1. Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System
- Author
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Na Gao, Xiaoning Yang, Shaocheng Wang, Liandong Hu, Yanjing Shi, Jian Heng Li, Queting Chen, Jing Ji, and Feng Niu
- Subjects
Male ,Curcumin ,Chemistry, Pharmaceutical ,Pharmaceutical Science ,Administration, Oral ,Biological Availability ,Polyethylene glycol ,Poloxamer ,Aquatic Science ,Polyethylene Glycols ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Castor wax ,Differential scanning calorimetry ,X-Ray Diffraction ,Drug Discovery ,PEG ratio ,Spectroscopy, Fourier Transform Infrared ,Animals ,Solubility ,Ecology, Evolution, Behavior and Systematics ,Chromatography ,Ecology ,Calorimetry, Differential Scanning ,Water ,General Medicine ,Bioavailability ,Rats ,chemistry ,Powders ,Agronomy and Crop Science ,Research Article - Abstract
The objective of this study was to improve the solubility and bioavailability of curcumin by a new curcumin dripping pills (Cur-DPs) formulation using melt mixing methods. The optimal formulation consisted of Polyethoxylated 40 hydrogenated castor oil (Cremophor RH40), Poloxamer 188, and Polyethylene glycol 4000 (PEG 4000). Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FT-IR) were used to verify the forming of Cur-DPs. All the physical characterization information proved the formation of Cur-DPs, and the results demonstrated the superiority of the dripping pills in dissolution rates. The pharmacokinetic study of Cur-DPs was performed in rats compared to the pure curcumin suspension. The oral bioavailability of poorly water-soluble curcumin was successfully improved by CUR-DPs. And the stability of prepared Cur-DP was also in a good state in 3 months. These results identified the Cur-DPs was an effective new approach for pharmaceutical application.
- Published
- 2015