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Hydrolytically stable PdII and PtII complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in a panel of cancer cell lines (IC50 0.07–0.81 μM) and up to 300‐fold selectivity for cancer cells over normal primary fibroblasts. The lead drug candidate was 300 times more potent than cisplatin in vitro and showed higher efficacy in reducing the growth of aggressive MDA‐MB‐231 xenograft tumors in mice. [ABSTRACT FROM AUTHOR]

The article titled "Metal-(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple-Negative Breast Cancer" discusses the use of a palladium compound to target aggressive tumors while sparing normal cells and tissues. The authors draw inspiration from the protective figure of Pallas Athena, which symbolizes the original meaning of the word "palladium." The research article provides more detailed information on this topic and can be accessed using the provided DOI. [Extracted from the article]

2-R-2 H-Tetrazol-5-ylacetic acids (abbreviated as 2-R-taa; R = Me, iPr, tBu) react with K2[PtCl4] in 1 m HCl in H2O at r.t. furnishing trans-platinum(II) complexes trans-[PtCl2(2-R-taa)2] ( 1- 3), whereas cis-isomeric species cis-[PtCl2(2-R-taa)2] (R = iPr, 4; tBu, 5) are isolated at lower temperature (4-6 °C). In the presence of EtOH in the reaction mixture, esterification of the tetrazol-5-ylacetoxy group of 2- tBu-taa leads to trans-[PtCl2(ethyl 2- tert-butyl-2 H-tetrazol-5-ylacetate)2] ( 6). Complexes 1- 6 were characterized by elemental analyses (CHN), HRESI+-MS, 1H, 13C{1H}, 195Pt{1H} NMR and IR spectroscopy, differential scanning calorimetry/thermogravimetry (DSC/TG), and X-ray diffraction (for 1·H2O, 2, 3·2H2O, 4, 5·2H2O, and 6). The generation of the tetrazole-based complexes in solution (1 m DCl in D2O, 25 °C) was studied by 1H NMR spectroscopy and HPLC-MS. The obtained data indicate the initial formation of anionic [PtCl3(2-R-taa)]- complexes that are subsequently converted into disubstituted isomeric platinum(II) species cis- and trans-[PtCl2(2-R-taa)2]. By contrast to cis- and trans-[PtCl2(2-R-taa)2] that were inactive in two human cancer models in vitro (IC50 > 100 µ m), complex 6 demonstrated noticeable antiproliferative effects in HT-29 colon and MCF-7 breast carcinoma cell lines with IC50 values of 14.2 ± 1.1 and 5.8 ± 1.2 µ m, respectively. [ABSTRACT FROM AUTHOR]

While bis(1-methyl-1 H-tetra­zol-5-yl)diazene, C4H6N10, (I), has no crystallographically imposed symmetry, in the two title chloro­copper(I) complexes, [Cu2Cl2(C4H6N10)] n, (II), and [CuCl(C4H6N10)] n, (III), the organic ligands lie across centres of inversion; in (III), the Cu and Cl atoms additionally lie about a twofold rotation axis in the space group P2/ c. Complex (II) forms a two-dimensional coordination polymer containing tetra­hedrally coordinated CuI atoms, and complex (III) forms a one-dimensional coordination polymer containing five-coordinate square-pyramidal CuI atoms. [ABSTRACT FROM AUTHOR]

While bis(1-methyl-1 H-tetra­zol-5-yl)diazene, C4H6N10, (I), has no crystallographically imposed symmetry, in the two title chloro­copper(I) complexes, [Cu2Cl2(C4H6N10)] n, (II), and [CuCl(C4H6N10)] n, (III), the organic ligands lie across centres of inversion; in (III), the Cu and Cl atoms additionally lie about a twofold rotation axis in the space group P2/ c. Complex (II) forms a two-dimensional coordination polymer containing tetra­hedrally coordinated CuI atoms, and complex (III) forms a one-dimensional coordination polymer containing five-coordinate square-pyramidal CuI atoms. [ABSTRACT FROM AUTHOR]

The crystal structure of the title polymeric complex, [CuCl(2)(C(3)H(6)N(4)O)(2)](n), was obtained by the Rietveld refinement from laboratory X-ray powder diffraction data collected at room temperature. The unique Cu(II) ion lies on an inversion center and is in a slightly distorted octa-hedral coordination environment. In the hydroxy-ethyl group, all H atoms, the O atom and its attached C atom are disordered over two positions; the site occupancy factors are ca 0.6 and 0.4. The OH group is involved in an intra-molecular O-H⋯N hydrogen bond.

While bis(1-methyl-1H-tetrazol-5-yl)diazene, C4H6N10, (I), has no crystallographically imposed symmetry, in the two title chlorocopper(I) complexes, [Cu2Cl2(C4H6N10)]n, (II), and [CuCl(C4H6N10)]n, (III), the organic ligands lie across centres of inversion; in (III), the Cu and Cl atoms additionally lie about a twofold rotation axis in the space group P2/c. Complex (II) forms a two-dimensional coordination polymer containing tetrahedrally coordinated Cu(I) atoms, and complex (III) forms a one-dimensional coordination polymer containing five-coordinate square-pyramidal Cu(I) atoms.