Search

Your search keyword '"Ochoa, Theresa J."' showing total 198 results
Start Over Author "Ochoa, Theresa J." Search Limiters Academic (Peer-Reviewed) Journals
198 results on '"Ochoa, Theresa J."'

3. The burden of antimicrobial resistance in the Americas in 2019: a cross-country systematic analysis

Author

Aguilar, Gisela Robles, Swetschinski, Lucien R., Weaver, Nicole Davis, Ikuta, Kevin S., Mestrovic, Tomislav, Gray, Authia P., Chung, Erin, Wool, Eve E., Han, Chieh, Hayoon, Anna Gershberg, Araki, Daniel T., Abdollahi, Ashkan, Abu-Zaid, Ahmed, Adnan, Mohammad, Agarwal, Ramesh, Dehkordi, Javad Aminian, Aravkin, Aleksandr Y., Areda, Demelash, Azzam, Ahmed Y., Berezin, Eitan N., Bhagavathula, Akshaya Srikanth, Bhutta, Zulfiqar A., Bhuyan, Soumitra S., Browne, Annie J., Castañeda-Orjuela, Carlos A., Chandrasekar, Eeshwar K., Ching, Patrick R., Dai, Xiaochen, Darmstadt, Gary L., De la Hoz, Fernando Pio, Diao, Nancy, Diaz, Daniel, Mombaque dos Santos, Wendel, Eyre, David, Garcia, Coralith, Haines-Woodhouse, Georgina, Hassen, Mohammed Bheser, Henry, Nathaniel J., Hopkins, Susan, Hossain, Md Mahbub, Iregbu, Kenneth Chukwuemeka, Iwu, Chidozie C.D., Jacobs, Jan Adriaan, Janko, Mark M., Jones, Ronald, Karaye, Ibraheem M., Khalil, Ibrahim A., Khan, Imteyaz A., Khan, Taimoor, Khubchandani, Jagdish, Khusuwan, Suwimon, Kisa, Adnan, Koyaweda, Giscard Wilfried, Krapp, Fiorella, Kumaran, Emmanuelle A.P., Kyu, Hmwe Hmwe, Lim, Stephen S., Liu, Xuefeng, Luby, Stephen, Maharaj, Sandeep B., Maronga, Christopher, Martorell, Miquel, May, Jürgen, McManigal, Barney, Mokdad, Ali H., Moore, Catrin E., Mostafavi, Ebrahim, Murillo-Zamora, Efrén, Mussi-Pinhata, Marisa Marcia, Nanavati, Ruchi, Nassereldine, Hasan, Natto, Zuhair S., Qamar, Farah Naz, Nuñez-Samudio, Virginia, Ochoa, Theresa J., Ojo-Akosile, Tolulope R., Olagunju, Andrew T., Olivas-Martinez, Antonio, Ortiz-Brizuela, Edgar, Ounchanum, Pradthana, Paredes, Jose L., Patthipati, Venkata Suresh, Pawar, Shrikant, Pereira, Marcos, Pollard, Andrew, Ponce-De-Leon, Alfredo, Sady Prates, Elton Junio, Qattea, Ibrahim, Reyes, Luis Felipe, Roilides, Emmanuel, Rosenthal, Victor Daniel, Rudd, Kristina E., Sangchan, Weerawut, Seekaew, Samroeng, Seylani, Allen, Shababi, Niloufar, Sham, Sunder, Sifuentes-Osornio, Jose, Singh, Harpreet, Stergachis, Andy, Tasak, Nidanuch, Tat, Nathan Y., Thaiprakong, Areerat, Valdez, Pascual R., Yada, Dereje Y., Yunusa, Ismaeel, Zastrozhin, Mikhail Sergeevich, Hay, Simon I., Dolecek, Christiane, Sartorius, Benn, Murray, Christopher J.L., and Naghavi, Mohsen

Published
2023
Full Text
View/download PDF

7. Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

Author

Lovesio, Luciano, Diez, Fabián, Grazziani, Franco, Ganaha, Maria Cristina, Zalatnik, Viviana Judith, Dittrich, Ricardo Julio, Espínola, Lidia, Lambert, Sandra, Longhi, Andrea, Vecchio, Claudia, Mastruzzo, María, Fernandez, Alberto, Borchowiek, Silvina, Potito, Roberto, Ahuad Guerrero, Rodolfo Andres, Guardiani, Fernando Martin, Castella, Sofia, Foccoli, Monica, Pedernera, Aldana, Braida, Ariel, Durigan, Virginia, Martella, Carolina, Bobat, Antonela, Boggia, Bruno Emilio, Nemi, Sergio Andrés, Tartaglione, Javier Gerardo, Piedimonte, Fabián César, De Bie, Jessie, Reynales Londoño, Humberto, Rodríguez Ordoñez, Paula Andrea, García Cruz, Johanna Marcela, Bautista Toloza, Leonardo, Ladino González, Margot Cecilia, Zambrano Ochoa, Adriana Pilar, Prieto Pradera, Iñigo, Torres Hernandez, Daniela, Mazo Elorza, Diana Patricia, Collazos Lennis, Maria Fernanda, Vanegas Dominguez, Beatriz, Solano Mosquera, Lina Marianur, Fendel, Rolf, Fleischmann, Wim Alexander, Koehne, Erik, Kreidenweiss, Andrea, Köhler, Carsten, Esen, Meral, Horn, Carola, Eberts, Sandra, Kroidl, Arne, Huber, Kristina, Thiel, Verena, Mazara Rosario, Sonia, Reyes, Gilda, Rivera, Laura, Donastorg, Yeycy, Lantigua, Flavia, Torres Almanzar, Dania, Candelario, Rosalba, Peña Mendez, Lourdes, Rosario Gomez, Nadia, Portolés-Pérez, Antonio, Ascaso del Río, Ana, Laredo Velasco, Leonor, Bustinduy Odriozola, Maria Jesus, Larrea Arranz, Igor, Martínez Alcorta, Luis Ignacio, Durán Laviña, María Isabel, Imaz-Ayo, Natale, Meijide, Susana, García-de-Vicuña, Aitor, Santorcuato, Ana, Gallego, Mikel, Aguirre-García, Gloria Mayela, Olmos Vega, Jocelyn, González Limón, Pablo, Vázquez Villar, Andrea, Chávez Barón, Jaime, Arredondo Saldaña, Felipe, Luján Palacios, Juan de Dios, Camacho Choza, Laura Julia, Vázquez Saldaña, Eduardo Gabriel, Ortega Dominguez, Sandra Janeth, Vega Orozco, Karen Sofia, Torres Quiroz, Ivonne Aimee, Martinez Avendaño, Alejandro, Herrera Sanchez, Javier, Guzman, Esperanza, Castro Castrezana, Laura, Ruiz Palacios y Santos, Guillermo Miguel, de Winter, Ronald Frank Jacobus, de Jonge, Hanna K, Schnyder, Jenny L, Boersma, Wim, Hessels, Lisa, Djamin, Remco, van der Sar, Simone, DeAntonio, Rodrigo, Peña, Moisés, Rebollon, Gabriel, Rojas, Marianela, Escobar, Johnny, Hammerschlag Icaza, Bruno, Wong T, Digna Y, Barrera Perigault, Paulo, Ruiz, Sergio, Chan, Milagros, Arias Hoo, Dommie Janneth, Gil, Ana I, Celis, Carlos R, Balmaceda, Maria Pia, Flores, Omar, Ochoa, Mayra, Peña, Bia, de la Flor, Carolina, Webb, Camille María, Cornejo, Enrique, Sanes, Fatima, Mayorga, Valerie, Valdiviezo, Gladys, Ramírez Lamas, Suzanne Pamela, Grandez Castillo, Gustavo Alberto, Lama, Javier R, Matta Aguirre, Milagros Erika, Arancibia Luna, Lesly Angela, Carbajal Paulet, Óscar, Zambrano Ortiz, José, Camara, Anais, Guzman Quintanilla, Fernanda, Diaz-Parra, Carmen, Morales-Oliva, Jose, Cornejo, Rubelio E, Ricalde, Sheby A, Vidal, Jhonny, Rios Nogales, Luis, Cheatham-Seitz, Darline, Gregoraci, Giorgia, Brecx, Alain, Walz, Lisa, Vahrenhorst, Dominik, Seibel, Tobias, Quintini, Gianluca, Kremsner, Peter G, Ahuad Guerrero, Rodolfo Andrés, Arana-Arri, Eunate, Aroca Martinez, Gustavo Jose, Bonten, Marc, Chandler, Reynaldo, Corral, Gonzalo, De Block, Eddie Jan Louis, Ecker, Lucie, Gabor, Julian Justin, Garcia Lopez, Carlos Alberto, Gonzales, Lucy, Granados González, María Angélica, Gorini, Nestor, Grobusch, Martin P, Hrabar, Adrian D, Junker, Helga, Kimura, Alan, Lanata, Claudio F, Lehmann, Clara, Leroux-Roels, Isabel, Mann, Philipp, Martinez-Reséndez, Michel Fernando, Ochoa, Theresa J, Poy, Carlos Alberto, Reyes Fentanes, Maria Jose, Rivera Mejia, Luis Maria, Ruiz Herrera, Vida Veronica, Sáez-Llorens, Xavier, Schönborn-Kellenberger, Oliver, Schunk, Mirjam, Sierra Garcia, Alexandra, Vergara, Itziar, Verstraeten, Thomas, Vico, Marisa, and Oostvogels, Lidia

Published
2022
Full Text
View/download PDF

9. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Author

Murray, Christopher J L, Ikuta, Kevin Shunji, Sharara, Fablina, Swetschinski, Lucien, Robles Aguilar, Gisela, Gray, Authia, Han, Chieh, Bisignano, Catherine, Rao, Puja, Wool, Eve, Johnson, Sarah C, Browne, Annie J, Chipeta, Michael Give, Fell, Frederick, Hackett, Sean, Haines-Woodhouse, Georgina, Kashef Hamadani, Bahar H, Kumaran, Emmanuelle A P, McManigal, Barney, Achalapong, Sureeruk, Agarwal, Ramesh, Akech, Samuel, Albertson, Samuel, Amuasi, John, Andrews, Jason, Aravkin, Aleskandr, Ashley, Elizabeth, Babin, François-Xavier, Bailey, Freddie, Baker, Stephen, Basnyat, Buddha, Bekker, Adrie, Bender, Rose, Berkley, James A, Bethou, Adhisivam, Bielicki, Julia, Boonkasidecha, Suppawat, Bukosia, James, Carvalheiro, Cristina, Castañeda-Orjuela, Carlos, Chansamouth, Vilada, Chaurasia, Suman, Chiurchiù, Sara, Chowdhury, Fazle, Clotaire Donatien, Rafai, Cook, Aislinn J, Cooper, Ben, Cressey, Tim R, Criollo-Mora, Elia, Cunningham, Matthew, Darboe, Saffiatou, Day, Nicholas P J, De Luca, Maia, Dokova, Klara, Dramowski, Angela, Dunachie, Susanna J, Duong Bich, Thuy, Eckmanns, Tim, Eibach, Daniel, Emami, Amir, Feasey, Nicholas, Fisher-Pearson, Natasha, Forrest, Karen, Garcia, Coralith, Garrett, Denise, Gastmeier, Petra, Giref, Ababi Zergaw, Greer, Rachel Claire, Gupta, Vikas, Haller, Sebastian, Haselbeck, Andrea, Hay, Simon I, Holm, Marianne, Hopkins, Susan, Hsia, Yingfen, Iregbu, Kenneth C, Jacobs, Jan, Jarovsky, Daniel, Javanmardi, Fatemeh, Jenney, Adam W J, Khorana, Meera, Khusuwan, Suwimon, Kissoon, Niranjan, Kobeissi, Elsa, Kostyanev, Tomislav, Krapp, Fiorella, Krumkamp, Ralf, Kumar, Ajay, Kyu, Hmwe Hmwe, Lim, Cherry, Lim, Kruy, Limmathurotsakul, Direk, Loftus, Michael James, Lunn, Miles, Ma, Jianing, Manoharan, Anand, Marks, Florian, May, Jürgen, Mayxay, Mayfong, Mturi, Neema, Munera-Huertas, Tatiana, Musicha, Patrick, Musila, Lilian A, Mussi-Pinhata, Marisa Marcia, Naidu, Ravi Narayan, Nakamura, Tomoka, Nanavati, Ruchi, Nangia, Sushma, Newton, Paul, Ngoun, Chanpheaktra, Novotney, Amanda, Nwakanma, Davis, Obiero, Christina W, Ochoa, Theresa J, Olivas-Martinez, Antonio, Olliaro, Piero, Ooko, Ednah, Ortiz-Brizuela, Edgar, Ounchanum, Pradthana, Pak, Gideok D, Paredes, Jose Luis, Peleg, Anton Yariv, Perrone, Carlo, Phe, Thong, Phommasone, Koukeo, Plakkal, Nishad, Ponce-de-Leon, Alfredo, Raad, Mathieu, Ramdin, Tanusha, Rattanavong, Sayaphet, Riddell, Amy, Roberts, Tamalee, Robotham, Julie Victoria, Roca, Anna, Rosenthal, Victor Daniel, Rudd, Kristina E, Russell, Neal, Sader, Helio S, Saengchan, Weerawut, Schnall, Jesse, Scott, John Anthony Gerard, Seekaew, Samroeng, Sharland, Mike, Shivamallappa, Madhusudhan, Sifuentes-Osornio, Jose, Simpson, Andrew J, Steenkeste, Nicolas, Stewardson, Andrew James, Stoeva, Temenuga, Tasak, Nidanuch, Thaiprakong, Areerat, Thwaites, Guy, Tigoi, Caroline, Turner, Claudia, Turner, Paul, van Doorn, H Rogier, Velaphi, Sithembiso, Vongpradith, Avina, Vongsouvath, Manivanh, Vu, Huong, Walsh, Timothy, Walson, Judd L, Waner, Seymour, Wangrangsimakul, Tri, Wannapinij, Prapass, Wozniak, Teresa, Young Sharma, Tracey E M W, Yu, Kalvin C, Zheng, Peng, Sartorius, Benn, Lopez, Alan D, Stergachis, Andy, Moore, Catrin, Dolecek, Christiane, and Naghavi, Mohsen

Published
2022
Full Text
View/download PDF

10. Randomized Controlled Trial of Bovine Lactoferrin for Prevention of Sepsis and Neurodevelopment Impairment in Infants Weighing Less Than 2000 Grams

Author

Medina, Pilar, Rivas, María, Chea, Irene, Villar, Alicia, Navarro, Carolina, Tucto, Lourdes, Mallma, Patricia, Calderon-Anyosa, Renzo, Rospigliosi, María Luz, Borda, Geraldine, Minauro, Orialit, Webb, Verónica, Bravo, Erika, Pacheco, Karen, Lino, Ana, Cama, Augusto, Llanos, Raúl, Chumbes, Oscar, Cuba, Liliana, Tresierra, Julio, Chincaro, Carmen, Tori, Alfredo, Ochoa, Theresa J., Zegarra, Jaime, Bellomo, Sicilia, Carcamo, Cesar P., Cam, Luis, Castañeda, Anne, Villavicencio, Aasith, Gonzales, Jorge, Rueda, Maria S., Turin, Christie G., Zea-Vera, Alonso, Guillen, Daniel, Campos, Miguel, and Ewing-Cobbs, Linda

Published
2020
Full Text
View/download PDF

11. Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study

Author

Brooks, Abdullah W, Corso, Alejandra, Davydov, Alexander, Maguire, Alison, Pollard, Andrew, Kiran, Anmol, Skoczynska, Anna, Moiane, Benild, Beall, Bernard, Sigauque, Betuel, Aanensen, David, Lehmann, Deborah, Faccone, Diego, Foster-Nyarko, Ebenezer, Bojang, Ebrima, Egorova, Ekaterina, Voropaeva, Elena, Sampane-Donkor, Eric, Sadowy, Ewa, Bigogo, Godfrey, Mucavele, Helio, Belabbès, Houria, Diawara, Idrissa, Moïsi, Jennifer, Verani, Jennifer, Keenan, Jeremy, Nair Thulasee Bhai, Jyothish N, Ndlangisa, Kedibone M, Zerouali, Khalid, Ravikumar, K L, Titov, Leonid, De Gouveia, Linda, Alaerts, Maaike, Ip, Margaret, de Cunto Brandileone, Maria Cristina, Hasanuzzaman, Md, Paragi, Metka, Nurse-Lucas, Michele, Ali, Mushal, Elmdaghri, Naima, Croucher, Nicholas, Wolter, Nicole, Porat, Nurit, Eser, Özgen Köseoglu, Akpaka, Patrick E, Turner, Paul, Gagetti, Paula, Tientcheu, Peggy-Estelle, Carter, Philip E, Mostowy, Rafal, Kandasamy, Rama, Ford, Rebecca, Henderson, Rebecca, Malaker, Roly, Shakoor, Sadia, Grassi Almeida, Samanta Cristine, Saha, Samir K, Doiphode, Sanjay, Madhi, Shabir A, Devi Sekaran, Shamala, Srifuengfung, Somporn, Obaro, Stephen, Clarke, Stuart C, Nzenze, Susan A, Kastrin, Tamara, Ochoa, Theresa J, Balaji, Veeraraghavan, Hryniewicz, Waleria, Urban, Yulia, Lo, Stephanie W, Gladstone, Rebecca A, van Tonder, Andries J, Lees, John A, du Plessis, Mignon, Benisty, Rachel, Givon-Lavi, Noga, Hawkins, Paulina A, Cornick, Jennifer E, Kwambana-Adams, Brenda, Law, Pierra Y, Ho, Pak Leung, Antonio, Martin, Everett, Dean B, Dagan, Ron, von Gottberg, Anne, Klugman, Keith P, McGee, Lesley, Breiman, Robert F, and Bentley, Stephen D

Published
2019
Full Text
View/download PDF

12. Lactoferrin extends its reach into South America

Author

Ochoa, Theresa J. and Vogel, Hans J.

Subjects
Learned institutions and societies -- Conferences, meetings and seminars, Lactoferrins -- Conferences, meetings and seminars, Biological sciences
Abstract

Introduction The 14th International Conference on Lactoferrin, Structure, Function, and Applications was held on 4-8 November 2019, in a new hotel conference center in the beautiful Miraflores district of Lima, [...]

Published
2021
Full Text
View/download PDF

18. International prospective observational cohort study of Zika in infants and pregnancy (ZIP study): study protocol

Author

Lebov, Jill F., Arias, Juan F., Balmaseda, Angel, Britt, William, Cordero, José F., Galvão, Luiz Augusto, Garces, Ana Lucía, Hambidge, K. Michael, Harris, Eva, Ko, Albert, Krebs, Nancy, Marques, Ernesto T. A., Martinez, Alexander M., McClure, Elizabeth, Miranda-Filho, Democrito B., Moreira, Maria Elisabeth Lopes, Mussi-Pinhata, Marisa M., Ochoa, Theresa J., Osorio, Jorge E., Scalabrin, Deolinda M. F., Schultz-Cherry, Stacey, Seage, III, George R., Stolka, Kristen, Ugarte-Gil, César Augusto, Vega, Carmen Milagros Velez, Welton, Michael, Ximenes, Ricardo, and Zorrilla, Carmen

Published
2019
Full Text
View/download PDF

22. Lactoferrin and prematurity: a promising milk protein?

Author

Ochoa, Theresa J. and Sizonenko, Stephane V.

Subjects
Milk -- Health aspects -- Usage -- Forecasts and trends, Lactoferrins -- Health aspects -- Usage -- Forecasts and trends, Infants (Premature) -- Care and treatment, Market trend/market analysis, Biological sciences
Abstract

Abstract: Lactoferrin (Lf) is the major whey protein in milk, with multiple beneficial health effects including direct antimicrobial activities, anti-inflammatory effects, and iron homeostasis. Oral Lf supplementation in human preterm [...]

Published
2017
Full Text
View/download PDF

23. Factors affecting lactoferrin concentration in human milk: how much do we know?

Author

Villavicencio, Aasith, Rueda, Maria S., Turin, Christie G., and Ochoa, Theresa J.

Subjects
Milk -- Composition, Lactoferrins -- Distribution -- Health aspects, Company distribution practices, Biological sciences
Abstract

Abstract: Lactoferrin (LF) is a breast milk glycoprotein with antimicrobial and anti-inflammatory effects. Its beneficial properties in infants, especially in those born preterm, are currently being studied in clinical trials. [...]

Published
2017
Full Text
View/download PDF

27. Oxacillin disk diffusion testing for the prediction of penicillin resistance in Streptococcus pneumoniae/Prueba de difusion con discos de oxacilina para predecir la resistencia a la penicilina de Streptococcus pneumoniae

Author

Horna, Gertrudis, Molero, Maria L., Benites, Liliana, Roman, Sigri, Carbajal, Luz, Mercado, Erik, Castillo, Maria E., Zerpa, Rito, Chaparro, Eduardo, Hernandez, Roger, Silva, Wilda, Campos, Francisco, Saenz, Andy, Reyes, Isabel, Villalobos, Alex, and Ochoa, Theresa J.

Published
2016

37. Clinical studies of lactoferrin in children

Author

Ochoa, Theresa J., Pezo, Alonso, Cruz, Karen, Chea-Woo, Elsa, and Cleary, Thomas G.

Subjects
Clinical chemistry -- Research, Children -- Health aspects, Lactoferrins -- Health aspects -- Physiological aspects, Biological sciences
Abstract

Much has been learned in recent years about the mechanisms by which breastfeeding improves child health and survival. However, there has been little progress in using these insights to improve pediatric care. The aim of this study was to review all clinical studies of lactoferrin (LF) in children in an effort to determine which interventions may improve pediatric care or require further research. We conducted a systematic and critical review of published literature and found 19 clinical studies that have used human or bovine LF for different outcomes: iron metabolisms and anemia (6 studies), fecal flora (5 studies), enteric infections (3 studies), common pediatric illnesses (1 study), immunomodulation (3 studies), and neonatal sepsis (1 study). Although the efficacies have varied in each trial, the main finding of all published studies is the safety of the intervention. Protection against enteric infections and neonatal sepsis are the most likely biologically relevant activities of LF in children. Future studies on neonatal sepsis should answer critically important questions. If the data from these sepsis studies are proven to be correct, it will profoundly affect the treatment of low birth weight neonates and will aid in the reduction of child mortality worldwide. Key words: lactoferrin, clinical studies, clinical trials, children. Au cours des dernieres annees, on en a appris beaucoup sur les mecanismes par lesquels l'allaitement ameliore la sante et la survie de l'enfant. Cependant, il y a eu peu de progres quant a l'utilisation de ces connaissances pour ameliorer les soins pediatriques. Cette etude vise a passer en revue toutes les etudes cliniques portant sur la lactoferrine chez les enfants, afin de determiner quelles sont les interventions qui peuvent ameliorer les soins pediatriques ou necessitent des recherches plus approfondies. Nous avons realise une revue systematique et critique de la litterature publiee et nous avons trouve 19 etudes cliniques dans lesquelles la lactoferrine bovine ou humaine avait ete utilisee a differentes fins : le metabolisme du fer et l'anemie (6 etudes), la flore fecale (5 etudes), les infections enteriques (3 etudes), les maladies pediatriques courantes (1 etude), l'immunomodulation (3 etudes) et la sepsie neonatale (1 etude). Malgre une efficacite variable selon les essais, la principale conclusion tiree de toutes ces etudes publiees etait la securite de l'intervention. La protection contre les infections enteriques et la sepsie neonatale constituent probablement les activites les plus pertinentes biologiquement de la lactoferrine chez les enfants. Si les donnees decoulant des etudes portant sur la sepsie s'averent justes, cela affectera profondement le traitement des nouveaux-nes de faible poids et contribuera a la reduction de la mortalite infantile dans le monde. Mots-cles : lactoferrine, etudes cliniques, essais cliniques, enfants., Introduction The World Health Organization (WHO) has estimated 8.7 million deaths in children younger than 5 years of age in 2008 globally (Black et al. 2010). Infectious diseases caused 68% [...]

Published
2012
Full Text
View/download PDF

38. Effect of bovine lactoferrin on the minimum inhibitory concentrations of ampicillin and trimethoprim-sulfamethoxazole for clinical Shigella spp. strains

Author

Mosquito, Susan, Zegarra, Gianina, Villanueva, Claudia, Ruiz, Joaquin, and Ochoa, Theresa J.

Subjects
Ampicillin -- Physiological aspects -- Health aspects, Sulfamethoxazole -- Physiological aspects -- Health aspects, Lactoferrins -- Physiological aspects -- Health aspects, Shigella -- Physiological aspects -- Health aspects, Biological sciences
Abstract

Here, we determined the effect of bovine lactoferrin (bLF) on the minimum inhibitory concentration (MIC) of ampicillin and trimethoprim-sulfamethoxazole in Shigella. Using a microdilution method, the MIC was determined in the presence or absence of bovine lactoferrin (10 mg/mL) on 88 Shigella strains (56 Shigella flexneri,15 Shigella boydii,13 Shigella sonnei, and 4 Shigella dysenteriae) previously isolated from peruvian children Key words: Shigella, resistance, lactoferrin, antibiotics. Nous determinons l'effet de la lactoferrine bovine (bLF) sur la concentration inhibitrice minimale (CIM) de l'ampicilline et du couple trimethoprime-sulfamethoxazole envers Shigella. En utilisant une methode de microdilution la CIM a ete determinee en presence ou en absence de bLF (10 mg/mL) sur 88 souches de Shigella (56 S. flexneri,15 S. boydii,13 S. sonnei et 4 S. dysenteriae) isolees precedemment chez des enfants peruviens de moins de deux ans. Un changement de valeur de CIM de deux fois ou plus etait considere significatif. Soixante-sept souches (76 %) etaient hautement resistantes a l'ampicilline; la presence de bLF diminuait la valeur de CIM de l'amplicilline sur le tiers des souches. Cette diminution des valeurs de CIM s'observait surtout sur les souches moins resistantes. La presence de bLF amenait sept souches resistantes a l'ampicilline (8 %) a l'interieur des limites permettant de les considerer comme sensibles. Quant au trimethoprime- sulfamethoxazole, 93 % des isolats y etaient hautement resistants, les valeurs de CIM n'etant diminuees par la bLF que sur 4 isolats seulement (5 %). Aucune souche resistante au trimethoprime-sulfamethoxazole ne devenait sensible en presence de lactoferrine. La diminution de CIM en presence de bLF semble dependre du mecanisme d'action de chaque antibiotique. Des etudes in vivo sont necessaries pour evaluer le potentiel de la bLF comme adjuvant au traitement antibiotique des souches de Shigella resistantes. Mots-cles: Shigella, resistance, lactoferrine, antibiotiques., Introduction Diarrheal diseases cause ~1.8 million deaths worldwide per year (Boschi-Pinto et al. 2008), with Shigella being one of the leading causes of diarrhea morbidity and mortality in children under [...]

Published
2012
Full Text
View/download PDF

42. Increase of Macrolide-Resistance in Streptococcus pneumoniae Strains After the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine in Lima, Peru.

Author

Gonzales, Brayan E., Mercado, Erik H., Pinedo-Bardales, Maria, Hinostroza, Noemi, Campos, Francisco, Chaparro, Eduardo, Del Águila, Olguita, Castillo, María E., Saenz, Andrés, Reyes, Isabel, and Ochoa, Theresa J.

Subjects
STREPTOCOCCUS pneumoniae, PNEUMOCOCCAL vaccines, COVID-19 treatment, COVID-19 pandemic, RESPIRATORY infections, CHILD patients
Abstract

Streptococcus pneumoniae upper respiratory infections and pneumonia are often treated with macrolides, but recently macrolide resistance is becoming an increasingly important problem. The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in the National Immunization Program of Peru in 2015. This study aimed to evaluate the temporal evolution of macrolide resistance in S. pneumoniae isolates collected in five cross-sectional studies conducted before and after this vaccine introduction, from 2006 to 2019 in Lima, Peru. A total of 521 and 242 S. pneumoniae isolates recovered from nasopharyngeal swabs from healthy carrier children < 2 years old (2 carriage studies) and samples from normally sterile body areas from pediatric patients with invasive pneumococcal disease (IPD) (3 IPD studies), respectively, were included in this study. Phenotypic macrolide resistance was detected using the Kirby-Bauer method and/or MIC test. We found a significant increase in macrolide resistance over time, from 33.5% to 50.0% in carriage studies, and from 24.8% to 37.5% and 70.8% in IPD studies. Macrolide resistance genes [ erm (B) and mef (A/E)] were screened using PCR. In carriage studies, we detected a significant decrease in the frequency of mef (A/E) genes among macrolide-resistant S. pneumoniae strains (from 66.7% to 50.0%) after introduction of PCV13. The most common mechanism of macrolide-resistant among IPD strains was the presence of erm (B) (96.0%, 95.2% and 85.1% in the 3 IPD studies respectively). Macrolide resistance was more common in serotype 19A strains (80% and 90% among carriage and IPD strains, respectively) vs. non-serotype 19A (35.5% and 34.4% among carriage and IPD strains, respectively). In conclusion, S. pneumoniae macrolide resistance rates are very high among Peruvian children. Future studies are needed in order to evaluate macrolide resistance trends among pneumococcal strains, especially now after the COVID-19 pandemic, since azithromycin was vastly used as empiric treatment of COVID-19 in Peru. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

44. High Prevalence of blacT)(-M in Fecal Commensal Escherichia coli from Healthy Children.

Author

Alcedo, Katherine, Ruiz, Joaquim, Ochoa, Theresa J., and Riveros, Maribel

Subjects
ESCHERICHIA coli, PUBLIC health surveillance, RURAL children, DRUG resistance in bacteria, ANTIBACTERIAL agents
Abstract

Background : Antibiotic-resistant Escherichia coli can colonize the intestinal tract of healthy children, causing concern when antibiotic resistance is related to the presence of transferable mechanisms, such as extended-spectrum 13-lactamases (ESBLs). Materials and Methods: Fecal samples from 41 healthy children from two villages of rural Peru were cultured on ceftriaxone-disks. ESBL production was confirmed with double disk synergy. In all ESBL-produced isolates, antibiotic susceptibility to 12 antibacterial agents was established by disk diffusion, while clonal relationships were determined by repetitive extragenic palindromic-polymerase chain reaction (REP-PCR). Presence of ST131 was determined using PCR. Results:Ceftriaxone-resistant microorganisms were recovered from 39 samples belonging to 22 out of41 children (53.7°/o). Of these, 80 ceftriaxone-resistant and two ceftriaxoneintermediate E. coli from inside ceftriaxone-halos were confirmed as ESBL-producers. All isolates were multidrug-resistant. In 79/80 (98.8%) ceftriaxone-resistant isolates, the presence of blacrx-M was detected alone (58 isolates, or together with other D-lactamase (blarEM 17 isolates; blaoxA-1-like, 3 isolates; blarEM + blao>

Published
2022
Full Text
View/download PDF

45. Effect of lactoferrin on Enteroaggregative E. coli (EAEC) (1)

Author

Ochoa, Theresa J., Brown, Eric L., Guion, Chase E., Chen, Jane Z., McMahon, Robert J., and Cleary, Thomas G.

Subjects
Cell research -- Analysis, Lactoferrins -- Research -- Analysis, Escherichia coli -- Research -- Analysis, Biological sciences, Analysis, Research
Abstract

Abstract: We previously demonstrated that lactoferrin inhibits adherence of enteropathogenic Escherichia coli to HEp-2 cells and decreases invasiveness of Shigella flexneri in HeLa cells by disruption of the type III [...]

Published
2006

47. Human milk secretory antibodies against attaching and effacing Escherichia coli antigens. (Research)

Author

Noguera-Obenza, Marita, Ochoa, Theresa J., Gomez, Henry F., Guerrero, M. Lourdes, Herrera-Insua, Irene, Morrow, Ardythe L., Ruiz-Palacios, Guillermo, Pickering, Larry K., Guzman, Carlos A., and Cleary, Thomas G.

Subjects
Breast milk -- Genetic aspects, Communicable diseases -- Genetic aspects, Communicable diseases -- Development and progression, Immunoglobulin A -- Genetic aspects, Pregnant women -- Health aspects
Abstract

Secretory immunoglobulin A (sIgA) is a primary factor responsible for preventing attachment of enteropathogens to gut epithelium in breastfeeding infants. We compared the frequency of sIgA to major surface antigens [...]

Published
2003

48. COVID-19 vaccine equity: a health systems and policy perspective.

Author

Van De Pas, Remco, Widdowson, Marc-Alain, Ravinetto, Raffaella, N Srinivas, Prashanth, Ochoa, Theresa J., Fofana, Thierno Oumar, and Van Damme, Wim

Subjects
COVID-19 vaccines, HEALTH equity, VACCINATION, COVID-19 pandemic, TECHNOLOGY transfer
Abstract

The global COVID-19 vaccine rollout has highlighted inequities in the accessibility of countries to COVID-19 vaccines. Populations in low- and middle-income countries have found it difficult to have access to COVID-19 vaccines. This perspective provides analyses on historical and contemporary policy trends of vaccine development and immunization programs, including the current COVID-19 vaccination drive, and governance challenges. Moreover, we also provide a comparative health system analysis of the COVID-19 vaccine deployment in some countries from different continents. It recommends that the international Access to COVID-19 Tools Accelerator (ACT-A) partnership requires a strong governance mechanism and urgent financial investment. All WHO member states should agree on technology transfer and voluntary license-sharing via a commonly governed technology access pool and supported by a just Intellectual Property regime. Contextualized, dynamic understandings and country-specific versions of health systems strengthening are needed to improve vaccine equity in a sustainable matter. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

50. Drug-resistant diarrheogenic Escherichia coli, Mexico

Author

Estrada-Garcia, Teresa, Cerna, Jorge F., Paheco-Gil, Leova, Velazquez, Raul F., Ochoa, Theresa J., Torres, Javier, and DuPont, Herbert L.

Subjects
Escherichia coli -- Case studies, Escherichia coli -- Health aspects, Escherichia coli -- Care and treatment, Escherichia coli -- Drug therapy, Escherichia coli -- Research
Abstract

Diarrheogenic Escherichia coli isolates from 45 (73%) of 62 hospitalized patients were resistant to common antimicrobial drugs. Sixty-two percent were multidrug resistant, and >70% were resistant to trimethoprim-sulfamethoxazole and ampicillin. [...]

Published
2005

Catalog

Books, media, physical & digital resources
See catalog results