1. SNP-Based Heritability Estimates of Common and Specific Variance in Self- and Informant-Reported Neuroticism Scales.
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Realo, Anu, van der Most, Peter J., Allik, Jüri, Esko, Tõnu, Jeronimus, Bertus F., Kööts‐Ausmees, Liisi, Mõttus, René, Tropf, Felix C., Snieder, Harold, and Ormel, Johan
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HERITABILITY , *NEUROTICISM , *HUMAN phenotype , *SINGLE nucleotide polymorphisms , *FIVE-factor model of personality , *GENOTYPE-environment interaction , *NEO Personality Inventory - Abstract
Objective: Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N = 3,292) and the Netherlands (Lifelines; N = 13,383).Method: Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self- and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism.Results: In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self- and informant-reported Neuroticism domain scores was 15.2% (p = .070, SE = .11) and 6.2% (p = .293, SE = .12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self- than for informant reports, and (b) for sum than for residual scores.Conclusions: Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene × Environment interaction across cohorts. [ABSTRACT FROM AUTHOR]- Published
- 2017
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