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1. SARS-CoV-2-specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID-19 vaccination.

Author

Jarisch A, Wiercinska E, Daqiq-Mirdad S, Hellstern H, Ajib S, Cremer A, Nguyen NTT, Dukat A, Ullrich E, Ciesek S, Chow KU, Serve H, Seifried E, Bader P, Bonig H, and Bug G

Subjects
Antibodies, Viral, COVID-19 Vaccines, Humans, Immunity, Cellular, Immunity, Humoral, SARS-CoV-2, T-Lymphocytes, Vaccination, COVID-19, Hematopoietic Stem Cell Transplantation
Abstract

Little is known about the cellular immune response to SARS-CoV-2 vaccination in patients after HSCT and B-NHL with iatrogenic B-cell aplasia. In nonseroconverted HSCT patients, induction of specific T-cell responses was assessed. The majority of allogeneic HSCT patients not showing humoral responses to vaccination also fail to mount antigen-specific T-cell responses., (© 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)

Published
2022
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