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Byline: L. A. Smit (1), N. Haagsma (1), A. Ruiter (1) Keywords: Key wordsaSulphadimidine; Fermented sausage; Carbon-14-labelling; Rat; Bound residues Abstract: aSulphadimidine (SDM), a drug frequently administered to pigs, is partially converted into other compounds by processing meat to produce raw, fermented sausage. With the aid of 14.sup.C-labelled SDM, evidence was obtained that part of the radioactive matter was covalently bound to the matrix. Part of these bound residues could be released in vitro by 4M HCl at 21aadegC or by 0.024M HCl at 37aadegC. Female rats were also able to release bound SDM residues and to excrete these in their urine, in amounts approaching those obtained by treatment with 4M HCl. Both the parent compound and its main metabolite, N .sup.4-acetyl-SDM, were observed in the urine of rats. Author Affiliation: (1) Department of the Science of Food of Animal Origin, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.175, 3508 TD Utrecht, The Netherlands, NL Article note: Received: 29 December 1997 / Revised version: 20 February 1998

Byline: Jan RA-zicka (1), KateAina Velclova (1), Rahula Janis (1), JiAi Krejci (1) Keywords: Monoacylglycerols; Antimicrobial activity; Bacteria; Fungi; Yeasts Abstract: This study was aimed at assessing the effects exhibited by two types of monoacylglycerols (monocaprin and monolaurin, prepared by reactions of glycidol with the corresponding fatty acids) against important species of bacteria, filamentous fungi and yeast-like organisms. Results of determined minimal inhibitory concentrations (MICs) showed that monocaprin at concentrations of 100--250 mg/l is able to stop completely the growth of all Gram-positive bacteria and yeasts tested, and at concentrations of 100--400 mg/l, the growth of most filamentous fungi. On the other hand, some Gram-negative bacteria and also the fungus Mucor racemosus proved to be resistant to monocaprin. The antimicrobial spectrum of monolaurin was clearly narrower, and almost exclusively involved Gram-positive bacterial species, with levels of MICs from 20 to 200 mg/l. Author Affiliation: (1) Faculty of Technology, Tomas Bata University in Zlin, T.G.M. 275, 762 72, Zlin, Czech Republic Article History: Received Date: 26/05/2003 Online Date: 14/08/2003