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Cone holography is a codimension-n doubly holographic model, which can be interpreted as the holographic dual of edge modes on defects. The initial model of cone holography is based on mixed boundary conditions. This paper formulates cone holography with Neumann boundary conditions, where the brane-localized gauge fields play an essential role. Firstly, we illustrate the main ideas in an AdS4/CFT1 toy model. We show that the U(1) gauge field on the end-of-the-world brane can make the typical solution consistent with Neumann boundary conditions. Then, we generalize the discussions to general codimension-n cone holography by employing brane-localized p-form gauge fields. We also investigate perturbative solutions and prove the mass spectrum of Kaluza-Klein gravitons is non-negative. Furthermore, we prove that cone holography obeys holographic c-theorem. Finally, inspired by the recently proposed chiral model in AdS/BCFT, we construct another type of cone holography with Neumann boundary conditions by applying massive vector (Proca) fields on the end-of-the-world brane. [ABSTRACT FROM AUTHOR]

Entanglement islands play an essential role in the recent breakthrough in addressing the black hole information paradox. Inspired by double holography, it is conjectured that the entanglement islands can exist only in massive gravity. There are many pieces of evidence but also debates for this conjecture. This paper recovers the massless entanglement island in wedge holography with negative DGP gravity on the brane. However, the spectrum of negative DGP gravity includes a massive ghost, implying the model is unstable. Our work supports the view that there is no entanglement island in a well-defined braneworld model of massless gravity if one divides the radiation and black hole regions by minimizing entanglement entropy. However, such a partition results in a zero radiation region containing no information. Whether there are other physical non-trivial partitions of the radiation region is an open question and deserves further study. [ABSTRACT FROM AUTHOR]

This paper investigates Page curves on the branes with higher codimensions and charges. We study two kinds of doubly holographic modes, the AdS/dCFT and cone holography. In AdS/dCFT, the gravitations on the brane are massive, and the black hole on the codim-m brane is coupled with the non-gravitational bath on the AdS boundary. Following the standard approach, we derive the Page curve for eternal black holes. On the other hand, cone holography includes massless graviton on the brane, and the bath becomes gravitating. By adding suitable DGP gravity on the end-of-the-world brane, we recover non-trivial entanglement islands and Page curves, which strongly support that the island is consistent with massless gravity. Finally, we analyze the effects of charges and find that, as the charges increase, the Page time increases, and the parameter space for non-trivial Page curves widens. [ABSTRACT FROM AUTHOR]

It is controversial whether entanglement islands can exist in massless gravity theories. Recently, it is found that the massless entanglement island appears in wedge holography with DGP gravity on the branes. In this paper, we generalize the discussions to the codim-n holography named cone holography. For simplicity, we focus on the case with a codim-2 E brane and a codim-1 Q brane. We discuss the effective action, mass spectrum and holographic entanglement entropy for cone holography with DGP terms. We verify that there is massless gravity on the branes, and recover non-trivial entanglement islands and Page curves. Besides, we work out the parameter space which allows entanglement islands and Page curves. Compared with wedge holography, there are several new features. First, one can not add DGP gravity on the codim-2 E brane. That is because the energy density has to be a constant on codim-2 branes for Einstein gravity in bulk. Second, the Hartman- Maldacena surface ends only on the codim-1 Q brane. Third, the Hartman-Maldacena surface can be defined only in a finite time. We notice that this unusual situation also appears in AdS/dCFT and even in AdS/CFT. Fortunately, it does not affect the Page curve since it happens after Page time. Our results provide more support that the entanglement island is consistent with massless gravity theories. [ABSTRACT FROM AUTHOR]

Entanglement islands play an essential role in the recent breakthrough in resolving the black hole information paradox. However, whether entanglement islands can exist in massless gravity theories is controversial. It is found that entanglement islands disappear in the initial model of wedge holography with massless gravity on the brane. As a result, the entanglement entropy of Hawking radiation becomes a time-independent constant, and there is no Page curve. In this paper, we recover massless entanglement islands in wedge holography with suitable DGP gravity or higher derivative gravity on the branes. We study two typical cases. In the first case, we consider a black hole on the strong-gravity brane and a bath on the weak-gravity brane. It is similar to the usual double holography with non-gravitational baths. In the second case, we discuss two black holes on the two branes with the same gravitational strength. We recover massless entanglement islands and non-trivial Page curves in both cases. We also argue that the entanglement island is consistent with massless gravity. Our results strongly support that entanglement islands can exist in long-range theories of gravity. [ABSTRACT FROM AUTHOR]

The previous studies of the island and double holography mainly focus on codimension-one branes. This paper explores the island on the codimension-two brane in AdS/dCFT. The codimension-two brane is closely related to conical singularity, which is very different from the codimension-one brane. We analyze the mass spectrum of gravitons on the codimension-two brane and find that the larger the brane tension is, the smaller the gravitational mass is. The massless mode is forbidden by either the boundary or normalization conditions. We prove that the first massive gravitational mode is located on the codimension-two brane; the larger the tension, the better the localization. It is similar to the case of codimension-one brane and builds an excellent physical foundation for the study of black hole evolution on codimension-two branes. We find that the Page curve of eternal black holes can be recovered due to the island ending on the codimension-two brane. The new feature is that the extremal surface passing the horizon cannot be defined after some finite time in the no-island phase. Fortunately, this unusual situation does not affect the Page curve since it happens after Page time. [ABSTRACT FROM AUTHOR]

In this paper, we investigate AdS/BCFT for curvature-squared gravity. To warm up, we start with Gauss-Bonnet gravity. We derive the one point function of stress tensor and show that the central charge related to the norm of displacement operator is positive for the couplings obeying causality constraints. Furthermore, by imposing the null energy condition on the end-of-the-world brane, we prove the holographic g-theorem for Gauss-Bonnet gravity. This corrects a wrong point of view in the literature, which claims that the holographic g-theorem is violated for Gauss-Bonnet gravity. As a by-product, we obtain the boundary entropy and A-type boundary central charges in general dimensions. We also study AdS/BCFT for general curvature-squared gravity. We find that it is too restrictive for the shape of the brane and the dual BCFT is trivial if one imposes Neumann boundary conditions for all of the gravitational modes. Instead, we propose to impose Dirichlet boundary condition for the massive graviton, while imposing Neumann boundary condition for the massless graviton. In this way, we obtain non-trivial shape dependence of stress tensor and well-defined central charges. In particular, the holographic g-theorem is satisfied by general curvature-squared gravity. Finally, we discuss the island and show that the Page curve can be recovered for Gauss-Bonnet gravity. Interestingly, there are zeroth-order phase transitions for the Page curve within one range of couplings obeying causality constraints. Generalizing the discussions to holographic entanglement entropy and holographic complexity in AdS/CFT, we get new constraints for the Gauss-Bonnet coupling, which is stronger than the causality constraint. [ABSTRACT FROM AUTHOR]

Background: Ferroptosis has attracted increasing interest in cancer therapy. Emerging evidences suggest that naturally occurring naphthoquinones exhibit potent anti-glioma effects via various mechanisms.Methods: The anti-glioma effects of plumbagin were evaluated by in vitro and in vivo experiments. Anti-glioma mechanism of plumbagin was studied by proteomics, flow cytometry, MDA assay, western blot, and RT-PCR. Gene knockdown/overexpression, molecular docking, PharmMappper database, and coimmunoprecipitation were used to study the targets of plumbagin.Results: Plumbagin showed higher blood-brain barrier penetration ability than that of lapachol and shikonin and elicited significant growth inhibitory effects in vitro and in vivo. Ferroptosis was the main mechanism of plumbagin-induced cell death. Mechanistically, plumbagin significantly downregulated the protein and mRNA levels of xCT and decreased GPX4 protein levels. NAD(P)H quinone dehydrogenase 1 (NQO1) was revealed as a plumbagin predictive target using PharmMappper database and molecular docking. Plumbagin enhanced NQO1 activity and decreased xCT expression, resulting in NQO1-dependent cell death. It also induced GPX4 degradation via the lysosome pathway and caused GPX4-dependent cell death.Conclusions: Plumbagin inhibited in vitro and in vivo glioma growth via targeting NQO1/GPX4-mediated ferroptosis, which might be developed as a novel ferroptosis inducer or anti-glioma candidate. [ABSTRACT FROM AUTHOR]

In this paper, we study the effective action, the mass spectrum and the first law of entanglement entropy for a novel doubly holographic model called wedge holography. We work out the effective action of quantum gravity on the branes. In the perturbative formulation, it is given by an infinite sum of Pauli-Fierz actions. In the non-perturbative formulation, the effective action is composed of a higher derivative gravity and a matter action. Usually, a higher derivative gravity can be renormalizable but suffers the ghost problem. For our case, since the effective theory on the brane is equivalent to Einstein gravity in the bulk, it must be ghost-free. We notice that the matter action plays an important role in eliminating the ghost. We also provide evidences that the higher derivative gravity on the brane is equivalent to a ghost-free multi-gravity. Besides, we prove that the effective action yields the correct Weyl anomaly. Interestingly, although the effective action on the brane is an infinite tower of higher derivative gravity, the holographic Weyl anomaly is exactly the same as that of Einstein gravity. We also analyze the mass spectrum of wedge holography. Remarkably, there is always a massless mode of gravitons on the end-of-the-world branes in wedge holography. This happens because one imposes Neumann boundary condition on both branes. On the other hand, the massless mode disappears if one imposes Dirichlet boundary condition on one of the branes as in brane world theory and AdS/BCFT. Finally, we verify the first law of entanglement entropy for wedge holography. Interestingly, the massive fluctuations are irrelevant to the first order perturbation of the holographic entanglement entropy. Thus, in many aspects, the effective theory on the brane behaves like massless Einstein gravity. [ABSTRACT FROM AUTHOR]

Recently, a codimension two holography called wedge holography is proposed as a generalization of AdS/CFT. It is conjectured that a gravitational theory in d + 1 dimensional wedge spacetime is dual to a d − 1 dimensional CFT on the corner of the wedge. In this paper, we give an exact construction of the gravitational solutions for wedge holography from the ones in AdS/CFT. By applying this construction, we prove the equivalence between wedge holography and AdS/CFT for vacuum Einstein gravity, by showing that the classical gravitational action and thus the CFT partition function in large N limit are the same for the two theories. The equivalence to AdS/CFT can be regarded as a “proof” of wedge holography in a certain sense. As an application of this powerful equivalence, we derive easily the holographic Weyl anomaly, holographic Entanglement/Rényi entropy and correlation functions for wedge holography. Besides, we discuss the general solutions of wedge holography and argue that they correspond to the AdS/CFT with suitable matter fields. Interestingly, we notice that the intrinsic Ricci scalar on the brane is always a constant, which depends on the tension. Finally, we generalize the discussions to dS/CFT and flat space holography. Remarkably, we find that AdS/CFT, dS/CFT and flat space holography can be unified in the framework of codimension two holography in asymptotically AdS. Different dualities are distinguished by different types of spacetimes on the brane. [ABSTRACT FROM AUTHOR]

Key message: OsWRKY36 represses plant height and grain size by inhibiting gibberellin signaling. Plant height and grain size are important agronomic traits affecting yield in cereals, including rice. Gibberellins (GAs) are plant hormones that promote plant growth and developmental processions such as stem elongation and grain size. WRKYs are transcription factors that regulate stress tolerance and plant development including height and grain size. However, the relationship between GA signaling and WRKY genes is still poorly understood. Here, we characterized a small grain and semi-dwarf 3 (sgsd3) mutant in rice cv. Hwayoung (WT). A T-DNA insertion in the 5′-UTR of OsWRKY36 induced overexpression of OsWRKY36 in the sgsd3 mutant, likely leading to the mutant phenotype. This was confirmed by the finding that overexpression of OsWRKY36 caused a similar small grain and semi-dwarf phenotype to the sgsd3 mutant whereas knock down and knock out caused larger grain phenotypes. The sgsd3 mutant was also hyposensitive to GA and accumulated higher mRNA and protein levels of SLR1 (a GA signaling DELLA-like inhibitor) compared with the WT. Further assays showed that OsWRKY36 enhanced SLR1 transcription by directly binding to its promoter. In addition, we found that OsWRKY36 can protect SLR1 from GA-mediated degradation. We thus identified a new GA signaling repressor OsWRKY36 that represses GA signaling through stabilizing the expression of SLR1. [ABSTRACT FROM AUTHOR]

This paper is an extended version of our short letter on a new proposal for holographic boundary conformal field, i.e., BCFT. By using the Penrose-Brown-Henneaux (PBH) transformation, we successfully obtain the expected boundary Weyl anomaly. The obtained boundary central charges satisfy naturally a c-like theorem holographically. We then develop an approach of holographic renormalization for BCFT, and reproduce the correct boundary Weyl anomaly. This provides a non-trivial check of our proposal. We also investigate the holographic entanglement entropy of BCFT and find that our proposal gives the expected orthogonal condition that the minimal surface must be normal to the spacetime boundaries if they intersect. This is another support for our proposal. We also find that the entanglement entropy depends on the boundary conditions of BCFT and the distance to the boundary; and that the entanglement wedge behaves a phase transition, which is important for the self-consistency of AdS/BCFT. Finally, we show that the proposal of is too restrictive that it always make vanishing some of the boundary central charges. [ABSTRACT FROM AUTHOR]

In this paper we investigate the entropy of gravitational Chern-Simons terms for the horizon with non-vanishing extrinsic curvatures, or the holographic entanglement entropy for arbitrary entangling surface. In 3D there is no anomaly of entropy. But the original squashed cone method can not be used directly to get the correct result. For higher dimensions the anomaly of entropy would appear, still, we can not use the squashed cone method directly. That is becasuse the Chern-Simons action is not gauge invariant. To get a reasonable result we suggest two methods. One is by adding a boundary term to recover the gauge invariance. This boundary term can be derived from the variation of the Chern-Simons action. The other one is by using the Chern-Simons relation dΩ = tr( R). We notice that the entropy of tr( R) is a total derivative locally, i.e. S = ds. We propose to identify s with the entropy of gravitational Chern-Simons terms Ω. In the first method we could get the correct result for Wald entropy in arbitrary dimension. In the second approach, in addition to Wald entropy, we can also obtain the anomaly of entropy with non-zero extrinsic curvatures. Our results imply that the entropy of a topological invariant, such as the Pontryagin term tr( R) and the Euler density, is a topological invariant on the entangling surface. [ABSTRACT FROM AUTHOR]

Recently it is found that, due to Weyl anomaly, a background scalar field induces a non-trivial Fermi condensation for theories with Yukawa couplings. For simplicity, the paper consider only scalar type Yukawa coupling and, in the BCFT case, only for a specific boundary condition. In these cases, the Weyl anomaly takes on a simple special form. In this paper, we generalize the results to more general situations. First, we obtain general expressions of Weyl anomaly due to a background scalar and pseudo scalar field in general 4d BCFTs. Then, we derive the general form of Fermi condensation from the Weyl anomaly. It is remarkable that, in general, Fermi condensation is non-zero even if there was not a non-vanishing scalar field background. Finally, we verify our results with free BCFT with Yukawa coupling to scalar and pseudo-scalar background potential with general chiral bag boundary condition and with holographic BCFT. In particular, we obtain the shape and curvature dependence of the Fermi condensate from the holographic one point function. [ABSTRACT FROM AUTHOR]

Seed dormancy is a complex agronomic trait that is not only controlled by genetics but also influenced by environmental conditions. Novel seed dormancy genes could improve rice yield and quality by preventing losses due to pre-harvest sprouting (PHS). Although there have been many reported studies related to seed dormancy in rice, little is known about seed dormancy genes derived from weedy rice. We used a weedy rice line 'Ludao' (with strong seed dormancy) as the donor parent and elite japonica variety 'Ninggeng 4' (with weak seed dormancy) as a recurrent parent for backcrossing. A BC4F2 population was developed for gene mapping, and germination percentage was used as the phenotype. Four quantitative trait loci (QTLs), qSdr7-1, qSdr7-2, qSdr7-3, and qSdr7-4, were identified on chromosome 7. Seed dormancy alleles of the QTLs were all derived from 'Ludao.' Located between markers RM21103 and RM5672, qSdr7-2 had the largest effect and explained 27.2% of the phenotypic variation with a LOD score of 14.5. Based on the closest linked marker for locus qSdr7-2, we developed near-isogenic lines (NILs) with the qSdr7-2 allele from 'Ludao' in 'Ninggeng 4' background. The qSdr7-2-NILs, which have strong seed dormancy and elite agronomic traits, should be useful as a parent in breeding for PHS resistance. [ABSTRACT FROM AUTHOR]

Neumann boundary condition plays an important role in the initial proposal of holographic dual of boundary conformal field theory, which has yield many interesting results and passed several non-trivial tests. In this paper, we show that Dirichlet boundary condition works as well as Neumann boundary condition. For instance, it includes AdS solution and obeys the g-theorem. Furthermore, it can produce the correct expression of one point function, the boundary Weyl anomaly and the universal relations between them. We also study the relative boundary condition for gauge fields, which is the counterpart of Dirichlet boundary condition for gravitational fields. Interestingly, the four-dimensional Reissner-Nordström black hole with magnetic charge is an exact solution to relative boundary condition under some conditions. This holographic model predicts that a constant magnetic field in the bulk can induce a constant current on the boundary in three dimensions. We suggest to measure this interesting boundary current in materials such as the graphene. [ABSTRACT FROM AUTHOR]