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3. Author Correction: Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities

Author

Teresa Pinto, Ana, Laranjeiro Pinto, Marta, Patrícia Cardoso, Ana, Monteiro, Cátia, Teixeira Pinto, Marta, Filipe Maia, André, Castro, Patrícia, Figueira, Rita, Monteiro, Armanda, Marques, Margarida, Mareel, Marc, dos Santos, Susana Gomes, Seruca, Raquel, Adolfo Barbosa, Mário, Rocha, Sónia, and José Oliveira, Maria

Published
2022
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18. Additional file 1 of Long non-coding RNA H19 regulates matrisome signature and impacts cell behavior on MSC-engineered extracellular matrices

Author

Moura, Sara Reis, Freitas, Jaime, Ribeiro-Machado, Cláudia, Lopes, Jorge, Neves, Nuno, Canhão, Helena, Rodrigues, Ana Maria, Barbosa, Mário Adolfo, and Almeida, Maria Inês

Abstract

Additional file 1: Fig. S1. Effect of siH19-2 on the expression levels of collagens, osteogenic markers and other H19-target candidates, assessed through RT-qPCR, 3 days after culture under osteogenic-inducing conditions (N = 6). Fig. S2. Decellularization of MSCs matrices. Primary MSCs from osteoporotic patients were differentiated for 10 days under osteogenic-inducing conditions before decellularization. After treatment with the decellularization buffer (urea 2 M), samples were stained with a) DAPI (blue) to visualize nuclei (scale: 100 μm) and b) hematoxylin (blue-purple color) to visualize nuclei and matrix integrity (scale: 100 μm). c) DNA and sGAGs content were measured. Non-decellularized matrices were used as a control. Fig. S3. In silico predictions for the binding site between miR-29-a/b/c and lncRNA H19. Fig. S4. Expression profile of H19 during early osteogenic differentiation stages in MSCs from healthy donors (N = 4) and osteoporotic patients (N = 4). Fig. S5. miR-29c-3p expression after transfection of MSCs with miR-29c-3p mimics, miR-29c-3p inhibitor or respective controls (NC-mimics and NC-inhibitor), and cultured for 3 days in osteogenic-inducing conditions (N = 6). Table SI. Donors of Human Mesenchymal Stem/Stromal Cells. Table SII. Primers used for reverse transcription quantitative real-time PCR. Table SIII. Mature miRNAs sequences according to miRbase annotations ( http://www.mirbase.org/ ). Table SIV. Antibodies used for immunocytochemistry stainings.

Published
2023
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21. Combining inflammatory miRNA molecules as diagnostic biomarkers for depression: a clinical study.

Author

Paulo Brás, João, Pinto, Sara, von Doellinger, Orlando, Prata, Joana, Coelho, Rui, Adolfo Barbosa, Mário, Inês Almeida, Maria, and Gomes Santos, Susana

Subjects
MONONUCLEAR leukocytes, GENE expression, INFLAMMATORY mediators, RECEIVER operating characteristic curves, MENTAL depression
Abstract

Background: Inflammation has been implicated in core features of depression pathophysiology and treatment resistance. Therefore, new challenges in the discovery of inflammatory mediators implicated in depression have emerged. MicroRNAs (miRNAs) have been found aberrantly expressed in several pathologies, increasing their potential as biomarkers and therapeutical targets. In this study, the aim was to assess the changes and biomarker potential of inflammation-related miRNAs in depression patients. Methods: Depression diagnosis was performed according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). 40 healthy controls and 32 depression patients were included in the study. The levels of inflammatory cytokines were measured in plasma, and expression levels of cytokines and inflammation-related miRNAs were evaluated in peripheral blood mononuclear cells (PBMCs). Results: Depression patients were found to have a pro-inflammatory profile in plasma, with significantly higher levels of TNF-α and CCL2 compared with controls. In PBMCs of depression patients, TNF-α and IL-6 expression levels were significantly up and downregulated, respectively. Moreover, miR-342 levels were found upregulated, while miR-146a and miR-155 were significantly downregulated. miR-342 expression levels were positively correlated with TNF-α. Importantly, when analyzed as a diagnostic panel, receiver operating characteristics (ROC) analysis of miR-342, miR-146a, miR-155 in combination, showed to be highly specific and sensitive in distinguishing between depression patients and healthy controls. Conclusion: In summary, these findings suggest that inflammation-related miRNAs are aberrantly expressed in depression patients. Moreover, we show evidences on the potential of the combination of dysregulated miRNAs as a powerful diagnostic tool for depression. [ABSTRACT FROM AUTHOR]

Published
2023
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26. The Paramount Importance of Renal Dysfunction in Heart Failure Prognosis - Results from the REFERENCE study.

Author

Barbosa, Mário, Matos, Andreia, Bicho, Manuel, and Menezes Falcão, Luiz

Subjects
CARDIO-renal syndrome, HEART failure, KIDNEY diseases, PROPORTIONAL hazards models, GLOMERULAR filtration rate, UNIVARIATE analysis, CREATININE, HEART failure patients, PROGNOSIS
Abstract

Copyright of Galicia Clínica is the property of Sociedad Gallega de Medicina Interna and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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30. WCN24-1326 ANTIHYPERTENSIVE TREATMENT AND SODIUM CONSUMPTION AS CONFOUNDING FACTORS IN THE ALDOSTERONE-RENIN RATIO, RENIN, AND ALDOSTERONE LEVELS IN AFRO-COLOMBIAN APPARENT RESISTANT HYPERTENSIVE PATIENTS: A PRI

Author

Duran, Carlos, Bustamante, Melissa, Useche Henao, Elena Maria, Barbosa, Mario, Moncayo, Paula Andrea, Meza, Sebastian, Bolaños, Juan sebastian, Schweineberg, Johanna, Posada, Juan Gillermo, Mesa, Liliana, Rivas, Adriana, Sandoval, Lina Marcela, Triviño, Jacobo, Quintero, Juan David, and Zapata, Juan Sebastian

Published
2024
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41. Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities

Author

Teresa Pinto, Ana, Laranjeiro Pinto, Marta, Patrícia Cardoso, Ana, Monteiro, Cátia, Teixeira Pinto, Marta, Filipe Maia, André, Castro, Patrícia, Figueira, Rita, Monteiro, Armanda, Marques, Margarida, Mareel, Marc, dos Santos, Susana Gomes, Seruca, Raquel, Adolfo Barbosa, Mário, Rocha, Sónia, and José Oliveira, Maria

Published
2016
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47. Melhoria de processos críticos numa empresa de transporte

Author

Barbosa, Mário Jorge Leite and Pereira, Maria Teresa Ribeiro

Subjects
Gestão, Process, Melhoria contínua e indicadores de desempenho, Proceso, BPMN, Continuous improvement and key performance indicator, Processo, Mejora continua y indicadores clave de rendimiento
Abstract

Versão final (Esta versão contém as críticas e sugestões dos elementos do júri) Submitted by Iolanda Valente (ivalente@iscap.ipp.pt) on 2021-04-05T09:23:28Z No. of bitstreams: 1 Mário_Barbosa_ML_2020.pdf: 2007130 bytes, checksum: c6dd1879b19681958b6e354eb28e5fb9 (MD5) Made available in DSpace on 2021-04-05T09:23:29Z (GMT). No. of bitstreams: 1 Mário_Barbosa_ML_2020.pdf: 2007130 bytes, checksum: c6dd1879b19681958b6e354eb28e5fb9 (MD5) Previous issue date: 2021-01-27

Published
2021

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