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Your search keyword '"Debruin, Danielle A"' showing total 9 results
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9 results on '"Debruin, Danielle A"'

2. Dimethyl fumarate modulates the dystrophic disease program following short-term treatment

Author

Timpani, Cara A., primary, Kourakis, Stephanie, additional, Debruin, Danielle A., additional, Campelj, Dean G., additional, Pompeani, Nancy, additional, Dargahi, Narges, additional, Bautista, Angelo Patrick R., additional, Bagaric, Ryan M., additional, Ritenis, Elya J., additional, Sahakian, Lauren, additional, Debrincat, Didier, additional, Stupka, Nicole, additional, Hafner, Patricia, additional, Arthur, Peter G., additional, Terrill, Jessica R., additional, Apostolopoulos, Vasso, additional, De Haan, Judy B., additional, Gueven, Nuri, additional, Fischer, Dirk, additional, and Rybalka, Emma, additional

Published
2023
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9. The importance of mitochondrial quality control for maintaining skeletal muscle function across health span.

Author

Sligar J, DeBruin DA, Saner NJ, Philp AM, and Philp A

Subjects
Muscle, Skeletal metabolism, Organelle Biogenesis, Mitochondria metabolism, Mitophagy physiology
Abstract

As the principal energy-producing organelles of the cell, mitochondria support numerous biological processes related to metabolism, growth, and regeneration in skeletal muscle. Deterioration in skeletal muscle functional capacity with age is thought to be driven in part by a reduction in skeletal muscle oxidative capacity and reduced fatigue resistance. Underlying this maladaptive response is the development of mitochondrial dysfunction caused by alterations in mitochondrial quality control (MQC), a term encompassing processes of mitochondrial synthesis (biogenesis), remodeling (dynamics), and degradation (mitophagy). Knowledge regarding the role and regulation of MQC in skeletal muscle and the influence of aging in this process has rapidly advanced in the past decade. Given the emerging link between aging and MQC, therapeutic approaches to manipulate MQC to prevent mitochondrial dysfunction during aging hold tremendous therapeutic potential.

Published
2022
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