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3 results on '"Nurcan Orhan"'

1. Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

Author

Galina P. Martynova, Anna Gerhartl, Arkadiusz Liskiewicz, Candan Gürses, David Bueno, Jens Pahnke, Mie Kristensen, Andrzej Małecki, Claus U. Surma, Edward A. Neuwelt, Lars Bo Nielsen, Sándor Valkai, László Puskás, Gerald A. Grant, Petra Majerova, Fruzsina R. Walter, Wendy W.J. Unger, Sercin Karahuseyinoglu, Matheus Uba Chupel, Inez Fręśko, Semyachkina-Glushkovskaya Oxana, Marta Martinez-Morga, Shinsuke Nakagawa, Marian M. Humphries, Niamh Doyle, Shareef Ali Esmat, A. Cubukova, Sabela Rodríguez-Lorenzo, Pietra Candela, James F. Meaney, Dóra V Lipka, Ruud D Fontijn, Malinovskaya Nataliya, Salmina Alla, H. Zieliński, Chih-Chieh Tsao, Svetlana Drndarski, Raquel Garcia-Lopez, Alon Friedman, Pavlov Valery, David A. Antonetti, Kinga G. Blecharz, Nobutaka Horie, Anna Huber, Ana Raquel Santa Maria, Mária Mészáros, Marco Metzger, Sonja Thom, Ronel Veksler, Vilmos Tubak, Emmanuel Sevin, Magdalena Zielińska, Holger Gerhardt, Samar Osmen, Bucharskaya Alla, Nadir Arican, Zsolt Török, Bragin Denis, David J. Begley, Szilvia Veszelka, Marta Kowalewska, Torben Moos, Takayuki Matsuo, Cathrin J. Czupalla, Vladimir Soukhoroukov, Alena Michalicova, Krzysztof Milewski, Chris H. Greene, Jianming Xiang, Alla B. Salmina, Mike Veenstra, Andrea Fuso, Lester R. Drewes, Peter Galajda, Udi Vazana, Christina Dilling, Gizem Nur Sahin, Guohua Xi, N. Joan Abbott, Conor Delaney, Natalie Hudson, Malgorzata Burek, Lisa Juul Routhe, Sabrina Engelhardt, Janina Skipor, Enming Joe Su, Simon J. O'Carroll, István A. Krizbai, Gergő Porkoláb, Tsuyoshi Izumo, Romain Versele, Poyraz Düzgün, Kenta Ujifuku, Mariangela Corsi, Dan Z. Milikovsky, Ana-Maria Pilbat, Muge Atis, Nurcan Orhan, Agata Krawczynska, Mária A. Deli, Dmitri Sisario, Isabelle Gruber, Andrej Kovac, Manuel Sarmiento Soto, Anna Schönegger, E. Scott Graham, Marta Skowrońska, Yana V. Gorina, Hans Christian Cederberg Helms, Minseon Park, András Kincses, Niloufar Zarghami, Judit Váradi, Michael G. Molloy, Michal Toborek, Anne Iltzsche, Anika M.S. Hartz, Sarah L. Doyle, Yoichi Morofuji, Zsolt Bozsó, Joan W. Berman, Morgun Andrey, Elizaveta B. Boytsova, Nicole Kachappilly, Susan Morgello, Ursula Wyneken, Gekalyuk Artem, Sheng-Fu Huang, Miklós Vecsernyés, David Male, John Kealy, Khorovodov Alexander, Victor Castro, Shushunova Anastasia, Bodrova Madina, Jaroslav Galba, Luciele Guerra Minuzzi, Karl-Heinz Plate, Helle S. Waagepetersen, Nicola R. Sibson, Janina Skipor-Lahuta, Khilazheva Elena, Ferenc Fenyvesi, Alwin Kamermans, Marta Nowacka-Chmielewska, Fang Niu, Rouhollah Khodadust, Josephin Wagner, Loránd Kiss, Lyna Solomon-Kamintsky, Peter Vajkoczy, Daniel A. Lawrence, Alexander Reitner, Niall Pender, Lucia Celkova, Sidar Aydin, Mikio Furuse, Kavi Devraj, Christina Simoglou Karali, Andrey V. Morgun, Aleksandra Szczepkowska, Guy Bar-Klein, Krzysztof Kucharz, Ádám Nyúl-Tóth, Lívia Fülöp, Martin Lauritzen, Yvonne Couch, Rémy Bruggmann, Mihály Kozma, Marta Obara-Michlewska, Julia Baumann, Franco Laccone, Hannes Steinkellner, A. Appelt-Menzel, Catherine E. Angel, Colin P. Doherty, Dan T Kho, Attila Farkas, Kathrin Hahn, Omolara Ogunshola, Arzu Temizyurek, Roman Fischer, Melissa A. Lopes-Pinheiro, Armelle Klopstein, Vodovozova Elena, Zsolt Radak, Sylvaine Guérit, Mehmet Kaya, Dror Rosenbach, Nikolay Kutuzov, M. Surma, Carsten Uhd Nielsen, Takeo Anda, Rita Businaro, Navolokin Nikita, Jennifer Pereira, András Dér, Alekseeva Anna, Kurths Jürgen, Richard F. Keep, Dionna W. Williams, Stefan Liebner, Nikolett Lénárt, Melinda E. Tóth, Edith Filaire, Boytsova Elizaveta, Elena D. Khilazheva, Ana Rita Bras, Péter Nagyőszi, Alexa Fries, Edyta Skonieczna, Bulent Ahishali, Daniel C. Anthony, Mutlu Küçük, Lydia Gabbert, Shirokov Alexander, Canan Yilmaz, Lars Winkler, A. Bach, Ulanova Mariya, Eoin Kelly, Rosiris Leon Rivera, Luca Marchetti, Hong Ye, Tuchin Artem, Jamie Lim, Helga E. de Vries, Salvador Martinez, Ágnes Kittel, Ágnes Zvara, Imola Wilhelm, Steffen E. Storck, Ana Pombero, Matthew Campbell, Luis Federico Bátiz, Sandra Mihaljevic, Laurence Fenart, Jordi Garcia-Fernàndez, Ignacio A. Romero, Birger Brodin, Daniela Kasprowska-Liśkiewicz, Brigitta Dukay, David M. F. Francisco, Karl Schoknecht, Ana C. Calpena, Neli Bounzina, Eugene Wallace, Ofer Prager, Jack van Horssen, Abdurashitov Arkady, Kinga Molnár, Michael Farrell, Miklós Sántha, Shilpa Buch, Marta Espina, Salmin Vladimir, Ya Hua, Serkan Emik, Ulf C. Schneider, Elena A. Pozhilenkova, Omolara O. Ogunshola, Eoin O’Keefe, Judit P. Vigh, David Francisco, Gijs Kooij, Takashi Fujimoto, Britta Engelhardt, Daisuke Watanabe, Z. Giżejewski, Alexandra Bocsik, Csilla Fazakas, Zsófia Hoyk, Marcelle Silva de Abreu, Stephanie Hughes, Vinton W.T. Cheng, Rebecca Johnson, Andrzej P. Herman, János Haskó, András Harazin, E. Fidan, Richard Kovács, Yang Yirong, Cherubino Di Lorenzo, Ana Maria Teixeira, Mette Mathiesen Janiurek, Krisztina Nagy, Umut Deniz Ceylan, Winfried Neuhaus, Uğur Akcan, Jadranka Macas, Kristian Strømgaard, Sagatova Artem, Christina Christoffersen, Ralph M. Garruto, Marta Przybyła, Maria Luisa García, Fabien Gosselet, Ruth Lyck, and Michal Novak

Subjects
0301 basic medicine, business.industry, General Medicine, Meeting Abstracts, lcsh:RC346-429, 03 medical and health sciences, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, Developmental Neuroscience, Neurology, Medicine, Signal transduction, business, Neuroscience, lcsh:Neurology. Diseases of the nervous system, 030217 neurology & neurosurgery
Published
2017
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2. Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis

Author

Erdem Tüzün, Sema Bilgic Gazioglu, Perihan Ergin Özcan, Murat Giriş, Melike Küçükerden, Nadir Arican, Uğur Akcan, Günseli Orhun, Nurcan Orhan, Evren Şentürk, Canan Yilmaz, Figen Esen, and Mehmet Kaya

Subjects
0301 basic medicine, Immunoglobulins, Apoptosis, Inflammation, Complement receptor, Pharmacology, Critical Care and Intensive Care Medicine, Glial cell proliferation, C5a receptor, 03 medical and health sciences, 0302 clinical medicine, Sepsis, medicine, biology, Glial fibrillary acidic protein, business.industry, Research, Cecal ligation and puncture, Complement activation, Complement system, 030104 developmental biology, Integrin alpha M, Gliosis, Immunology, biology.protein, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Background Intravenous (IV) immunoglobulin (Ig) treatment is known to alleviate behavioral deficits and increase survival in the experimentally induced model of sepsis. To delineate the mechanisms by which IVIg treatment prevents neuronal dysfunction, an array of immunological and apoptosis markers was investigated. Methods Sepsis was induced by cecal ligation perforation (CLP) in rats. The animals were divided into five groups: sham, control, CLP + saline, CLP + immunoglobulin G (IgG) (250 mg/kg, iv), and CLP + immunoglobulins enriched with immunoglobulin M (IgGAM) (250 mg/kg, iv). Blood and brain samples were taken in two sets of experiments to see the early (24 h) and late (10 days) effects of treatment. Total complement activity, complement 3 (C3), and soluble complement C5b-9 levels were measured in the sera of rats using ELISA-based methods. Cerebral complement, complement receptor, NF-κB, Bax, and Bcl-2 expressions were analyzed by western blot and/or RT-PCR methods. Immune cell infiltration and gliosis were examined by immunohistochemistry using CD3, CD4, CD8, CD11b, CD19, and glial fibrillary acidic protein antibodies. Apoptotic neuronal death was investigated by TUNEL staining. Results IVIgG and IgGAM administration significantly reduced systemic complement activity and cerebral C5a and C5a receptor expression. Likewise, both treatment methods reduced proapoptotic NF-κB and Bax expressions in the brain. IVIgG and IgGAM treatment induced considerable amelioration in glial cell proliferation and neuronal apoptosis which were increased in non-treated septic rats. Conclusions We suggest that IVIgG and IgGAM administration ameliorates neuronal dysfunction and behavioral deficits by reducing apoptotic cell death and glial cell proliferation. In both treatment methods, these beneficial effects might be mediated through reduction of anaphylatoxic C5a activity and subsequent inhibition of inflammation and apoptosis pathways. Electronic supplementary material The online version of this article (doi:10.1186/s40635-016-0114-1) contains supplementary material, which is available to authorized users.

Published
2017
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3. Effects of different doses and serotypes of LPS on blood-brain barrier permeability in Sprague-Dawley rats

Author

Mehmet Kaya, Mutlu Küçük, P Ergin Ozcan, Figen Esen, Günseli Orhun, Nurcan Orhan, Evren Şentürk, and Nadir Arican

Subjects
Serotype, Pathology, medicine.medical_specialty, Lipopolysaccharide, business.industry, Central nervous system, Pharmacology, Critical Care and Intensive Care Medicine, Septic encephalopathy, chemistry.chemical_compound, medicine.anatomical_structure, nervous system, chemistry, Permeability (electromagnetism), Poster Presentation, cardiovascular system, Sprague dawley rats, medicine, Blood brain barrier permeability, business
Abstract

The blood-brain barrier (BBB) is highly restrictive of the transport of substances between blood and the central nervous system. Lipopolysaccharide (LPS) from Gram-negative bacteria was reported to affect the permeability of the BBB. BBB disruption using a LPS is used as a model of septic encephalopathy in mice. The present study was designed to investigate the effects of different doses and serotypes of LPS on BBB integrity in Sprague-Dawley rats.

Published
2013
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