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The reaction of acyclic enaminones with methoxymethylene Meldrum's acid afforded N-adduct and/or C-adduct of enaminones in moderate to good yields. The regiochemistry of this reaction depends on the N-amino substituent of the enaminone. The C-adduct is a precursor to 2-pyridones. X-ray analysis of two N-adducts were investigated and the Z-s-Z configuration assigned.

The reaction of N-(p-tolyl)-maleimide with enaminones afforded succinimide-containing enaminones in moderate to good yields, and these compounds were evaluated against E. coli and S. aureus, but no significant antibacterial activity was observed. The regiochemistry of the compounds was examined mechanistically within frontier molecular orbital considerations. In the solid state three-dimensional structure there is the formation of cooperative inter- and intramolecular NH...O and CH...O hydrogen bonding.

The article discusses research on arylsulfonamides and the discrete role of choline substitutions in its supramolecular and conformation architecture. Researchers used two arylsulfonamide derivatives including N-(-4-acetylphenyl)-2,5-dichlorobenzenesulfonamide (II) and N-(4-acetylphenyl)benzenesulfonamide (I) for X-ray diffraction. The study showed that intramolecular geometry of two sulfonamides (I) and (II) are similar although there is slight rotation in the sulfamyl bridge bond axis.

The article offers information on the characterization of a bis-y-lactone analogous to avenaciolide with the use of elemental analysis, mass spectrometry and infrared and nuclear magnetic resonance (NMR) spectroscopy. The authors explain that the structures of the compound and of the synthetic precursor were determined by X-ray diffraction analysis. Researchers found antifungal activity against Colletotrichum gloeosporioides while the synthetic precursor was inactive under the in vitro test conditions.

The Cu atom of the title compound, [Cu(C4H7N2O3)2], is in a tetragonally distorted octahedral environment. A carboxyl O atom and the α-amino N atom from each ligand coordinate to Cu in a trans square-planar configuration [Cu—O = 2.003 (3) and 2.020 (3) Å, and Cu—N = 2.029 (4) and 2.049 (4) Å]. The octa­hedron is completed by bridging amide O atoms from adjacent mol­ecules [Cu—O = 2.229 (4) Å and Cu—O = 2.885 (4) Å] separated by c translations. This arrangement creates infinite chains linked in the [001] direction, stabilized by intra- and intermolecular N—H⋯O bonds. The structure has already been published [Stephens, Vagg & Williams (1975). Acta Cryst. B 31, 841–845]; this redetermination reports the structure with higher precision. [ABSTRACT FROM AUTHOR]

The article focuses on the crystallization of the compound calycanthine monohydrate. In the crystal structure the solvent water molecule plays an important role as a bridge between calycanthine molecules. To form the compound the ethanolic extract of Palicourea coriacea was submitted to acid-base treatment. Recrystallization was done from chloroform and methanol. This compound was isolated by silica-gel chromatography.

The title compound, C15H16N2O2S, is of interest with respect to antibacterial and anticancer activity and shows some trypanocidal activity. The crystal structure displays O—H...N hydrogen bonding, forming a chain along [001]. A weak non-classical hydrogen bond of type C—H...S connects molecules across an inversion centre. The packing is also mediated by an intermolecular C=O...π ring interaction connecting centrosymmetrically related molecules. Steric effects are responsible for the molecular conformation. [ABSTRACT FROM AUTHOR]

The title compound, C16H16N2O5, is a β-ketoether derivative closely related to natural 8,4′-oxyneolignans, which are of interest because of their moderate antifungal activity against systemic mycosis. The nitro group is not coplanar with the aromatic ring, as shown by a torsion angle of 47.2 (4)°. The molecules are linked by two non-classical intermolecular C—H⋯O hydrogen bonds with distances between donors and acceptors of 3.441 (5) and 3.539 (5) Å, leading to the formation of molecular stacking perpendicular to the bc plane. [ABSTRACT FROM AUTHOR]

The title compound, C16H15N1O5, is a β-ketoether derivative, closely related to natural 8.4′-oxy­neolignans, which are of interest because of their antiprotozoal activity. The nitro group is not coplanar with the aromatic ring, as is shown by a torsion angle of 49.4 (3)°. The mol­ecules are connected in the crystal structure by two non-classical intermolecular hydrogen bonds with C⋯O distances of 3.363 (3) and 3.274 (2) Å; repetition of these hydrogen bonds leads to the formation of sheets of molecules parallel to the (001) plane. [ABSTRACT FROM AUTHOR]

The solid-state structure of the title en­amino­ne, C15H17N1O7, the C adduct obtained from the reaction of 4-amino­pent-3-en-2-one with methoxy­methyl­ene Meldrum's acid, has been investigated by X-ray diffraction, and several structural features are different from the previously described structure of the corresponding N adduct. The carbonyl group of the en­amino­ne moiety of the C adduct is not coplanar with the en­amine fragment. One bifurcated intramolecular N—H⋯O hydrogen bond [2.688 (2) and 2.668 (2) Å] and two intermolecular C—H⋯O hydrogen bonds [3.339 (3) and 3.379 (3) Å] are observed. The structure packs in a linear fashion along the [100] direction. [ABSTRACT FROM AUTHOR]

The title compound, C11H12ClN3O, is composed of a planar azoen­amine skeleton, which forms a six-membered ring through an intramolecular hydrogen bond. In the solid state only the azoen­amine tautomer was observed. The molecular packing is through adjacent mol­ecules linked by N—H⋯O bonds, resulting in a two-dimensional sheet structure. [ABSTRACT FROM AUTHOR]