1. Research on 1-aza two-ring systems
- Author
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L. N. Astakhova, I. M. Skvortsov, I. Ya. Evtushenko, S. N. Kuz'min, E. V. Cheslavskaya, and S. P. Voronin
- Subjects
chemistry.chemical_classification ,Hydrogen ,Hydrogen bond ,Stereochemistry ,Organic Chemistry ,chemistry.chemical_element ,Ring (chemistry) ,chemistry.chemical_compound ,chemistry ,Ethyl diazoacetate ,Squalane ,Diazo ,Spectral data ,Alkyl - Abstract
Mixtures of isomeric 5-, 6-, and 7-carbethoxymethyl-1,2-dihydropyrrolizines were obtained by reaction of 1,2-dihydropyrrolizines with ethyl diazoacetate. The effect of the position of the alkyl groups in the two-membered ring on the ratio of isomers in the reaction products is demonstrated. A method for the isolation of 5-carbethoxymethyl-1,2-dihydropyrrolizines from the mixtures of isomers based on the difference in their reactivities in diazo coupling is described. The preferred conformations of the two-membered rings in the 5-carbethoxymethyl-1,2-dihydropyrrolizines are judged from the PMR spectral data.
- Published
- 1980
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