1. Reconstructing Prehistoric African Population Structure
- Author
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Saioa López, Audax Mabulla, Douglas J. Kennett, Elizabeth Gomani-Chindebvu, Svante Pääbo, Kendra Sirak, Iñigo Olalde, Mateja Hajdinjak, Mark Horton, Chrissy Chiumia, Johannes Krause, Mary E. Prendergast, Ceri Shipton, Eadaoin Harney, David Reich, Alison Crowther, Anja Heinze, Pontus Skoglund, Richard F. Helm, Matthew Ferry, Nick Patterson, Jessica I. Cerezo-Román, Kristin Stewardson, Ron Pinhasi, Nicole Boivin, Menno Welling, Mark G. Thomas, Alexander Peltzer, Megan Michel, Agness Gidna, Katherine M. Grillo, Ruth Tibesasa, Vanessa M. Hayes, John Parkington, Nadin Rohland, I. Taneli Helenius, Swapan Mallick, Raj Ramesar, Alissa Mittnik, Garrett Hellenthal, Jessica C. Thompson, Alan G. Morris, Tasneem Salie, and Matthias Meyer
- Subjects
0301 basic medicine ,Male ,Genetics, Medical ,Pastoralism ,Population ,Population genetics ,Black People ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Article ,Bone and Bones ,Lineage (anthropology) ,Prehistory ,03 medical and health sciences ,0302 clinical medicine ,parasitic diseases ,Humans ,DNA, Ancient ,education ,Life Style ,education.field_of_study ,Fossils ,Genome, Human ,Population ecology ,biology.organism_classification ,030104 developmental biology ,Ancient DNA ,Tanzania ,Genetics, Population ,Africa ,Ethnology ,Female ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
We assembled genome-wide data from 16 prehistoric Africans. We show that the anciently divergent lineage that comprises the primary ancestry of the southern African San had a wider distribution in the past, contributing approximately two-thirds of the ancestry of Malawi hunter-gatherers ∼8,100-2,500 years ago and approximately one-third of the ancestry of Tanzanian hunter-gatherers ∼1,400 years ago. We document how the spread of farmers from western Africa involved complete replacement of local hunter-gatherers in some regions, and we track the spread of herders by showing that the population of a ∼3,100-year-old pastoralist from Tanzania contributed ancestry to people from northeastern to southern Africa, including a ∼1,200-year-old southern African pastoralist. The deepest diversifications of African lineages were complex, involving either repeated gene flow among geographically disparate groups or a lineage more deeply diverging than that of the San contributing more to some western African populations than to others. We finally leverage ancient genomes to document episodes of natural selection in southern African populations. PAPERCLIP.
- Published
- 2017