153 results on '"Noel M"'
Search Results
2. Discrepancies in Non-Mohs Micrographic Surgery for Non-melanoma Skin Cancer Between Lighter-Skinned and Darker-Skinned Patients
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Borda, Luis J, primary, Encarnacion, Iain Noel M, additional, Saal, Ryan C, additional, Higgins II, H. William, additional, and Pariser, Robert J, additional
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- 2024
- Full Text
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3. Estimation of soil moisture and soil temperature over India using the Noah multi-parameterisation land surface model
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Noel M. Chawang, Sai Krishna V. S. Sakuru, Anoop Sampelli, Srinivasulu Jella, Kusuma G. Rao, and M. V. Ramana
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Computers in Earth Sciences ,Statistics, Probability and Uncertainty ,General Agricultural and Biological Sciences ,General Environmental Science - Published
- 2022
4. Treatments for the amelioration of persistent factors in complex anal fistula
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Noel M. Gately, Daniel P. Fitzpatrick, Carmel Kealey, Damien Brady, Martin Goodman, Athlone Institute of Technology, and Athlone Institute of Technology President Doctoral Scholarship
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Anal fistula ,medicine.medical_specialty ,Fistula ,Anal Canal ,Bioengineering ,Stem cells ,Disease ,Biologics ,Applied Microbiology and Biotechnology ,Persistence ,Quality of life ,medicine ,Humans ,Rectal Fistula ,Tissue engineering ,Intensive care medicine ,Depression (differential diagnoses) ,business.industry ,Mesenchymal Stem Cells ,General Medicine ,Anal canal ,medicine.disease ,Anus ,Treatment Outcome ,medicine.anatomical_structure ,Drug delivery ,Quality of Life ,Materials Research Institute AIT ,Anxiety ,medicine.symptom ,business ,Biotechnology - Abstract
Anal fistulae are abnormal hollow connections between the wall of the anal canal and the perianal skin around the anus that have remained a burden on the medical sector for centuries. The complexity of this disease is attributed to a number of factors such as the degree of associated sphincter muscle, concomitant illnesses, existence of multiple fistulous tracts and the number of previous interventions. Persistence of a complex anal fistula can cause a decline in patient's physical quality of life as well as impact on the psychological status of patients who often suffer from anxiety and depression. Surgical intervention remains the gold standard for treatment, however; the risk of incontinence and high recurrence potential has led to interest into developing alternative treatment approaches such as the use of biologics, bioactives and biomaterials. One potential reason for these varied outcomes could be the multifactorial interplay between genetic, immune-related, environmental, and microbial persistence factors on tissue regeneration. Recent observations have proposed that adverse inflammatory mediators may contribute more than microbial factors. The moderate to high success rates of biotechnological advances (mesenchymal stem cells and biomaterial scaffolds) show promise as therapies for the amelioration of adverse persistent factors while facilitating a means to closing the fistula tract. The purpose of this review is to outline recent advances in biologics and combination therapies to treat persistent factors associated with complex anal fistula.
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- 2021
5. Augmented Hill-Climb increases reinforcement learning efficiency for language-based de novo molecule generation
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Morgan Thomas, Noel M. O’Boyle, Andreas Bender, Chris de Graaf, Apollo - University of Cambridge Repository, and Thomas, Morgan [0000-0002-1610-3499]
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SBDD ,Artificial intelligence ,Research ,Generative models ,Recurrent neural network ,Deep learning ,Library and Information Sciences ,Computer Graphics and Computer-Aided Design ,Computer Science Applications ,REINVENT ,De novo design ,Hill-Climb ,AI ,Molecular docking ,Reinforcement learning ,REINFORCE ,Structure-based drug design ,Physical and Theoretical Chemistry - Abstract
A plethora of AI-based techniques now exists to conduct de novo molecule generation that can devise molecules conditioned towards a particular endpoint in the context of drug design. One popular approach is using reinforcement learning to update a recurrent neural network or language-based de novo molecule generator. However, reinforcement learning can be inefficient, sometimes requiring up to 105 molecules to be sampled to optimize more complex objectives, which poses a limitation when using computationally expensive scoring functions like docking or computer-aided synthesis planning models. In this work, we propose a reinforcement learning strategy called Augmented Hill-Climb based on a simple, hypothesis-driven hybrid between REINVENT and Hill-Climb that improves sample-efficiency by addressing the limitations of both currently used strategies. We compare its ability to optimize several docking tasks with REINVENT and benchmark this strategy against other commonly used reinforcement learning strategies including REINFORCE, REINVENT (version 1 and 2), Hill-Climb and best agent reminder. We find that optimization ability is improved ~ 1.5-fold and sample-efficiency is improved ~ 45-fold compared to REINVENT while still delivering appealing chemistry as output. Diversity filters were used, and their parameters were tuned to overcome observed failure modes that take advantage of certain diversity filter configurations. We find that Augmented Hill-Climb outperforms the other reinforcement learning strategies used on six tasks, especially in the early stages of training or for more difficult objectives. Lastly, we show improved performance not only on recurrent neural networks but also on a reinforcement learning stabilized transformer architecture. Overall, we show that Augmented Hill-Climb improves sample-efficiency for language-based de novo molecule generation conditioning via reinforcement learning, compared to the current state-of-the-art. This makes more computationally expensive scoring functions, such as docking, more accessible on a relevant timescale.
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- 2022
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- View/download PDF
6. Invasive Plants as Foci of Mosquito-Borne Pathogens: Red Cedar in the Southern Great Plains of the USA
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Justin L. Talley, Bruce H. Noden, Michael H. Reiskind, and Noel M. Cote
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Abiotic component ,Ecology ,biology ,Culex ,viruses ,Health, Toxicology and Mutagenesis ,fungi ,virus diseases ,Mosquito Vectors ,Vegetation ,biology.organism_classification ,United States ,Invasive species ,Culicidae ,Deciduous ,Habitat ,Animal ecology ,parasitic diseases ,Culex pipiens ,Animals ,Humans ,West Nile virus ,West Nile Fever - Abstract
West Nile virus (WNV) is the most significant mosquito-borne disease affecting humans in the United States. Eastern redcedar (ERC) is a native encroaching plant in the southern Great Plains that greatly alters abiotic conditions and bird and mosquito populations. This study tested the hypotheses that mosquito communities and their likelihood of WNV infection differ between ERC and other habitats in the southern Great Plains of the United States. We found support for our first hypothesis, with significantly more Culex tarsalis and Culex erraticus in ERC than deciduous and grass habitats. Mosquito communities in Central Oklahoma were more diverse (21 species) than western Oklahoma (11 species) but this difference was not associated with vegetation. Our second hypothesis was also supported, with significantly more WNV-infected Culex from ERC in both regions, as was our third hypothesis, with significantly more Culex tarsalis and Culex pipiens collected in ERC than other habitats in urban areas. The connection of mosquito-borne disease with invasive plants suggests that land management initiatives can affect human health and should be considered in light of public health impact. Evidence from other vector-borne disease suggests invasive plants, both in the Great Plains and globally, may facilitate the transmission of vector-borne pathogens.
- Published
- 2021
7. A purposeful approach for measuring greenhouse gas emissions of material flow accounts for the accomplishment of territorial sustainable development and cultural economy goals on climate. The case of the Basque Country
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Roberto Alvaro-Hermana, Macarena Larrea Basterra, Noel M. Muniz, and Nuria Ceular-Villamandos
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Sustainable development ,Economics and Econometrics ,Product lifecycle ,Natural resource economics ,United Nations Framework Convention on Climate Change ,Greenhouse gas ,Circular economy ,Geography, Planning and Development ,Climate change ,Business ,Management, Monitoring, Policy and Law ,Productivity ,Gross domestic product - Abstract
This study aims at developing a purposeful approach for estimating greenhouse gas (GHG) emissions and its possible use to recreate alternative scenarios that might potentially facilitate the attainment of the material productivity (MP) ratio needed for achieving territorial sustainable development (SDGs) and circular economy goals on climate. The propounded method associates these two key concepts (GHG-MP) with the domestic material consumption (DMC) and international trade of materials, including product life cycle emissions in the overarching GHG total estimation. Developed utilizing the United Nations Framework Convention on Climate Change (UNFCCC) and diverse data, linked to the suggested scheme, from the Basque Country (Spain), this work also relies its scientific foundation upon leading literature in this field to align territorial models of production and consumption with a more localized measurement of GHG emissions. According to its results, the emissions estimated allow advising more contextualized scenarios for the potential achievement of local MP target indicator, when expressed as the amount of economic output―based on gross domestic product (GDP)—generated per unit of materials consumed and traded―in terms of DMC. From a theoretical perspective, this work contributes to the local strategic management of circular economy research and 2030 Agenda, particularly on the subject of measuring progress in the achievement of territorial climate and circular economy goals. From a utilitarian perspective, the findings comprise promising implications for both multilevel policy makers and public/private organizations that further sustainable development and actions against climate change.
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- 2021
8. Entanglement transitivity problems
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Gelo Noel M. Tabia, Kai-Siang Chen, Chung-Yun Hsieh, Yu-Chun Yin, and Yeong-Cherng Liang
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Quantum Physics ,Computational Theory and Mathematics ,Computer Networks and Communications ,Computer Science (miscellaneous) ,FOS: Physical sciences ,Statistical and Nonlinear Physics ,Quantum Physics (quant-ph) - Abstract
One of the goals of science is to understand the relation between a whole and its parts, as exemplified by the problem of certifying the entanglement of a system from the knowledge of its reduced states. Here, we focus on a different but related question: can a collection of marginal information reveal new marginal information? We answer this affirmatively and show that (non-) entangled marginal states may exhibit (meta)transitivity of entanglement, i.e., implying that a different target marginal must be entangled. By showing that the global $n$-qubit state compatible with certain two-qubit marginals in a tree form is unique, we prove that transitivity exists for a system involving an arbitrarily large number of qubits. We also completely characterize -- in the sense of providing both the necessary and sufficient conditions -- when (meta)transitivity can occur in a tripartite scenario when the two-qudit marginals given are either the Werner states or the isotropic states. Our numerical results suggest that in the tripartite scenario, entanglement transitivity is generic among the marginals derived from pure states., Comment: 8+10 pages, 9 figures, 2 tables. Virtually the same as the published version
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- 2022
9. Augmented Hill-Climb increases reinforcement learning efficiency for language-based de novo molecule generation
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Thomas, Morgan, primary, O’Boyle, Noel M., additional, Bender, Andreas, additional, and de Graaf, Chris, additional
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- 2022
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10. Entanglement transitivity problems
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Tabia, Gelo Noel M., primary, Chen, Kai-Siang, additional, Hsieh, Chung-Yun, additional, Yin, Yu-Chun, additional, and Liang, Yeong-Cherng, additional
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- 2022
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11. Evaluation and Analysis of Fracture Modes in Single Composite Basalt/Epoxy Fibres by Photoelastic Method and Single Fibre Fragmentation Test
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Thornton, Eoghan, primary, Ghabezi, Pouyan, additional, Ralph, Calvin, additional, Strain, Findhan, additional, and Harrison, Noel M., additional
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- 2022
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12. Deflating the Deep Brain Stimulation Causes Personality Changes Bubble: the Authors Reply
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C. Ineichen, John Noel M. Viaña, and Frederic Gilbert
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Health Policy ,media_common.quotation_subject ,Cognition ,06 humanities and the arts ,0603 philosophy, ethics and religion ,03 medical and health sciences ,Psychiatry and Mental health ,Personality changes ,0302 clinical medicine ,Empirical research ,Neurology ,Agency (sociology) ,Personality ,060301 applied ethics ,Meaning (existential) ,Psychology ,Neuroethics ,030217 neurology & neurosurgery ,Autonomy ,media_common ,Cognitive psychology - Abstract
To conclude that there is enough or not enough evidence demonstrating that deep brain stimulation (DBS) causes unintended postoperative personality changes is an epistemic problem that should be answered on the basis of established, replicable, and valid data. If prospective DBS recipients delay or refuse to be implanted because they are afraid of suffering from personality changes following DBS, and their fears are based on unsubstantiated claims made in the neuroethics literature, then researchers making these claims bear great responsibility for prospective recipients' medical decisions and subsequent well-being. Our article “Deflating the ‘DBS causes personality’ bubble” reported an increase in theoretical neuroethics publications suggesting putative DBS-induced changes to personality, identity, agency, autonomy, authenticity and/or self (PIAAAS) and a critical lack of supporting primary empirical studies. This special issue of Neuroethics brings together responses to our initial publication, with our own counter-responses organized according to common themes. We provide a brief summary for each commentary and its main criticisms as well as a discussion of the way in which these responses can: 1) help clarify the meaning of PIAAAS, suggesting supplementary frameworks for understanding the impact of DBS on PIAAAS; 2) provide further empirical evidence of PIAAAS by presenting results from the researchers’ own work; and/or 3) offer a critique of our research approach and/or findings. Unintended postoperative putative changes to PIAAAS remain a critical ethical concern. It is beyond dispute that we need to develop reliable empirical and conceptual instruments able to measure complex cognitive, affective, and behavioural changes in order to investigate whether they are attributable to DBS alone.
- Published
- 2020
13. Single-step process of microstructural functionally graded Ti6Al4V by laser powder bed fusion additive manufacturing
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Brendan Phelan, Yaoyi Geng, Ramesh Raghavendra, and Noel M. Harrison
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0209 industrial biotechnology ,Fusion ,Materials science ,Mechanical Engineering ,Metals and Alloys ,Titanium alloy ,02 engineering and technology ,Process variable ,Microstructure ,Laser ,Functionally graded material ,020501 mining & metallurgy ,law.invention ,020901 industrial engineering & automation ,0205 materials engineering ,Mechanics of Materials ,law ,Solid mechanics ,Laser power scaling ,Composite material - Abstract
The objectives of this study are: (1) to verify whether using linear heat input alone is sufficient to predict the resulting microstructure of Ti6Al4V and (2) to demonstrate the potential of single-step process of functionally graded material using powder bed fusion. In laser powder bed fusion, linear heat input is defined as the ratio of laser power to scan speed. It is a key process variable that describes the unit energy input. Therefore, linear heat input has been extensively linked with the resulting microstructure. However, review of existing studies shows that when similar linear heat input was used, a marked difference in mechanical properties exists. Using proportionally changed laser power and scan speed in five zones, functionally graded specimens were fabricated in this study. All other parameters remain the same for these zones. Variation of microstructure and hardness across the five zones were obtained. This implies that linear heat input is not sufficient to determine the resulting microstructure and mechanical properties. The amplitude of laser power and scan speed has an effect on the resulting microstructure, so they need to be separately considered in future studies.
- Published
- 2020
14. Hygrothermal deterioration in carbon/epoxy and glass/epoxy composite laminates aged in marine-based environment (degradation mechanism, mechanical and physicochemical properties)
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Ghabezi, Pouyan, primary and Harrison, Noel M., additional
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- 2022
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15. Computational modelling of dynamic recrystallisation of Ni-based superalloy during linear friction welding
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Okeke, Saviour I., primary, Harrison, Noel M., additional, and Tong, Mingming, additional
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- 2022
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16. Friction modulation in limbless, three-dimensional gaits and heterogeneous terrains
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Mattia Gazzola, Tejaswin Parthasarathy, Xiaotian Zhang, and Noel M. Naughton
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Friction ,Computer science ,Science ,FOS: Physical sciences ,General Physics and Astronomy ,Terrain ,Article ,General Biochemistry, Genetics and Molecular Biology ,Through-the-lens metering ,Computational biophysics ,Modulation (music) ,Refraction (sound) ,Animals ,Physics - Biological Physics ,Gait ,Lenses ,Multidisciplinary ,Behavior, Animal ,Snakes ,General Chemistry ,Terrestrial locomotion ,Biomechanical Phenomena ,Biological Physics (physics.bio-ph) ,Sidewinding ,Reflection (physics) ,Biological system ,Biological physics ,Locomotion - Abstract
Motivated by a possible convergence of terrestrial limbless locomotion strategies ultimately determined by interfacial effects, we show how both 3D gait alterations and locomotory adaptations to heterogeneous terrains can be understood through the lens of local friction modulation. Via an effective-friction modeling approach, compounded by 3D simulations, the emergence and disappearance of a range of locomotory behaviors observed in nature is systematically explained in relation to inhabited environments. Our approach also simplifies the treatment of terrain heterogeneity, whereby even solid obstacles may be seen as high friction regions, which we confirm against experiments of snakes ‘diffracting’ while traversing rows of posts, similar to optical waves. We further this optic analogy by illustrating snake refraction, reflection and lens focusing. We use these insights to engineer surface friction patterns and demonstrate passive snake navigation in complex topographies. Overall, our study outlines a unified view that connects active and passive 3D mechanics with heterogeneous interfacial effects to explain a broad set of biological observations, and potentially inspire engineering design., A long puzzle in snake’s locomotion, sidewinding allows them to travel at an angle and reorient in some environments without loss of speed. Here, authors provide a mathematical argument to the evolution of sidewinding gaits and reinforce an analogy between limbless terrestrial locomotion and optics.
- Published
- 2021
17. Invasive Plants as Foci of Mosquito-Borne Pathogens: Red Cedar in the Southern Great Plains of the USA
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Noden, Bruce H., primary, Cote, Noel M., additional, Reiskind, Michael H., additional, and Talley, Justin L., additional
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- 2021
- Full Text
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18. A purposeful approach for measuring greenhouse gas emissions of material flow accounts for the accomplishment of territorial sustainable development and cultural economy goals on climate. The case of the Basque Country
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Larrea Basterra, Macarena, primary, Alvaro-Hermana, Roberto, additional, Ceular-Villamandos, Nuria, additional, and Muniz, Noel M., additional
- Published
- 2021
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19. Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
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Pablo Gurman, Sebastian D’hers, Noel M. Elman, and Agustín N. Abad Vazquez
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Active ingredient ,Materials science ,Chromatography ,Glass Vial ,Drug Storage ,Pharmaceutical Science ,Equipment Design ,02 engineering and technology ,Glucagon ,021001 nanoscience & nanotechnology ,030226 pharmacology & pharmacy ,03 medical and health sciences ,Improved performance ,Drug Delivery Systems ,Freeze Drying ,0302 clinical medicine ,Drug Stability ,Printing, Three-Dimensional ,Drug delivery ,Stable storage ,0210 nano-technology ,Drug Packaging - Abstract
Current emergency injectors of glucagon require manual reconstitution, which involves several steps that may lead to dosage errors. Rapid reconstitution packages (RRPs) are new devices, designed using computational fluid dynamics (CFD) to optimize fluid mixing, integrating physical properties of active pharmaceutical ingredients (APIs), excipients and diluents. RRPs improve drug stability for long-term storage and ease of delivery. Device prototypes were manufactured using advanced stereolithography apparatus (SLA) 3D printing technology. Reconstitution of glucagon with RRPs was evaluated by high-performance liquid chromatography (HPLC) and optical spectroscopy methods. Enzyme-linked immunosorbent assays were performed to test in vitro activity. Experimental results showed that RRPs effectively reconstituted glucagon even after exposure to 60 °C for a 24-h period. RRPs exhibited improved performance at maintaining drug stability compared to lyophilized glucagon stored in a standard glass vial under the same temperature conditions. RRPs represent a portable platform for rapid reconstitution of lyophilized drugs, compatible with standard syringes available in any clinical setting. The RRP provides an alternative to manual reconstitution process, especially designed for medical emergencies.
- Published
- 2019
20. Dissolution of delta phase in Ni-based superalloy during linear friction welding: integrated multiphysics computational process modelling
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Okeke, Saviour I., primary, Harrison, Noel M., additional, and Tong, Mingming, additional
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- 2021
- Full Text
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21. Comparison of structure- and ligand-based scoring functions for deep generative models: a GPCR case study
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Thomas, Morgan, primary, Smith, Robert T., additional, O’Boyle, Noel M., additional, de Graaf, Chris, additional, and Bender, Andreas, additional
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- 2021
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22. Chiari 1: Is decompression always necessary previous to scoliosis surgery?
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Rodriguez, V. Vazquez, primary, Tello, C. A., additional, Piantoni, L., additional, Wilson, I. A. Francheri, additional, Galareto, E., additional, Remondino, R. G., additional, Bersusky, S. E., additional, Davies, R., additional, and Noel, M. A., additional
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- 2021
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23. Mesenchymal stromal cell derived CCL2 is required for accelerated wound healing
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Noel M. Caplice, Derek Whelan, and A.J.P. Clover
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Stromal cell ,Angiogenesis ,medicine.medical_treatment ,lcsh:Medicine ,Neovascularization, Physiologic ,Mice, Transgenic ,Receptors, Cell Surface ,CCL2 ,Article ,Stem-cell biotechnology ,Immunomodulation ,Neovascularization ,Re-Epithelialization ,medicine ,Animals ,Macrophage ,Tissue engineering ,Lectins, C-Type ,lcsh:Science ,Chemokine CCL2 ,Inflammation ,Wound Healing ,Multidisciplinary ,business.industry ,Macrophages ,lcsh:R ,Mesenchymal stem cell ,Cell Polarity ,Mesenchymal Stem Cells ,Translational research ,Immunity, Innate ,Mice, Inbred C57BL ,Disease Models, Animal ,Mannose-Binding Lectins ,Cytokine ,Cancer research ,lcsh:Q ,Female ,medicine.symptom ,Wound healing ,business ,Mannose Receptor - Abstract
Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is a potent cytokine involved in the recruitment of macrophages. We hypothesised that MSC derived CCL2 may be involved in the MSC therapeutic effect by facilitating macrophage repolarisation. To further delineate this mechanism, MSC isolated from CCL2 deficient mice (MSC-KO) were applied to excisional wounds in wild-type (WT) mice. CCL2 deficiency in MSC completely abrogated the therapeutic response compared to MSC-WT. MSC-KO were unable to repolarise macrophages to the same extent as WT and this was accompanied by a reduced angiogenesis and re-epithelialisation of the wounds at day 10. This study demonstrates that MSC derived CCL2 is required for MSC induced accelerated wound healing. The role of CCL2 in the interaction between MSC and Macrophages has not been previously demonstrated in accelerated wound healing. CCL2 has a potent effect on the ability to reduce the inflammatory response through local recruitment of macrophages. This research highlights CCL2 as a possible target for augmentation of MSC therapy to enhance therapeutic potential.
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- 2020
24. Deflating the 'DBS causes personality changes' bubble
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John Noel M. Viaña, C. Ineichen, and Frederic Gilbert
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Health Policy ,media_common.quotation_subject ,Agency (philosophy) ,06 humanities and the arts ,0603 philosophy, ethics and religion ,Scientific evidence ,03 medical and health sciences ,Psychiatry and Mental health ,Personality changes ,0302 clinical medicine ,Empirical research ,Neurology ,Personality ,060301 applied ethics ,Neuroethics ,Psychology ,Empirical evidence ,030217 neurology & neurosurgery ,Autonomy ,media_common ,Cognitive psychology - Abstract
The idea that deep brain stimulation (DBS) induces changes to personality, identity, agency, authenticity, autonomy and self (PIAAAS) is so deeply entrenched within neuroethics discourses that it has become an unchallenged narrative. In this article, we critically assess evidence about putative effects of DBS on PIAAAS. We conducted a literature review of more than 1535 articles to investigate the prevalence of scientific evidence regarding these potential DBS-induced changes. While we observed an increase in the number of publications in theoretical neuroethics that mention putative DBS-induced changes to patients’ postoperative PIAAAS, we found a critical lack of primary empirical studies corroborating these claims. Our findings strongly suggest that the theoretical neuroethics debate on putative effects of DBS relies on very limited empirical evidence and is, instead, reliant on unsubstantiated speculative assumptions probably in lieu of robust evidence. As such, this may reflect the likelihood of a speculative neuroethics bubble that may need to be deflated. Nevertheless, despite the low number of first-hand primary studies and large number of marginal and single case reports, potential postoperative DBS changes experienced by patients remain a critical ethical concern. We recommend further empirical research in order to enhance theoretical neuroethics work in the area. In particular, we call for the development of better instruments capable of capturing potential postoperative variations of PIAAAS.
- Published
- 2018
25. Aneurysmal bone cyst and osteoblastoma: an extremely rare combination in the pediatric spine
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Lazaro, F. A., primary, Remondino, R. G., additional, Piantoni, L., additional, Tello, C. A., additional, Galaretto, E., additional, Francheri Wilson, I. A., additional, and Noel, M. A., additional
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- 2020
- Full Text
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26. Mesenchymal stromal cell derived CCL2 is required for accelerated wound healing
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Whelan, Derek S., primary, Caplice, Noel M., additional, and Clover, Anthony J. P., additional
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- 2020
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27. The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence
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Boyaji, Shafik, primary, Merkow, Justin, additional, Elman, R. Noel M., additional, Kaye, Alan D., additional, Yong, R. Jason, additional, and Urman, Richard D., additional
- Published
- 2020
- Full Text
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28. Ab-initio calculations of chemical and optoelectronic properties of 7-atom Pt-Y [Y = Li, Na, K]
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Bruno S. Dandogbessi, F. Hontinfinde, and Noel M. Hounye
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Materials science ,Absorption spectroscopy ,Binding energy ,Bioengineering ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Molecular physics ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Nanoclusters ,Condensed Matter::Materials Science ,Absorption band ,Modeling and Simulation ,Atom ,Physics::Atomic and Molecular Clusters ,General Materials Science ,Molecular orbital ,Density functional theory ,0210 nano-technology ,HOMO/LUMO - Abstract
Using density functional theory, we investigated structural, chemical, electronic, and optical properties of the 7 neutral atom Pt-Y [Y = Li, Na, K] pure and nanoalloys. The generalized gradient approximation and ultrasoft pseudopotential are considered. Interesting results are achieved. In particular, Pt6Li cluster shows a higher absolute value of the binding energy (BE) whereas in all other Pt7-mYm systems, this value decreases when m increases. The more the atomic radius increases, the less the resulting alkali metal nanoclusters are cohesive. The most stable structure of Pt7-mYm cluster is obtained when m = 4 for Li and Na atoms, whereas for K atom, this occurs for m = 3. Moreover, the calculated absorption spectra of the Pt7-mYm (m = 2, 4, 6) have revealed that the doping with Li, Na, and K widens the absorption band. Also, the absorption spectra obtained are more pronounced in the low energy zone. It appears that the electron absorption strength is high in low excitation energy zone. On the other hand, the nanoclusters with m = 1, 3, 5, 7 (odd numbers of electrons) showed metallic character with absorption spectra that could not be easily guessed through the present numerical calculations. The nanoclusters Pt7-mYm with even numbers of dopant atoms showed semiconductor properties with the highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap increasing as the number of doping atoms increases.
- Published
- 2019
29. Analytical models integrated with satellite images for optimized pest management
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Ulrich R. Bernier, Noel M. Elman, L. Anders Brownworth, L. Zack Bright, Sebastian Curi, Isabel Chien, Michael Handley, Sebastian D’hers, and Pablo Gurman
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Integrated pest management ,Engineering ,business.industry ,030231 tropical medicine ,Real-time computing ,Control engineering ,04 agricultural and veterinary sciences ,Drone ,03 medical and health sciences ,0302 clinical medicine ,Proof of concept ,040103 agronomy & agriculture ,0401 agriculture, forestry, and fisheries ,General Agricultural and Biological Sciences ,business ,Graphical user interface - Abstract
The global field protection (GFP) was developed to protect and optimize pest management resources integrating satellite images for precise field demarcation with physical models of controlled release devices of pesticides to protect large fields. The GFP was implemented using a graphical user interface to aid the end-user to select location and define an arbitrary perimeter for protection. The system provides coordinates of drop points for the controlled release devices which can be delivered using drone technology, e.g. unmanned air vehicles. In this work, we present the first proof of concept of this technology. A vast number of pest management applications can benefit from this work, including prevention against vector-borne diseases as well as protection of large agriculture fields.
- Published
- 2016
30. Correction to: Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
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Agustín N. Abad Vazquez, Pablo Gurman, Sebastian D’hers, and Noel M. Elman
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Chromatography ,Chemistry ,Pharmaceutical Science ,Stable storage ,Glucagon ,Syringe - Abstract
Following are updated Figs. 1, 3, 5, and 7. The original article has also been updated: Fig. 1 a RRP. b RRP dimensions. c RRP inside of syringe. Fig. 3 RRP activation and fluid flow.
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- 2019
31. Ab-initio calculations of chemical and optoelectronic properties of 7-atom Pt-Y [Y = Li, Na, K]
- Author
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Dandogbessi, Bruno S., primary, Hounye, Noel M., additional, and Hontinfinde, Félix, additional
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- 2019
- Full Text
- View/download PDF
32. Correction to: Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
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D’hers, Sebastian, primary, Abad Vazquez, Agustín N., additional, Gurman, Pablo, additional, and Elman, Noel M., additional
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- 2019
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33. Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe
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Ryan, Paul M., primary, Stolte, Ellen H., additional, London, Lis E. E., additional, Wells, Jerry M., additional, Long, Sarah L., additional, Joyce, Susan A., additional, Gahan, Cormac G. M., additional, Fitzgerald, Gerald F., additional, Ross, R. Paul, additional, Caplice, Noel M., additional, and Stanton, Catherine, additional
- Published
- 2019
- Full Text
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34. Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
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D’hers, Sebastian, primary, Abad Vazquez, Agustín N., additional, Gurman, Pablo, additional, and Elman, Noel M., additional
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- 2019
- Full Text
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35. What counts? The influence of school attendance on Australia’s urban Indigenous students’ educational achievement
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Baxter, Lindy P., primary and Meyers, Noel M., additional
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- 2019
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36. Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions
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Paul M. Ryan, Noel M. Caplice, Catherine Stanton, Science Foundation Ireland, Enterprise Ireland, SFI/12/RC/2273, and CF/2013/3030A/B
- Subjects
0301 basic medicine ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,Microbiome – ,Review ,Disease ,030204 cardiovascular system & hematology ,Bioinformatics ,03 medical and health sciences ,0302 clinical medicine ,Internal Medicine ,Medicine ,Microbiome ,lcsh:RC620-627 ,Bile acid ,business.industry ,Human gastrointestinal tract ,Cardiovascular disease ,medicine.disease ,Metabolic syndrome ,G protein-coupled bile acid receptor ,Bile acids ,lcsh:Nutritional diseases. Deficiency diseases ,030104 developmental biology ,medicine.anatomical_structure ,Clinical research ,Signal transduction ,business - Abstract
This work is supported in part by the APC Microbiome Institute (under Science Foundation Ireland [SFI] Grant Number: SFI/12/RC/2273) and by Enterprise Ireland Commercialization Fund (Contract Reference: CF/2013/3030A/B). peer-reviewed While basic and clinical research over the last several decades has recognized a number of modifiable risk factors associated with cardiometabolic disease progression, additional and alternative biological perspectives may offer novel targets for prevention and treatment of this disease set. There is mounting preclinical and emerging clinical evidence indicating that the mass of metabolically diverse microorganisms which inhabit the human gastrointestinal tract may be implicated in initiation and modulation of cardiovascular and metabolic disease outcomes. The following review will discuss this gut microbiome–host metabolism axis and address newly proposed bile-mediated signaling pathways through which dysregulation of this homeostatic axis may influence host cardiovascular risk. With a central focus on the major nuclear and membrane-bound bile acid receptor ligands, we aim to review the putative impact of microbial bile acid modification on several major phenotypes of metabolic syndrome, from obesity to heart failure. Finally, attempting to synthesize several separate but complementary hypotheses, we will review current directions in preclinical and clinical investigation in this evolving field. Enterprise Ireland Science Foundation Ireland
- Published
- 2017
37. Controlled release spatial repellent devices (CRDs) as novel tools against malaria transmission: a semi-field study in Macha, Zambia
- Author
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Stevenson, Jennifer C., primary, Simubali, Limonty, additional, Mudenda, Twig, additional, Cardol, Esther, additional, Bernier, Ulrich R., additional, Vazquez, Agustin Abad, additional, Thuma, Philip E., additional, Norris, Douglas E., additional, Perry, Melynda, additional, Kline, Daniel L., additional, Cohnstaedt, Lee W., additional, Gurman, Pablo, additional, D’hers, Sebastian, additional, and Elman, Noel M., additional
- Published
- 2018
- Full Text
- View/download PDF
38. Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice
- Author
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R. Paul Ross, Noel M. Caplice, David S. Wishart, Gerald F. Fitzgerald, Paul M. Ryan, Catherine Stanton, Fergus Shanahan, Rupasri Mandal, Trent C. Bjorndahl, Kiera Murphy, Lis E. E. London, Teagasc Walsh Fellowship Programme, Science Foundation Ireland, Enterprise Ireland, Ireland Canada University Foundation (ICUF) Dobbin Scholarship, SFI/12/RC/2273, and CF/2013/3030A/B
- Subjects
Limosilactobacillus reuteri ,Male ,0301 basic medicine ,Apolipoprotein E ,beta-Glucans ,Atorvastatin ,Acetates ,030204 cardiovascular system & hematology ,Pharmacology ,Gut flora ,Cholesterol, Dietary ,Feces ,Mice ,chemistry.chemical_compound ,0302 clinical medicine ,biology ,Apo-E-deficient ,Cardiovascular disease ,Butyrates ,Cholesterol ,Cardiovascular Diseases ,Metabolome ,medicine.drug ,Microbiology (medical) ,Diet, High-Fat ,Microbiology ,03 medical and health sciences ,Apolipoproteins E ,Hemiterpenes ,Metabolomics ,Carnitine ,medicine ,Animals ,Obesity ,Microbiome ,Pentanoic Acids ,Research ,Probiotics ,Atherosclerosis ,biology.organism_classification ,Gastrointestinal Microbiome ,Lactobacillus reuteri ,030104 developmental biology ,chemistry ,Dietary Supplements - Abstract
peer-reviewed Background There is strong evidence indicating that gut microbiota have the potential to modify, or be modified by the drugs and nutritional interventions that we rely upon. This study aims to characterize the compositional and functional effects of several nutritional, neutraceutical, and pharmaceutical cardiovascular disease interventions on the gut microbiome, through metagenomic and metabolomic approaches. Apolipoprotein-E-deficient mice were fed for 24 weeks either high-fat/cholesterol diet alone (control, HFC) or high-fat/cholesterol in conjunction with one of three dietary interventions, as follows: plant sterol ester (PSE), oat β-glucan (OBG) and bile salt hydrolase-active Lactobacillus reuteri APC 2587 (BSH), or the drug atorvastatin (STAT). The gut microbiome composition was then investigated, in addition to the host fecal and serum metabolome. Results We observed major shifts in the composition of the gut microbiome of PSE mice, while OBG and BSH mice displayed more modest fluctuations, and STAT showed relatively few alterations. Interestingly, these compositional effects imparted by PSE were coupled with an increase in acetate and reduction in isovalerate (p
- Published
- 2017
39. Fractal Analysis of AFM Images of the Surface of Bowman’s Membrane of the Human Cornea
- Author
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Ştefan Ţălu, Vivian M. Sueiras, Noel M. Ziebarth, and Sebastian Stach
- Subjects
Materials science ,business.industry ,Biomedical Engineering ,Statistical parameter ,Microscopy, Atomic Force ,Fractal dimension ,Fractal analysis ,Bowman's membrane ,Fractals ,Imaging, Three-Dimensional ,medicine.anatomical_structure ,Fractal ,Optics ,Cornea ,Microscopy ,Surface roughness ,medicine ,Humans ,sense organs ,Bowman Membrane ,business - Abstract
The objective of this study is to further investigate the ultrastructural details of the surface of Bowman's membrane of the human cornea, using atomic force microscopy (AFM) images. One representative image acquired of Bowman's membrane of a human cornea was investigated. The three-dimensional (3-D) surface of the sample was imaged using AFM in contact mode, while the sample was completely submerged in optisol solution. Height and deflection images were acquired at multiple scan lengths using the MFP-3D AFM system software (Asylum Research, Santa Barbara, CA), based in IGOR Pro (WaveMetrics, Lake Oswego, OR). A novel approach, based on computational algorithms for fractal analysis of surfaces applied for AFM data, was utilized to analyze the surface structure. The surfaces revealed a fractal structure at the nanometer scale. The fractal dimension, D, provided quantitative values that characterize the scale properties of surface geometry. Detailed characterization of the surface topography was obtained using statistical parameters, in accordance with ISO 25178-2: 2012. Results obtained by fractal analysis confirm the relationship between the value of the fractal dimension and the statistical surface roughness parameters. The surface structure of Bowman's membrane of the human cornea is complex. The analyzed AFM images confirm a fractal nature of the surface, which is not taken into account by classical surface statistical parameters. Surface fractal dimension could be useful in ophthalmology to quantify corneal architectural changes associated with different disease states to further our understanding of disease evolution.
- Published
- 2014
40. How Scientific Links Combine to Thrive Academic Research in Universities: A Social Network Analysis Approach on the Generation of Knowledge
- Author
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Noel M. Muniz, J. A. Ariza-Montes, and H. Molina
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Sociology of scientific knowledge ,Social network ,business.industry ,media_common.quotation_subject ,Organizational network analysis ,Public relations ,Education ,Intellectual capital ,Educational research ,Institution ,Sociology ,Sociology of Education ,business ,Social network analysis ,media_common - Abstract
The generation of knowledge enables the development of adaptive capacities required by organizations that aspire to survive in competitive context; academic institutions are not oblivious to this. In fact, the generation and dissemination of scientific knowledge are ingrained within the DNA of university institutions, assuming knowledge creation as primary function to breed scientific publications. In this sense, the organizational study of social network structures turns to be a robust tool for the analysis and comprehension of formal or informal collaborative relationships engaged in the core of any social entity. Through the co-authorship analysis in scientific publications and the utilization of social network analysis (SNA) approach, the present paper examines the structure of influences that reigns in a particular university, identifying those authors who have been capable to generate, foster, and boost a relational network and the entirely intellectual capital of the institution. The conclusions unveil the prevalence of a non-cohesive, uncompleted, and inequitable social network, in which the academic category or status neither determines nor assures a key position within the network.
- Published
- 2014
41. Rapid Reconstitution Packages (RRPs) implemented by integration of computational fluid dynamics (CFD) and 3D printed microfluidics
- Author
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Noel M. Elman, David Luciano, Kevin Clayton, Sebastian Curi, Alfredo Alexander-Katz, Albert Chi, Kameron Klauber, Sebastian D’hers, Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Department of Materials Science and Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Chi, Albert H., Curi, Sebastian Martin, Clayton, Kevin A., Luciano, David A., Klauber, Kameron L., Alexander-Katz, Alfredo, D'hers, Sebastian, and Elman, Noel
- Subjects
Active ingredient ,Rapid prototyping ,3d printed ,Materials science ,business.industry ,Microfluidics ,Pharmaceutical Science ,Nanotechnology ,Computational fluid dynamics ,Drug activity ,Fluidics ,Rapid mixing ,business ,Process engineering - Abstract
Rapid Reconstitution Packages (RRPs) are portable platforms that integrate microfluidics for rapid reconstitution of lyophilized drugs. Rapid reconstitution of lyophilized drugs using standard vials and syringes is an error-prone process. RRPs were designed using computational fluid dynamics (CFD) techniques to optimize fluidic structures for rapid mixing and integrating physical properties of targeted drugs and diluents. Devices were manufactured using stereo lithography 3D printing for micrometer structural precision and rapid prototyping. Tissue plasminogen activator (tPA) was selected as the initial model drug to test the RRPs as it is unstable in solution. tPA is a thrombolytic drug, stored in lyophilized form, required in emergency settings for which rapid reconstitution is of critical importance. RRP performance and drug stability were evaluated by high-performance liquid chromatography (HPLC) to characterize release kinetics. In addition, enzyme-linked immunosorbent assays (ELISAs) were performed to test for drug activity after the RRPs were exposed to various controlled temperature conditions. Experimental results showed that RRPs provided effective reconstitution of tPA that strongly correlated with CFD results. Simulation and experimental results show that release kinetics can be adjusted by tuning the device structural dimensions and diluent drug physical parameters. The design of RRPs can be tailored for a number of applications by taking into account physical parameters of the active pharmaceutical ingredients (APIs), excipients, and diluents. RRPs are portable platforms that can be utilized for reconstitution of emergency drugs in time-critical therapies., United States. Army Research Office. Institute for Soldier Nanotechnologies (contract: W911NF-07-D-0004)
- Published
- 2014
42. The magnitude of muscular activation of four canine forelimb muscles in dogs performing two agility-specific tasks
- Author
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Noel M. M. Moens, Jeffrey J. Thomason, Leah R. Bent, Stephanie Nykamp, Stephen H. M. Brown, James P. Dickey, and Kimberley Cullen
- Subjects
Male ,030110 physiology ,0301 basic medicine ,040301 veterinary sciences ,Electromyography ,Motor Activity ,medicine.disease_cause ,Biceps ,0403 veterinary science ,03 medical and health sciences ,Dogs ,Jumping ,Forelimb ,Dog ,Animals ,Medicine ,Muscle, Skeletal ,Monitoring, Physiologic ,General Veterinary ,medicine.diagnostic_test ,business.industry ,Forelimb muscles ,Significant difference ,Muscle activation ,04 agricultural and veterinary sciences ,General Medicine ,Anatomy ,veterinary(all) ,medicine.anatomical_structure ,Agility ,Female ,business ,Research Article - Abstract
Background The purpose of this study was to measure the muscular activation in four forelimb muscles while dogs performed agility tasks (i.e., jumping and A-frame) and to provide insight into potential relationships between level of muscular activation and risk of injury. Muscle activation in eight healthy, client-owned agility dogs was measured using ultrasound-guided fine-wire electromyography of four specific forelimb muscles: Biceps Brachii, Supraspinatus, Infraspinatus, and Triceps Brachii – Long Head, while dogs performed a two jump sequence and while dogs ascended and descended an A-frame obstacle at two different competition heights. Results The peak muscle activations during these agility tasks were between 1.7 and 10.6 fold greater than walking. Jumping required higher levels of muscle activation compared to ascending and descending an A-frame, for all muscles of interest. There was no significant difference in muscle activation between the two A-frame heights. Conclusions Compared to walking, all of the muscles were activated at high levels during the agility tasks and our findings indicate that jumping is an especially demanding activity for dogs in agility. This information is broadly relevant to understanding the pathophysiology of forelimb injuries related to canine athletic activity.
- Published
- 2016
43. Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions
- Author
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Ryan, Paul M., primary, Stanton, Catherine, additional, and Caplice, Noel M., additional
- Published
- 2017
- Full Text
- View/download PDF
44. Canine atlantoaxial optimal safe implantation corridors – description and validation of a novel 3D presurgical planning method using OsiriX™
- Author
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Noel M. M. Moens, Luis Gaitero, Alex zur Linden, Fiona James, Gabrielle Monteith, Guillaume Leblond, and John Runciman
- Subjects
Joint Instability ,Anatomical axis ,medicine.medical_specialty ,040301 veterinary sciences ,Computer science ,Bone Screws ,Arthrodesis ,Computed tomography ,Canine ,0403 veterinary science ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,medicine ,Animals ,Dog Diseases ,Reproducibility ,Preoperative planning ,General Veterinary ,medicine.diagnostic_test ,Methodology Article ,04 agricultural and veterinary sciences ,General Medicine ,veterinary(all) ,Surgery ,Implant placement ,Atlanto-Axial Joint ,Atlantoaxial joint ,Presurgical planning ,Atlantoaxial surgery ,Implant ,Tolerance interval ,Neurosurgical methods ,Three-dimensional ,Tomography, X-Ray Computed ,030217 neurology & neurosurgery ,Biomedical engineering - Abstract
Background Canine ventral atlantoaxial (AA) stabilization is most commonly performed in very small dogs and is technically challenging due to extremely narrow bone corridors. Multiple implantation sites have been suggested but detailed anatomical studies investigating these sites are lacking and therefore current surgical guidelines are based upon approximate anatomical landmarks. In order to study AA optimal safe implantation corridors (OSICs), we developed a method based on computed tomography (CT) and semi-automated three-dimensional (3D) mathematical modelling using OsiriX™ and Microsoft®Excel software. The objectives of this study were 1- to provide a detailed description of the bone corridor analysis method and 2- to assess the reproducibility of the method. CT images of the craniocervical junction were prospectively obtained in 27 dogs and our method of OSIC analysis was applied in all dogs. For each dog, 13 optimal implant sites were simulated via geometrical simplification of the bone corridors. Each implant 3D position was then defined with respect to anatomical axes using 2 projected angles (ProjA). The safety margins around each implant were also estimated with angles (SafA) measured in 4 orthogonal directions. A sample of 12 simulated implants was randomly selected and each mathematically calculated angle was compared to direct measurements obtained within OsiriX™ from 2 observers repeated twice. The landmarks simulating anatomical axes were also positioned 4 times to determine their effect on ProjA reproducibility. Results OsiriX could be used successfully to simulate optimal implant positions in all cases. There was excellent agreement between the calculated and measured values for both ProjA (ρc = 0.9986) and SafA (ρc = 0.9996). Absolute differences between calculated and measured values were respectively [ProjA = 0.44 ± 0.53°; SafA = 0.27 ± 0.25°] and [ProjA = 0.26 ± 0.21°; SafA = 0.18 ± 0.18°] for each observer. The 95 % tolerance interval comparing ProjA obtained with 4 different sets of anatomical axis landmarks was [−1.62°, 1.61°] which was considered appropriate for clinical use. Conclusions A new method for determination of optimal implant placement is provided. Semi-automated calculation of optimal implant 3D positions could be further developed to facilitate preoperative planning and to generate large descriptive anatomical datasets. Electronic supplementary material The online version of this article (doi:10.1186/s12917-016-0824-3) contains supplementary material, which is available to authorized users.
- Published
- 2016
45. Failure modelling of trabecular bone using a non-linear combined damage and fracture voxel finite element approach
- Author
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Niall Wilson, Peter E. McHugh, Noel M. Harrison, D. O'Mahoney, Liam Mullins, and Pat McDonnell
- Subjects
Materials science ,Finite Element Analysis ,Bending ,Bone tissue ,Models, Biological ,Bone and Bones ,Stress (mechanics) ,Fractures, Bone ,Ultimate tensile strength ,medicine ,Animals ,Computer Simulation ,Composite material ,Softening ,Sheep ,business.industry ,Tension (physics) ,Mechanical Engineering ,Structural engineering ,Compression (physics) ,Biomechanical Phenomena ,medicine.anatomical_structure ,Nonlinear Dynamics ,Modeling and Simulation ,Fracture (geology) ,Stress, Mechanical ,business ,Software ,Biotechnology - Abstract
Trabecular bone tissue failure can be considered as consisting of two stages: damage and fracture; however, most failure analyses of 3D high-resolution trabecular bone samples are confined to damage mechanisms only, that is, without fracture. This study aims to develop a computational model of trabecular bone consisting of an explicit representation of complete failure, incorporating damage criteria, fracture criteria, cohesive forces, asymmetry and large deformation capabilities. Following parameter studies on a test specimen, and experimental testing of bone sample to complete failure, the asymmetric critical tissue damage and fracture strains of ovine vertebral trabecular bone were calibrated and validated to be compression damage -1.16 %, tension damage 0.69 %, compression fracture -2.91 % and tension fracture 1.98 %. Ultimate strength and post-ultimate strength softening were captured by the computational model, and the failure of individual struts in bending and shear was also predicted. This modelling approach incorporated a cohesive parameter that provided a facility to calibrate ductile-brittle behaviour of bone tissue in this non-linear geometric and non-linear constitutive property analyses tool. Finally, the full accumulation of tissue damage and tissue fracture has been monitored from range of small magnitude (normal daily loading) through to specimen yielding, ultimate strength and post-ultimate strength softening.
- Published
- 2012
46. Exploring Heteronormativity in the Public Discourse of Jamaican Legislators
- Author
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Noel M. Cowell and Tanzia S. Saunders
- Subjects
Cultural Studies ,Human rights ,media_common.quotation_subject ,Popular culture ,Public policy ,Gender studies ,Gender Studies ,Politics ,Empirical research ,Sociology ,Homosexuality ,Industrial relations ,Heteronormativity ,media_common - Abstract
In Jamaica the public discourse on homosexuality is voluminous, however little or no empirical research or suitably detached policy-oriented discussion is in evidence. This multidisciplinary qualitative paper uses the content analysis of publicly available information to explore the posture of key public-policy actors on homosexuals and homosexuality. The observable implications of the findings for society and the rights of homosexuals are articulated. The paper concludes that this discourse evinces a settled heteronormative value system, reflecting a consensus on either side of the political divide and applauded by popular culture and popular opinion. At a time when most of the western world is embracing sexual diversity, these conclusions carry profound implications for legal reform, employment relations, social justice and public policy in Jamaica.
- Published
- 2011
47. Correction to: Deflating the 'DBS Causes Personality Changes' Bubble
- Author
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John Noel M. Viaña, Frederic Gilbert, and C. Ineichen
- Subjects
Psychoanalysis ,Health Policy ,Neuropsychology ,Internet portal ,06 humanities and the arts ,0603 philosophy, ethics and religion ,03 medical and health sciences ,Psychiatry and Mental health ,Personality changes ,0302 clinical medicine ,Neurology ,060301 applied ethics ,Psychology ,030217 neurology & neurosurgery ,Neuroradiology - Abstract
The article Deflating the "DBS causes personality changes" bubble, written by Frederic Gilbert, J. N. M. Viana and C. Ineichen, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on 19 June 2018 without open access.
- Published
- 2018
48. Reproductive isolation and the expansion of an invasive hybrid swarm
- Author
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Noel M. Burkhead, Byron J. Freeman, Brady A. Porter, David M. Walters, and Michael J. Blum
- Subjects
Ecology ,biology ,Assortative mating ,Zoology ,Reproductive isolation ,Interspecific competition ,biology.organism_classification ,Fecundity ,Mating preferences ,Red shiner ,Blacktail shiner ,Hybrid swarm ,Ecology, Evolution, Behavior and Systematics - Abstract
Biological invasions involving hybridization proceed according to prezygotic and postzygotic reproductive isolating mechanisms. Yet few comparisons of reproductive isolation have been carried out to understand how different mechanisms prevent or promote invasions involving hybridization. Here we present a study of prezygotic and postzygotic isolation between non-native red shiner (Cyprinella lutrensis) and native blacktail shiner (C. venusta stigmatura) from the Coosa River basin (USA) to better understand the formation and expansion of invasive hybrid swarms. We conducted spawning trials to measure mating preferences and raised broods from crosses to assay hybrid viability through early juvenile development. Females of both species were more responsive to conspecific mates, although blacktail shiner females responded more often to heterospecific mates than did red shiner females. Fecundity of red shiner females was also higher than blacktail shiner females. Heterospecific crosses resulted in lower fertilization and egg hatching rates, but we found no other evidence of inviability. Rather, we found comparatively low larval mortality of F1 hybrids, which is suggestive of heterosis. These findings support prior inferences of assortative mating from genetic descriptions of hybridization, and that the invasion in the Coosa River is likely proceeding due to interspecific competition and intrinsic hybrid viability.
- Published
- 2010
49. Super permeable nano-channel membranes defined with laser interferometric lithography
- Author
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Noel M. Elman, Michael J. Cima, Farzad Jalali-Yazdi, and Karen Daniel
- Subjects
Amorphous silicon ,Materials science ,Fabrication ,business.industry ,technology, industry, and agriculture ,Analytical chemistry ,Condensed Matter Physics ,Laser ,Electronic, Optical and Magnetic Materials ,law.invention ,chemistry.chemical_compound ,Membrane ,chemistry ,law ,Permeability (electromagnetism) ,Nano ,Materials Chemistry ,Optoelectronics ,Interferometric lithography ,business ,Porosity - Abstract
We report the design, fabrication, and testing of super permeable nano-channel membranes, characterized by the absolute control in the pore size at the nano-scale dimensions, large surface area, very high permeability, mechanical stability and durability. The membranes were fabricated using a unique nanotechnology process that combines laser interferometric lithography to define nano-channels (pores) and micro-machining to produce free-standing amorphous silicon membranes, allowing rapid and cost-effective mass production. The suspended membranes were defined as 50 nm thick a-Si, characterized by a very high porosity of approximately 20%, achieved by definition of large arrays of nano-channels. The dimensions of each individual nano-channel was 65 nm wide, 250 nm long. The measured apparent permeability was 0.14 ± 0.05 cm/min for each individual 70 μm × 70 μm membrane, representing one of the highest permeability values ever reported for this scale.
- Published
- 2009
50. Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice
- Author
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Ryan, Paul M., primary, London, Lis E. E., additional, Bjorndahl, Trent C., additional, Mandal, Rupasri, additional, Murphy, Kiera, additional, Fitzgerald, Gerald F., additional, Shanahan, Fergus, additional, Ross, R. Paul, additional, Wishart, David S., additional, Caplice, Noel M., additional, and Stanton, Catherine, additional
- Published
- 2017
- Full Text
- View/download PDF
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