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4-Hydroxy-4, 7-dimethyl-α-tetralone (1), 4,5-dihydroblumenol A (2), N-trans-feruloyltyramine (3), and 24-methylenelanosta-7, 9(11)-dien-3-β, 15α-diol (4) were isolated from the stem bark of Polyalthia jucunda (Piere) Finet & Gagnep (Annonaceae). All the compounds were evaluated for their effects on growth of four human tumor cell lines [ER(+) MCF-7, ER(-) MDA-MB-23, SF 268, and NCI-H460] and of a non-tumor cell line (MRC-5). Only compound 4 exhibited a dose-dependent growth inhibitory effect against both tumor and non-tumor cell lines but with less effect on the latter. Using the TUNEL assay, it was found that the inhibitory effect of compound 4 on NCI-H460 cells was probably caused by apoptosis. [ABSTRACT FROM AUTHOR]

1,2- bis -(4-Hydroxy-3-methoxyphenyl)-3-hydroxypropan-1-one (evafolin B, 1 ), 1-(4-hydroxy-3-methoxyphenyl)-3-hydroxypropan-1-one ( 2 ), were isolated for the first time from the genus Schisandra , along with abscisic acid ( 3 ), 4-hydroxybenzaldehyde ( 4 ), 4-hydroxybenzoic acid ( 5 ), methyl 4-hydroxybenzoate ( 6 ), methyl 3,4-dihydroxybenzoate ( 7 ), and vanillic acid ( 8 ). All the compounds were evaluated for their antitumor, antiproliferative, and antioxidant activities. Only compound 7 exhibited moderate activity against three human cancer cell lines and human lymphocytic proliferation, as well as strong inhibitory activity for DPPH free radicals, only slightly less than ascorbic acid. [ABSTRACT FROM AUTHOR]

A new xanthone ( 2 ), 3-(2-hydroxyethoxy)xanthone, and three known compounds, 1-hydroxyxanthone, salicylic acid and the sesquiterpene oplopanone, were isolated for the first time from the rhizomes of Hedychium gardnerianum Rosc. The structures of these compounds were elucidated on the basis of detailed spectral analysis, including 2D NMR experiments. [ABSTRACT FROM AUTHOR]

An isocoumarin was isolated from the aerial parts of Centaurium erythraea Rafn. (Gentianaceae). Its structure was established by spectroscopic means as 5-formyl-2,3-dihydroisocoumarin. [ABSTRACT FROM AUTHOR]