166 results on '"Safi, Alexias"'
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2. Transcriptome and epigenome landscape of human cortical development modeled in organoids
3. Comprehensive functional genomic resource and integrative model for the human brain
4. Integrative functional genomic analysis of human brain development and neuropsychiatric risks
5. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
6. Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.
7. Transcriptome and epigenome landscape of human cortical development modeled in organoids
8. Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains
9. Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription
10. Profiling the quantitative occupancy of myriad transcription factors across conditions by modeling chromatin accessibility data
11. Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration
12. Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus
13. Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration
14. Targeted long-read sequencing identifies missing disease-causing variation
15. Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes
16. Additional file 2 of Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains
17. An integrated encyclopedia of DNA elements in the human genome
18. The accessible chromatin landscape of the human genome
19. Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains
20. Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance
21. Experimental validation of the docking orientation of Cdc25 with its Cdk2-CycA protein substrate
22. Cell‐type‐specific and sex‐dependent changes in the chromatin accessibility landscape in late‐onset Alzheimer’s disease brains
23. Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration.
24. Quantitative occupancy of myriad transcription factors from one DNase experiment enables efficient comparisons across conditions
25. Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation
26. Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders.
27. Evaluating Chromatin Accessibility Differences Across Multiple Primate Species Using a Joint Modeling Approach
28. Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits
29. Comparative Analyses of Chromatin Landscape in White Adipose Tissue Suggest Humans May Have Less Beigeing Potential than Other Primates
30. Evaluating chromatin accessibility differences across multiple primate species using a joint modelling approach
31. Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation
32. Human cardiac cis-regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants
33. Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding
34. Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia
35. Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids
36. O4‐01‐02: DECODING THE GENETIC ARCHITECTURE OF LATE‐ONSET ALZHEIMER'S DISEASE USING SINGLE CELL ANALYSES
37. Comparative Serum Challenges Show Divergent Patterns of Gene Expression and Open Chromatin in Human and Chimpanzee
38. Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice
39. Evaluation of Chromatin Accessibility in Prefrontal Cortex of Schizophrenia Cases and Controls
40. CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome
41. Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome
42. Differential contribution ofcis-regulatory elements to higher order chromatin structure and expression of theCFTRlocus
43. DECODING THE GENETIC ARCHITECTURE OF LATE-ONSET ALZHEIMER’S DISEASE USING SINGLE CELL ANALYSES
44. Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
45. Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
46. 485. Targeted Epigenome Editing by CRISPR/Cas9-Based Repressors for Silencing of Distal Regulatory Elements
47. Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum
48. Interactions of Chromatin Context, Binding Site Sequence Content, and Sequence Evolution in Stress-Induced p53 Occupancy and Transactivation
49. Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites
50. Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions
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