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Your search keyword '"HAN Jun-jie"' showing total 2 results
Start Over Author "HAN Jun-jie" Publisher taylor & francis ltd
2 results on '"HAN Jun-jie"'

1. Three new cyathane diterpenoids from the medicinal fungus Cyathus africanus.

Author

Han, Jun-Jie, Zhang, Lei, Xu, Jie-Kun, Bao, Li, Zhao, Feng, Chen, Yu-Hui, Zhang, Wei-Ku, and Liu, Hong-Wei

Subjects
*ANIMAL experimentation, *ANTI-inflammatory agents, *BIOLOGICAL assay, *CELL culture, *CHROMATOGRAPHIC analysis, *FUNGI, *HYDROCORTISONE, *MACROPHAGES, *MASS spectrometry, *MICE, *MOLECULAR structure, *NITRIC oxide, *NUCLEAR magnetic resonance spectroscopy, *RESEARCH funding, *TERPENES, *TOXICITY testing, *LIPOPOLYSACCHARIDES, *DESCRIPTIVE statistics
Abstract

Three new cyathane diterpenoids, cyathin W (1), cyathin V (2), and cyathin T (3), were isolated from the solid culture ofCyathus africanus. The structures and configurations of these new compounds were elucidated on the basis of comprehensive spectroscopic analysis including 1D NMR, 2D NMR (HSQC, HMBC, NOESY), and HR-ESI-MS experiments. Compounds1and3showed moderate inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with IC50value of 80.07 and 88.87 μM, respectively. In cytotoxicity assay, compound1showed weak cytotoxicity against K562 cell line with IC50value of 12.1 μM. [ABSTRACT FROM PUBLISHER]

Published
2015
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2. 2H-Pyranone and isocoumarin derivatives isolated from the plant pathogenic fungus Leptosphaena maculans.

Author

Liao, Ming-Fang, Wang, Kai, Ren, Jin-Wei, Liu, Li, Cai, Lei, Han, Jun-Jie, and Liu, Hong-Wei

Subjects
*ANIMAL experimentation, *BENZOPYRANS, *BIOLOGICAL assay, *FUNGI, *GASTRIC mucosa, *GLYCOSIDASES, *HIGH performance liquid chromatography, *SMALL intestine, *MOLECULAR structure, *NUCLEAR magnetic resonance spectroscopy, *RATS, *RESEARCH funding, *SPECTROPHOTOMETRY, *THIN layer chromatography, *PLANT extracts
Abstract

Two new 2H-pyranones and two new isocoumarin derivatives, maculanslines A-D (1–4), together with seven known compounds (5–11), were isolated from the plant pathogenic fungus Leptosphaena maculans. Their planar structures and absolute configuration were elucidated by comprehensive spectroscopic techniques including high-resolution electrospray ionization mass spectrum, 1D and 2D nuclear magnetic resonance, as well as electronic circular dichroism. All 11 compounds were tested for their inhibitory activity against α-glucosidase. Compound 1 showed moderate inhibitory activity against α-glucosidase with IC50 of 74.35 μM. [ABSTRACT FROM AUTHOR]

Published
2019
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