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Uniform Al2O3:Eu3+microfibres were synthesized via a hydrothermal route and heat treatment (1173 K/2 h) of a precursor of Eu3+-doped ammonium aluminium hydroxide carbonate (NH4Al(OH)2CO3). The length and diameter of these Eu3+-doped Al2O3microfibres are about 4–7 μm and 400 nm, respectively. Upon excitation at 394 nm, the orange-red emission bands were from5D0 → 7FJ(J = 1, 2) transitions. The asymmetry ratio of (5D0 → 7F2)/(5D0 → 7F1) intensity is about 0.99, 1.43, 2.24, 2.40, 1.63 for the Eu3+concentration 0.05, 0.30, 0.70, 0.90 and 1.20 mol-%, respectively. These values suggest that the asymmetry ratio of Eu3+ions is related to the doping concentration. The maximum doping concentration of Eu3+ions in Al2O3is 0.9 mol-%. According to Dexter’s theory, the critical distance between Eu3+ions for energy transfer was determined to be 17 Å. [ABSTRACT FROM AUTHOR]

Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2's functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH9 is a new strategy to tackle metabolism-addicted tumors. [ABSTRACT FROM AUTHOR]