1. Comparison of automated erythrocytapheresis versus manual exchange transfusion to treat cerebral macrovasculopathy in sickle cell anemia
- Author
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Pauline Voultoury, Hendy Abdoul, Laurent Holvoet, Nathalie Couque, Florence Missud, Suzanne Verlhac, André Baruchel, Julie Sommet, Berengere Koehl, Fatiha Sellami, Ghislaine Ithier, Malika Benkerrou, and Priscilla Boizeau more...
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Erythrocytapheresis ,Pediatrics ,medicine.medical_specialty ,Anemia ,business.industry ,medicine.medical_treatment ,Immunology ,Exchange transfusion ,Retrospective cohort study ,Hematology ,030204 cardiovascular system & hematology ,medicine.disease ,Sickle cell anemia ,Transcranial Doppler ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,medicine ,Immunology and Allergy ,business ,Stroke ,030215 immunology - Abstract
BACKGROUND Chronic exchange transfusion is effective for primary and secondary prevention of stroke in children with sickle cell anemia (SCA). Erythrocytapheresis is recognized to be the most efficient approach; however, it is not widely implemented and is not suitable for all patients. The aim of our study was to compare automated exchange transfusion (AET) with our manual method of exchange transfusion and, in particular, to evaluate the efficacy, safety, and cost of our manual method. STUDY DESIGN AND METHODS Thirty-nine SCA children with stroke and/or abnormal findings on transcranial Doppler were included in the study. We retrospectively analyzed 1353 exchange sessions, including 333 sessions of AET and 1020 sessions of manual exchange transfusion (MET). RESULTS Both methods were well tolerated. The median decrease in hemoglobin (Hb)S per session was 21.5% with AET and 18.8% with our manual method (p more...
- Published
- 2016
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