1. Non-invasive ICG-clearance: a useful tool for the management of hepatic artery thrombosis following liver transplantation.
- Author
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Levesque, E., Hoti, E., Azoulay, D., Adam, R., Samuel, D., Castaing, D., and Saliba, F.
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LIVER transplantation , *HEPATIC artery , *THROMBOSIS , *INDOCYANINE green , *DOPPLER ultrasonography , *BLOOD testing , *REVASCULARIZATION (Surgery) - Abstract
Levesque E, Hoti E, Azoulay D, Adam R, Samuel D, Castaing D, Saliba F. Non-invasive ICG-clearance: a useful tool for the management of hepatic artery thrombosis following liver transplantation. Clin Transplant 2011: 25: 297-301. © 2010 John Wiley & Sons A/S. The clinical presentation of hepatic artery thrombosis (HAT) post-liver transplantation (LT) varies considerably. Doppler ultrasonography (Doppler US) is the first line investigation, with a diagnostic sensitivity for HAT as high as 92%. Because indocyanine green (ICG) elimination from the blood depends among other factors on the hepatic blood flow, we hypothesized that plasma disappearance rate of indocyanine green (PDR-ICG) can be influenced by the flow in the hepatic artery. Thus, we evaluated the role of PDR-ICG measurement in HAT diagnosis in post-LT patients. Fourteen liver transplant patients with no visible flow in the hepatic artery (Doppler US) were identified. Of the 14, seven patients had HAT confirmed by CT-angiography. The PDR-ICG measurement, an investigation routinely used in our center, was performed in all 14 patients. The PDR-ICG in patients with HAT was significantly lower than in patients without HAT (5.8 ± 4.3 vs. 23.8 ± 7.4%/min, p = 0.0009). In patients with HAT, after the revascularization, the PDR-ICG value increased (5.8 ± 4.3 vs. 15.6 ± 3.5%/min, p = 0.006). The ICG elimination may be an adjunct diagnostic tool in the management of patients with suspected HAT following LT. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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