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Background: Pharyngocutaneous fistula (PCF) is one of the most common complications of total laryngectomy. This study is to investigate the efficacy of a novel platform called transnasal negative pressure therapy (TNPT) in the management of PCF. Methods: We retrospectively reviewed 47 patients who underwent total laryngectomy between April 2015 and February 2021 and developed PCF in our hospital. We focused on the healing rate, dressing change frequency, and healing time between the TNPT and non‐TNPT groups. The 2 years overall survival (OS) was compared through the log‐rank test. Results: There were 18 patients in the TNPT group and 29 in the non‐TNPT group. There was no significant between‐group difference in the healing rate (chi‐square test). However, the frequency of dressing changes was significantly lower (p < 0.001) and the healing time was significantly shorter (p = 0.0194) in the TNPT group than in the non‐TNPT group. The 2‐year OS rate was significantly higher in the TNPT group (p = 0.0473, log‐rank test). Conclusion: TNPT promoted wound healing after surgery for PCF and improved the 2‐year OS rate. This tool is worthy of clinical application and promotion. [ABSTRACT FROM AUTHOR]

Optical coherence tomography angiography (OCTA) can provide in vivo three‐dimensional microvasculature information of bio‐tissues, but it is sensitive to motion and time‐consuming. To overcome these limitations, we propose an adaptive multiple time interval correlation mapping OCTA with a time‐efficient scanning protocol and motion compensation algorithms. A spectral‐domain OCT with a center wavelength of 850 nm, A‐scan rate of 120 kHz and spatial resolution of 4.1 μm (axial) × 6.9 μm (lateral) is built to reconstruct the microvascular networks in the human arm. By adaptive optimization of the weights of different time interval B‐scan angiograms, our novel OCTA technique achieves better performance with a visible vascular density increase of ~67% and a signal‐to‐noise ratio enhancement of ~11.6%. [ABSTRACT FROM AUTHOR]

OCTA can provide in‐vivo 3D microvasculature of bio‐tissue but faces challenges with motion sensitivity and time constraints. Our adaptive, efficient scanning protocol and motion compensation algorithms address these issues. Employing a high‐resolution spectral‐domain OCT system, our innovative OCTA method enhances vascular imaging performance and reconstructs human skin's relative blood speed imaging. Further details can be found in the article by Bin He, Yuxin Zhang, Zhe Meng, Zhijun He, Chengming Wang, Zhenyu Chen, Zichen Yin, Zhangwei Hu, Yejiong Shi, Ning Zhang, Wenxin Zhang, Guihuai Wang, and Ping Xue (e202200340) [ABSTRACT FROM AUTHOR]