87 results on '"A.M. Silva"'
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2. Metabolic stress and reproductive features in post-partum goats supplemented for a long period with detoxified castor meal as the source of dietary nitrogen
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L.M. Silva, C.H.A. Oliveira, A.M. Silva, A.R. Montenegro, C.C.L. Fernandes, C.M.G. Silva, R. Rossetto, and D. Rondina
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Ricinus communis L ,postpartum ,lactation ,goat kids ,progesterone ,Animal culture ,SF1-1100 - Abstract
ABSTRACT This study evaluated the effect of detoxified castor meal on the reproductive performance, metabolic stress, milk production, and kid development in peripartum goats. The diet of the animals were with (DCM, n= 20) or without (WDCM, n= 21) detoxified castor meal during the entire gestation and until weaning, 60 days post-birth. No differences were observed in the gestation period, litter size, rate of multiple births, and mortality between the two groups. The postpartum plasma concentrations of progesterone remained below 1ng/mL in all animals, thus, confirming the absence of active corpora lutea. The thickness of sternum adipose tissue and loin area, levels of urea and cholesterol, milk production, and daily weight gain in the kids were low in the DCM group when compared to those in the WDCM group (P< 0.05). To conclude, the use of detoxified castor meal in peripartum goats resulted in lower level of performance in the kids because of reductions in the amount of milk received from their mothers during lactation. In addition, the diet containing detoxified castor meals was not efficient in recovering from the loss of stored body reserves able to initiate the recovery of the cyclic activity of the goats.
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- 2020
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3. Beneficios de la actividad física inclusiva para personas con síndrome de Down: revisión sistemática.
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A.M. Silva-Ortiz, J.M. Gamonales, L. Gámez-Calvo, and J. Muñoz-Jiménez
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Actividad física ,inclusión ,síndrome de Down ,Sports ,GV557-1198.995 - Abstract
El objetivo del trabajo fue realizar una revisión de la literatura relacionada con la actividad física como medio de inclusión para personas con Síndrome de Down. Para la búsqueda de referencias, se utilizó las siguientes palabras clave: Inclusion, Down Syndrome, y Physical Activity. Las bases de datos utilizadas fueron Web Of Science y SCOPUS. Para limitar la búsqueda, se establecieron cinco criterios de inclusión: i) Mencionar al menos alguna de las características de las personas con Síndrome de Down, ii) Utilizar la Actividad Física como herramienta de mejora de la calidad de vida iii) Seleccionar solamente artículos científicos, iiii) Disponibilidad del texto completo, y iiiii) Estar escrito en lengua inglesa. Se seleccionaron veintiún estudios, donde se extrajeron los datos de los artículos incluidos en la revisión. Los documentos abordan tópicos de investigación diferentes y han permitido conocer los principales beneficios de la actividad física para mejorar la calidad de vida de las personas con Síndrome de Down.
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- 2020
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4. ANÁLISE DA PREVALÊNCIA DO PERFIL RH DE PACIENTES ONCO-HEMATOLÓGICOS ATENDIDOS EM UM HOSPITAL TERCIÁRIO DE SÃO PAULO
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P.S. Batista, T.A.O. Paula, P.E. Kamioka, A. Bousso, D. Nóbrega, A.M. Silva, and C.Y. Nakazawa
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2020
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5. Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection
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T. Andreani, J. Dias-Ferreira, J.F. Fangueiro, A.L.R. Souza, C.P. Kiill, M.P.D. Gremião, M.L. García, A.M. Silva, and E.B. Souto
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Pharmaceutical science ,Pharmaceutical chemistry ,Nanotechnology ,Octyl methoxycinnamate ,Solid lipid nanoparticles ,SLN ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Sunscreens have been employed on daily skin care for centuries. Their role in protecting the skin from sun damage, avoiding accelerated photoaging and even limiting the risk of development of skin cancer is unquestionable. Although several chemical and physical filters are approved as sunscreens for human use, their safety profile is dependent on their concentration in the formulation which governs their acceptance by the regulatory agencies. A strategic delivery of such molecules should provide a UV protection and limit the skin penetration. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) may offer an alternative approach to achieve a synergistic effect on the UV protection when loaded with sunscreens as particles themselves also have a UV light scattering effect. Besides, the lipid character of SLN and NLC improves the encapsulation of lipophilic compounds, with enhanced loading capacity. Silica nanoparticles have also been employed in sunscreen formulations. Due to the formed sol-gel complexes, which covalently entrap sunscreen molecules, a controlled release is also achieved. In the present work, we have developed a new sunscreen formulation composed of hybrid SLN-Silica particles loaded with octyl methoxycinnamate (Parsol®MCX), and their further incorporation into a hydrogel for skin administration. Hybrid SLN-silica particles of 210.0 ± 3.341 nm of mean size, polydispersity below 0.3, zeta potential of ca. |7| mV, loading capacity of 19.9% and encapsulation efficiency of 98.3% have been produced. Despite the slight negative surface charge, the developed hybrid nanoparticles remained physicochemically stable over the study period. Turbiscan transmission profiles confirmed the colloidal stability of the formulations under stress conditions. The texture profile analysis of Parsol-SLN and Parsol-SLN-Si revealed semi-solid properties (e.g. adhesiveness, hardness, cohesiveness, springiness, gumminess, chewiness, resilience) suitable for topical application, together with the bioadhesiveness in the skin of pig ears. The non-irritation profile of the hybrid nanoparticles before and after dispersion into Carbopol hydrogels was confirmed by HET-CAM test.
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- 2020
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6. Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs
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A.R. Fernandes, N.R. Ferreira, J.F. Fangueiro, A.C. Santos, F.J. Veiga, C. Cabral, A.M. Silva, and E.B. Souto
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Therapeutics. Pharmacology ,RM1-950 - Abstract
The reduction of the particle size of drugs of pharmaceutical interest down to the nano-sized range has dramatically changed their physicochemical properties. The greatest disadvantage of nanocrystals is their inherent instability, due to the risk of crystal growth. Thus, the selection of an appropriate stabilizer is crucial to obtain long-term physicochemically stable nanocrystals. High pressure homogenization has enormous advantages, including the possibility of scaling up, lack of organic solvents and the production of small particles diameter with low polydispersity index. The sequential use of high shear homogenization followed by high pressure homogenization, can modulate nanoparticles’ size for different administration routes. The present study focuses on the optimization of the production process of two formulations composed of different surfactants produced by High Shear Homogenization followed by hot High Pressure Homogenization. To build up the surface response charts, a 22 full factorial design experiment, based on 2 independent variables, was used to develop optimized formulations. The effects of the production process on the mean particle size and polydispersity index were evaluated. The best ibuprofen nanocrystal formulations were obtained using 0.20% Tween 80 and 1.20% PVP K30 (F1) and 0.20% Tween 80 and 1.20% Span 80 (F2). The estimation of the long-term stability of the aqueous suspensions of ibuprofen nanocrystals was studied using the LUMISizer. The calculated instability index suggests that F1 was more stable when stored at 4 °C and 22 °C, whereas F2 was shown to be more stable when freshly prepared. Keywords: Factorial design, Nanocrystals, High pressure homogenization, Physicochemical stability, Ibuprofen, Surfactants
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- 2017
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7. d-α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity
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M.C. Teixeira, P. Severino, T. Andreani, P. Boonme, A. Santini, A.M. Silva, and E.B. Souto
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d-α-tocopherol ,Nanoemulsions ,High-pressure homogenization ,Rheology ,Osmolarity ,Surface tension ,Caco-2-cells ,Cytotoxicity ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The aim of this study was the assessment of the physicochemical stability of d-α-tocopherol formulated in medium chain triglyceride nanoemulsions, stabilized with Tween®80 and Lipoid®S75 as surfactant and co-surfactant, respectively. d-α-tocopherol was selected as active ingredient because of its well-recognized interesting anti-oxidant properties (such as radical scavenger) for food and pharmaceutical industries. A series of nanoemulsions of mean droplet size below 90 nm (polydispersity index
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- 2017
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8. Respiratory sleep disturbance in children and adolescents with cystic fibrosis
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A.M. Silva, A. Descalço, M. Salgueiro, L. Pereira, C. Barreto, T. Bandeira, and R. Ferreira
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Diseases of the respiratory system ,RC705-779 - Abstract
Sleep disturbance has been described in cystic fibrosis (CF) patients as relevant to clinical and lung function predictive factors helping to improve the diagnosis and early intervention. Related paediatric studies are scarce. Objective: To describe respiratory sleep disturbance (RSD) and its association with spirometric indices in a population of CF children. A second aim was to determine if spirometric indices and wake-time SpO2 are predictors of sleep disturbance. Methods: A cross-sectional study involving 33CF paediatric patients. All participants underwent in-lab polysomnography (PSG), pulse oximetry and spirometry. A standardized sleep questionnaire was completed for each patient. Two subgroups were considered: I â Normal (FEV1 > â1.64 z-score); II â Obstructed (FEV1 â¤Â â1.64 z-score). Results: Participant's median age was 12 (6â18) years, 16 (48.5%) were male. Twenty-nine patients (87.9%) presented sleep complaints. Sleep efficiency was reduced; sleep latency and waking after sleep onset (WASO) increased. N1 increased, N2, N3, REM and awakenings were normal. The apnoeaâhypopnoea index was 0.6/h (sd 0.9); respiratory disturbance index (RDI) was 6.6/h (sd 5.2). Mean awaking (97% (sd 1.1)) and sleep SpO2 (95% (sd 2.7)) were normal; mean nocturnal oximetry desaturation index was 2.36/h; minimal nocturnal SpO2 was 89% (sd 4.1).We found associations between mean nocturnal SPO2 and mean values of FEV1 (r = 0.528; p = 0.002) and FEF25â75 (r = 0.426; p = 0.013). There were significant differences in nocturnal SpO2 between normal and obstructed patients (pÂ
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- 2016
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9. Expressão gênica de adipocinas em ovelhas alimentadas com resíduos da indústria do biodiesel da mamona
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S.S. Duarte, M.A. Gomes-Filho, D.M.F. Silva, L.M. Silva, C.H.A. Oliveira, F.V. Rodrigues, A.M. Silva, C.C.L. Fernandes, C.M.G. Silva, and D. Rondina
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ovino ,tecido adiposo ,reprodução ,adipocinas ,Animal culture ,SF1-1100 - Abstract
A expressão de RNAm para leptina, receptor de leptina (obRb), adiponectina, receptor de adiponectina (AdipoR1) e resistina foi avaliada por meio da técnica de PCR em tempo real, em tecidos ovariano, hipofisário, adiposo do omento e da região perirrenal, em ovelhas alimentadas sem farelo de mamona ou com farelo de mamona detoxificada durante 14 meses. O tipo de dieta não afetou os níveis de RNAm para leptina, obRb, adiponectina, AdipoR1 e resistina nos diferentes tecidos avaliados (P>0,05). Nos tecidos ovariano e hipofisário, não foi verificada a expressão da adiponecina e da resistina, respectivamente. Como consequência, pode-se concluir que o farelo de mamona detoxificada pode ser utilizado como fonte proteica na dieta de ovelhas, sem afetar a expressão do gene resistina e dos genes leptina e adiponectina, bem como de seus receptores.
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- 2014
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10. Qualidade do leite cru refrigerado sob inspeção federal na região Nordeste
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A.C. Ribeiro Neto, S.B.P. Barbosa, R.B. Jatobá, A.M. Silva, C.X. Silva, M.J.A. Silva, and K.R. Santoro
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gordura ,proteína ,qualidade do leite ,Animal culture ,SF1-1100 - Abstract
Estudou-se a influência sazonal sobre a composição química, a contagem de células somáticas (CCS) e a contagem bacteriana total (CBT) de leite cru refrigerado em vários estados da região Nordeste. Os dados foram obtidos de 116.989 amostras de leite de tanques coletadas pelas indústrias com cadastro no serviço de inspeção federal. As amostras foram separadas em três períodos (I, II, III), de acordo com aplicação da Instrução Normativa-51 (IN-51). O teor de gordura, média de 3,7%, foi o componente do leite que apresentou maior variação. Proteína e lactose tiveram amplitude de 0,04% entre os períodos e apresentaram médias de 3,2 e 4,4%, respectivamente. Maiores valores de CCS foram observados entre os meses de maio e julho, 594,33 a 625,28 mil cel/mL, enquanto para CBT os maiores valores ocorreram nos meses de maio e junho, 1308,54 e 1333,83 UFC/mL. Observaram-se diferenças significativas nos componentes do leite entre os estados, principalmente no que se refere à qualidade higiênico-sanitária.
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- 2012
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11. Exposição ao fumo do tabaco (EFT) e morbilidade respiratória em crianças em idade escolar
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C. Constant, I. Sampaio, F. Negreiro, P. Aguiar, A.M. Silva, M. Salgueiro, and T. Bandeira
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Diseases of the respiratory system ,RC705-779 - Abstract
Resumo: Introdução: A exposição ao fumo do tabaco (EFT) é factor de risco para Doença Pulmonar Obstrutiva Crónica e um problema major de saúde pública. A EFT pré e/ou pós-natal determina redução precoce da função pulmonar e aumento da morbilidade respiratória, dependente da dose. Tem sido sugerido que a EFT domiciliária é influenciada por factores socioeconómicos. Métodos: Estudo de rastreio epidemiológico transversal de dados de 313 crianças (52% rapazes) de 4 Escolas Básicas de Lisboa [1.° ano (54%) e 4.° ano]. A EFT e sintomatologia respiratória foram avaliadas a partir de questionário auto-preenchido pelos pais. Todas as crianças efectuaram espirometria na escola e 54% foram consideradas aceitáveis de acordo com critérios ATS/ERS. Efectuou-se análise descritiva e bivariada das variáveis com maior interesse e análise de regressão logÃstica múltipla ajustada para as variáveis com significado clÃnico/estatÃstico. Resultados: Em 41% dos casos a criança convivia com fumadores no domicÃlio (EFT na gravidez 18%, mãe fumadora 32%, pai fumador 38%). Os pais fumadores tinham escolaridade inferior e ocupações menos qualificadas. Tosse foi mais frequente nas crianças com mãe fumadora (OR ajustado = 2,1 95%CI 1,1â4,0) e sibilância nas crianças com EFT na gravidez e com mãe/pai fumadores. Todas as diferenças foram significativas (p <  0,05). Não se encontrou associação entre educação parental e sintomatologia respiratória ou ETF e infecções respiratórias/asma/diminuição de valores espirométricos. Conclusão: A EFT é frequente em crianças em idade escolar em Lisboa e condiciona morbilidade respiratória significativa. Intervenções dirigidas devem ter em conta condições sociais. Neste estudo a espirometria de campo foi pouco útil na detecção precoce de diminuição da função pulmonar em crianças associada à EFT. Abstract: Introduction: Tobacco smoke is a risk factor for Chronic Obstructive Pulmonary Disease and a major public health problem. Prenatal maternal smoking and post-natal environmental tobacco smoke (ETS) lead to dose-dependent decrease in lung function and respiratory morbidity. Influence of different socioeconomic indicators and ETS in the home has also been suggested. Methods: Data on 313 children (52% male) from 4 public schools in Lisbon was analyzed [1st (46%) and 4th graders]. ETS assessment and respiratory symptoms were based on a self-answered questionnaire. All children performed standard spirometry in the school setting and 54% were acceptable according to ATS/ERS criteria. Descriptive and bivariate analysis of the most relevant variables was done, followed by multiple logistic regression analysis adjusted to the variables with clinical/statistical relevance. Results: ETS in the home was found in 41% (maternal smoking during pregnancy 18%, smoking mother 32%, smoking father 38%). Smoking fathers had lower education and less qualified occupation. Cough was more frequent in children with a smoking mother (adjusted OR = 2.1 95CI 1.1â4.0) and wheezing in children with maternal smoking during pregnancy and smoking parents. All differences were significant (pÂ
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- 2011
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12. Haematological and biochemical parameters in Churra-da-Terra-Quente ewes from the northeast of Portugal Parâmetros hematológicos e bioquímicos de ovelhas da raça Churra da Terra Quente do nordeste de Portugal
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I.R. Dias, C.A. Viegas, A.M. Silva, H.F. Pereira, C.P. Sousa, P.P. Carvalho, A.S. Cabrita, P.J. Fontes, S.R. Silva, and J.M.T. Azevedo
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ovelha ,Churra da Terra Quente ,parâmetros hematológicos e bioquímicos ,eletrólitos ,hormônio da tiroide ,ewe ,Portuguese Churra-da-Terra-Quente ,hematological and biochemical parameters ,electrolytes ,thyroid hormone ,Animal culture ,SF1-1100 - Abstract
Hematological and biochemical parameters, including plasma electrolytes and thyroid hormones, were determined in 73 clinically healthy Churra-da-Terra-Quente ewes, a typical breed from the northeast of Portugal. The hemogram values were: erythrocytes 9.8±1.5×10(12)/L; haemoglobin 118.1±19.1g/L; haematocrit 40.8±5.9%; leukocytes 5.7±1.8×10(9)/L; and platelets 544.3±177.2×10(9)/L. The thrombin time was 17.3±1.7 seconds. The values of biochemical parameters were: total protein 76.4±6.1g/L; glucose 2.87±0.60mmol/L; total cholesterol 1.65±0.33mmol/L; aspartate aminotransferase 155.9±49.2U/L; alanine aminotransferase 23.2±9.6U/L; γ-glutamyl transferase 48.0±18.7U/L; total alkaline phosphatase 121.6±76.1U/L; glutamate dehydrogenase 6.4±3.7U/L; urea 7.32±2.22mmol/L; creatinine 123.0±54.1μmol/L; total calcium 2.53±0.25mmol/L; phosphorus 2.10±0.46mmol/L; magnesium 1.01±0.09mmol/L; sodium 152.04±3.65mmol/L; potassium 4.7±0.4mmol/L; ionized calcium 1.32±0.07mmol/L; total thyroxine 111.75±42.29nmol/L; total triiodothyronine 1.01±0.28nmol/L; free T4 11.93±1.78pmol/L; free T3 4.22±1.33pmol/L; and thyroid-stimulating hormone 0.18±0.19μIU/mL. Although differences among the Churra-da-Terra-Quente breed and other breeds may occur, the hematological and biochemical parameters, plasma electrolytes, and thyroid hormones, for this indigenous breed, were generally situated within the reference intervals previously reported for sheep.Os valores hematológicos e bioquímicos, incluindo os eletrólitos plasmáticos e os hormônios da tireoide, foram determinados em 73 ovelhas, clinicamente saudáveis, da raça Churra da Terra Quente, raça ovina característica do nordeste de Portugal. Os valores obtidos para o hemograma foram: eritrócitos 9,8±1,5×10(12) /L; hemoglobina 118,1±19,1g/L; hematócrito 40,8±5,9%; leucócitos 5,7±1,8×10(9) /L e plaquetas 544,3±177,2×10(9)/L. O tempo de trombina foi de 17,3±1,7 segundos. Os valores dos parâmetros bioquímicos avaliados foram: proteínas totais 76,4±6,1g/L; glicose 2,87±0,60mmol/L; colesterol total 1,65±0,33mmol/L; aspartato amino transferase 155,9±49,2U/L; alanina amino transferase 23,2±9,6U/L; gama-glutamil transferase 48,0±18,7U/L; fosfatase alcalina total 121,6±76,1U/L; glutamato desidrogenase 6,4±3,7U/L; ureia 7,32±2,22mmol/L; creatinina 123,0±54,1μmol/L; cálcio total 2,53±0,25mmol/L; fósforo 2,10±0,46mmol/L e magnésio 1,01±0,09mmol/L; sódio 152,04±3,65mmol/L; potássio 4,7±0,4mmol/L e cálcio ionizado 1,32±0,07mmol/L; tiroxina total 111,75±42,29nmol/L; tri-iodotironina total 1,01±0,28nmol/L; T4 livre 11,93±1,78pmol/L; T3 livre 4,22±1,33pmol/L e hormônio estimulante da tireoide 0,18±0,19μIU/mL. Apesar de terem sido observadas algumas diferenças entre a raça Churra da Terra Quente e outras raças, os valores hematológicos e bioquímicos, eletrólitos plasmáticos e hormônios da tireóide, desta raça autóctone apresentam-se no geral situados dentro dos intervalos de referência publicados para a espécie ovina.
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- 2010
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13. Identificação de portadores de Staphylococcus enterotoxigênicos e avaliação da sensibilidade a antimicrobianos Identification of enterotoxigenic Staphylococcus carriers and antimicrobial susceptibility evaluation
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A.S. Bartels, A.D. Andrade, E. Neumann, and A.M. Silva
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Animal culture ,SF1-1100 - Published
- 2009
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14. Role of the caudal pressor area in the regulation of sympathetic vasomotor tone
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R.R. Campos, B.A. Carillo, E.B. Oliveira-Sales, A.M. Silva, N.F. Silva, H.A. Futuro Neto, and C.T. Bergamaschi
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Rostral ventrolateral medulla ,Rat ,Glutamate ,Blood pressure ,Caudal pressor area ,Sympathetic vasomotor tone ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
It is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and are involved in the maintenance of resting sympathetic vasomotor tone. A significant proportion of tonic activity in the RVLM sympathetic premotor neurons is driven by neurons located in a third region of the ventrolateral medulla denominated caudal pressor area (CPA). The CPA is a pressor region located at the extreme caudal part of the ventrolateral medulla that appears to have an important role controlling the activity of RVLM neurons. In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA.
- Published
- 2008
15. Association of Bacillus subtilis and Bacillus amyloliquefaciens: minimizes the adverse effects of necrotic enteritis in the gastrointestinal tract and improves zootechnical performance in broiler chickens
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Romário A. Rodrigues, Leandro A.M. Silva, Heloisa C. Brugnera, Natália Pereira, Mariana F. Casagrande, Lilian C. Makino, Caio R.S. Bragança, Rubén Pablo Schocken-Iturrino, and Marita V. Cardozo
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Bacillus spp. ,coccidiosis ,growth performance ,gut function ,one health ,Animal culture ,SF1-1100 - Abstract
ABSTRACT: This study aimed to evaluate the efficiency and capacity of the probiotic composed of Bacillus subtilis and Bacillus amyloliquefaciens, in improving the zootechnical performance of broiler chickens challenged with Eimeria spp. and Clostridium perfringens. The broilers were distributed in a completely randomized design in poultry isolators (12 birds each), resulting in 3 treatments: T1 (control, no challenge and no Bacillus in diet), T2 (challenged with Eimeria spp., followed by Clostridium perfringens infection and no Bacillus in the diet), and T3 (challenged with Eimeria spp., Clostridium perfringens and treated with Bacillus subtilis and Bacillus amyloliquefaciens). They were evaluated for a period of 29 d, divided into preinitial (1–7 d of age), initial (8–21 d), and growth (22–29 d) phases. Assessments of body weight, weight gain, feed consumption, and feed conversion were conducted, along with the classification of the scores and optical microscopy of the tract gastrointestinal. The animals challenged and treated with the probiotic containing Bacillus spp. showed improved indicators of zootechnical performance. Additionally, the animals challenged and treated (T3) had a better score for intestinal lesions compared to the other treatment groups. Therefore, the probiotic consisting of Bacillus subtilis and Bacillus amyloliquefaciens could be considered an effective option for disease prevention and improving the zootechnical performance of broiler chickens
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- 2024
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16. FREQUENZA DEL GENOTIPO 4 DI HCV IN CALABRIA
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M.C. Liberto, G.S. Barreca, A. Quirino, R. Capicotto, A.G. Lamberti, M. Vinci, C. Di Cello, M. De Rosa, A.M. Silva, C. Giraldi, F. Greco, G. Matera, and A. Focà
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Microbiology ,QR1-502 - Published
- 2006
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17. ANDAMENTO DELLA PREVALENZA DEL GENOTIPO 4 DI HCV IN CALABRIA
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G.S. Barreca, A. Quirino, R. Capicotto, A.G. Lamberti, C. Di Cello, M. De Rosa, A.M. Silva, C. Giraldi, F. Greco, M.C. Liberto, and A. Focà
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Microbiology ,QR1-502 - Published
- 2005
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18. Analytical methodologies used for screening micro(nano)plastics in (eco)toxicity tests
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Ana L. Patrício Silva, Sara A.M. Silva, Armando Duarte, Damià Barceló, and Teresa Rocha-Santos
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Haemocytometry ,Flow Cytometry Microscopy/Imaging ,Confocal Raman Microscopy ,Fluorescence Lifetime Imaging Technology ,Analytical chemistry ,QD71-142 - Abstract
Micro(nano)plastics accumulate in natural environments worldwide, threatening biota, ecosystem functions, and services. In the last decade, there has been a substantial increase in the number of ecotoxicity studies to address the potential effects of micro(nano)plastics, including their plasticisers and adsorbed hazardous substances. Their environmental relevance has been under scrutiny due to the non-environmentally relevant testing conditions besides the lack of a proper characterization of the particles under study (e.g., size range, surface properties, crystallinity, chemical composition, including additives compounds), thus compromising the significance of the risk assessment and management strategies.This paper reviews the analytical methodologies applied in ecotoxicity tests for identifying, quantifying, and eventual characterising micro(nano)plastics before, during (monitoring), and after exposure, addressing their advantages and limitations. It also discusses emerging and cost-efficient methodologies that may speed up the detection and quantification of micro(nano)plastics and motivate their characterization for a deeper understanding of the underlying (eco)toxicity mechanisms.
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- 2022
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19. Bloqueio do plexo braquial em um tamanduá-mirim (Tamandua tetradactyla) utilizando estimulador de nervos periféricos: relato de caso
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A.M. Silva, K.F. Silva, L.M. Santos, L.B.S. Azuaga, P.H.A. Jardim, V. B. Albuquerque, and F.O. Frazílio
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bloqueio nervoso ,anestesia locorregional ,membro torácico ,Animal culture ,SF1-1100 - Abstract
RESUMO Objetivou-se relatar a utilização do neurolocalizador para bloqueio do plexo braquial bilateral em tamanduá-mirim (Tamandua tetradactyla). O animal, pesando 5kg, atendido pelo Centro de Reabilitação de Animais Silvestres, foi encaminhado ao Hospital Veterinário da Universidade Federal de Mato Grosso do Sul para realização de exames complementares, sendo, posteriormente, encaminhado para cirurgia de osteossíntese de úmero e rádio/ulna esquerdo e colocação de fio de cerclagem em olécrano direito. O paciente foi pré-medicado com cetamina S (5mg/kg) + midazolam (0,15mg/kg), indução anestésica com propofol (5mg/kg) e manutenção anestésica com isoflurano, com o auxílio de máscara. Os parâmetros cardiovasculares e respiratórios foram monitorados durante todo o procedimento. Realizou-se o bloqueio do plexo braquial em ambos os membros utilizando-se estimulador de nervos periféricos. Os anestésicos locais empregados foram lidocaína 2% sem vasoconstritor (3mg/kg) + ropivacaína 0,75% sem vasoconstritor (1mg/kg). O bloqueio foi realizado primeiramente no membro torácico direito, e, após realização do procedimento cirúrgico, o mesmo bloqueio foi realizado no membro contralateral. O paciente teve recuperação tranquila ausente de vocalização e expressão álgica, e a soltura ocorreu após 120 dias.
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20. Diagnostic performance of a commercial ELISA used as a complementary test for bovine tuberculosis in two bovine herds with different disease status
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P.M. Soares Filho, A.K. Ramalho, A.M. Silva, M.A. Issa, P.M.P.C. Mota, C.H.O. Silva, A.C.C.L. Ribeiro, J.K.P. Rei, and R.C. Leite
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comparative cervical tuberculin test ,tuberculosis serology ,diagnostic test evaluation ,Animal culture ,SF1-1100 - Abstract
ABSTRACT Bovine tuberculosis is a worldwide spread zoonotic disease. Intradermal tuberculinizations are the most used diagnostic tests in the world. Serological tests can be an ancillary diagnosis for bovine tuberculosis. The objective of this study was to evaluate the diagnostic performance of the ELISA Mycobacterium Bovis Antibody Test Kit IDEXX ™ in infected herds, which were in different disease control stages. One hundred and twenty animals from two dairy herds of Minas Gerais state, Brazil, were subjected to the ELISA serological test and the comparative cervical tuberculin test (CCT). Diagnostic test parameters were estimated using Bayesian latent class models and concordance between tests estimated by the frequentist approach. The ELISA test presented lower sensitivity than CCT in both herds. Its sensitivity was higher in the herd in sanitation process. Specificity estimates were above 95% in both herds. Kappa index indicated low concordance or even disagreement between tests. According to the results, the ELISA IDEXX should not be used as substitution for CCT. The tests must not be associated in series. Parallel association increased diagnostic sensitivity in the herd which was in the process of sanitation.
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21. HFMEA-Fuzzy Model: Risk Assessment of 47 Emergency Care Units (ECU's)
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Harvey J. S. R Cosenza, Nilra A.M. Silva, Ana Paula B. Sobral, Stephanie D. Nascimento, and Robisom D. Calado
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Control and Systems Engineering - Published
- 2022
22. Microplastics altered cellular responses, physiology, behaviour, and regeneration of planarians feeding on contaminated prey
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Sara A.M. Silva, Joana C. Prata, Patrícia Dias-Pereira, Andreia C.M. Rodrigues, Amadeu M.V.M. Soares, Renato A. Sarmento, Teresa Rocha-Santos, Carlos Gravato, and Ana L. Patrício Silva
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Environmental Engineering ,Environmental Chemistry ,Pollution ,Waste Management and Disposal - Published
- 2023
23. Implementing nitrogen multiple breath washout as a clinical tool – A feasibility study
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Andreia Descalço, Celeste Barreto, Teresa Bandeira, Luísa Pereira, A.M. Silva, and Carolina Constant
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Pulmonary and Respiratory Medicine ,RC705-779 ,Nitrogen ,business.industry ,Lung Clearance Index ,medicine.disease ,Cystic fibrosis ,Respiratory Function Tests ,Lung clearance index ,Diseases of the respiratory system ,Primary ciliary dyskinesia ,Forced Expiratory Volume ,Anesthesia ,Feasibility Studies ,Humans ,Medicine ,Multiple breath washout ,business ,Children ,MULTIPLE BREATH WASHOUT - Published
- 2021
24. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
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Iurilli, M.L.C. Zhou, B. Bennett, J.E. Carrillo-Larco, R.M. Sophiea, M.K. Rodriguez-Martinez, A. Bixby, H. Solomon, B.D. Taddei, C. Danaei, G. Di Cesare, M. Stevens, G.A. Riley, L.M. Savin, S. Cowan, M.J. Bovet, P. Damasceno, A. Chirita-Emandi, A. Hayes, A.J. Ikeda, N. Jackson, R.T. Khang, Y.-H. Laxmaiah, A. Liu, J. Miranda, J.J. Saidi, O. Sebert, S. Sorić, M. Starc, G. Gregg, E.W. Abarca-Gómez, L. Abdeen, Z.A. Abdrakhmanova, S. Ghaffar, S.A. Rahim, H.F.A. Abu-Rmeileh, N.M. Garba, J.A. Acosta-Cazares, B. Adams, R.J. Aekplakorn, W. Afsana, K. Afzal, S. Agdeppa, I.A. Aghazadeh-Attari, J. Aguilar-Salinas, C.A. Agyemang, C. Ahmad, M.H. Ahmad, N.A. Ahmadi, A. Ahmadi, N. Ahmed, S.H. Ahrens, W. Aitmurzaeva, G. Ajlouni, K. Al-Hazzaa, H.M. Al-Lahou, B. Al-Raddadi, R. Alarouj, M. AlBuhairan, F. AlDhukair, S. Ali, M.M. Alkandari, A. Alkerwi, A. Allin, K. Alvarez-Pedrerol, M. Aly, E. Amarapurkar, D.N. Amiri, P. Amougou, N. Amouyel, P. Andersen, L.B. Anderssen, S.A. Ängquist, L. Anjana, R.M. Ansari-Moghaddam, A. Aounallah-Skhiri, H. Araújo, J. Ariansen, I. Aris, T. Arku, R.E. Arlappa, N. Aryal, K.K. Aspelund, T. Assah, F.K. Assunção, M.C.F. Aung, M.S. Auvinen, J. Mária Avdicová Avi, S. Azevedo, A. Azimi-Nezhad, M. Azizi, F. Azmin, M. Babu, B.V. Bæksgaard Jørgensen, M. Baharudin, A. Bahijri, S. Baker, J.L. Balakrishna, N. Bamoshmoosh, M. Banach, M. Bandosz, P. Banegas, J.R. Baran, J. Barbagallo, C.M. Barceló, A. Barkat, A. Barros, A.J.D. Barros, M.V.G. Basit, A. Bastos, J.L.D. Bata, I. Batieha, A.M. Batista, R.L. Battakova, Z. Batyrbek, A. Baur, L.A. Beaglehole, R. Bel-Serrat, S. Belavendra, A. Romdhane, H.B. Benedics, J. Benet, M. Bergh, I.H. Berkinbayev, S. Bernabe-Ortiz, A. Bernotiene, G. Bettiol, H. Bezerra, J. Bhagyalaxmi, A. Bharadwaj, S. Bhargava, S.K. Bhutta, Z.A. Bi, H. Bi, Y. Bia, D. Lele, E.C.B. Bikbov, M.M. Bista, B. Bjelica, D.J. Bjerregaard, P. Bjertness, E. Bjertness, M.B. Björkelund, C. Bloch, K.V. Blokstra, A. Bo, S. Bobak, M. Boddy, L.M. Boehm, B.O. Boeing, H. Boggia, J.G. Bogova, E. Boissonnet, C.P. Bojesen, S.E. Bonaccio, M. Bongard, V. Bonilla-Vargas, A. Bopp, M. Borghs, H. Braeckevelt, L. Braeckman, L. Bragt, M.C.E. Brajkovich, I. Branca, F. Breckenkamp, J. Breda, J. Brenner, H. Brewster, L.M. Brian, G.R. Brinduse, L. Brophy, S. Bruno, G. Bueno-de-Mesquita, H.B. Bugge, A. Buoncristiano, M. Burazeri, G. Burns, C. de León, A.C. Cacciottolo, J. Cai, H. Cama, T. Cameron, C. Camolas, J. Can, G. Candido, A.P.C. Cañete, F. Capanzana, M.V. Capková, N. Capuano, E. Capuano, V. Cardol, M. Cardoso, V.C. Carlsson, A.C. Carmuega, E. Carvalho, J. Casajús, J.A. Casanueva, F.F. Celikcan, E. Censi, L. Cervantes-Loaiza, M. Cesar, J.A. Chamukuttan, S. Chan, A.W. Chan, Q. Chaturvedi, H.K. Chaturvedi, N. Rahim, N.C.A. Chee, M.L. Chen, C.-J. Chen, F. Chen, H. Chen, S. Chen, Z. Cheng, C.-Y. Cheraghian, B. Chetrit, A. Chikova-Iscener, E. Chiolero, A. Chiou, S.-T. Chirlaque, M.-D. Cho, B. Christensen, K. Christofaro, D.G. Chudek, J. Cifkova, R. Cilia, M. Cinteza, E. Claessens, F. Clarke, J. Clays, E. Cohen, E. Concin, H. Confortin, S.C. Cooper, C. Coppinger, T.C. Corpeleijn, E. Costanzo, S. Cottel, D. Cowell, C. Craig, C.L. Crampin, A.C. Crujeiras, A.B. Csilla, S. Cucu, A.M. Cui, L. Cureau, F.V. Czenczek-Lewandowska, E. D’Arrigo, G. d’Orsi, E. Dacica, L. Dal Re Saavedra, M.A. Dallongeville, J. Damsgaard, C.T. Dankner, R. Dantoft, T.M. Dasgupta, P. Dastgiri, S. Dauchet, L. Davletov, K. De Backer, G. De Bacquer, D. de Gaetano, G. De Henauw, S. de Oliveira, P.D. De Ridder, D. De Ridder, K. de Rooij, S.R. De Smedt, D. Deepa, M. Deev, A.D. DeGennaro, V., Jr Dehghan, A. Delisle, H. Delpeuch, F. Demarest, S. Dennison, E. Dereń, K. Deschamps, V. Dhimal, M. Di Castelnuovo, A.F. Dias-da-Costa, J.S. Díaz-Sánchez, M.E. Diaz, A. Dika, Z. Djalalinia, S. Djordjic, V. Do, H.T.P. Dobson, A.J. Donati, M.B. Donfrancesco, C. Donoso, S.P. Döring, A. Dorobantu, M. Dorosty, A.R. Doua, K. Dragano, N. Drygas, W. Duan, J.L. Duante, C.A. Duboz, P. Duda, R.B. Duleva, V. Dulskiene, V. Dumith, S.C. Dushpanova, A. Dzerve, V. Dziankowska-Zaborszczyk, E. Eddie, R. Eftekhar, E. Egbagbe, E.E. Eggertsen, R. Eghtesad, S. Eiben, G. Ekelund, U. El-Khateeb, M. Ati, J.E. Eldemire-Shearer, D. Eliasen, M. Elliott, P. Engle-Stone, R. Enguerran, M. Erasmus, R.T. Erbel, R. Erem, C. Eriksen, L. Eriksson, J.G. Escobedo-de la Peña, J. Eslami, S. Esmaeili, A. Evans, A. Faeh, D. Fakhretdinova, A.A. Fall, C.H. Faramarzi, E. Farjam, M. Sant’Angelo, V.F. Farzadfar, F. Fattahi, M.R. Fawwad, A. Felix-Redondo, F.J. Ferguson, T.S. Fernandes, R.A. Fernández-Bergés, D. Ferrante, D. Ferrao, T. Ferrari, M. Ferrario, M.M. Ferreccio, C. Ferrer, E. Ferrieres, J. Figueiró, T.H. Fijalkowska, A. Fink, G. Fischer, K. Foo, L.H. Forsner, M. Fouad, H.M. Francis, D.K. Maria do Carmo Franco Frikke-Schmidt, R. Frontera, G. Fuchs, F.D. Fuchs, S.C. Fujiati, I.I. Fujita, Y. Fumihiko, M. Furusawa, T. Gaciong, Z. Gafencu, M. Galbarczyk, A. Galenkamp, H. Galeone, D. Galfo, M. Galvano, F. Gao, J. Garcia-de-la-Hera, M. García-Solano, M. Gareta, D. Garnett, S.P. Gaspoz, J.-M. Gasull, M. Gaya, A.C.A. Gaya, A.R. Gazzinelli, A. Gehring, U. Geiger, H. Geleijnse, J.M. Ghanbari, A. Ghasemi, E. Gheorghe-Fronea, O.-F. Giampaoli, S. Gianfagna, F. Gill, T.K. Giovannelli, J. Gironella, G. Giwercman, A. Gkiouras, K. Godos, J. Gogen, S. Goldberg, M. Goldsmith, R.A. Goltzman, D. Gómez, S.F. Gomula, A. da Silva, B.G.C. Gonçalves, H. Gonzalez-Chica, D.A. Gonzalez-Gross, M. González-Leon, M. González-Rivas, J.P. González-Villalpando, C. González-Villalpando, M.-E. Gonzalez, A.R. Gottrand, F. Graça, A.P. Graff-Iversen, S. Grafnetter, D. Grajda, A. Grammatikopoulou, M.G. Gregor, R.D. Grodzicki, T. Grøholt, E.K. Grøntved, A. Grosso, G. Gruden, G. Gu, D. Gualdi-Russo, E. Guallar-Castillón, P. Gualtieri, A. Gudmundsson, E.F. Gudnason, V. Guerrero, R. Guessous, I. Guimaraes, A.L. Gulliford, M.C. Gunnlaugsdottir, J. Gunter, M.J. Guo, X.-H. Guo, Y. Gupta, P.C. Gupta, R. Gureje, O. Gurzkowska, B. Gutiérrez-González, E. Gutierrez, L. Gutzwiller, F. Ha, S. Hadaegh, F. Hadjigeorgiou, C.A. Haghshenas, R. Hakimi, H. Halkjær, J. Hambleton, I.R. Hamzeh, B. Hange, D. Hanif, A.A.M. Hantunen, S. Hao, J. Kumar, R.H. Hashemi-Shahri, S.M. Hassapidou, M. Hata, J. Haugsgjerd, T. He, J. He, Y. He, Y. Heidinger-Felso, R. Heinen, M. Hejgaard, T. Hendriks, M.E. dos Santos Henrique, R. Henriques, A. Cadena, L.H. Herrala, S. Herrera, V.M. Herter-Aeberli, I. Heshmat, R. Hill, A.G. Ho, S.Y. Ho, S.C. Hobbs, M. Holdsworth, M. Homayounfar, R. Homs, C. Hopman, W.M. Horimoto, A.R.V.R. Hormiga, C.M. Horta, B.L. Houti, L. Howitt, C. Htay, T.T. Htet, A.S. Htike, M.M.T. Hu, Y. Huerta, J.M. Huhtaniemi, I.T. Huiart, L. Petrescu, C.H. Huisman, M. Husseini, A. Huu, C.N. Huybrechts, I. Hwalla, N. Hyska, J. Iacoviello, L. Ibarluzea, J.M. Ibrahim, M.M. Wong, N.I. Ikram, M.A. Iotova, V. Irazola, V.E. Ishida, T. Islam, M. Islam, S.M.S. Iwasaki, M. Jacobs, J.M. Jaddou, H.Y. Jafar, T. James, K. Jamil, K.M. Jamrozik, K. Janszky, I. Janus, E. Jarani, J. Jarvelin, M.-R. Jasienska, G. Jelakovic, A. Jelakovic, B. Jennings, G. Jha, A.K. Jiang, C.Q. Jimenez, R.O. Jöckel, K.-H. Joffres, M. Johansson, M. Jokelainen, J.J. Jonas, J.B. Jonnagaddala, J. Jørgensen, T. Joshi, P. Joukar, F. Jovic, D.P. Jóźwiak, J.J. Juolevi, A. Jurak, G. Simina, I.J. Juresa, V. Kaaks, R. Kaducu, F.O. Kafatos, A. Kajantie, E.O. Kalmatayeva, Z. Kalter-Leibovici, O. Kameli, Y. Kampmann, F.B. Kanala, K.R. Kannan, S. Kapantais, E. Karakosta, A. Kårhus, L.L. Karki, K.B. Katibeh, M. Katz, J. Katzmarzyk, P.T. Kauhanen, J. Kaur, P. Kavousi, M. Kazakbaeva, G.M. Keil, U. Boker, L.K. Keinänen-Kiukaanniemi, S. Kelishadi, R. Kelleher, C. Kemper, H.C.G. Kengne, A.P. Keramati, M. Kerimkulova, A. Kersting, M. Key, T. Khader, Y.S. Khalili, D. Khaw, K.-T. Kheiri, B. Kheradmand, M. Khosravi, A. Khouw, I.M.S.L. Kiechl-Kohlendorfer, U. Kiechl, S. Killewo, J. Kim, D.W. Kim, H.C. Kim, J. Kindblom, J.M. Klakk, H. Klimek, M. Klimont, J. Klumbiene, J. Knoflach, M. Koirala, B. Kolle, E. Kolsteren, P. König, J. Korpelainen, R. Korrovits, P. Korzycka, M. Kos, J. Koskinen, S. Kouda, K. Kovacs, V.A. Kowlessur, S. Koziel, S. Kratenova, J. Kratzer, W. Kriemler, S. Kristensen, P.L. Krokstad, S. Kromhout, D. Kruger, H.S. Kubinova, R. Kuciene, R. Kujala, U.M. Kujundzic, E. Kulaga, Z. Kumar, R.K. Kunešová, M. Kurjata, P. Kusuma, Y.S. Kuulasmaa, K. Kyobutungi, C. La, Q.N. Laamiri, F.Z. Laatikainen, T. Lachat, C. Laid, Y. Lam, T.H. Lambrinou, C.-P. Landais, E. Lanska, V. Lappas, G. Larijani, B. Latt, T.S. Lauria, L. Lazo-Porras, M. Le Coroller, G. Bao, K.L.N. Le Port, A. Le, T.D. Lee, J. Lee, J. Lee, P.H. Lehmann, N. Lehtimäki, T. Lemogoum, D. Levitt, N.S. Li, Y. Liivak, M. Lilly, C.L. Lim, W.-Y. Lima-Costa, M.F. Lin, H.-H. Lin, X. Lin, Y.-T. Lind, L. Linneberg, A. Lissner, L. Litwin, M. Liu, L. Lo, W.-C. Loit, H.-M. Long, K.Q. Lopes, L. Lopes, O. Lopez-Garcia, E. Lopez, T. Lotufo, P.A. Lozano, J.E. Lukrafka, J.L. Luksiene, D. Lundqvist, A. Lundqvist, R. Lunet, N. Lunogelo, C. Lustigová, M. Łuszczki, E. Ma, G. Ma, J. Ma, X. Machado-Coelho, G.L.L. Machado-Rodrigues, A.M. Macieira, L.M. Madar, A.A. Maggi, S. Magliano, D.J. Magnacca, S. Magriplis, E. Mahasampath, G. Maire, B. Majer, M. Makdisse, M. Mäki, P. Malekzadeh, F. Malekzadeh, R. Malhotra, R. Rao, K.M. Malyutina, S.K. Maniego, L.V. Manios, Y. Mann, J.I. Mansour-Ghanaei, F. Manzato, E. Margozzini, P. Markaki, A. Markey, O. Ioannidou, E.M. Marques-Vidal, P. Marques, L.P. Marrugat, J. Martin-Prevel, Y. Martin, R. Martorell, R. Martos, E. Maruszczak, K. Marventano, S. Mascarenhas, L.P. Masoodi, S.R. Mathiesen, E.B. Mathur, P. Matijasevich, A. Matsha, T.E. Mavrogianni, C. Mazur, A. Mbanya, J.C.N. McFarlane, S.R. McGarvey, S.T. McKee, M. McLachlan, S. McLean, R.M. McLean, S.B. McNulty, B.A. Benchekor, S.M. Medzioniene, J. Mehdipour, P. Mehlig, K. Mehrparvar, A.H. Meirhaeghe, A. Meisfjord, J. Meisinger, C. Menezes, A.M.B. Menon, G.R. Mensink, G.B.M. Menzano, M.T. Mereke, A. Meshram, I.I. Metspalu, A. Meyer, H.E. Mi, J. Michaelsen, K.F. Michels, N. Mikkel, K. Milkowska, K. Miller, J.C. Minderico, C.S. Mini, G.K. Miquel, J.F. Mirjalili, M.R. Mirkopoulou, D. Mirrakhimov, E. Mišigoj-Durakovic, M. Mistretta, A. Mocanu, V. Modesti, P.A. Moghaddam, S.S. Mohajer, B. Mohamed, M.K. Mohamed, S.F. Mohammad, K. Mohammadi, Z. Mohammadifard, N. Mohammadpourhodki, R. Mohan, V. Mohanna, S. Yusoff, M.F.M. Mohebbi, I. Mohebi, F. Moitry, M. Molbo, D. Møllehave, L.T. Møller, N.C. Molnár, D. Momenan, A. Mondo, C.K. Monroy-Valle, M. Monterrubio-Flores, E. Monyeki, K.D.K. Moon, J.S. Moosazadeh, M. Moreira, L.B. Morejon, A. Moreno, L.A. Morgan, K. Morin, S.N. Mortensen, E.L. Moschonis, G. Mossakowska, M. Mostafa, A. Mota-Pinto, A. Mota, J. Motlagh, M.E. Motta, J. Moura-dos-Santos, M.A. Mridha, M.K. Msyamboza, K.P. Mu, T.T. Muc, M. Mugoša, B. Muiesan, M.L. Mukhtorova, P. Müller-Nurasyid, M. Murphy, N. Mursu, J. Murtagh, E.M. Musa, K.I. Milanovic, S.M. Musil, V. Mustafa, N. Nabipour, I. Naderimagham, S. Nagel, G. Naidu, B.M. Najafi, F. Nakamura, H. Námešná, J. Nang, E.E.K. Nangia, V.B. Nankap, M. Narake, S. Nardone, P. Nauck, M. Neal, W.A. Nejatizadeh, A. Nekkantti, C. Nelis, K. Nelis, L. Nenko, I. Neovius, M. Nervi, F. Nguyen, C.T. Nguyen, N.D. Nguyen, Q.N. Nieto-Martínez, R.E. Nikitin, Y.P. Ning, G. Ninomiya, T. Nishtar, S. Noale, M. Noboa, O.A. Nogueira, H. Norat, T. Nordendahl, M. Nordestgaard, B.G. Noto, D. Nowak-Szczepanska, N. Al Nsour, M. Nuhoglu, I. Nurk, E. O’Neill, T.W. O’Reilly, D. Obreja, G. Ochimana, C. Ochoa-Avilés, A.M. Oda, E. Oh, K. Ohara, K. Ohlsson, C. Ohtsuka, R. Olafsson, O. Olinto, M.T.A. Oliveira, I.O. Omar, M.A. Onat, A. Ong, S.K. Ono, L.M. Ordunez, P. Ornelas, R. Ortiz, A.P. Ortiz, P.J. Osler, M. Osmond, C. Ostojic, S.M. Ostovar, A. Otero, J.A. Overvad, K. Owusu-Dabo, E. Paccaud, F.M. Padez, C. Pagkalos, I. Pahomova, E. de Paiva, K.M. Pajak, A. Palli, D. Palloni, A. Palmieri, L. Pan, W.-H. Panda-Jonas, S. Pandey, A. Panza, F. Papandreou, D. Park, S.-W. Park, S. Parnell, W.R. Parsaeian, M. Pascanu, I.M. Pasquet, P. Patel, N.D. Pecin, I. Pednekar, M.S. Peer, N. Pei, G. Peixoto, S.V. Peltonen, M. Pereira, A.C. Peres, M.A. Pérez-Farinós, N. Pérez, C.M. Peterkova, V. Peters, A. Petersmann, A. Petkeviciene, J. Petrauskiene, A. Pettenuzzo, E. Peykari, N. Pham, S.T. Pichardo, R.N. Pierannunzio, D. Pigeot, I. Pikhart, H. Pilav, A. Pilotto, L. Pistelli, F. Pitakaka, F. Piwonska, A. Pizarro, A.N. Plans-Rubió, P. Poh, B.K. Pohlabeln, H. Pop, R.M. Popovic, S.R. Porta, M. Posch, G. Poudyal, A. Poulimeneas, D. Pouraram, H. Pourfarzi, F. Pourshams, A. Poustchi, H. Pradeepa, R. Price, A.J. Price, J.F. Providencia, R. Puder, J.J. Pudule, I. Puhakka, S.E. Puiu, M. Punab, M. Qasrawi, R.F. Qorbani, M. Bao, T.Q. Radic, I. Radisauskas, R. Rahimikazerooni, S. Rahman, M. Rahman, M. Raitakari, O. Raj, M. Rakhimova, E. Rakhmatulloev, S. Rakovac, I. Rao, S.R. Ramachandran, A. Ramke, J. Ramos, E. Ramos, R. Rampal, L. Rampal, S. Rarra, V. Rascon-Pacheco, R.A. Rasmussen, M. Rech, C.R. Redon, J. Reganit, P.F.M. Regecová, V. Revilla, L. Rezaianzadeh, A. Ribas-Barba, L. Ribeiro, R. Riboli, E. Richter, A. Rigo, F. Rinaldo, N. de Wit, T.F.R. Rito, A. Ritti-Dias, R.M. Rivera, J.A. Robitaille, C. Roccaldo, R. Rodrigues, D. Rodríguez-Artalejo, F. del Cristo Rodriguez-Perez, M. Rodríguez-Villamizar, L.A. Roggenbuck, U. Rojas-Martinez, R. Rojroongwasinkul, N. Romaguera, D. Romeo, E.L. Rosario, R.V. Rosengren, A. Rouse, I. Roy, J.G.R. Rubinstein, A. Rühli, F.J. Ruidavets, J.-B. Ruiz-Betancourt, B.S. Ruiz-Castell, M. Moreno, E.R. Rusakova, I.A. Jonsson, K.R. Russo, P. Rust, P. Rutkowski, M. Sabanayagam, C. Sacchini, E. Sachdev, H.S. Sadjadi, A. Safarpour, A.R. Safiri, S. Saki, N. Salanave, B. Martinez, E.S. Salmerón, D. Salomaa, V. Salonen, J.T. Salvetti, M. Samoutian, M. Sánchez-Abanto, J. Sans, S. Marina, L.S. Santos, D.A. Santos, I.S. Santos, L.C. Santos, M.P. Santos, O. Santos, R. Sanz, S.S. Saramies, J.L. Sardinha, L.B. Sarrafzadegan, N. Sathish, T. Saum, K.-U. Savva, S. Savy, M. Sawada, N. Sbaraini, M. Scazufca, M. Schaan, B.D. Rosario, A.S. Schargrodsky, H. Schienkiewitz, A. Schipf, S. Schmidt, C.O. Schmidt, I.M. Schnohr, P. Schöttker, B. Schramm, S. Schramm, S. Schröder, H. Schultsz, C. Schutte, A.E. Sein, A.A. Selamat, R. Sember, V. Sen, A. Senbanjo, I.O. Sepanlou, S.G. Sequera, V. Serra-Majem, L. Servais, J. Ševcíková, L. Shalnova, S.A. Shamah-Levy, T. Shamshirgaran, M. Shanthirani, C.S. Sharafkhah, M. Sharma, S.K. Shaw, J.E. Shayanrad, A. Shayesteh, A.A. Shengelia, L. Shi, Z. Shibuya, K. Shimizu-Furusawa, H. Shin, D.W. Shirani, M. Shiri, R. Shrestha, N. Si-Ramlee, K. Siani, A. Siantar, R. Sibai, A.M. Silva, A.M. Silva, D.A.S. Simon, M. Simons, J. Simons, L.A. Sjöberg, A. Sjöström, M. Skodje, G. Slowikowska-Hilczer, J. Slusarczyk, P. Smeeth, L. So, H.-K. Soares, F.C. Sobek, G. Sobngwi, E. Sodemann, M. Söderberg, S. Soekatri, M.Y.E. Soemantri, A. Sofat, R. Solfrizzi, V. Somi, M.H. Sonestedt, E. Song, Y. Sørensen, T.I.A. Sørgjerd, E.P. Jérome, C.S. Soto-Rojas, V.E. Soumaré, A. Sovic, S. Sparboe-Nilsen, B. Sparrenberger, K. Spinelli, A. Spiroski, I. Staessen, J.A. Stamm, H. Stathopoulou, M.G. Staub, K. Stavreski, B. Steene-Johannessen, J. Stehle, P. Stein, A.D. Stergiou, G.S. Stessman, J. Stevanovic, R. Stieber, J. Stöckl, D. Stocks, T. Stokwiszewski, J. Stoyanova, E. Stratton, G. Stronks, K. Strufaldi, M.W. Sturua, L. Suárez-Medina, S. Suka, M. Sun, C.-A. Sundström, J. Sung, Y.-T. Sunyer, J. Suriyawongpaisal, P. Swinburn, B.A. Sy, R.G. Syddall, H.E. Sylva, R.C. Szklo, M. Szponar, L. Tai, E.S. Tammesoo, M.-L. Tamosiunas, A. Tan, E.J. Tang, X. Tanrygulyyeva, M. Tanser, F. Tao, Y. Tarawneh, M.R. Tarp, J. Tarqui-Mamani, C.B. Braunerová, R.T. Taylor, A. Taylor, J. Tchibindat, F. Tebar, W.R. Tell, G.S. Tello, T. Tham, Y.C. Thankappan, K.R. Theobald, H. Theodoridis, X. Thijs, L. Thomas, N. Thuesen, B.H. Tichá, L. Timmermans, E.J. Tjonneland, A. Tolonen, H.K. Tolstrup, J.S. Topbas, M. Topór-Madry, R. Torheim, L.E. Tormo, M.J. Tornaritis, M.J. Torrent, M. Torres-Collado, L. Toselli, S. Touloumi, G. Traissac, P. Tran, T.T.-H. Trichopoulos, D. Trichopoulou, A. Trinh, D.T.H. Trivedi, A. Tshepo, L. Tsigga, M. Tsugane, S. Tuliakova, A.M. Tulloch-Reid, M.K. Tullu, F. Tuomainen, T.-P. Tuomilehto, J. Turley, M.L. Twig, G. Tynelius, P. Tzotzas, T. Tzourio, C. Ueda, P. Ugel, E. Ukoli, F.A.M. Ulmer, H. Unal, B. Usupova, Z. Uusitalo, H.M.T. Uysal, N. Vaitkeviciute, J. Valdivia, G. Vale, S. Valvi, D. van Dam, R.M. Van der Heyden, J. van der Schouw, Y.T. Van Herck, K. Van Minh, H. Van Schoor, N.M. van Valkengoed, I.G.M. Vanderschueren, D. Vanuzzo, D. Varbo, A. Varela-Moreiras, G. Varona-Pérez, P. Vasan, S.K. Vega, T. Veidebaum, T. Velasquez-Melendez, G. Velika, B. Veronesi, G. Verschuren, W.M.M. Victora, C.G. Viegi, G. Viet, L. Villalpando, S. Vineis, P. Vioque, J. Virtanen, J.K. Visser, M. Visvikis-Siest, S. Viswanathan, B. Vladulescu, M. Vlasoff, T. Vocanec, D. Vollenweider, P. Völzke, H. Voutilainen, A. Voutilainen, S. Vrijheid, M. Vrijkotte, T.G.M. Wade, A.N. Wagner, A. Waldhör, T. Walton, J. Wambiya, E.O.A. Bebakar, A.M.W. Mohamud, W.N.W. de Souza Wanderley Júnior, R. Wang, M.-D. Wang, N. Wang, Q. Wang, X. Wang, Y.X. Wang, Y.-W. Wannamethee, S.G. Wareham, N. Weber, A. Wedderkopp, N. Weerasekera, D. Weghuber, D. Wei, W. Weres, A. Werner, B. Whincup, P.H. Widhalm, K. Widyahening, I.S. Wiecek, A. Wilks, R.J. Willeit, J. Willeit, P. Williams, J. Wilsgaard, T. Wojtyniak, B. Wong-McClure, R.A. Wong, A. Wong, J.E. Wong, T.Y. Woo, J. Woodward, M. Wu, F.C. Wu, J. Wu, L.J. Wu, S. Xu, H. Xu, L. Yaacob, N.A. Yamborisut, U. Yan, W. Yang, L. Yang, X. Yang, Y. Yardim, N. Yaseri, M. Yasuharu, T. Ye, X. Yiallouros, P.K. Yoosefi, M. Yoshihara, A. You, Q.S. You, S.-L. Younger-Coleman, N.O. Yusof, S.M. Yusoff, A.F. Zaccagni, L. Zafiropulos, V. Zainuddin, A.A. Zakavi, S.R. Zamani, F. Zambon, S. Zampelas, A. Zamrazilová, H. Zapata, M.E. Zargar, A.H. Zaw, K.K. Zdrojewski, T. Zejglicova, K. Vrkic, T.Z. Zeng, Y. Zhang, L. Zhang, Z.-Y. Zhao, D. Zhao, M.-H. Zhao, W. Zhen, S. Zheng, W. Zheng, Y. Zholdin, B. Zhou, M. Zhu, D. Zins, M. Zitt, E. Zocalo, Y. Cisneros, J.Z. Zuziak, M. Ezzati, M. Filippi, S. NCD Risk Factor Collaboration (NCD-RisC)
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nutritional and metabolic diseases ,sense organs ,skin and connective tissue diseases - Abstract
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions. © Copyright.
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- 2021
25. A pilot metabolomics study of tuberculosis immune reconstitution inflammatory syndrome
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Sebabrata Mahapatra, Kristofor J. Webb, Reem Almubarak, Samantha Bokatzian, John T. Belisle, Diane V. Havlir, Anne F Luetkemeyer, Michelle A. Kendall, Laura Hovind, Barbara Graham, Carlos A.M. Silva, Marisa Harton, Laura V. Ashton, and Mary Ann De Groote
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Male ,0301 basic medicine ,Human immunodeficiency virus (HIV) ,HIV Infections ,Pilot Projects ,urologic and male genital diseases ,Bioinformatics ,medicine.disease_cause ,chemistry.chemical_compound ,0302 clinical medicine ,Immune Reconstitution Inflammatory Syndrome ,Tandem Mass Spectrometry ,Medicine ,030212 general & internal medicine ,Chromatography ,Liquid ,Pulmonary ,General Medicine ,female genital diseases and pregnancy complications ,3. Good health ,AIDS ,Infectious Diseases ,Medical Microbiology ,Public Health and Health Services ,HIV/AIDS ,Female ,Arachidonic acid ,Infection ,Adult ,Microbiology (medical) ,Tuberculosis ,Biosignature features ,Anti-HIV Agents ,Clinical Trials and Supportive Activities ,030106 microbiology ,Microbiology ,Article ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Rare Diseases ,Metabolomics ,Acquired immunodeficiency syndrome (AIDS) ,Immune reconstitution inflammatory syndrome ,Clinical Research ,Humans ,lcsh:RC109-216 ,cardiovascular diseases ,Tuberculosis, Pulmonary ,urogenital system ,business.industry ,fungi ,IRIS ,medicine.disease ,Sphingolipid ,Clinical trial ,Emerging Infectious Diseases ,Good Health and Well Being ,chemistry ,business ,Chromatography, Liquid - Abstract
Background: Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS. Methods: Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Molecular features with p
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- 2019
26. Physicochemical characteristics and gene expression of meat from does fed with dried carnauba wax palm fruit
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Stephen Rathinaraj Benjamin, A.M. Silva, C.H.A. Oliveira, César Carneiro Linhares Fernandes, Maria Izabel Florindo Guedes, and Davide Rondina
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chemistry.chemical_classification ,Meat ,Linoleic acid ,food and beverages ,Fatty acid ,Quality ,Biology ,Loin ,lcsh:S1-972 ,Palmitic acid ,chemistry.chemical_compound ,Genes ,chemistry ,Lipogenesis ,Gene expression ,Goat ,Composition (visual arts) ,Food science ,Fatty acids ,lcsh:Agriculture (General) ,Carnauba wax ,General Agricultural and Biological Sciences - Abstract
This trial was carried out with the objective to evaluate the effect of feeding dried carnauba wax palm fruit on the quality of goat meat. Initially, the animals were divided into two groups: a control group, fed with ground corn-based concentrate, and a treatment group, fed with dried carnauba wax palm fruit included in the concentrate. After 28 days of feeding, the animals were slaughtered, and different muscles (Longissimus lumborum and semimembranosus) were evaluated for physicochemical characteristics, fatty acid profile, and expression of some genes related to meat quality. The diet with carnauba wax palm fruit does not interfere in the chemical composition of the meat in terms of moisture content, protein, fat, pH, and meat color. On the other hand, palmitic (C16:0) and linoleic (C18:2) fatty acids presented differences between muscles in the group fed carnauba wax palm fruit. The treatment with carnauba wax palm fruit reduces the expression of genes related to lipogenesis and cholesterol metabolism, suggesting the production of a tender meat with lower cholesterol content. The inclusion of carnauba wax palm fruit in the diet of does maintained the physicochemical characteristics of the loin and leg, and it reduced the expression of the analyzed genes, suggesting improvement in meat quality.
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- 2019
27. Desenvolvimento de material sustentável aplicado à construção de aeromodelos: reutilização de isopor
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Maísa G. Silva, Cláudio F. Nogueira, Vinícius A. Jager, Youry S. Marques, Bruno A.M. Silva, and Wilma P. Santos
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- 2021
28. Altered composition and functional profile of high-density lipoprotein in leprosy patients
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Cleverson Teixeira Soares, Maria Ângela de Melo Marques, José Augusto da Costa Nery, Georgia C. Atella, Maria Cristina Vidal Pessolani, Carlos A.M. Silva, Prithwiraj De, Delphi Chatterjee, Maria Renata Sales Nogueira, Patrícia Sammarco Rosa, Cristiana Santos de Macedo, and Robertha Mariana Rodrigues Lemes
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0301 basic medicine ,Male ,Bacterial Diseases ,Apolipoprotein B ,RC955-962 ,Leprostatic Agents ,Pathology and Laboratory Medicine ,Biochemistry ,Mass Spectrometry ,chemistry.chemical_compound ,Plasma ,White Blood Cells ,0302 clinical medicine ,High-density lipoprotein ,Animal Cells ,Arctic medicine. Tropical medicine ,Medicine and Health Sciences ,Immune Response ,Chromatography, High Pressure Liquid ,medicine.diagnostic_test ,biology ,Liver Diseases ,Fatty liver ,Middle Aged ,Lipids ,Mycobacterium Leprae ,Actinobacteria ,Infectious Diseases ,Cholesterol ,Female ,lipids (amino acids, peptides, and proteins) ,Autopsy ,Cellular Types ,Public aspects of medicine ,RA1-1270 ,Lipoproteins, HDL ,Research Article ,Neglected Tropical Diseases ,Adult ,medicine.medical_specialty ,Adolescent ,Immune Cells ,030231 tropical medicine ,Immunology ,Surgical and Invasive Medical Procedures ,Gastroenterology and Hepatology ,03 medical and health sciences ,Young Adult ,Signs and Symptoms ,Diagnostic Medicine ,Internal medicine ,Leprosy ,Lipidomics ,medicine ,Humans ,Aged ,Inflammation ,Blood Cells ,Bacteria ,Macrophages ,Public Health, Environmental and Occupational Health ,Organisms ,Biology and Life Sciences ,Lipid metabolism ,Cell Biology ,medicine.disease ,Tropical Diseases ,Fatty Liver ,030104 developmental biology ,Endocrinology ,chemistry ,biology.protein ,Lipid profile ,Lipoprotein - Abstract
The changes in host lipid metabolism during leprosy have been correlated to fatty acid alterations in serum and with high-density lipoprotein (HDL) dysfunctionality. This is most evident in multibacillary leprosy patients (Mb), who present an accumulation of host lipids in Schwann cells and macrophages. This accumulation in host peripheral tissues should be withdrawn by HDL, but it is unclear why this lipoprotein from Mb patients loses this function. To investigate HDL metabolism changes during the course of leprosy, HDL composition and functionality of Mb, Pb patients (paucibacillary) pre- or post-multidrug therapy (MDT) and HC (healthy controls) were analyzed. Mb pre-MDT patients presented lower levels of HDL-cholesterol compared to HC. Moreover, Ultra Performance Liquid Chromatography-Mass Spectrometry lipidomics of HDL showed an altered lipid profile of Mb pre-MDT compared to HC and Pb patients. In functional tests, HDL from Mb pre-MDT patients showed impaired anti-inflammatory and anti-oxidative stress activities and a lower cholesterol acceptor capacity compared to other groups. Mb pre-MDT showed lower concentrations of ApoA-I (apolipoprotein A-I), the major HDL protein, when compared to HC, with a post-MDT recovery. Changes in ApoA-I expression could also be observed in M. leprae-infected hepatic cells. The presence of bacilli in the liver of a Mb patient, along with cell damage, indicated hepatic involvement during leprosy, which may reflect on ApoA-I expression. Together, altered compositional and functional profiles observed on HDL of Mb patients can explain metabolic and physiological changes observed in Mb leprosy, contributing to a better understanding of its pathogenesis., Author summary Leprosy is a chronic disease caused by Mycobacterium leprae, which causes lesions on the skin and peripheral nerves. Some patients do not present an efficient immune response and have a disseminated infection (multibacillary, Mb). Mb patients have lipid accumulation in infected tissues that is important for microorganism survival. High-density lipoprotein (HDL) is composed of proteins and lipids and is produced in the liver. It removes excess of lipids from peripheral tissues and presents anti-inflammatory activity; however, these activities are not being properly performed in leprosy. To understand more about HDL metabolism on leprosy, the chemical composition and functionality of HDL from leprosy patients were analyzed before and after treatment with antibiotics (multidrug therapy, MDT). It was observed that HDL has an altered lipid composition in Mb patients before MDT, which may lead to an impairment of its functions. Apolipoprotein A-I (ApoA-I), the main HDL protein, seems to be highly affected during infection. These functions can be slightly recovered after MDT, but not in the levels of healthy individuals. Our data open new perspectives to elucidate the modulation of lipid metabolism in leprosy and consequently to prevent disease complications.
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- 2020
29. Metabolic stress and reproductive features in post-partum goats supplemented for a long period with detoxified castor meal as the source of dietary nitrogen
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R. Rossetto, A.M. Silva, Davide Rondina, L. D. M. Silva, Cleidson Manoel Gomes da Silva, C.H.A. Oliveira, Assis Rubens Montenegro, and César Carneiro Linhares Fernandes
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Litter (animal) ,Adipose tissue ,Gestation period ,lactation ,Biology ,progesterone ,SF1-1100 ,Animal science ,Lactation ,medicine ,Weaning ,postpartum ,Meal ,General Veterinary ,0402 animal and dairy science ,04 agricultural and veterinary sciences ,goat kids ,040201 dairy & animal science ,Ricinus communis L ,Animal culture ,medicine.anatomical_structure ,040103 agronomy & agriculture ,0401 agriculture, forestry, and fisheries ,Gestation ,medicine.symptom ,Weight gain - Abstract
This study evaluated the effect of detoxified castor meal on the reproductive performance, metabolic stress, milk production, and kid development in peripartum goats. The diet of the animals were with (DCM, n= 20) or without (WDCM, n= 21) detoxified castor meal during the entire gestation and until weaning, 60 days post-birth. No differences were observed in the gestation period, litter size, rate of multiple births, and mortality between the two groups. The postpartum plasma concentrations of progesterone remained below 1ng/mL in all animals, thus, confirming the absence of active corpora lutea. The thickness of sternum adipose tissue and loin area, levels of urea and cholesterol, milk production, and daily weight gain in the kids were low in the DCM group when compared to those in the WDCM group (P< 0.05). To conclude, the use of detoxified castor meal in peripartum goats resulted in lower level of performance in the kids because of reductions in the amount of milk received from their mothers during lactation. In addition, the diet containing detoxified castor meals was not efficient in recovering from the loss of stored body reserves able to initiate the recovery of the cyclic activity of the goats.
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- 2020
30. ρDCCA applied between air temperature and relative humidity: An hour/hour view
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Andrea de Almeida Brito, Gilney Figueira Zebende, A.M. Silva Filho, and A.P. Castro
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Statistics and Probability ,Scale (ratio) ,Meteorology ,Air temperature ,Local time ,Contour line ,0103 physical sciences ,Environmental science ,Relative humidity ,010306 general physics ,Condensed Matter Physics ,01 natural sciences ,010305 fluids & plasmas - Abstract
In this paper we propose to study the cross-correlation between the air temperature and the air relative humidity using the DCCA cross-correlation coefficient ρ D C C A . We choose four cities (meteorological stations) located in the State of Bahia (Brazil), as our case study. Our data were available hourly from the Brazilian Institute of Meteorology. Accordingly, in addition to showing that the variables have a negative cross-correlation, we present a new vision about these variables, producing the detrended cross-correlation contour map. As a result, we can see (or not) islands of cross-correlations, that depend on the local time and also the time scale involved.
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- 2018
31. Viability and growth of feline preantral folliclesin vitrocultured with insulin growth factor and epidermal growth factor supplemented medium
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Maricy Apparicio, Luciana Cristina Padilha-Nakaghi, Gaia Cecilia Luvoni, W. R. R. Vicente, A. E. Alves, E. A. Pires-Butler, N. A.M. Silva, and T. F. Motheo
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endocrine system ,medicine.medical_specialty ,medicine.medical_treatment ,Reproductive technology ,Biology ,Tissue Culture Techniques ,Andrology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Ovarian Follicle ,Epidermal growth factor ,Internal medicine ,Follicular phase ,medicine ,Animals ,Insulin-Like Growth Factor I ,Antrum ,Cells, Cultured ,Granulosa Cells ,030219 obstetrics & reproductive medicine ,CATS ,Epidermal Growth Factor ,Growth factor ,0402 animal and dairy science ,Embryo ,04 agricultural and veterinary sciences ,040201 dairy & animal science ,In vitro ,Culture Media ,Cats ,Oocytes ,Female ,Animal Science and Zoology ,Follicle Stimulating Hormone ,Biotechnology - Abstract
In vitro culture of ovarian preantral follicles has emerged as a reproductive technology aimed at obtaining large amount of oocytes for in vitro embryo production. The addition of growth factors (GF) in the in vitro culture of preantral follicles of different species has provided superior results of follicular development, antrum formation and proliferation of granulosa cells. However, there are only few reports regarding the use of these factors on feline preantral follicle in vitro culture. Thus, the aim of this study was to investigate the effect of a combination of IGF-1 and EGF on in vitro viability and growth of preantral follicles and enclosed oocytes collected from domestic cats. A total of 64 follicles characterized by multilayer granulosa cells were isolated and individually cultured for 6 days (T6) in minimum essential medium supplemented with IGF-1+ EGF (100 ng/ml each) or without (control). A higher percentage of follicles were viable after culture with GF than without, and an increase in size when IGF-1+ EGF were added to the medium (170 ± 32.4 μm (T0) vs. 201 ± 22.3 μm (T6); p .05) was observed. An increase in the diameter was also observed in follicles cultured without GF, but this increase was only 8.3% compared to 15.4% of those cultured with GF (p .05). No differences were found in the diameter of oocytes contained in follicles cultured in the non-supplemented or supplemented media (107.9 ± 11.8 μm (T0) vs. 113.2 ± 15.6 μm (T6); p .05). These data suggest that the addition of IGF-1 and EGF to the culture medium promotes the in vitro development of preantral follicles of cats.
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- 2016
32. Bioleaching of fluoride-bearing secondary copper sulphides: Column experiments with Acidithiobacillus ferrooxidans
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Hamilton Cristiano Leôncio, Klinger Carlos Silva Lopes, Michael Leonardo Marques Rodrigues, Larissa A.M. Silva, and Versiane Albis Leão
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inorganic chemicals ,General Chemical Engineering ,Metallurgy ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,Copper ,Industrial and Manufacturing Engineering ,020501 mining & metallurgy ,chemistry.chemical_compound ,0205 materials engineering ,chemistry ,Fluoride toxicity ,Aluminium ,Bioleaching ,Environmental Chemistry ,Gangue ,Leaching (metallurgy) ,Dissolution ,Fluoride ,Nuclear chemistry - Abstract
Bioleaching is a mature technology, which is widely employed commercially in the leaching of low-grade secondary copper sulphide ores. In this work, the bioleaching potential of a low-grade (marginal) ore with a significant content of fluoride was assessed. Small columns were inoculated with a strain of At. ferrooxidans, at 30 °C, and resulted in copper extractions above 89%, in 255 days. The dissolution of fluorite from the gangue minerals accounted for up to 2.5 g/L fluoride in solution, which affected bioleaching shortly after column inoculation. However, both the released of aluminium from the ore and ferric iron production by the bacteria reduced fluoride toxicity. A fluoride-toxicity parameter (η) was proposed to represent the mass ratio between total fluoride, total aluminium and total ferric iron concentrations in the system. Low values of the η parameter resulted from high ferric iron and aluminium concentrations and implied in large bacterial population in the systems. Thus, the presence of fluoride-bearing minerals in the ore may be an important issue, but the content of both cations should be also considered. Despite the absence of ferric iron and a high fluoride concentration prior to first solution bleeding, the η parameter was lower than 0.3 in the column containing an external aluminium source. In this condition, as the aluminium content surpassed that of fluoride the bacterial population reached 107 cells/mL and enabled copper bioleaching.
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- 2016
33. P169 Implementing nitrogen Multiple Breath Washout - a feasibility study
- Author
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Luísa Pereira, Carolina Constant, A. Descalço, A.M. Silva, Teresa Bandeira, and Celeste Barreto
- Subjects
Pulmonary and Respiratory Medicine ,business.industry ,Anesthesia ,Pediatrics, Perinatology and Child Health ,medicine ,medicine.disease ,business ,MULTIPLE BREATH WASHOUT ,Cystic fibrosis - Published
- 2020
34. Identificação de micro-organismos presentes em sistemas de biolixiviação de cobre a 35 e 50°C
- Author
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Versiane Albis Leão, Renata Guerra-Sá Cota, Isabel C.B. Rodrigues, Larissa A.M. Silva, and Roberta D’Angelo Azevedo
- Subjects
Chemistry ,02 engineering and technology ,Molecular biology ,micro-organismos termófilos moderados ,lcsh:TD1-1066 ,020501 mining & metallurgy ,lcsh:Environmental engineering ,micro-organismos mesófilos ,0205 materials engineering ,RNA ribossomal 16S ,lcsh:Environmental technology. Sanitary engineering ,lcsh:TA170-171 ,Waste Management and Disposal ,mesophilic microorganisms ,moderate thermophilic microorganisms ,16S ribosomal RNA - Abstract
RESUMO A biolixiviação de minérios de baixo teor e com elevado conteúdo de impurezas tem se mostrado alternativa importante para o aproveitamento destes, uma vez que a recuperação do metal por métodos pirometalúrgicos convencionais mostra-se economicamente inviável. A identificação e quantificação dos micro-organismos capazes de promover a biolixiviação mostram-se estratégicas para alcançar bons rendimentos no controle do processo e na recuperação de metais. Nesse sentido, as técnicas de biologia molecular são as ferramentas mais utilizadas para tal propósito. Este trabalho, utilizando técnicas de reação em cadeia da polimerase (PCR), polimorfismos de comprimento dos fragmentos de restrição (RFLP) e reação em cadeia da polimerase seguida de eletroforese em gel com gradiente desnaturante (PCR-DGGE), mostrou que a diversidade nas colunas de biolixiviação de cobre estudadas é baixa e que a temperatura é importante na manutenção de determinadas espécies, havendo predominância de Acidithiobacillus ferroxidans a 35°C e de Sulfobacillus thermosulfidooxidans a 50°C. ABSTRACT Bioleaching is an alternative to pyrometallurgy for the production of metals from low-grade ores containing high level of impurities, once that live pyrometallurgical methods are economically unfeasible. The quantification and identification of those microorganisms related to bioleaching is an important strategy for process control and thus metal recovery. In this regard, molecular biology is one of the main techniques utilized for such objective. This study applied PCR, RFLP and PCR-DGGE techniques to show that the microbial diversity in copper bioleaching columns under investigation is low and the temperature is important to define the species found, with predominance of Acidithiobacillus ferroxidans, at 35°C and Sulfobacillus thermosulfidooxidans at 50°C.
- Published
- 2018
35. Giant magnetoimpedance effect in Co2FeAl single layered and Co2FeAl/Ag multilayered films in amorphous substrates
- Author
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C. Chesman, Marcio Assolin Correa, Felipe Bohn, K. Agra, A.M. Silva, Vivian Montardo Escobar, and Gustavo Luiz Callegari
- Subjects
Magnetization dynamics ,Materials science ,Spintronics ,Condensed matter physics ,Ferromagnetic films ,Mechanical Engineering ,Giant magnetoimpedance ,Substrate (electronics) ,Condensed Matter Physics ,Amorphous solid ,Magnetic field ,CFA ,Condensed Matter::Materials Science ,Magnetic anisotropy ,Nuclear magnetic resonance ,Mechanics of Materials ,General Materials Science ,Magnetoimpedance ,Anisotropy - Abstract
We investigate the structural, quasi-static and dynamic magnetic properties of a Co 2 FeAl single layered film and a Co 2 FeAl/Ag multilayer, both grown onto amorphous substrate. We verify that both films have A2 structure and anisotropic magnetic behavior, as well as present the well-known magnetoimpedance behavior of anisotropic systems. The magnetization dynamics is discussed in terms of the mechanisms that govern the magnetoimpedance effect in a wide range of frequencies, as well as of the orientation between the external magnetic field and electrical current with respect to the magnetic anisotropy. The single layer has the largest magnetoimpedance variations values of ~ 50 % for 3.0 GHz, while the multilayer present considerable higher values, reaching to ~ 200 % at the same frequency. The association of kind of sample structure, anisotropic magnetic behavior and low damping parameter α of the CFA alloy opens possibilities to reach higher magnetoimpedance performances. The results place the CFA full-Heusler alloy as a promising candidate for applications in magnetoimpedance-based sensors and radio frequency range devices.
- Published
- 2015
36. Avaliação da atividade antimicrobiana da planta Tradescantia pallida Munt (Taboquinha Roxa)
- Author
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E.E. Ribeiro, N.C. Costa, A.M.A.P Silva, R.D. Masson, and A.M Silva
- Subjects
Pharmacology ,Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) ,Minimum bactericidal concentration ,biology ,lcsh:RS1-441 ,Tradescantia ,biology.organism_classification ,Antimicrobial ,In vitro ,Tradescantia pallida munt ,Microbiology ,lcsh:QK1-989 ,lcsh:Pharmacy and materia medica ,Minimum inhibitory concentration ,Complementary and alternative medicine ,lcsh:Botany ,Concentração Inibitória Mínima (CIM) e Concentração Bactericida Mínima (CBM) ,Tradescantia pallida Munt ,Food science ,Agar diffusion test ,Bacteria ,Gram - Abstract
RESUMO O objetivo deste estudo foi pesquisar o efeito antimicrobiano in vitro do extrato hidroalcóolico das folhas Tradescantia pallida Munt conhecida como Taboquinha roxa. Foram realizados testes em meio sólido, onde não observou qualquer halo de inibição, e o método de microdiluição, em que os resultados foram expressivos, com determinação da Concentração Inibitória Mínima (CIM) e Concentração Bactericida Mínima (CBM), com resultados em diferentes concentrações. Foram utilizadas cepas padrão de bactérias Gram positivas e Gram negativas. De acordo com os resultados, sugere-se que essa planta apresenta um potencial antimicrobiano. ABSTRACT The aim of this study was to investigate the in vitro antimicrobial effect of the hydroalcoholic extract of the Tradescantia pallida Munt leaves,known as Taboquinha roxa. The tests were both conducted on solid mean, where it was not observed any zone of inhibition, and by the micro dilution method, in which the results of the Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) were significant and related with the different concentrations. Standard strains of bacteria type Gram positive and Gram negative were employed. According to the results, this plant has an antimicrobial potential.
- Published
- 2015
37. Post-partum reproductive activity and estrus synchronization responsiveness in anglonubian x sprd fed with dried carnauba wax palm fruit (Copernicia prunifera) long term
- Author
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Davide Rondina, Liliane Moreira Silva, Diana Célia Sousa Nunes-Pinheiro, César Carneiro Linhares Fernandes, I.M.T. Lima, A.M. Silva, Antonio Amaury Oriá Fernandes, C.H.A. Oliveira, and Cleidson Manoel Gomes da Silva
- Subjects
medicine.medical_specialty ,Estrus synchronization ,Biology ,lcsh:S1-972 ,Surgery ,chemistry.chemical_compound ,Animal science ,chemistry ,medicine ,Carnauba wax palm ,Goats ,Pregnancy rate ,Progesterone ,Carnauba wax ,lcsh:Agriculture (General) ,General Agricultural and Biological Sciences ,Palm fruit ,Postpartum period ,Post partum - Abstract
O presente estudo avaliou o uso do fruto da carnaubeira desidratado em 28 cabras no periodo pos-parto alimentadas com dieta contendo feno de Tifton e concentrado comercial a base de milho (WCWP) ou com o fruto da carnaubeira (CWP). A sincronizacao de estro foi realizada aos 90 dias pos-parto e todas as femeas foram cobertas. No grupo CWP, em relacao ao grupo WCWP, o consumo de materia seca foi significativamente menor (646.48 ± 11.03 g vs. 739.29 ± 3.24 g, respectivamente; P < 0.01). O tempo para o aparecimento do primeiro corpo luteo funcional foi semelhante entre os grupos, ocorrendo em media aos 66 dias pos-parto. No momento da sincronizacao do estro, o grupo CWP apresentou uma menor espessura do tecido adiposo subcutâneo esternal quando comparado ao grupo WCWP (13,69 ± 0,57 mm vs. 11,93 ± 0,45 mm, respectivamente; P < 0,05) e uma menor taxa de gestacao (86,67% vs. 46,15%, respectivamente; P < 0.02). A taxa de crescimento da vesicula embrionaria e do comprimento crânio-caudal, assim como no diâmetro biparietal, toracico e abdominal aos 45 dias de gestacao estavam em ambos os grupos dentro do esperado para a especie em questao. Ao parto a prolificidade nao diferiu entre os grupos, com media de 1,39 ± 0,11. Em conclusao, a substituicao total do milho pelo fruto da carnaubeira no concentrado fornecido as femeas caprinas no periodo pos-parto nao apresentou efeitos positivos. A reducao da ingestao da dieta nas femeas alimentadas com carnauba levou a uma diminuicao das reservas corporais, a qual provavelmente foi a principal causa da diminuicao na taxa de gestacao nas femeas.
- Published
- 2015
38. Validação da Bioimpedância Elétrica por Multifrequência em Atletas
- Author
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Vitor Hugo Teixeira, C.M. Matias, D.S. Santos, A.M. Silva, M. Mouad, L.B. Sardinha, and Faculdade de Ciências da Nutrição e Alimentação
- Subjects
Health sciences, Medical and Health sciences ,Ciências médicas e da saúde ,Medical and Health sciences ,General Engineering ,Ciências da Saúde, Ciências médicas e da saúde - Abstract
É reconhecida a importância de avaliar a composição corporal na população atlética. Para o efeito é preciso utilizar técnicas válidas na determinação dos principais componentes moleculares. A Densitometria Radiológica de Dupla Energia (DXA) é um método preciso e válido para avaliação de composição corporal. No entanto, a DXA é uma técnica ainda pouco acessível em contextos não laboratoriais. Desta forma, é importante utilizar técnicas mais simples e práticas como a bioimpedância eléctrica (BIA). No entanto poucos estudos validaram a BIA especialmente de multifrequência na avaliação da composição corporal em atletas. Assim, o objetivo desta investigação é testar a validade da BIA de multifrequência (Tanita, modelo MC-180) na determinação do conteúdo mineral ósseo (CMO), massa gorda (MG) e massa isenta de gordura e osso (MIGO) em atletas. Um total de 79 atletas (35 homens) foram avaliados pela BIA e pela DXA. Comparação de médias, coeficiente de correlação de concordância, regressão múltipla, e o método Bland-Altman foram realizados. A Tanita apresentou um poder explicativo de 76 %, 72%, 95% e 73% da variabilidade total observada a partir do método de referência para a MG (kg), MG (%), MIGO e CMO, respectivamente. O coeficiente de correlação de concordância para a MIGO apresentou uma força de concordância substancial de 0.927. Observaram-se limites de concordância relativamente elevados na estimativa dos vários componentes corporais. Em conclusão, a Tanita MC-180 é uma alternativa válida especialmente na estimação da massa isenta de gordura e de osso, num grupo de atletas. Contudo, devido aos limites de concordância obtidos na determinação das vários componentes este equipamento apresenta uma validade limitada na estimação individual da composição corporal. Palavras-chave: Atleta; Avaliação Física; Composição Corporal. It is recognized the importance of assessing body composition in athletic populations. Therefore, it is necessary to use valid techniques for the determination of the main molecular components. Dual-energy X-ray absorptiometry (DXA) is a precise and valid method for assessing body composition. However, DXA is still not available at the clinical and field settings. Thus, it is important to use simple techniques such as electrical bioimpedance analysis (BIA) but few studies validated this technique specifically multifrequency BIA in body composition assessment in athletes. Therefore, the aim of this research is to test the validity of multifrequency BIA (Tanita, Model MC-180) in the determination of bone mineral content (BMC), lean soft tissue (LST) and fat mass (FM) in athletes. A total of 79 elite athletes (35 males) were assessed by DXA and BIA. Comparison of means, concordance coefficient correlation, multiple regression and Bland-Altman analysis were performed. Tanita explained 76%, 72%, 95% and 73% of the total variability observed from the reference method for FM (kg), FM (%), LST and BMC, respectively. The concordance coefficient correlation for MIGO presented a substantial strength of agreement of 0,927. However, relatively larger limits of agreement were found between BIA and DXA for the several body components. These findings reveal that the Tanita MC-180 is a valid alternative, particularly in the estimation of LST, in a group of athletes. However, due to the limits of agreement obtained in the determination of the body components this equipment presents a more limited validity in the estimation of individual body composition. Key Words: Athletes; Physical Assessment; Body Composition.
- Published
- 2015
39. Anatomic and tissue characteristics in goats fed for extended periods with residue of castor biodiesel production
- Author
-
C.H.A. Oliveira, Frederico Jose Bezerra, Luciana Relly Bertolini, Liliane Moreira Silva, Manoel Adrião Gomes Filho, Fabiana Vinhas Rodrigues, A.M. Silva, Davide Rondina, Karla Leylanne Sousa Góes, César Carneiro Linhares Fernandes, and S. S. Duarte
- Subjects
chemistry.chemical_classification ,Muscle tissue ,Meal ,Stomach ,Soybean meal ,Fatty acid ,Adipose tissue ,Anatomy ,Biology ,Loin ,lcsh:S1-972 ,medicine.anatomical_structure ,Animal science ,chemistry ,medicine ,Hay ,Castor bean ,Goat ,lcsh:Agriculture (General) ,General Agricultural and Biological Sciences - Abstract
Twenty-five adult crossbred goats, divided in two groups, were fed over a period of 16 months with diets based on Tifton hay and concentrate feed with (DCO) or without (WDCO) detoxified castor bean meal as a substitute for soybean meal. Throughout 480 days, blood samples were taken to measure lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, urea, albumin and creatinine. The animals were euthanized, and the anatomical components (lungs, heart, spleen, liver, kidneys, tongue, empty stomach, empty intestines, omentum, cardiac and renal adipose tissue), carcass and commercial cuts (shoulder, ham, loin, ribs and neck) were weighed. Thereafter, an anatomic dissection of the loin was performed, separating the muscle, adipose and bone tissues. On the muscular part of the loin, longissimus dorsi , the proximate composition, fatty acid profile and the expression of SEW-1, IGF-I and IGF-II were analyzed. A higher incidence of bone tissue was observed in the anatomical dissections of the loin and a lower incidence of fat in the proximate composition of the longissimus dorsi of the DCO group compared to the WDCO group (p
- Published
- 2013
40. The effects of fluoride and aluminum ions on ferrous-iron oxidation and copper sulfide bioleaching with Sulfobacillus thermosulfidooxidans
- Author
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Versiane Albis Leão, Isabel C.B. Rodrigues, Larissa A.M. Silva, Tácia Costa Veloso, and Lázaro C. Sicupira
- Subjects
Thermophiles ,chemistry.chemical_classification ,Environmental Engineering ,Sulfide ,Chemistry ,Inorganic chemistry ,Biomedical Engineering ,chemistry.chemical_element ,Batch processing ,Bioengineering ,Bacterial growth ,Copper ,Aluminum complexes ,Ferrous ,chemistry.chemical_compound ,Copper sulfide ,Fluoride toxicity ,Bioleaching ,Growth kinetics ,Fluoride ,Biotechnology - Abstract
Microorganisms that grow at high temperatures can improve Fe(II) bio-oxidation and thereby its technological applications, such as bioleaching and H 2 S removal. Conversely, elements present in industrial growth media, such as fluoride, can inhibit bacterial growth and iron bio-oxidation. In this work, the influence of fluoride on the kinetics of ferrous-iron bio-oxidation with Sulfobacillus thermosulfidooxidans was investigated. The effects of fluoride concentrations (0–0.5 mmol L −1 ) on both iron oxidation and bacterial growth rates were assessed. In addition, the effect of the addition of aluminum, which was intended to complex free fluoride and reduce the concentration of HF through the formation of aluminum–fluoride complexes, was also investigated. The results show that 0.5 mmol L −1 NaF completely inhibited bacterial growth within 60 h. Nevertheless, fluoride toxicity to S. thermosulfidooxidans was minimized by control of the aluminum–fluoride ratio in the system because, at a 2:1 aluminum–fluoride molar ratio, bacterial growth was similar to that observed in the absence of fluoride ions. Despite a slower bacterial growth rate, fluoride concentrations less than the inhibitory concentration increased the Fe(II) oxidation rate. Successful copper bioleaching (80–100%) from fluoride-containing sulfide ores (1% total fluoride) was demonstrated in the presence of aluminum.
- Published
- 2012
41. MELORREOSTOSE MONOSTÓTICA: RELATO DE UM CASO
- Author
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R.C. Silva, L.C.T. Correia, A.M. Silva, K.D. Pereira, C.M.C. Andrade, and A.K.G. Melo
- Subjects
030203 arthritis & rheumatology ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,business.industry ,Medicine ,030211 gastroenterology & hepatology ,business ,Humanities - Published
- 2017
42. Desempenho e características da carcaça de cordeiros alimentados com bagaço de caju
- Author
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M. R. C. Rodrigues, Frederico José Beserra, A.M. Silva, Fabiana Vinhas Rodrigues, C.H.A. Oliveira, D. Rondina, L. D. M. Silva, J.C. Lemos, and Antonio Amaury Oriá Fernandes
- Subjects
Animal Science and Zoology - Abstract
Com o objetivo de avaliar o desempenho e as caracteristicas da carcaca, foram utilizados 14 cordeiros desmamados inteiros, alimentados com dietas contendo racao comercial e silagem de sorgo ou bagaco de caju desidratado (BCD), como fonte unica de volumoso. Os animais apresentaram peso corporal inicial medio de 12 kg e foram abatidos quando atingiram peso medio de 25 kg. Utilizou-se um delineamento inteiramente casua- lizado, com duas dietas e sete repeticoes. A conversao alimentar do grupo alimentado com BCD (8,08 ± 0,32) foi melhor (p
- Published
- 2011
43. Environmental tobacco smoke (ETS) exposure and respiratory morbidity in school age children
- Author
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Filipa Negreiro, M. Salgueiro, Teresa Bandeira, Pedro Aguiar, A.M. Silva, Isabel Sampaio, and Carolina Constant
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,Respiratory Tract Diseases ,Tobacco smoke ,Pulmonary function testing ,Environmental health ,Air Pollution ,Respiratory morbidity ,Materials Chemistry ,Medicine ,Humans ,Risk factor ,Child ,Socioeconomic status ,Retrospective Studies ,lcsh:RC705-779 ,School age child ,business.industry ,Public health ,Retrospective cohort study ,Environmental Exposure ,lcsh:Diseases of the respiratory system ,Child, Preschool ,Female ,Tobacco Smoke Pollution ,business - Abstract
Introduction: Tobacco smoke is a risk factor for Chronic Obstructive Pulmonary Disease and a major public health problem. Prenatal maternal smoking and post-natal environmental tobacco smoke (ETS) lead to dose-dependent decrease in lung function and respiratory morbidity. Influence of different socioeconomic indicators and ETS in the home has also been suggested. Methods: Data on 313 children (52 % male) from 4 public schools in Lisbon was analyzed [1st (46 %) and 4th graders]. ETS assessment and respiratory symptoms were based on a self-answered questionnaire. All children performed standard spirometry in the school setting and 54 % were acceptable according to ATS/ERS criteria. Descriptive and bivariate analysis of the most relevant variables was done, followed by multiple logistic regression analysis adjusted to the variables with clinical/statistical relevance. Results: ETS in the home was found in 41 % (maternal smoking during pregnancy 18 %, smoking mother 32 %, smoking father 38 %). Smoking fathers had lower education and less qualified occupation. Cough was more frequent in children with a smoking mother (adjusted ORÂ =Â 2.1; 95 %CI, 1.1â4) and wheezing in children with maternal smoking during pregnancy and smoking parents. All differences were significant (pÂ
- Published
- 2011
44. Exposição ao fumo do tabaco (EFT) e morbilidade respiratória em crianças em idade escolar
- Author
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Filipa Negreiro, M. Salgueiro, A.M. Silva, Carolina Constant, Isabel Sampaio, Teresa Bandeira, and Pedro Aguiar
- Subjects
lcsh:RC705-779 ,Pulmonary and Respiratory Medicine ,Gynecology ,medicine.medical_specialty ,Wheezing ,Sibilância ,Crianças ,Questionnaire ,business.industry ,lcsh:Diseases of the respiratory system ,Pulmonary function testing ,Environmental tobacco smoke (ETS) ,Medicine ,business ,Exposição ao fumo do tabaco (EFT) ,Questionário ,Children ,Função respiratória - Abstract
Resumo: Introdução: A exposição ao fumo do tabaco (EFT) é factor de risco para Doença Pulmonar Obstrutiva Crónica e um problema major de saúde pública. A EFT pré e/ou pós-natal determina redução precoce da função pulmonar e aumento da morbilidade respiratória, dependente da dose. Tem sido sugerido que a EFT domiciliária é influenciada por factores socioeconómicos. Métodos: Estudo de rastreio epidemiológico transversal de dados de 313 crianças (52% rapazes) de 4 Escolas Básicas de Lisboa [1.° ano (54%) e 4.° ano]. A EFT e sintomatologia respiratória foram avaliadas a partir de questionário auto-preenchido pelos pais. Todas as crianças efectuaram espirometria na escola e 54% foram consideradas aceitáveis de acordo com critérios ATS/ERS. Efectuou-se análise descritiva e bivariada das variáveis com maior interesse e análise de regressão logÃstica múltipla ajustada para as variáveis com significado clÃnico/estatÃstico. Resultados: Em 41% dos casos a criança convivia com fumadores no domicÃlio (EFT na gravidez 18%, mãe fumadora 32%, pai fumador 38%). Os pais fumadores tinham escolaridade inferior e ocupações menos qualificadas. Tosse foi mais frequente nas crianças com mãe fumadora (OR ajustado = 2,1 95%CI 1,1â4,0) e sibilância nas crianças com EFT na gravidez e com mãe/pai fumadores. Todas as diferenças foram significativas (p <  0,05). Não se encontrou associação entre educação parental e sintomatologia respiratória ou ETF e infecções respiratórias/asma/diminuição de valores espirométricos. Conclusão: A EFT é frequente em crianças em idade escolar em Lisboa e condiciona morbilidade respiratória significativa. Intervenções dirigidas devem ter em conta condições sociais. Neste estudo a espirometria de campo foi pouco útil na detecção precoce de diminuição da função pulmonar em crianças associada à EFT. Abstract: Introduction: Tobacco smoke is a risk factor for Chronic Obstructive Pulmonary Disease and a major public health problem. Prenatal maternal smoking and post-natal environmental tobacco smoke (ETS) lead to dose-dependent decrease in lung function and respiratory morbidity. Influence of different socioeconomic indicators and ETS in the home has also been suggested. Methods: Data on 313 children (52% male) from 4 public schools in Lisbon was analyzed [1st (46%) and 4th graders]. ETS assessment and respiratory symptoms were based on a self-answered questionnaire. All children performed standard spirometry in the school setting and 54% were acceptable according to ATS/ERS criteria. Descriptive and bivariate analysis of the most relevant variables was done, followed by multiple logistic regression analysis adjusted to the variables with clinical/statistical relevance. Results: ETS in the home was found in 41% (maternal smoking during pregnancy 18%, smoking mother 32%, smoking father 38%). Smoking fathers had lower education and less qualified occupation. Cough was more frequent in children with a smoking mother (adjusted OR = 2.1 95CI 1.1â4.0) and wheezing in children with maternal smoking during pregnancy and smoking parents. All differences were significant (pÂ
- Published
- 2011
45. Probiotic yogurt produced with goat milk supplemented with Bifidobacterium spp
- Author
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Jacques Robert Nicoli, A.M Silva, C.H Val, F.E Matos Júnior, Mazochi, A.F Resende, and D.N Diniz
- Subjects
Bifidobacterium longum ,law.invention ,functional food ,yogurt ,chemistry.chemical_compound ,Probiotic ,goat milk ,law ,Lactobacillus ,Medicine ,Food science ,Lactose ,alimento funcional ,Flavor ,Aroma ,Bifidobacterium ,lcsh:SF1-1100 ,General Veterinary ,biology ,business.industry ,iogurte ,biology.organism_classification ,Streptococcus salivarius ,probiotics ,chemistry ,probiótico ,lcsh:Animal culture ,business ,leite de cabra - Abstract
Avaliaram-se iogurtes de leite de cabra contendo ou não Bifidobacterium longum, B. breve, B. pseudolongum ou B. bifidum, adicionados ou não de aroma de morango. Os dados obtidos nas análises higiênico-sanitárias e físico-químicas foram dentro dos valores exigidos pela legislação brasileira; apenas o valor encontrado para lactose esteve abaixo do recomendado. Quanto às bactérias do iogurte, não houve diferença na contagem de Streptococcus salivarius subsp. thermophilus durante a estocagem, e não foi detectado Lactobacillus delbrueckii subsp. bulgaricus nas diluições utilizadas. A enumeração de Bifidobacterium spp. manteve-se entre 10(6) e 10(8)UFC/mL e não diferiu entre as espécies ao longo do tempo. Considerando-se a adição ou não de aroma, a análise das variáveis tempo e aroma não mostrou diferença estatística. A contagem entre os Bifidobacterium spp. demonstrou que nenhum microrganismo apresentou um comportamento superior a outro. Na análise sensorial, as amostras de iogurtes adicionados ou não de Bifidobacterium spp. e adicionados de aroma de morango não apresentaram diferenças entre si. O estudo mostrou ser possível a elaboração de iogurte de leite de cabra adicionado de Bifidobacterium spp. e de aroma de morango com qualidade assegurada, potencial para uso probiótico e boa aceitação pelo consumidor. Goat milk yogurt with or without Bifidobacterium longum, B. breve, B. pseudolongum, or B. bifidum, and supplemented or not with strawberry aroma were evaluated. Data obtained from hygienic-sanitary and physicochemical analyses were within the values recommended by the Brazilian legislation, except for lactose contents, which were lower than the recommended. In relation to the yogurt bacteria, there was no difference in the counts of Streptococcus salivarius subsp. thermophilus during the storage, and Lactobacillus delbrueckii subsp. bulgaricus was not detected. The counts of Bifidobacterium spp.ranged from 10(6) to 10(8)CFU/mL, without difference between the species along the time. Considering the addition of flavor or not, the analysis of aroma and time variables showed no statistical difference. The counts of Bifidobacterium spp. demonstrated that none showed a superior value. For the hedonic scale test, there was no difference between yogurts supplemented or not with Bifidobacterium spp., and added or not with strawberry aroma. The study showed to be possible the elaboration of goat milk yogurt supplemented with Bifidobacterium spp. and strawberry aroma, presenting safety, potential for probiotic use, and good acceptability by consumers.
- Published
- 2010
46. PO-420 Harnessing chitosan/Poly(Y)-glutamic acid nanoparticles for immunomodulation at the tumour microenvironment
- Author
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R. M. Gonçalves, Olivier De Wever, S. G. Santos, Karine Serre, M. A. Barbosa, M. J. Oliveira, A.M. Silva, Catarina Leite Pereira, M.L. Pinto, and Flávia Castro
- Subjects
CD86 ,Cancer Research ,Cellular immunity ,CD40 ,biology ,Cell growth ,Chemistry ,medicine.medical_treatment ,T cell ,Cell ,Cytokine ,medicine.anatomical_structure ,Oncology ,Cancer cell ,biology.protein ,Cancer research ,medicine - Abstract
Introduction The tumour microenvironment is a complex and dynamic niche that has a fundamental role in tumour cell proliferation, angiogenesis, invasion and metastasis. Macrophages (Mac) are described as having a central role in tumour progression and dendritic cells (DC) as having an immature/immunosuppressive profile, which limits T cells activity. Therapeutic strategies targeting these cells have been emerging as adjuvants to anticancer conventional treatments, aiming at their recruitment and repolarization towards an immunostimulatory phenotype favouring cancer cell elimination. Here, we focused on the potential of Chitosan/Poly(γ-glutamic acid) nanoparticles (NPs) to modulate cellular immunity and, consequently, to affect cancer-cell related activities. Material and methods NPs were prepared by co-acervation method. Primary human monocyte-derived M2 Mac (obtained by stimulation with IL-10) were incubated with NPs. Control experiments with unstimulated Mac and LPS-stimulated Mac (M1 phenotype) were performed. After 72 hour, cell metabolic activity, cell phenotype and cytokine production were evaluated. Mac ability to induce T cell proliferation/activation and tumour cell invasion were also assessed. The same studies were performed with human-monocyte derived DC. For in vivo models, 1 × 106 E0771 cells were injected in the mammary fat pad of C57BL/6 mice. After 10 days of tumour implantation, animals were treated every two days with NPs. Tumour growth was assessed by calliper every two days. Results and discussions NPs re-educated IL-10-stimulated Mac towards a pro-inflammatory profile, decreasing CD163 expression and promoting IL-12p40 and TNF-α secretion. NPs also induced an immunostimulatory phenotype on DC, enhancing the expression of the co-stimulatory molecules CD86, CD40 and HLA-DR, and secretion of the pro-inflammatory cytokines TNF-α, IL-12 and IL-6. Interestingly, these phenotypic alterations induced both CD4+ and CD8+ T cell activation/proliferation and counteracted cancer cell invasion, in vitro. Regarding the in vivotumour model, we observed a decrease in tumour growth in NPs-treated animals comparing to the control, after 23 days of E0771 cell implantation. Additional experiments with other tumour models are currently being explored. Conclusion Overall, our findings open new perspectives on the use of NPs as an immunomodulatory therapy for tumour microenvironment reprogramming, providing a new tool for anticancer therapies.
- Published
- 2018
47. Relationship Between Water Quality and Land use Along a Stretch of the Sorocaba River (SP)
- Author
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F.M. Antunes, D.P. Nogueira, SS Lessa, A.H. Rosa, and A.M. Silva
- Subjects
Hydrology ,Land use ,Environmental science ,Water quality - Published
- 2009
48. The Essential Role of Cholesterol Metabolism in the Intracellular Survival of Mycobacterium leprae Is Not Coupled to Central Carbon Metabolism and Energy Production
- Author
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Ana Carolina Ramos Guimarães, William H. Wheat, Georgia C. Atella, Maria Angela M. Marques, Robertha Mariana Rodrigues Lemes, Leticia M. S. Lery, Venugopal Pujari, Thabatta L. S. A. Rosa, Dean C. Crick, Patrick J. Brennan, John T. Belisle, Maria Cristina Vidal Pessolani, Carlos A.M. Silva, and Marcia Berrêdo-Pinho
- Subjects
Microbiology ,chemistry.chemical_compound ,Lipid droplet ,Leprosy ,Humans ,Spotlight ,Molecular Biology ,Mycobacterium leprae ,Phagosome ,chemistry.chemical_classification ,Microbial Viability ,biology ,Catabolism ,Cholesterol ,Articles ,biology.organism_classification ,Sterol ,Carbon ,Enzyme ,Biochemistry ,chemistry ,lipids (amino acids, peptides, and proteins) ,Energy Metabolism ,Intracellular - Abstract
Mycobacterium leprae induces the formation of lipid droplets, which are recruited to pathogen-containing phagosomes in infected macrophages and Schwann cells. Cholesterol is among the lipids with increased abundance in M. leprae -infected cells, and intracellular survival relies on cholesterol accumulation. The present study investigated the capacity of M. leprae to acquire and metabolize cholesterol. In silico analyses showed that oxidation of cholesterol to cholest-4-en-3-one (cholestenone), the first step of cholesterol degradation catalyzed by the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD), is apparently the only portion of the cholesterol catabolic pathway seen in Mycobacterium tuberculosis preserved by M. leprae . Incubation of bacteria with radiolabeled cholesterol confirmed the in silico predictions. Radiorespirometry and lipid analyses performed after incubating M. leprae with [4- 14 C]cholesterol or [26- 14 C]cholesterol showed the inability of this pathogen to metabolize the sterol rings or the side chain of cholesterol as a source of energy and carbon. However, the bacteria avidly incorporated cholesterol and, as expected, converted it to cholestenone both in vitro and in vivo . Our data indicate that M. leprae has lost the capacity to degrade and utilize cholesterol as a nutritional source but retains the enzyme responsible for its oxidation to cholestenone. Thus, the essential role of cholesterol metabolism in the intracellular survival of M. leprae is uncoupled from central carbon metabolism and energy production. Further elucidation of cholesterol metabolism in the host cell during M. leprae infection will establish the mechanism by which this lipid supports M. leprae intracellular survival and will open new avenues for novel leprosy therapies. IMPORTANCE Our study focused on the obligate intracellular pathogen Mycobacterium leprae and its capacity to metabolize cholesterol. The data make an important contribution for those interested in understanding the mechanisms of mycobacterial pathogenesis, since they indicate that the essential role of cholesterol for M. leprae intracellular survival does not rely on its utilization as a nutritional source. Our findings reinforce the complexity of cholesterol's role in sustaining M. leprae infection. Further elucidation of cholesterol metabolism in the host cell during M. leprae infection will establish the mechanism by which this lipid supports M. leprae intracellular survival and will open new avenues for novel leprosy therapies.
- Published
- 2015
49. Comparison of UASB and fluidized-bed reactors for sulfate reduction
- Author
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Sueli Moura Bertolino, Sergio Francisco de Aquino, Larissa A.M. Silva, and Versiane Albis Leão
- Subjects
Glycerol ,Chromatography ,Chemistry ,General Chemical Engineering ,lcsh:TP155-156 ,Fluidized bed bioreactors ,Wastewater treatment ,chemistry.chemical_compound ,Fluidized bed ,Bioreactor ,Sulfate reduction ,Upflow anaerobic sludge blanket ,Sewage treatment ,Fermentation ,Sulfate ,lcsh:Chemical engineering ,Effluent ,Anaerobic exercise ,Anaerobic processes - Abstract
Reactor hydrodynamics is important for sulfidogenesis because sulfate reduction bacteria (SRB) do not granulate easily. In this work, the sulfate reduction performance of two continuous anaerobic bioreactors was investigated: (i) an upflow anaerobic sludge blanket (UASB) reactor and (ii) a fluidized bed reactor (FBR). Organic loading, sulfate reduction, and COD removal were the main parameters monitored during lactate and glycerol degradation. The UASB reactor with biomass recirculation showed a specific sulfate reduction rate of 0.089±0.014 g.gSSV-1.d-1 (89% reduction), whereas values twice as high were achieved in the FBR treating either lactate (0.200±0.017 g.gSSV-1.d-1) or glycerol (0.178±0.010 g.gSSV-1.d-1). Sulfate reduction with pure glycerol produced a smaller residual COD (1700 mg.L-1) than that produced with lactate (2500 mg.L-1) at the same COD.sulfate-1 mass ratio. It was estimated that 50% of glycerol degradation was due to sulfate reduction and 50% to fermentation, which was supported by the presence of butyrate in the FBR effluent. The UASB reactor was unable to produce effluents with sulfate concentrations below 250 mg.L-1 due to poor mixing conditions, whereas the FBR consistently ensured residual sulfate concentrations below such a value.
- Published
- 2015
50. Reboot-based recovery of performance anomalies in adaptive bitrate video-streaming services
- Author
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Carlos A.S. Cunha and Luis A.M. Silva
- Subjects
Computer Networks and Communications ,Hardware and Architecture ,Software - Published
- 2017
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