1. An exploration of actigraphy in the context of ketamine and treatment‐resistant depression.
- Author
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Punturieri, Claire, Duncan, Wallace C., Greenstein, Dede, Shandler, Gavi, Zarate, Carlos A., and Evans, Jennifer W.
- Subjects
ACTIGRAPHY ,KETAMINE ,KETAMINE abuse ,MENTAL depression ,TIME series analysis - Abstract
Objectives: This study explored the potential of non‐parametric and complexity analysis metrics to detect changes in activity post‐ketamine and their association with depressive symptomatology. Methods: Individuals with treatment‐resistant depression (TRD: n = 27, 16F, 35.9 ± 10.8 years) and healthy volunteers (HVs: n = 9, 4F, 36.4 ± 9.59 years) had their activity monitored during an inpatient, double‐blind, crossover study where they received an infusion of ketamine or saline placebo. All participants were 18–65 years old, medication‐free, and had a MADRS score ≥20. Non‐parametric metrics averaged over each study day, metrics derived from complexity analysis, and traditionally calculated non‐parametric metrics averaged over two weeks were calculated from the actigraphy time series. A separate analysis was conducted for a subsample (n = 17) to assess the utility of these metrics in a hospital setting. Results: In HVs, lower intradaily variability was observed within daily rest/activity patterns post‐ketamine versus post‐placebo (F = 5.16(1,15), p = 0.04). No other significant effects of drug or drug‐by‐time or correlations between depressive symptomatology and activity were detected. Conclusions: Weak associations between non‐parametric variables and ketamine were found but were not consistent across actigraphy measures. Clinical Trial registration: ClinicalTrials.gov, NCT00088699. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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