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Abstract Background Schizophrenia is characterized by several core behavioral features, in which the gastrointestinal symptoms are frequently reported. Maternal immune activation (MIA) has been developed in a rodent model to study neurodevelopmental disorders such as schizophrenia. However, the changes in the gut environment of MIA rats remain largely unknown. Methods 10 mg/kg of polyinosinic:polycytidylic acid (Poly I:C) on gestational day 9 was intravenously administered to rats to induce MIA in order to assess changes in behavior, the intestinal barrier and microbiota in offspring. Results Maternal immune activation offspring shown increased anxiety as indicated by reduced exploration of central area in open field test and decreased exploration of open arms in elevated plus test. Cognitive impairment of MIA offspring was confirmed by reduced exploration of novel arm in Y maze test and deficiency of PPI. Intestinal muscle thickness became thinner and some specific microbial anomalies previously identified clinically were observed in MIA offspring. In addition, an increase of inflammatory responses was found in the gut of MIA offspring. Conclusions Maternal immune activation alters behavior, intestinal integrity, gut microbiota and the gut inflammation in adult offspring.

In vehicular ad hoc networks, attackers can disguise as replicas of legitimate vehicles by cracking or colluding and then use the identity replicas in a malicious way. Not only the generation of replicas itself poses an aggressive behavior, but also the replicas can enable other insider attacks, such as denial of service, information interception, and replay attack. To solve this issue, researchers have presented many solutions in wireless sensor network or in mobile ad hoc networks. However, majority of current schemes are not good at dealing with conspiracy replicas or lack of considering peculiar characteristics of high mobility of vehicles. For detecting identity replicas in vehicular ad hoc networks, we propose a detection method with sequential trajectory segment based on semi-supervised support vector machine. In terms of semi-supervised support vector machine, we establish a detection model using spatio-temporal trajectories of different identities as input samples, which include features of both conspiracy and non-conspiracy attack scenarios. To validate our approach, we apply sequential trajectory segment to simulation environment. The performance analysis and experimental studies suggest that our proposed method provides high detection accuracy, which is almost impervious to the replica identity ratios in vehicular ad hoc networks. Furthermore, the time performance of replica detection is less affected by the distance between compromised nodes and their clones than that of existing solutions.

Sustained release of anesthesia has shown great promise in the treatment of chronic pain in patients. In this research, we used neutralized ropivacaine as an anesthesia and poly(ε-caprolactone) (PCL) with different architectures to systematically study how these architectures affect the release of ropivacaine. After optimizing the parameters of the preparation of microspheres, ropivacaine-loaded 1-PCL microspheres and 4-PCL microspheres were obtained. Fourier Transform infrared spectra (FT-IR) and X-ray diffraction spectra (XRD) confirmed that ropivacaine was encapsulated within the microsphere rather than inserted on the surface of the microsphere. Ropivacaine was found to be buried deeper in the 1-PCL microsphere than in the 4-PCL microsphere. In vitro release assay revealed that small crystalline grains interfered with ropivacaine release in 4-PCL microspheres during the initial release period, but then two kinds of microspheres showed a similar ropivacaine release rate. We basically proved that the architecture of PCL has a negligible effect on ropivacaine release. Cell proliferation test revealed that the release of products from the microspheres resulted in insignificant toxicity towards mammalian cells.

Objective. The present study aimed to explore the association between SUA and NAFLD in women with different menstrual statuses. Methods. A total of 6043 women were selected from the Jidong and Kailuan communities for inclusion in the present study. The SUA levels of participants were divided into quartiles. NAFLD was determined by abdominal ultrasonography. Data from laboratory tests and clinical examination were collected, and basic information was obtained from standardized questionnaires. The menstrual status was stratified into menstrual period, menopause transition period, and postmenopause. Multivariate logistic regression models were used to determine the relationship between menstrual status, SUA, and NAFLD. Results. The levels of SUA in subjects with NAFLD in the menstrual period, menopause transition period, and postmenopause were 268.0 ± 71.1, 265.6 ± 67.8, and 286.7 ± 75.8 (mmol/L), respectively, and were higher than those in subjects without NAFLD. The adjusted odds ratios (ORs) with 95% confidence interval (CI) for NAFLD among participants in the menopause transition period and postmenopausal period were 1.10 (0.89–1.37) and 1.28 (1.04–1.58), respectively, compared with the menstrual period women. Compared to the lowest quartile of SUA, the adjusted ORs with 95% CI of the highest quartile for NAFLD were 2.24 (1.69–2.99) for females in the menstrual period, 1.92 (1.10–3.37) for females in the menopause transition period, and 1.47 (1.06–2.03) for females in postmenopause. Conclusions. Menstrual status was significantly correlated with NAFLD. High levels of SUA were associated with NAFLD in females during the three menstrual periods.

In this study, we developed a suite of spatially and temporally scalable Water Cycle Indicators (WCI) to examine the long-term changes in water cycle variability and demonstrated their use over the contiguous US (CONUS) during 1979–2013 using the MERRA reanalysis product. The WCI indicators consist of six water balance variables monitoring the mean conditions and extreme aspects of the changing water cycle. The variables include precipitation (P), evaporation (E), runoff (R), terrestrial water storage (dS/dt), moisture convergence flux (C), and atmospheric moisture content (dW/dt). Means are determined as the daily total value, while extremes include wet and dry extremes, defined as the upper and lower 10th percentile of daily distribution. Trends are assessed for annual and seasonal indicators at several different spatial scales. Our results indicate that significant changes have occurred in most of the indicators, and these changes are geographically and seasonally dependent. There are more upward trends than downward trends in all eighteen annual indicators averaged over the CONUS. The spatial correlations between the annual trends in means and extremes are statistically significant across the country and are stronger for P, E, R, and C compared to dS/dt and dW/dt.

Background. The aim of this study was to detect the effect of the laryngeal mask airway (LMA) versus the endotracheal tube (ETT) on postoperative nasal bleedings in and outside the operation room (OR) after intranasal surgery. Methods. 134 patients undergoing elective intranasal surgeries were randomly allocated to receive LMA or ETT during general anesthesia. The incidence, episodes, and severity of nasal bleeding were evaluated in the OR and within the postoperative 24 hours in the ward. Furthermore, medical assistance and severe complications were assessed. Results. The overall incidence of postoperative nasal bleeding throughout the observation period was similar between the two groups. The LMA reduced nasal bleeding in the OR. However, outside the OR, the incidence of the first episode of postoperative nasal bleeding in the LMA group was higher than that in the ETT group (difference: −26.5%; 95% CI: −42.2% to −10.7%; P