 87.8%. Subgroup analysis identified Outerbridge grade 3-4 (Hazard ratio [HR], 3.8; P =.004) and a lateral meniscal implant (HR, 3.2; P =.048) as risk factors for failure. The survival rate was 90.4% for medial implants and 77.4% for lateral implants. An Outerbridge grade 3-4 (HR, 2.8; P <.001) and time from meniscectomy to scaffold >10 years (HR, 2.8; P =.020) were predictive of surgical or clinical failure. Conclusion: CMI for partial meniscal deficiency provided good long-term results, with 87.8% of the implants still in situ at a mean 10.9 years of follow-up. Outerbridge grade 3-4, lateral meniscal implants, and longer time from the meniscectomy to implantation of the CMI were identified as risk factors for clinical and surgical failure. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Poster 312: Prospective and Randomized Evaluation of Three Different Anterior Cruciate Ligament (ACL) Reconstruction Techniques Including a Lateral Extra-Articular Tenodesis (LET): A Clinical and Radiographic Evaluation at Minimum 20 Years Follow-Up.
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Lucidi, Gian Andrea, Agostinone, Piero, Grassi, Alberto, Viotto, Marianna, Serra, Margherita, Dal Fabbro, Giacomo, Di Paolo, Stefano, and Zaffagnini, Stefano
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- 2024
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11. Poster 232: Clinical Outcomes of Medial Meniscus Allograft Transplantation (MAT) with or without High Tibial Osteotomy (HTO): A Case-Control Study up to 8 Years of Follow-up.
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Grassi, Alberto, Lucidi, Gian Andrea, Di Paolo, Stefano, Altovino, Emanuele, Agostinone, Piero, Dal Fabbro, Giacomo, Romandini, Iacopo, Filardo, Giuseppe, and Zaffagnini, Stefano
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- 2024
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12. Anterior Cruciate Ligament Reconstruction and Lateral Plasty in High-Risk Young Adolescents: Revisions, Subjective Evaluation, and the Role of Surgical Timing on Meniscal Preservation.
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Grassi, Alberto, Macchiarola, Luca, Lucidi, Gian Andrea, Dal Fabbro, Giacomo, Mosca, Massimilano, Caravelli, Silvio, and Zaffagnini, Stefano
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ANTERIOR cruciate ligament surgery ,YOUNG adults - Abstract
Background: In adolescents, the rate of meniscal injury at the time of anterior cruciate ligament (ACL) reconstruction, the rate of ACL graft revision, and clinical outcomes has not yet been investigated. Hypothesis: In patients younger than 16 years, the rate of meniscal injuries at the time of ACL reconstruction increases with time from injury. The mid-term revision rate and reoperation rate after ACL reconstruction with hamstrings and lateral tenodesis are lower than those reported in literature for isolate ACL reconstruction. Study Design: Case series. Level of Evidence: Level 4. Methods: Patients younger than 16 years who underwent ACL reconstruction with hamstring and lateral tenodesis, with a follow-up ≥2 years were included. The number of meniscal lesions was stratified according to the delay between injury-to-surgery (<3, 3-12, >12 months). All reoperations, Lysholm score, Knee Injury and Osteoarthritis Outcome Score subscales for pain (at rest and during activity), and return to sport were collected. Results: A total of 151 patients (mean age 14.8 ± 1.2 years) were included. Patients undergoing surgery at <3 months after injury had a lower meniscal injury rate (36%) than those treated at 3 to 12 months (55%) and >12 months (63%) after injury (P = 0.04). Medial meniscal lesions were more likely to be repaired when surgery was performed <3 months after injury (91%). Subjective follow-up data were available for 132 patients, and 19 were lost to follow-up. At 6.0 ± 2.6 years, 6% of patients underwent ACL revision; 1 of 20 (5%) patients with posterior tibial slope ≥12° and 4 of 45 (9%) patients with Tegner level ≥8. Nine new meniscal procedures were performed; 19% of repaired menisci underwent meniscectomy. Good or excellent Lysholm score was reported by 88% of patients; 56% of patients with concurrent lateral meniscectomy had pain during activity, 91% returned to sport, and 79% were still participating at final follow-up. Conclusion: Patients younger than 16 years undergoing ACL reconstruction within 3 months from injury had the lowest rate of meniscal injuries. ACL reconstruction with lateral tenodesis had low revision rate (6%) and good or excellent clinical outcomes in 88% of young adolescents. Clinical Relevance: Sport physicians should be aware that adolescent patients undergoing ACL reconstruction within 3 months after injury have the lowest rate of meniscal injuries; the mid-term revision rate of ACL reconstruction with lateral plasty is lower than 10% and the patients' perceived outcomes are good with almost all patients returning to sport activity. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Clinical Outcomes and Osteoarthritis at Very Long-term Follow-up After ACL Reconstruction: A Systematic Review and Meta-analysis.
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Grassi, Alberto, Pizza, Nicola, Al-zu'bi, Belal Bashar Hamdan, Fabbro, Giacomo Dal, Lucidi, Gian Andrea, and Zaffagnini, Stefano
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- 2022
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14. Do Clinical Outcomes and Failure Rates Differ in Patients With Combined ACL and Grade 2 MCL Tears Versus Isolated ACL Tears?: A Prospective Study With 14-Year Follow-up.
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Lucidi, Gian Andrea, Agostinone, Piero, Grassi, Alberto, Di Paolo, Stefano, Dal Fabbro, Giacomo, Bonanzinga, Tommaso, and Zaffagnini, Stefano
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- 2022
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15. Dynamic Radiostereometry Evaluation of 2 Different Anterior Cruciate Ligament Reconstruction Techniques During a Single-Leg Squat.
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Di Paolo, Stefano, Agostinone, Piero, Grassi, Alberto, Lucidi, Gian Andrea, Pinelli, Erika, Bontempi, Marco, Marchiori, Gregorio, Bragonzoni, Laura, and Zaffagnini, Stefano
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- 2021
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16. Minimum 10-Year Clinical Outcome of Lateral Collagen Meniscal Implants for the Replacement of Partial Lateral Meniscal Defects: Further Results From a Prospective Multicenter Study.
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Grassi, Alberto, Lucidi, Gian Andrea, Filardo, Giuseppe, Agostinone, Piero, Macchiarola, Luca, Bulgheroni, Paolo, Bulgheroni, Erica, and Zaffagnini, Stefano
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- 2021
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17. In Vivo Kinematic Analysis of Lateral Meniscal Allograft Transplantation With Soft Tissue Fixation.
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Macchiarola, Luca, Di Paolo, Stefano, Grassi, Alberto, Dal Fabbro, Giacomo, Lucidi, Gian Andrea, Cucurnia, Ilaria, and Zaffagnini, Stefano
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- 2021
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18. Poster 214: Posterior Tibial Slope Reducing Osteotomy in Complex Revision Anterior Cruciate Ligament Reconstruction.
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Thomassen, Stephan, Winkler, Philipp, Lucidi, Gian Andrea, Firth, Andrew, Musahl, Volker, Getgood, Alan, and Vivacqua, Thiago
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- 2022
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19. The Lateral Femoral Notch Sign Is Correlated With Increased Rotatory Laxity After Anterior Cruciate Ligament Injury: Pivot Shift Quantification With A Surgical Navigation System.
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Lucidi, Gian Andrea, Grassi, Alberto, Di Paolo, Stefano, Agostinone, Piero, Neri, Maria Pia, Macchiarola, Luca, Dal Fabbro, Giacomo, and Zaffagnini, Stefano
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MAGNETIC resonance imaging , *ANTERIOR cruciate ligament injuries - Abstract
Background: The lateral femoral notch sign (LNS) is a bony impression on the lateral femoral condyle correlated with anterior cruciate ligament (ACL) injury. Its presence is associated with lateral meniscal injury and higher cartilage degradation on the lateral femoral condyle. Purpose/Hypothesis: The purpose was to investigate the effect of the presence and magnitude of LNS on rotatory instability. The hypothesis was that a positive LNS is correlated with a high-grade pivot shift (PS). Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 90 consecutive patients with complete ACL tears between 2013 and 2017 underwent intraoperative kinematic evaluation with the surgical navigation system and were included in the present study. The same surgeon performed a standardized PS under anesthesia. The PS was quantified through the acceleration of the lateral compartment during tibial reduction (PS ACC) and the internal-external rotation (PS IE). Presence and depth of LNS were evaluated on sagittal magnetic resonance images (1.5-T). Results: In 47 patients, the LNS was absent; in 33, the LNS depth was between 1 mm and 2 mm; and in 10 patients, it was deeper than 2 mm. Patients with a notch deeper than 2 mm showed increased PS ACC and PS IE compared with the group without the LNS. However, no significant differences were present between the group with a notch between 1 and 2 mm and the patients without LNS. Receiver operating characteristic curve analysis showed that 2 mm was the most predictive cutoff value to identify the "high-grade rotatory instability" group, with an accuracy of 77.8% and 74.4% and a specificity of 95.5% and 93.9% referred to the PS ACC and PS IE, respectively. Conclusion: The presence of a lateral LNS deeper than 2 mm could be used for the preoperative identification of patients with a high risk of increased rotatory instability. [ABSTRACT FROM AUTHOR]
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- 2021
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20. Ten-Year Survivorship, Patient-Reported Outcome Measures, and Patient Acceptable Symptom State After Over-the-Top Hamstring Anterior Cruciate Ligament Reconstruction With a Lateral Extra-articular Reconstruction: Analysis of 267 Consecutive Cases.
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Grassi, Alberto, Macchiarola, Luca, Lucidi, Gian Andrea, Silvestri, Annamaria, Dal Fabbro, Giacomo, Marcacci, Maurilio, and Zaffagnini, Stefano
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HAMSTRING muscle surgery ,ANTERIOR cruciate ligament surgery ,AUTOGRAFTS ,CONFIDENCE intervals ,FISHER exact test ,PATIENT aftercare ,KNEE injuries ,LONGITUDINAL method ,MENISCECTOMY ,MENISCUS injuries ,ORTHOPEDIC surgery ,HEALTH outcome assessment ,PAIN ,SPORTS medicine ,QUALITY of life ,REOPERATION ,SEX distribution ,PLASTIC surgery ,SURVIVAL ,T-test (Statistics) ,LOGISTIC regression analysis ,ACTIVITIES of daily living ,MULTIPLE regression analysis ,TREATMENT effectiveness ,DATA analysis software ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator ,MANN Whitney U Test ,EVALUATION - Abstract
Background: Long-term patient-reported outcome measures (PROMs) and predictors of success or failure after anterior cruciate ligament (ACL) reconstruction are not fully understood, especially when combined with a lateral extra-articular reconstruction. Purpose: To assess the long-term PROMs, revision rate, and predictors of success or failure after ACL reconstructions using an over-the-top surgical technique with single-bundle hamstring tendon autografts and a lateral extra-articular reconstruction. Study Design: Case series; Level of evidence, 4. Methods: The study cohort consisted of 267 consecutive patients (mean age, 30.7 years) who underwent ACL reconstruction with an over-the-top surgical technique with single-bundle hamstring tendon autografts and a lateral extra-articular augmentation between November 2007 and May 2009. The number of subsequent ACL revisions and reoperations were recorded. Subjective clinical status was assessed with PROMs—specifically, the Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm, Tegner, and visual analog scale for pain—at a minimum follow-up of 10 years. Results: Overall, 3% of patients underwent ACL revision, with a 10-year survival rate of 96.3%. High sport activity (hazard ratio, 6.9; P =.285) and concomitant meniscal lesion (hazard ratio, 2.6; P =.0487) were predictors of ACL revision or new meniscectomy. The mean ± SD Lysholm score was 94.1 ± 10.8, while that for the visual analog scale for pain was 0.2 ± 0.9 at rest and 2.1 ± 2.6 during activity. KOOS subscale scores were as follows: 95.7 ± 8.1 for Pain, 92.5 ± 10.5 for Symptoms, 98.4 ± 7.4 for Activities of Daily Living, 90.7 ± 17.2 for Sport, and 91.2 ± 17.1 for Quality of Life; respectively, 88%, 99%, 81%, 89%, and 91% of patients achieved the Patient Acceptable Symptom State. Female sex and chondropathy with Outerbridge grade ≥2 were predictors of worse KOOS subscales. Overall, 82% of patients returned to sport, and 57% were still participating at the 10-year evaluation. Conclusion: ACL reconstruction with an over-the-top surgical technique with single-bundle hamstring autografts and a lateral extra-articular reconstruction provided satisfactory results in terms of function, symptoms, sports, and quality of life in 80% to 90% of patients after 10 years. Long-term survivorship was 96%. Sport participation declined from 82% postoperatively to 57% at long-term follow-up. A concomitant medial meniscal lesion was a predictor of higher risk of ACL failure or new meniscal lesion, while advanced chondropathy and female sex were predictors of higher pain, lower function, and poor quality of life scores. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Long-term Outcomes and Survivorship of Fresh-Frozen Meniscal Allograft Transplant With Soft Tissue Fixation: Minimum 10-Year Follow-up Study.
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Grassi, Alberto, Macchiarola, Luca, Lucidi, Gian Andrea, Coco, Vito, Romandini, Iacopo, Filardo, Giuseppe, Neri, Maria Pia, Marcacci, Maurilio, and Zaffagnini, Stefano
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ARTHROSCOPY ,CONFIDENCE intervals ,GRAFT versus host reaction ,HOMOGRAFTS ,LONGITUDINAL method ,CASE studies ,MENISCUS injuries ,REOPERATION ,RISK assessment ,SURVIVAL analysis (Biometry) ,LOGISTIC regression analysis ,VISUAL analog scale ,TREATMENT effectiveness ,PROPORTIONAL hazards models ,DATA analysis software ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator ,LOG-rank test ,MANN Whitney U Test ,EVALUATION - Abstract
Background: Meniscal allograft transplant (MAT) is considered an effective procedure for reducing pain and improving knee function. Nevertheless, the current knowledge regarding the results of MAT is limited to short- to mid-term follow-up studies, especially for arthroscopic techniques. Purpose: To evaluate the long-term clinical outcomes, reoperations, and failures with a minimum follow-up of 10 years after fresh-frozen MAT performed arthroscopically with soft tissue fixation. Study Design: Case series; Level of evidence, 4. Methods: A total of 46 patients (age, 36.6 ± 10.6 years; 36 male, 10 female) who underwent medial MAT (n = 27) or lateral MAT (n = 19) with a minimum 10-year follow-up were evaluated with the Lysholm score, Knee injury and Osteoarthritis Outcome Score (KOOS), visual analog scale for pain, and Tegner score. Surgical failure was defined as the need for partial or total graft removal (meniscectomy or knee replacement), and clinical failure was defined as the need for partial or total graft removal in addition to a poor Lysholm score (<65 points) at final follow-up. Survival analysis was performed with Kaplan-Meier curve, and clinical scores were analyzed based on the Patient Acceptable Symptom State (PASS) for MAT. Results: 10-year survival and clinical data were available for 38 patients. Because 6 meniscectomies were required, the rate of survival free from surgical failure was 91% at 5 years and 86% at 10 years. Lower survival was reported in lateral MAT (73%) compared with medial MAT (96%). Because a further 4 patients had poor Lysholm scores, the rate of survival free from surgical and clinical failure was 87% at 5 years and 70% at 10 years. The average Lysholm score at final follow-up was 82 ± 20, and 60% to 82% of patients achieved PASS of the various KOOS subscales. The Tegner score and the KOOS Sport score significantly decreased from mid-term to long-term evaluation (P <.001 and P <.05, respectively). Other KOOS subscales and the Lysholm score remained stable at long-term evaluation. No significant differences were found between isolated MAT or combined MAT regarding subjective scores, surgical failures, or clinical failures. Conclusion: Up to 10 years after surgery, 86% of fresh-frozen MATs with soft tissue fixation were still in situ, and satisfactory clinical results were present for about 70% of patients. Decline of clinical outcomes from midterm to long term was noted only in sports-related scores. A higher number of overall reoperations was noted in female patients, whereas a higher risk of failure was present in the patients with lateral MAT. [ABSTRACT FROM AUTHOR]
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- 2020
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22. Epidemiology of Anterior Cruciate Ligament Injury in Italian First Division Soccer Players.
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Grassi, Alberto, Macchiarola, Luca, Filippini, Matteo, Lucidi, Gian Andrea, Della Villa, Francesco, and Zaffagnini, Stefano
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SOCCER ,DISEASE incidence ,DISEASE relapse ,ANTERIOR cruciate ligament surgery - Abstract
Background: The burden of anterior cruciate ligament (ACL) injury in professional soccer players is particularly relevant as it represents a potentially career-threatening injury.Hypothesis: Our hypotheses were that (1) injury incidence rate would be similar to that reported in the literature, (2) we would identify a uniform distribution of the injuries along the season, and (3) injury incidence rate would be similar in high-ranked and lower ranked teams, based on final placement in the league.Study Design: Descriptive epidemiological study.Level Of Evidence: Level 4.Methods: Professional male soccer players participating in the Serie A championship league in 7 consecutive seasons (2011-2012 to 2017-2018) were screened to identify ACL injuries through the online football archive transfermarkt.com . Exposure in matches and training were calculated.Results: There were 84 ACL injuries found (mean player age, 25.3 ± 4.2 years). Overall, 25% of ACL injuries were reruptures (15%) or contralateral injuries (10%). ACL incidence rate was 0.4215 per 1000 hours of play during Serie A matches, 0.0305 per 1000 hours of training (rate ratio [RR], 13.8; 95% CI, 8.4-22.7; P < 0.0001), and 0.0618 per 1000 hours of total play. Injury distribution had a bimodal peak, with the highest number of events in October and March. Alternatively, training injuries peaked in June and July. A significantly higher incidence rate was found for the teams ranked from 1st to 4th place compared with those ranked 5th to 20th (0.1256 vs 0.0559 per 1000 hours of play; RR, 2.2; 95% CI, 1.4-3.6; P = 0.0003). A similar finding was found for injury incidence proportion (3.76% vs 1.64%; P = 0.0003).Conclusion: The overall incidence rate of ACL injuries in Italian Serie A was 0.062 per 1000 hours, with a 14-fold risk in matches compared with training. Relevantly, 25% were second injuries. Most injuries occurred in October and March, and an almost 2-fold incidence rate and incidence proportion were noted in those teams ranked in the first 4 positions of the championship league.Clinical Relevance: Knowing the precise epidemiology of ACL injury in one of the most competitive professional football championship leagues could help delineate fields of research aimed to investigate its risk factors. [ABSTRACT FROM AUTHOR]- Published
- 2020
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23. More Than a 2-Fold Risk of Contralateral Anterior Cruciate Ligament Injuries Compared With Ipsilateral Graft Failure 10 Years After Primary Reconstruction.
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Grassi, Alberto, Macchiarola, Luca, Lucidi, Gian Andrea, Stefanelli, Federico, Neri, Mariapia, Silvestri, Annamaria, Della Villa, Francesco, and Zaffagnini, Stefano
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SURGICAL complication risk factors ,INJURY risk factors ,AGE distribution ,ANTERIOR cruciate ligament surgery ,ANTERIOR cruciate ligament injuries ,AUTOGRAFTS ,COMPARATIVE studies ,CONFIDENCE intervals ,FISHER exact test ,GRAFT versus host reaction ,LONGITUDINAL method ,CASE studies ,RISK assessment ,SEX distribution ,STATISTICS ,T-test (Statistics) ,TIME ,MULTIPLE regression analysis ,TREATMENT effectiveness ,PROPORTIONAL hazards models ,MEDICAL equipment reliability ,PHYSICAL activity ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator ,LOG-rank test ,ODDS ratio ,MANN Whitney U Test - Abstract
Background: Failure of anterior cruciate ligament (ACL) reconstruction or an injury to the ACL in the contralateral knee represents a devastating event for patients, especially those young and physically active. However, controversies are still present regarding long-term failure rates and risk factors. Purpose: To assess the long-term rate of ipsilateral graft failure and contralateral ACL injuries after ACL reconstruction performed at a single center using the same surgical technique with a hamstring autograft and to investigate the effect of sex, age, and preinjury activity level as predictors of second ACL injuries. Study Design: Case series; Level of evidence, 4. Methods: The study cohort consisted of 244 consecutive patients (mean age, 30.7 years) who underwent ACL reconstruction with a single bundle plus lateral plasty technique using the hamstring tendon between November 2007 and May 2009. The number of subsequent ACL injuries (ipsilateral ACL revision or contralateral ACL reconstruction) was determined at a minimum follow-up of 10 years. Survivorship of either knee and subgroup analysis included sex, age, preoperative Tegner activity level, timing of ACL reconstruction, body mass index, and smoking status. Results: Ipsilateral ACL revision was performed in 8 (3.4%) patients and contralateral ACL reconstruction in 19 (7.8%) patients. Only 1 patient had both ipsilateral and contralateral injuries. No predictors were found for ipsilateral ACL revision, while age <18 years and preoperative Tegner level ≥7 had a higher risk of contralateral ACL reconstruction. The highest rate of a second ACL reconstruction procedure was in young (<18 years) and active (Tegner ≥7) patients, in whom the 10-year survival of either knee was 61.1%. Six years after primary ACL reconstruction, the rate of contralateral ACL reconstruction was significantly higher than that of ipsilateral ACL revision (hazard ratio, 2.4-3.6). Conclusion: In the long term, a second injury to either the ipsilateral or the contralateral knee in young and active populations could reach 40%, with a more than double-fold risk of contralateral ACL reconstruction compared with ipsilateral ACL revision. [ABSTRACT FROM AUTHOR]
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- 2020
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24. The Contribution of Partial Meniscectomy to Preoperative Laxity and Laxity After Anatomic Single-Bundle Anterior Cruciate Ligament Reconstruction: In Vivo Kinematics With Navigation.
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Grassi, Alberto, Di Paolo, Stefano, Lucidi, Gian Andrea, Macchiarola, Luca, Raggi, Federico, and Zaffagnini, Stefano
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ANTERIOR cruciate ligament surgery ,ANTERIOR cruciate ligament injuries ,JOINT hypermobility ,KINEMATICS ,MENISCECTOMY ,PREOPERATIVE care ,TREATMENT effectiveness ,CROSS-sectional method ,PREOPERATIVE period ,MANN Whitney U Test ,KRUSKAL-Wallis Test - Abstract
Background: Limited in vivo kinematic information exists on the effect of clinical-based partial medial and lateral meniscectomy in the context of anterior cruciate ligament (ACL) reconstruction. Hypothesis: In patients with ACL deficiency, partial medial meniscus removal increases the anteroposterior (AP) laxity with compared with those with intact menisci, while partial lateral meniscus removal increases dynamic laxity. In addition, greater postoperative laxity would be identified in patients with partial medial meniscectomy. Study design: Cross-sectional study; Level of evidence, 3. Methods: A total of 164 patients with ACL tears were included in the present study and divided into 4 groups according to the meniscus treatment they underwent: patients with partial lateral meniscectomy (LM group), patients with partial medial meniscectomy (MM group), patients with partial medial and lateral meniscectomy (MLM group), and patients with intact menisci who did not undergo any meniscus treatment (IM group). A further division in 2 new homogeneous groups was made based on the surgical technique: 46 had an isolated single-bundle anatomic ACL reconstruction (ACL group), while 13 underwent a combined single-bundle anatomic ACL reconstruction and partial medial meniscectomy (MM-ACL group). Standard clinical laxities (AP translation at 30° of knee flexion, AP translation at 90° of knee flexion) and pivot-shift (PS) tests were quantified before and after surgery by means of a surgical navigation system dedicated to kinematic assessment. The PS test was quantified through 3 different parameters: the anterior displacement of the lateral tibial compartment (lateral AP); the posterior acceleration of the lateral AP during tibial reduction (posterior acceleration); and finally, the area included by the lateral AP translation with respect to the flexion/extension angle (area). Results: In the ACL-deficient status, the MM group showed a significantly greater tibial translation compared with the IM group (P <.0001 for AP displacement at 30° [AP30] and 90° [AP90] of flexion) and the LM group (P =.002 for AP30 and P <.0001 for AP90). In the PS test, the area of LM group was significantly larger (57%; P =.0175) than the one of the IM group. After ACL reconstruction, AP translation at 30° was restored, while the AP90 remained significantly greater at 1.3 mm (P =.0262) in the MM-ACL group compared with those with intact menisci. Conclusion: Before ACL reconstruction, partial medial meniscectomy increased AP laxity at 30° and 90° and lateral meniscectomy increased dynamic PS laxity with respect to intact menisci. Anatomic single-bundle ACL reconstruction decreased laxities, but a residual anterior translation of 1.3 mm at 90° remained in patients with partial medial meniscectomy, with respect to those with intact menisci. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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25. Effects of Anterolateral Structure Augmentation on the In Vivo Kinematics of ACL-Reconstructed Knees: Letter to the Editor.
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Agostinone, Piero, Lucidi, Gian Andrea, Paolo, Stefano Di, Grassi, Alberto, and Zaffagnini, Stefano
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KNEE surgery , *ANTERIOR cruciate ligament surgery , *BIOMECHANICS , *KINEMATICS , *KNEE - Published
- 2021
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26. Paper 31: Risk factors affecting the survival rate of Collagen Meniscus Implant (CMI) for partial meniscus deficiency. An analysis of 156 consecutive cases at a mean 10 years of follow-up.
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Zaffagnini, Stefano, Grassi, Alberto, Agostinone, Piero, Fabbro, Giacomo Dal, Pizza, Nicola, Di Paolo, Stefano, and Lucidi, Gian Andrea
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- 2022
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