1. Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma
- Author
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Min Ye, Qun-dan Wu, Min Zhang, and Jinbei Huang
- Subjects
0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Population ,Apoptosis ,HNSCC ,Biochemistry ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Cell Line, Tumor ,Internal medicine ,Genetics ,medicine ,Anticarcinogenic Agents ,Humans ,Neoplasm Invasiveness ,Protein kinase A ,education ,Molecular Biology ,Protein kinase B ,education.field_of_study ,Cell growth ,Articles ,Cell cycle ,lycopene ,cell invasion ,Carotenoids ,Lycopene ,cell proliferation ,030104 developmental biology ,chemistry ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Cancer research ,Molecular Medicine ,Growth inhibition ,A431 cells - Abstract
Lycopene has been shown to be associated with anticancer effects in numerous tumor types. However, the underlying mechanisms of lycopene in human head and neck squamous cell carcinoma (HNSCC) remain to be determined. The present study aimed to investigate the involvement of lycopene overload and the cytotoxic effects of lycopene on HNSCC cells, and to determine the possible mechanisms involved. Treatment with lycopene at a dose of >10 µM for >24 h inhibited the growth of FaDu and Cal27 cells in a time- and dose-dependent manner. The clearest increase in growth inhibition was due to the apoptotic population being significantly increased. The invasion abilities decreased with 25 µM lycopene exerting significant inhibitory effects (P
- Published
- 2016