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Ovarian cancer ranks third among the tumors of the reproductive system in women. This disease has no screening.It is characterized by a latent course and, as a result, is diagnosed at the advanced stages of the tumor process. There are two methods of treatment for this disease: aggressive cytoreductive surgery and anticancer drug therapy. However, the phasing of approaches causes controversy among oncologists. This article will consider approaches to choosing the stage of treatment for patients with advanced ovarian cancer based on the analysis of international studies.

The article deals with forecasting the values of economic growth factors in a region on the example of the Udmurt Republic. A statistically significant multiple linear regression equation (that explains the dynamics of the gross regional product from the signs-factors) is derived, a factorial forecast is developed and the results obtained are interpreted. Deflation method has been applied to eliminate the impact of price growth and GRP value has been calculated in 2007 prices. On the basis of multiple regression analysis, a matrix of paired correlation coefficients is calculated and informative factors of the model are selected. The significance of paired correlation coefficients is checked. The model is constructed in its natural form with informative factors only. The statistical significance of the regression coefficients is evaluated with the help of the Student's t -criterion, the quality of the equation is estimated through the average approximation error, which confirm the sufficiently high quality of the model. The predicted value of the result is calculated. It was found that if the current trends in the dynamics of these factors persist, we can expect the growth of real (physical volume) GRP over the period 2016-2020 by 26 % or 5.5 % annually, which meets the requirements of economic security of the region. The above information can be used to develop programs of regional economic development and design in the system of state and municipal administration.

The opinion article is devoted to the analysis of a large-scale comprehensive systematic review of relevant and practically oriented studies of vortioxetine use in depression for the period to 2020. The mechanisms of multimodal action, issues of efficacy and safety of the drug, including direct procognitive effects, effects on anhedonia, anxiety, sleep disorders, analgesic and anti-inflammatory effects are highlighted. An increase in the efficacy of vortioxetine when the dose is increased to 20 mg/day is emphasized. Prospective directions for antidepressant research are outlined.Публикация посвящена анализу масштабного систематического обзора актуальных и практически ориентированных исследований применения вортиоксетина при депрессии за период до 2020 г. Освещаются механизмы мультимодального действия, вопросы эффективности и безопасности применения препарата, в том числе прямого прокогнитивного эффекта, воздействия на ангедонию, тревогу, нарушения сна, анальгетического и противовоспалительного действия. Подчеркивается возрастание эффективности вортиоксетина при повышении дозы до 20 мг/сут. Намечены перспективные направления исследования антидепрессанта.

We report on detailed susceptibility, magnetization and magnetoresistance studies in La1−xSrxMnO3 for x⩽0.2. We arrive at a phase diagram which shows a ferromagnetic and insulating ground state for 0.1⩽x⩽0.15, followed by a canted antiferromagnetic phase at higher temperatures. The ferromagnetic transition is strongly coupled to a structural transition from a Jahn–Teller distorted phase to a pseudocubic orthorhombic phase, and is accompanied by the appearance of large positive magnetoresistance effects. We interpret the rich phase diagram close to x= 1 8 in terms of orbital ordering, due to an interplay of superexchange interactions and Jahn–Teller distortions. In addition, we report on the temperature dependence of phonon spectra and on optical conductivities. The temperature dependence of bending and stretching modes clearly indicate the structural and magnetic-phase transitions. The optical conductivities are explained in terms of small polaron absorption.