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The cross section of the 89 Y(n, γ ) reaction has important implications in nuclear astrophysics and for advanced nuclear technology. Given its neutron magic number N = 50 and a consequent small neutron capture cross section, 89 Y represents one of the key nuclides for the stellar s-process. It acts as a bottleneck in the neutron capture chain between the Fe seed and the heavier elements. Moreover, it is located at the overlapping region, where both the weak and main s-process components take place. 89 Y, the only stable yttrium isotope, is also used in innovative nuclear reactors. Neutron capture and transmission measurements were performed at the time-of-flight facilities n_TOF at CERN and GELINA at JRC-Geel. Resonance parameters of individual resonances were extracted from a resonance analysis of the experimental transmission and capture yields, up to a neutron incident energy of 95 keV. Even though a comparison with results reported in the literature shows differences in resonance parameters, the present data are consistent with the Maxwellian averaged cross section suggested by the astrophysical database KADoNiS. [ABSTRACT FROM AUTHOR]

Mitochondrial dysfunction has pleiotropic effects and is frequently caused by mitochondrial DNA mutations. However, factors such as significant variability in clinical manifestations make interpreting the pathogenicity of variants in the mitochondrial genome challenging. Here, we present APOGEE 2, a mitochondrially-centered ensemble method designed to improve the accuracy of pathogenicity predictions for interpreting missense mitochondrial variants. Built on the joint consensus recommendations by the American College of Medical Genetics and Genomics/Association for Molecular Pathology, APOGEE 2 features an improved machine learning method and a curated training set for enhanced performance metrics. It offers region-wise assessments of genome fragility and mechanistic analyses of specific amino acids that cause perceptible long-range effects on protein structure. With clinical and research use in mind, APOGEE 2 scores and pathogenicity probabilities are precompiled and available in MitImpact. APOGEE 2's ability to address challenges in interpreting mitochondrial missense variants makes it an essential tool in the field of mitochondrial genetics. APOGEE 2 is a machine-learning tool for assessing the fragility of the mitochondrial genome, evaluating genetic variant pathogenicity and ultimately enhancing our understanding of the clinical heterogeneity of mitochondrial genetic diseases. [ABSTRACT FROM AUTHOR]

We report the Sr and Ba isotopic compositions of 18 presolar SiC grains of types Y (11) and Z (7), rare types commonly argued to have formed in lower-than-solar metallicity asymptotic giant branch (AGB) stars. We find that the Y and Z grains show higher 88Sr/87Sr and more variable 138Ba/136Ba ratios than mainstream (MS) grains. According to FRANEC Torino AGB models, the Si, Sr, and Ba isotopic compositions of our Y and Z grains can be consistently explained if the grains came from low-mass AGB stars with 0.15 Z⊙ ≤ Z < 1.00 Z⊙, in which the 13C neutron exposure for the slow neutron-capture process is greatly reduced with respect to that required by MS grains for a 1.0 Z⊙ AGB star. This scenario is in line with the previous finding based on Ti isotopes, but it fails to explain the indistinguishable Mo isotopic compositions of MS, Y, and Z grains. [ABSTRACT FROM AUTHOR]

In the multidrug resistant (MDR) pathogen Acinetobacter baumannii the global repressor H-NS was shown to modulate the expression of genes involved in pathogenesis and stress response. In addition, H-NS inactivation results in an increased resistance to colistin, and in a hypermotile phenotype an altered stress response. To further contribute to the knowledge of this key transcriptional regulator in A. baumannii behavior, we studied the role of H-NS in antimicrobial resistance. Using two well characterized A. baumannii model strains with distinctive resistance profile and pathogenicity traits (AB5075 and A118), complementary transcriptomic and phenotypic approaches were used to study the role of H-NS in antimicrobial resistance, biofilm and quorum sensing gene expression. An increased expression of genes associated with β-lactam resistance, aminoglycosides, quinolones, chloramphenicol, trimethoprim and sulfonamides resistance in the Δhns mutant background was observed. Genes codifying for efflux pumps were also up-regulated, with the exception of adeFGH. The wild-type transcriptional level was restored in the complemented strain. In addition, the expression of biofilm related genes and biofilm production was lowered when the transcriptional repressor was absent. The quorum network genes aidA, abaI, kar and fadD were up-regulated in Δhns mutant strains. Overall, our results showed the complexity and scope of the regulatory network control by H-NS (genes involved in antibiotic resistance and persistence). These observations brings us one step closer to understanding the regulatory role of hns to combat A. baumannii infections. [ABSTRACT FROM AUTHOR]

Fagus sylvatica (beech) dominates the montane forests of the Apennines and builds old-growth high-conservation value stands. However, recent severe drought-induced diebacks raise concern on the future persistence of these forests and of Southern European mesophilous woodlands overall, growing at their dry edge. To explore the history of Apennine beech-dominated forests, we draw on the multiproxy paleoecological record from Lago Verdarolo, which includes a robust vegetation-independent temperature reconstruction. Numerical techniques are used to investigate the drivers of long-term Mediterranean mountain forest dynamics. Specifically, we focus on disentangling the ecological factors that caused the shift from high-diversity mixed forests to beech-dominated stands and on assessing the occurrence of legacy effects on present-day forests. Abrupt climate change largely drove vegetation dynamics during the Late Glacial and Early Holocene. Species-rich mixed Abies alba (silver fir) forests dominated about 10,500—5500 years ago, under rather dry and warmer-than-today conditions (+ 1—2 °C) and limited fire occurrence. Cooler and moister summers and increasing fire activity caused declines in several fire-sensitive temperate deciduous trees (for example, Ulmus, Tilia, Fraxinus) and favored the establishment of fir-beech forests around 5500 years ago. Further enhancement of fire activity and farming around 2000 years ago led to local Abies alba extinction and forest impoverishment. We conclude that the currently widespread monospecific Apennine beech forests are the result of multi-millennial land-use intensification superimposed on Late Holocene cooling and moistening. Given their higher drought-tolerance compared to beech stands, reviving ancient species-rich mixed fir forests represents a feasible and 'tested' possibility to adapt forests to climate change. [ABSTRACT FROM AUTHOR]

COVID-19 pandemic has become a significant international public health problem. In addition to dealing with the pandemic's impact on mental health, parents need to cope with specific changes in their routines caused by social distance measures. This study aimed to investigate common mental disorders (CMD) symptoms in Brazilian parents during the COVID-19 pandemic and its associated factors. A total of 232 Brazilian parents ranging from 20 to 48 years old (M = 33.85; SD = 4.83) with children aged 1–36 months (M = 17.00; SD = 9,87) participated in an online survey. Parents answered a sociodemographic questionnaire, Self-Report Questionnaire (SRQ-20), Perceived Stress Scale (PSS-4), and Parenting Sense of Competence Scale. Chi-square tests, correlations, and multiple linear regression were performed. Results showed that parents' symptoms of CMD were negatively associated to perceived parental competence (β =− 0.130; p = 0.011) and family income (β =− 0.190; p = 0.024). Furthermore, perceived stress was the most related variable to parents' symptoms of CMD (β = 0.618; p < 0.001), showing a positive association. The model explained 49.5% of the variation. Results suggest that lower family income may increase symptoms of CMD in Brazilian parents, which is a concern in a country of high social inequality. Parental sense of competence may be a relevant protective factor. Interventions targeting parental competence and stress reduction should be considered to address the mental health impacts of the pandemic. [ABSTRACT FROM AUTHOR]

We study the discretized worldsheet of Type IIB strings in the Gubser-Klebanov-Polyakov background in a new setup, which eliminates a complex phase previously detected in the fermionic determinant. A sign ambiguity remains, which a study of the fermionic spectrum shows to be related to Yukawa-like terms, including those present in the original Lagrangian before the linearization standard in a lattice QFT approach. Monte Carlo simulations are performed in a large region of the parameter space, where the sign problem starts becoming severe and instabilities appear due to the zero eigenvalues of the fermionic operator. To face these problems, simulations are conducted using the absolute value of a fermionic Pfaffian obtained introducing a small twisted-mass term, acting as an infrared regulator, into the action. The sign of the Pfaffian and the low modes of the quadratic fermionic operator are then taken into account by a reweighting procedure of which we discuss the impact on the measurement of the observables. In this setup we study bosonic and fermionic correlators and observe a divergence in the latter, which we argue — also via a one-loop analysis in lattice perturbation theory — to originate from the U(1)-breaking of our Wilson-like discretization for the fermionic sector. [ABSTRACT FROM AUTHOR]

The purpose of this study was to examine the intra-individual variation of heart rate variability (HRV) and heart rate using an orthostatic challenge in elite male athletes during a training camp. Heart rate (variability) was measured upon waking. Log-transformed HRV metrics were evaluated in three segments (first min discarded for stabilization): 0–3 min supine, 3–6 min supine, and standing. Heart rate was assessed while supine, 15 s after standing and average final 30 s standing (Rusko protocol). A RM-ANOVA compared intra-individual means, standard deviations (SD) and coefficients of variation (CV%) for HRV and heart rate. The intraclass correlation coefficient (ICC) and standard error of measurement (SEmeas) were used for relative and absolute reliability, respectively. Time and frequency domain HRV metrics had low variation (CV% <8.5%; SEmeas% ≤4.0%) for 0–3 min supine which was not improved during 3–6 min. Standing HRV had lower ICC and higher SEmeas than supine values. Variability and reliability outcomes for heart rate were comparable to log-transformed HRV metrics. This study uniquely describes the intra-individual variation of HRV metrics during an orthostatic challenge and demonstrated low variability in this cohort of elite male athletes. These data can be helpful for identifying when true individual changes occur for the autonomic nervous system indices in supine and standing positions. [ABSTRACT FROM AUTHOR]

Photobiomodulation (PBM) is a non-invasive treatment that uses laser or led devices making its effects a response to light and not to heat. The possibility of accelerating dental implant osteointegration and orthodontic movements and the need to treat refractory bone lesions, such as bisphosphonate related osteonecrosis of the jaws, has led researchers to consider the effects of PBM on bone for dentistry purposes. The aim of our study was to investigate the effects of 915 nm light supplied with a GaAs diode laser on human osteoblasts in vitro. Osteoblasts were isolated from mandibular cortical bone of a young healthy donor. The irradiation parameters were as follows: doses = 5, 15 and 45 J/cm2; power densities = 0.12 and 1.25 W/cm2; and irradiation times = 41.7, 125 and 375 s. We performed one irradiation per day for 3 and 6 days to study proliferation and differentiation, respectively. Microscopic analysis showed a greater amount of bone nodules in samples treated with 5 J/cm2 and 0.12 W/cm2 compared to controls (56.00 ± 10.44 vs 19.67 ± 7.64, P = 0.0075). Cell growth and quantification of calcium deposition did not show any differences when comparing irradiated and non-irradiated samples. Photobiomodulation, with the parameters investigated in the present study, positively modulated the mineralization process in human osteoblasts, inducing the formation of a greater amount of bone nodules, but did not increase cell proliferation. [ABSTRACT FROM AUTHOR]

In this paper we study the Bremsstrahlung functions for the 1/6 BPS and the 1/2 BPS Wilson lines in ABJM theory. First we use a superconformal defect approach to prove a conjectured relation between the Bremsstrahlung functions associated to the geometric (Bφ1/6) and R-symmetry (Bθ1/6) deformations of the 1/6 BPS Wilson line. This result, non-trivially following from a defect supersymmetric Ward identity, provides an exact expression for Bθ1/6 based on a known result for Bφ1/6. Subsequently, we explore the consequences of this relation for the 1/2 BPS Wilson line and, using the localization result for the multiply wound Wilson loop, we provide an exact closed form for the corresponding Bremsstrahlung function. Interestingly, for the comparison with integrability, this expression appears particularly natural in terms of the conjectured interpolating function h(λ). During the derivation of these results we analyze the protected defect supermultiplets associated to the broken symmetries, including their two- and three-point correlators. [ABSTRACT FROM AUTHOR]

We revisit the computation of the 1-loop string correction to the 'latitude' minimal surface in AdS × S representing 1/4 BPS Wilson loop in planar $$ \mathcal{N}=4 $$ SYM theory previously addressed in and . We resolve the problem of matching with the subleading term in the strong coupling expansion of the exact gauge theory result (derived previously from localization) using a different method to compute determinants of 2d string fluctuation operators. We apply perturbation theory in a small parameter (angle of the latitude) corresponding to an expansion near the AdS minimal surface representing 1/2 BPS circular Wilson loop. This allows us to compute the corrections to the heat kernels and zeta-functions of the operators in terms of the known heat kernels on AdS . We apply the same method also to two other examples of Wilson loop surfaces: generalized cusp and k-wound circle. [ABSTRACT FROM AUTHOR]

Background: Mechanical loading during exercise has been shown to promote tissue remodeling. Safe and accessible exercise may be beneficial to populations at risk of diminished bone and joint health. We examined the effect of drop height and instruction on knee loading during a drop-landing task and proposed a task that makes use of drop heights that may be appropriate for rehabilitation purposes and functional in daily life to examine transient knee joint loads. Methods: Twenty males (22.0 ± 2.8 years) performed drop landings from 22 cm (low) and 44 cm (high) heights, each under three instructions: 'land naturally' (natural), 'softly' (soft), and 'stiffly' (stiff). Knee compression force and external flexion moment were estimated using three-dimensional inverse dynamics and normalized to body mass. Results: Peak knee compression force was larger ( p < 0.001) for high (17.8 ± 0.63 N/kg) than low (14.8 ± 0.61 N/kg) heights. There was an increase ( p < 0.001) in the knee compression force across soft (11.8 ± 0.40 N/kg), natural (17.0 ± 0.62 N/kg), and stiff (20.2 ± 0.67 N/kg) instructions. Peak knee flexion moment in high-natural (2.12 ± 0.08 Nm/kg) was larger ( p < 0.001) than in high-soft (1.88 ± 0.08 Nm/kg), but lower than in high-stiff (2.23 ± 0.08 Nm/kg). No differences in peak knee flexion moment were observed across instructions for the low height. Conclusions: We propose a drop-landing task that creates a scalable increase in knee compression loading. The absence of increased knee flexion moment with drop from the low height, compared to high, suggests that individuals could perform the task without incremental risk of knee injury. This task could be used in future studies to examine the effect of acute bouts of mechanical loading on bone and cartilage metabolism. [ABSTRACT FROM AUTHOR]

Knowledge about vegetation and fire history of the mountains of Northern Sicily is scanty. We analysed five sites to fill this gap and used terrestrial plant macrofossils to establish robust radiocarbon chronologies. Palynological records from Gorgo Tondo, Gorgo Lungo, Marcato Cixé, Urgo Pietra Giordano and Gorgo Pollicino show that under natural or near natural conditions, deciduous forests ( Quercus pubescens, Q. cerris, Fraxinus ornus, Ulmus), that included a substantial portion of evergreen broadleaved species ( Q. suber, Q. ilex, Hedera helix), prevailed in the upper meso-mediterranean belt. Mesophilous deciduous and evergreen broadleaved trees ( Fagus sylvatica, Ilex aquifolium) dominated in the natural or quasi-natural forests of the oro-mediterranean belt. Forests were repeatedly opened for agricultural purposes. Fire activity was closely associated with farming, providing evidence that burning was a primary land use tool since Neolithic times. Land use and fire activity intensified during the Early Neolithic at 5000 bc, at the onset of the Bronze Age at 2500 bc and at the onset of the Iron Age at 800 bc. Our data and previous studies suggest that the large majority of open land communities in Sicily, from the coastal lowlands to the mountain areas below the thorny-cushion Astragalus belt (ca. 1,800 m a.s.l.), would rapidly develop into forests if land use ceased. Mesophilous Fagus- Ilex forests developed under warm mid Holocene conditions and were resilient to the combined impacts of humans and climate. The past ecology suggests a resilience of these summer-drought adapted communities to climate warming of about 2 °C. Hence, they may be particularly suited to provide heat and drought-adapted Fagus sylvatica ecotypes for maintaining drought-sensitive Central European beech forests under global warming conditions. [ABSTRACT FROM AUTHOR]

We consider possible discretizations for a gauge-fixed Green-Schwarz action of Type IIB superstring. We use them for measuring the action, from which we extract the cusp anomalous dimension of planar $$ \mathcal{N}=4 $$ SYM as derived from AdS/CFT, as well as the mass of the two AdS excitations transverse to the relevant null cusp classical string solution. We perform lattice simulations employing a Rational Hybrid Monte Carlo (RHMC) algorithm and two Wilson-like fermion discretizations, one of which preserves the global SO(6) symmetry the model. We compare our results with the expected behavior at various values of $$ g=\frac{\sqrt{\lambda }}{4\pi } $$. For both the observables, we find a good agreement for large g, which is the perturbative regime of the sigma-model. For smaller values of g, the expectation value of the action exhibits a deviation compatible with the presence of quadratic divergences. After their non-perturbative subtraction the continuum limit can be taken, and suggests a qualitative agreement with the non-perturbative expectation from AdS/CFT. Furthermore, we detect a phase in the fermion determinant, whose origin we explain, that for small g leads to a sign problem not treatable via standard reweigthing. The continuum extrapolations of the observables in the two different discretizations agree within errors, which is strongly suggesting that they lead to the same continuum limit. Part of the results discussed here were presented earlier in [1]. [ABSTRACT FROM AUTHOR]

Purpose: Laser therapy has been used for the prevention and management of medication-related ostenecrosis of the jaw (MRONJ). The aim of this paper was to investigate the action of laser therapy on extraction socket healing in rats in conditions at risk for MRONJ, evaluating the expression of markers of bone metabolism.Methods: Thirty male Sprague-Dawley rats were divided in four groups: control group (C, n = 5), laser group (L, n = 5), treatment group (T, n = 10), and treatment plus laser group (T + L, n = 10). Rats of group T and T + L received zoledronate 0.1 mg/kg and dexamethasone 1 mg/kg every 2 days for 10 weeks. Rats of group C and L were infused with vehicle. After 9 weeks, the left maxillary molars were extracted in all rats. Rats of groups L and T + L received laser therapy (Nd:YAG, 1064 nm, 1.25 W, 15 Hz, 5 min, 14.37 J/cm(2)) in the socket area at days 0, 2, 4, and 6 after surgery. Western blot analysis was performed to evaluate the alveolar expression of osteopontin (OPN) and osteocalcin (OCN) 8 days after extraction.Results: Rats of groups L and T + L showed a significant higher expression of OCN compared to rats of groups C and T (+348 and +400 %, respectively; P = 0.013 and P = 0.002, respectively). The expression of OPN did not show significant differences among the different groups.Conclusions: Our findings suggest that laser irradiation after tooth extraction can promote osteoblast differentiation, as demonstrated by the higher expression of OCN. Thus, laser irradiation could be considered a way to improve socket healing in conditions at risk for MRONJ development. [ABSTRACT FROM AUTHOR]

This article is part of the topical collection: Flow regimes and phase transitions in granular matter. Wang et al. (2020) carry out DEM simulations of superquadric particles to investigate the effect of particle shape on the steady flow pattern inside a conical silo. From the discrete side, Discrete Element Methods (DEM) or coarse-grained DEM are ways to model assemblies of grains, keeping the focus on the microscopic properties and the discrete nature of the granular matter, while providing reference data for continuum models. [Extracted from the article]

The aim of this study is to evaluate the possible intraoperative advantages of Nd:YAG laser and quantic molecular resonance (QMR) scalpel in oral soft tissue surgery. One hundred sixty-three interventions were evaluated. Group 1 (G1) included 77 interventions performed with Nd:YAG laser, group 2 (G2) 45 with QMR scalpel, and group 3 (G3) 41 with cold blade. Parameters analyzed were as follows: speed of incision, time of intervention, intraoperative bleeding, number of stitches, patient compliance, and operator comfort. Data were analyzed using software STATA 12 (StataCorp LP, College Station, TX, USA). Mean speed of incision was 0.54 mm/s in G1, 2.83 mm/s in G2, and 1.58 mm/s in G3, Nd:YAG laser being the slowest. However, no significant differences among times of intervention were found. In particular, interventions in G1 (221.15 ± 220.89 s) have a mean duration lower than G2 (280.56 ± 248.31 s) and G3 (316.10 ± 248.69 s). Intraoperative bleeding occurred in 29.9 % ( n = 23/77) of interventions in G1, 97.8 % ( n = 44/45) in G2, and 97.6 % ( n = 40/41) in G3 ( p < 0.0001). Mean number of stitches in G1 was statistically lower (G1, 0.10; G2, 2.07; G3, 2.29; p < 0.0001). No differences with regard to patient compliance were detected. Operator comfort was higher in G1 ( p < 0.0003). Nd:YAG laser and QMR scalpel give several advantages in oral mucosal surgery: Nd:YAG laser cuts tissue slowly, but it provides a good visibility and excellent hemostasis. QMR scalpel allows a very rapid cutting with no considerable temperature increase, but there is major risk of bleeding and need for sutures with lower operator comfort. [ABSTRACT FROM AUTHOR]

The implant surgery consists of two distinct techniques, the transmucosal, also known as 'one-stage' and the 'two-stage' technique. Lasers represent a possible aid in implant dentistry, especially in the two-stage technique and its main characteristics are represented by a decreased trauma to bone and soft tissues, a reduction of pain as well as a reduction of the risk of postoperative infections. The aim of this study was to analyze in an animal model the thermal elevation induced by four different laser wavelengths (diode, Nd:YAG, Er:YAG, KTP) during the implant uncovering. Four pig jaws were used to carry out this study. Five implants were placed in each anatomical specimen for a total of 20 fixtures. Four wavelengths (532, 810, 1,064 and 2,940 nm) were used to uncover the implants. Two thermocouples were used to measure temperature changes during laser irradiation at bone level, peri-implant tissues and on the fixture surface The thermocouples were connected with two probes of 1.5 mm in diameter, in order to simultaneously recording two temperature variations. Surface temperature was also checked during all procedures with a thermal camera (Thermovision A 800, Flyr Systems, Stockolm, Sweden) connected to a PC. The mean temperatures of each specimen (five fixtures) were calculated (TM1, mean temperature at the beginning; TM2, mean peak temperature). Furthermore, a record of the temperature at 1 min after the end of the surgical procedure was taken (mean: TM3). All the recorded values were statistically evaluated by one-way analysis of variance (ANOVA). The thermocouples recorded a lower increase in temperature for Er:YAG and KTP laser; Nd:YAG and diode laser produced similar increases characterized by higher values. The thermo-camera pointed out the lower increase for Er:YAG and higher for diode laser. KTP laser resulted faster in uncovering implants and diode laser was the one that needed more time. This ex vivo study showed that laser utilization with the recommended parameters gives no risks of dangerous thermal elevation to the tissues and implants. [ABSTRACT FROM AUTHOR]

Cadmium exposure causes health problems that may result from increased oxidative stress and from changes in enzyme metalloproteases activities as angiotensin-converting enzyme (ACE). In fact, cadmium produces inhibition of serum ACE but is not known how cadmium acts on tissue ACE activity and whether following acute exposure tissue cadmium content is increased. In order to elucidate these issues, a cadmium bolus was injected intravenously in Wistar rats, and the cadmium content and the ACE activity were measured in the serum, lungs, aorta and kidneys. Moreover, in order to clarify if the cadmium affects directly tissue ACE activity, acute metal exposure in vitro was performed. Our results demonstrated that 120 min following cadmium administration, blood and organ cadmium content were both increased. Serum and lung ACE activity were reduced following acute cadmium exposure, but aortic and kidney ACE activities were not affected. The inhibitory effects induced by cadmium on ACE activity were also observed in the serum, as well as the lungs and the aorta, but not in the kidneys following in vitro exposure. Moreover, the inhibitory effects induced by cadmium on ACE activity were partially restored in vitro by zinc supplementation, suggesting a possible interaction or competition between cadmium and zinc by at the active site of ACE. Summarising, our results suggest that acute cadmium exposure promotes an increase in the tissue metal content that was accompanied by direct inhibition of serum, aorta and lung ACE activity, an effect that is cadmium concentration-dependent and is partially reversed by zinc. [ABSTRACT FROM AUTHOR]

Congenital heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live births; the incidence of CHD is up to tenfold higher in human fetuses. A genetic contribution is strongly suggested by the association of CHD with chromosome abnormalities and high recurrence risk. Here we report findings from a recessive forward genetic screen in fetal mice, showing that cilia and cilia-transduced cell signalling have important roles in the pathogenesis of CHD. The cilium is an evolutionarily conserved organelle projecting from the cell surface with essential roles in diverse cellular processes. Using echocardiography, we ultrasound scanned 87,355 chemically mutagenized C57BL/6J fetal mice and recovered 218 CHD mouse models. Whole-exome sequencing identified 91 recessive CHD mutations in 61 genes. This included 34 cilia-related genes, 16 genes involved in cilia-transduced cell signalling, and 10 genes regulating vesicular trafficking, a pathway important for ciliogenesis and cell signalling. Surprisingly, many CHD genes encoded interacting proteins, suggesting that an interactome protein network may provide a larger genomic context for CHD pathogenesis. These findings provide novel insights into the potential Mendelian genetic contribution to CHD in the fetal population, a segment of the human population not well studied. We note that the pathways identified show overlap with CHD candidate genes recovered in CHD patients, suggesting that they may have relevance to the more complex genetics of CHD overall. These CHD mouse models and >8,000 incidental mutations have been sperm archived, creating a rich public resource for human disease modelling. [ABSTRACT FROM AUTHOR]

The purpose of this study was to perform a preliminary in vitro test on the possible use of two different laser wavelengths, 405 and 532 nm, to improve the dental bleaching results. To perform the test, the degradation of a dye, rhodamine B, under the effects of hydrogen peroxide was used. One hundred and twenty vials were divided into four groups of 30 samples each and, while three of them were irradiated with different wavelengths, 365 nm (reference), 405 nm and 532 nm, the fourth was the non-irradiated control group. Each of the four groups was further divided into three subgroups of 10 cuvettes ( n = 10) each. The three subgroups included a group with a rhodamine (RH) solution, a rhodamine and hydrogen peroxide (RH + HP) solution and a rhodamine plus hydrogen peroxide and ferrous gluconate (RH + FR) solution. When hydrogen peroxide was present, only UVA irradiation was able to produce significant results, whereas when the photo-Fenton reaction occurred, all the three wavelengths were able to produce a significant degradation of rhodamine B, with better results for longer wavelengths in comparison with short wavelengths. Within the limitations of this in vitro study, the light of the two laser devices, even remaining less effective than UV activation, showed its ability to improve the performance of bleaching agents based on Fenton photocatalysis, whereas when used in combination with hydrogen peroxide only, the 405-nm laser displayed a small effect and the 532-nm laser produced no effects. [ABSTRACT FROM AUTHOR]