384 results on '"Delcourt, Cécile"'
Search Results
2. Association of Lipopolysaccharide-Type Endotoxins with Retinal Neurodegeneration: The Alienor Study
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Larsen, Petra P., Féart, Catherine, Pais de Barros, Jean-Paul, Gayraud, Laure, Delyfer, Marie-Noëlle, Korobelnik, Jean-François, Schweitzer, Cédric, and Delcourt, Cécile
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- 2025
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3. Management of Neovascular Age-Related Macular Degeneration Treatment in France from 2008–2018: The Nationwide LANDSCAPE Study
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Creuzot Garcher, Catherine P., Srour, Mayer, Baudin, Florian, Dot, Corinne, Nghiem-Buffet, Sylvia, Girmens, Jean-Francois, Collin, Cedric, Ponthieux, Anne, and Delcourt, Cécile
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- 2023
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4. Response to the Letter to the Editor Regarding “Blue Light Exposure: Ocular Hazards and Prevention—A Narrative Review” by Iqbal et al.
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Cougnard-Gregoire, Audrey and Delcourt, Cécile
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- 2023
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5. Prospective, Observational, Multicenter, Real-World Study of the Efficacy, Safety, and Pattern of Use of the Dexamethasone Intravitreal Implant in Diabetic Macular Edema in France: Short-Term Outcomes of LOUVRE 3
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Kodjikian, Laurent, Delcourt, Cécile, Creuzot-Garcher, Catherine, Massin, Pascale, Conrath, John, Velard, Marie-Ève, Lassalle, Thibaut, Pinchinat, Sybil, and Dupont-Benjamin, Laure
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- 2023
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6. Blue Light Exposure: Ocular Hazards and Prevention—A Narrative Review
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Cougnard-Gregoire, Audrey, Merle, Bénédicte M. J., Aslam, Tariq, Seddon, Johanna M., Aknin, Isabelle, Klaver, Caroline C. W., Garhöfer, Gerhard, Layana, Alfredo Garcia, Minnella, Angelo Maria, Silva, Rufino, and Delcourt, Cécile
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- 2023
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7. Using Artificial Intelligence to Analyse the Retinal Vascular Network: The Future of Cardiovascular Risk Assessment Based on Oculomics? A Narrative Review
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Arnould, Louis, Meriaudeau, Fabrice, Guenancia, Charles, Germanese, Clément, Delcourt, Cécile, Kawasaki, Ryo, Cheung, Carol Y., Creuzot-Garcher, Catherine, and Grzybowski, Andrzej
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- 2023
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8. Association of long-term exposure to ambient air pollution with retinal neurodegeneration: the prospective Alienor study
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Gayraud, Laure, Mortamais, Marion, Schweitzer, Cédric, de Hoogh, Kees, Cougnard-Grégoire, Audrey, Korobelnik, Jean-François, Delyfer, Marie-Noelle, Rougier, Marie-Bénédicte, Leffondré, Karen, Helmer, Catherine, Vienneau, Danielle, Berr, Claudine, and Delcourt, Cécile
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- 2023
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9. A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration
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Bailey-Wilson, Joan E., Baird, Paul N., Barathi, Veluchamy A., Biino, Ginevra, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching-Yu, Chew, Emily Y., Craig, Jamie E., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Haarman, Annechien E.G., Haller, Toomas, Hammond, Christopher J., Han, Xikun, Hayward, Caroline, He, Mingguang, Hewitt, Alex W., Hoang, Quan, Hysi, Pirro G., Iglesias, Adriana I., Igo, Robert P., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Khawaja, Anthony P., Klein, Barbara E., Lass, Jonathan H., Lee, Kris, Lehtimäki, Terho, Lewis, Deyana, Li, Qing, Li, Shi-Ming, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mackey, David A., Martin, Nicholas G., Meguro, Akira, Metspalu, Andres, Middlebrooks, Candace, Miyake, Masahiro, Mizuki, Nobuhisa, Musolf, Anthony, Nickels, Stefan, Oexle, Konrad, Pang, Chi Pui, Pärssinen, Olavi, Paterson, Andrew D., Pfeiffer, Norbert, Polasek, Ozren, Rahi, Jugnoo S., Raitakari, Olli, Rudan, Igor, Sahebjada, Srujana, Saw, Seang-Mei, Simpson, Claire L., Stambolian, Dwight, Tai, E-Shyong, Tedja, Milly S., Tideman, J. Willem L., Tsujikawa, Akitaka, van Duijn, Cornelia M., Verhoeven, Virginie J.M., Vitart, Veronique, Wang, Ningli, Wang, Ya Xing, Wedenoja, Juho, Wei, Wen Bin, Williams, Cathy, Williams, Katie M., Wilson, James F., Wojciechowski, Robert, Yam, Jason C.S., Yamashiro, Kenji, Yap, Maurice K.H., Yazar, Seyhan, Yip, Shea Ping, Young, Terri L., Zhou, Xiangtian, Allen, Naomi, Aslam, Tariq, Atan, Denize, Barman, Sarah, Barrett, Jenny, Bishop, Paul, Black, Graeme, Bunce, Catey, Carare, Roxana, Chakravarthy, Usha, Chan, Michelle, Chua, Sharon, Cipriani, Valentina, Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew, Doney, Alexander, Egan, Cathy, Ennis, Sarah, Foster, Paul, Fruttiger, Marcus, Gallacher, John, Garway-Heath, David, Gibson, Jane, Gore, Dan, Guggenheim, Jeremy, Hammond, Chris, Hardcastle, Alison, Harding, Simon, Hogg, Ruth, Hysi, Pirro, Keane, Pearse A., Khaw, Peng Tee, Khawaja, Anthony, Lascaratos, Gerassimos, Littlejohns, Thomas, Lotery, Andrew, Luthert, Phil, MacGillivray, Tom, Mackie, Sarah, McGuinness, Bernadette, McKay, Gareth, McKibbin, Martin, Mitry, Danny, Moore, Tony, Morgan, James, Muthy, Zaynah, O'Sullivan, Eoin, Owen, Chris, Patel, Praveen, Paterson, Euan, Peto, Tunde, Petzold, Axel, Pontikos, Nikolas, Rahi, Jugnoo, Rudnicka, Alicja, Self, Jay, Sergouniotis, Panagiotis, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Tapp, Robyn, Thaung, Caroline, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vernon, Stephen, Viswanathan, Ananth, Williams, Katie, Woodside, Jayne, Yates, Max, Yip, Jennifer, Zheng, Yalin, Clark, Rosie, Lee, Samantha Sze-Yee, Du, Ran, Wang, Yining, Kneepkens, Sander C.M., Charng, Jason, Huang, Yu, Hunter, Michael L., Jiang, Chen, Tideman, J.Willem L., Melles, Ronald B., Klaver, Caroline C.W., Choquet, Hélène, and Ohno-Matsui, Kyoko
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- 2023
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10. Real-Life Efficacy, Safety, and Use of Dexamethasone Intravitreal Implant in Posterior Segment Inflammation Due to Non-infectious Uveitis (LOUVRE 2 Study)
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Bodaghi, Bahram, Brézin, Antoine P., Weber, Michel, Delcourt, Cécile, Kodjikian, Laurent, Provost, Alexandra, Velard, Marie-Ève, Barnier-Ripet, Doris, Pinchinat, Sybil, and Dupont-Benjamin, Laure
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- 2022
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11. Incidence and Prevalence of Neovascular Age-Related Macular Degeneration in France between 2008 and 2018: The LANDSCAPE Study
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Creuzot-Garcher, Catherine P., Srour, Mayer, Baudin, Florian, Daien, Vincent, Dot, Corinne, Nghiem-Buffet, Sylvia, Girmens, Jean-Francois, Coulombel, Nicolas, Ponthieux, Anne, and Delcourt, Cecile
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- 2022
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12. DeepAlienorNet: A deep learning model to extract clinical features from colour fundus photography in age‐related macular degeneration.
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Mathieu, Alexis, Ajana, Soufiane, Korobelnik, Jean‐François, Le Goff, Mélanie, Gontier, Brigitte, Rougier, Marie‐Bénédicte, Delcourt, Cécile, and Delyfer, Marie‐Noëlle
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MACULAR degeneration ,DEEP learning ,IMAGE analysis ,SYMPTOMS ,PHOTOGRAPHY - Abstract
Objective: This study aimed to develop a deep learning (DL) model, named 'DeepAlienorNet', to automatically extract clinical signs of age‐related macular degeneration (AMD) from colour fundus photography (CFP). Methods and Analysis: The ALIENOR Study is a cohort of French individuals 77 years of age or older. A multi‐label DL model was developed to grade the presence of 7 clinical signs: large soft drusen (>125 μm), intermediate soft (63–125 μm), large area of soft drusen (total area >500 μm), presence of central soft drusen (large or intermediate), hyperpigmentation, hypopigmentation, and advanced AMD (defined as neovascular or atrophic AMD). Prediction performances were evaluated using cross‐validation and the expert human interpretation of the clinical signs as the ground truth. Results: A total of 1178 images were included in the study. Averaging the 7 clinical signs' detection performances, DeepAlienorNet achieved an overall sensitivity, specificity, and AUROC of 0.77, 0.83, and 0.87, respectively. The model demonstrated particularly strong performance in predicting advanced AMD and large areas of soft drusen. It can also generate heatmaps, highlighting the relevant image areas for interpretation. Conclusion: DeepAlienorNet demonstrates promising performance in automatically identifying clinical signs of AMD from CFP, offering several notable advantages. Its high interpretability reduces the black box effect, addressing ethical concerns. Additionally, the model can be easily integrated to automate well‐established and validated AMD progression scores, and the user‐friendly interface further enhances its usability. The main value of DeepAlienorNet lies in its ability to assist in precise severity scoring for further adapted AMD management, all while preserving interpretability. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Associations of drusen location with risk factors and incidence of late age‐related macular degeneration in the Alienor study.
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Sénéclauze, Arnaud, Le Goff, Mélanie, Cougnard‐Grégoire, Audrey, Korobelnik, Jean‐François, Rougier, Marie‐Bénédicte, Delyfer, Marie‐Noëlle, Delcourt, Cécile, and Gattoussi, Sarra
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MACULAR degeneration ,CATARACT surgery ,BLOOD lipids ,MEDICAL prescriptions - Abstract
Purpose: To test the hypothesis that central drusen location is strongly linked with known Age‐related Macular Degeneration (AMD) risk factors and risk of incident late AMD. Methods: The Alienor study is a prospective population‐based cohort study of residents of Bordeaux, France, followed from 2009 to 2017. On retinal photographs, we defined central drusen as at least one soft drusen (>63 μm) within 500 μm from fovea and pericentral drusen as at least one drusen 500–3000 μm from fovea, in the absence of any central drusen. Late AMD (atrophic and/or neovascular) was diagnosed using multimodal imaging. In total, 481 eyes were included in the analysis: 160 central and 321 pericentral. We investigated associations with systemic (age, sex, smoking, medical prescriptions, plasma concentrations of lipids and nutrients, UV exposure, blood pressure), ocular (retinal thickness, cataract extraction) and genetic risk scores (GRS). Results: In multivariate logistic regression central drusen were associated with smoking (OR, 2.95 for smoking more than 20 pack‐years, p = 0.02), HDL‐cholesterol (OR, 1.57 for 1 standard deviation (SD) increase, p = 0.0048), pulse pressure (OR, 0.77 for 1 SD increase, p = 0.04), Age‐Related Maculopathy Susceptibility 2 (ARMS2) GRS (OR, 1.42; 95% CI, 1.11–1.83) and complement GRS (OR, 1.55; 95% CI, 1.15–2.10). In Cox modelling, the central location of drusen (at baseline or during the follow‐up) was associated with a 4.41‐fold increased risk (95% CI,1.98–9.81) for an incident late AMD. Conclusion: Central drusen were strongly associated with AMD risk factors and incident late AMD, suggesting that it represents a key marker for AMD progression. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Service delivery system design for risk management in sharing-based product service systems: a customer-oriented approach
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Hazée, Simon, Van Vaerenbergh, Yves, Delcourt, Cécile, and Kabadayi, Sertan
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- 2020
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15. Retinal microvasculature and incident dementia over 10 years: The Three‐City‐Alienor cohort
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Rebouças, Sara Cristina Lima, primary, Cougnard‐Gregoire, Audrey, additional, Arnould, Louis, additional, Delyfer, Marie‐Noëlle, additional, Schweitzer, Cédric, additional, Korobelnik, Jean‐François, additional, Foubert‐Samier, Alexandra, additional, Cheung, Carol Y., additional, Wong, Tien Y., additional, Delcourt, Cécile, additional, and Helmer, Catherine, additional
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- 2023
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16. Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error
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Cheng, Ching-Yu, Schache, Maria, Ikram, M Kamran, Young, Terri L, Guggenheim, Jeremy A, Vitart, Veronique, MacGregor, Stuart, Verhoeven, Virginie JM, Barathi, Veluchamy A, Liao, Jiemin, Hysi, Pirro G, Bailey-Wilson, Joan E, St. Pourcain, Beate, Kemp, John P, McMahon, George, Timpson, Nicholas J, Evans, David M, Montgomery, Grant W, Mishra, Aniket, Wang, Ya Xing, Wang, Jie Jin, Rochtchina, Elena, Polasek, Ozren, Wright, Alan F, Amin, Najaf, van Leeuwen, Elisabeth M, Wilson, James F, Pennell, Craig E, van Duijn, Cornelia M, de Jong, Paulus TVM, Vingerling, Johannes R, Zhou, Xin, Chen, Peng, Li, Ruoying, Tay, Wan-Ting, Zheng, Yingfeng, Chew, Merwyn, Error and Myopia, Consortium for Refractive, Cohort, 1958 British Birth, Rahi, Jugnoo S, cohort, Aichi, Yoshimura, Nagahisa, Yamashiro, Kenji, Miyake, Masahiro, ALIENOR, Delcourt, Cécile, Maubaret, Cecilia, ALSPAC, Williams, Cathy, Northstone, Kate, Ring, Susan M, Davey-Smith, George, ANZRAG, Craig, Jamie E, Burdon, Kathryn P, Fogarty, Rhys D, AREDS1a, Iyengar, Sudha K, Igo, Robert P, Chew, Emily, Janmahasathian, Sarayut, AREDS1b, AREDS1c, Stambolian, Dwight, Wilson, Joan E Bailey, BATS, Lu, Yi, Study, Beijing Eye, Jonas, Jost B, Xu, Liang, Saw, Seang-Mei, BMES, Baird, Paul N, Mitchell, Paul, CIEMS, Nangia, Vinay, CROATIA-Korčula, Hayward, Caroline, CROATIA-Split, Campbell, Harry, CROATIA-Vis, Rudan, Igor, Vatavuk, Zoran, DCCT, Paterson, Andrew D, Hosseini, S Mohsen, GWAS, FECD Fuchs Dystrophy, Fondran, Jeremy R, Study, Myopia, Feng, Sheng, and Study, Erasmus Rucphen Family
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Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Allied Health and Rehabilitation Science ,Health Sciences ,Ophthalmology and Optometry ,Human Genome ,Eye Disease and Disorders of Vision ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Eye ,Adolescent ,Adult ,Aged ,Asian People ,Axial Length ,Eye ,Eye Proteins ,Female ,Gene Expression ,Genetic Loci ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Male ,Middle Aged ,Polymorphism ,Single Nucleotide ,Refractive Errors ,Signal Transduction ,White People ,Consortium for Refractive Error and Myopia ,Fuchs' Genetics Multi-Center Study Group ,Wellcome Trust Case Control Consortium 2 ,Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions ,and Complications Research Group ,Medical and Health Sciences ,Genetics & Heredity ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Refractive errors are common eye disorders of public health importance worldwide. Ocular axial length (AL) is the major determinant of refraction and thus of myopia and hyperopia. We conducted a meta-analysis of genome-wide association studies for AL, combining 12,531 Europeans and 8,216 Asians. We identified eight genome-wide significant loci for AL (RSPO1, C3orf26, LAMA2, GJD2, ZNRF3, CD55, MIP, and ALPPL2) and confirmed one previously reported AL locus (ZC3H11B). Of the nine loci, five (LAMA2, GJD2, CD55, ALPPL2, and ZC3H11B) were associated with refraction in 18 independent cohorts (n = 23,591). Differential gene expression was observed for these loci in minus-lens-induced myopia mouse experiments and human ocular tissues. Two of the AL genes, RSPO1 and ZNRF3, are involved in Wnt signaling, a pathway playing a major role in the regulation of eyeball size. This study provides evidence of shared genes between AL and refraction, but importantly also suggests that these traits may have unique pathways.
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- 2013
17. Association of retinal nerve layers thickness and brain imaging in healthy young subjects from the i‐Share‐Bordeaux study
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Lima Rebouças, Sara Cristina, primary, Crivello, Fabrice, additional, Tsuchida, Ami, additional, Tzourio, Christophe, additional, Schweitzer, Cédric, additional, Korobelnik, Jean‐François, additional, Delcourt, Cécile, additional, and Helmer, Catherine, additional
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- 2023
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18. P23-054-23 Serum Vitamins and Retinal Nerve Fiber Layer Changes on SD-OCT: The Alienor Study
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Merle, Benedicte, primary, Rougier, Marie-Bénédicte, additional, Feart, Catherine, additional, Le Goff, Mélanie, additional, Gayraud, Laure, additional, Delyfer, Marie-Noëlle, additional, Korobelnik, Jean-françois, additional, Schweitzer, Cédric, additional, and Delcourt, Cécile, additional
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- 2023
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19. Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies.
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van der Heide, Frank C. T., Khawaja, Anthony, Berendschot, Tos T. J. M., Littlejohns, Thomas J., Kuźma, Elżbieta, Luben, Robert, Patel, Praveen J., Foster, Paul J., Bertelsen, Geir, von Hanno, Therese, Johnsen, Bente, Schirmer, Henrik, Rebouças, Sara C. L., Grasset, Leslie, Delcourt, Cécile, Helmer, Catherine, and Stehouwer, Coen D. A.
- Abstract
INTRODUCTION: Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all‐cause dementia and Alzheimer's disease (AD). METHODS: We performed an individual participant data meta‐analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = 1087 cases of incident all‐cause dementia; n = 520 cases incident AD; follow‐up time median [interquartile range] 11.3 [8.8–11.5] years). RESULTS: General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women. After adjustment, lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all‐cause dementia and AD, respectively. Lower baseline macular ganglion cell‐inner plexiform layer thickness was not significantly associated with these outcomes. DISCUSSION: These findings suggest that retinal neurodegeneration precedes the onset of clinical dementia. Retinal imaging tools may be informative biomarkers for the study of the early pathophysiology of dementia. [ABSTRACT FROM AUTHOR]
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- 2024
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20. A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration
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Clark, Rosie, primary, Lee, Samantha Sze-Yee, additional, Du, Ran, additional, Wang, Yining, additional, Kneepkens, Sander C.M., additional, Charng, Jason, additional, Huang, Yu, additional, Hunter, Michael L., additional, Jiang, Chen, additional, Tideman, J.Willem L., additional, Melles, Ronald B., additional, Klaver, Caroline C.W., additional, Mackey, David A., additional, Williams, Cathy, additional, Choquet, Hélène, additional, Ohno-Matsui, Kyoko, additional, Guggenheim, Jeremy A., additional, Bailey-Wilson, Joan E., additional, Baird, Paul N., additional, Barathi, Veluchamy A., additional, Biino, Ginevra, additional, Burdon, Kathryn P., additional, Campbell, Harry, additional, Chen, Li Jia, additional, Cheng, Ching-Yu, additional, Chew, Emily Y., additional, Craig, Jamie E., additional, Deangelis, Margaret M., additional, Delcourt, Cécile, additional, Ding, Xiaohu, additional, Fan, Qiao, additional, Fossarello, Maurizio, additional, Foster, Paul J., additional, Gharahkhani, Puya, additional, Guo, Xiaobo, additional, Haarman, Annechien E.G., additional, Haller, Toomas, additional, Hammond, Christopher J., additional, Han, Xikun, additional, Hayward, Caroline, additional, He, Mingguang, additional, Hewitt, Alex W., additional, Hoang, Quan, additional, Hysi, Pirro G., additional, Iglesias, Adriana I., additional, Igo, Robert P., additional, Iyengar, Sudha K., additional, Jonas, Jost B., additional, Kähönen, Mika, additional, Kaprio, Jaakko, additional, Khawaja, Anthony P., additional, Klein, Barbara E., additional, Lass, Jonathan H., additional, Lee, Kris, additional, Lehtimäki, Terho, additional, Lewis, Deyana, additional, Li, Qing, additional, Li, Shi-Ming, additional, Lyytikäinen, Leo-Pekka, additional, MacGregor, Stuart, additional, Martin, Nicholas G., additional, Meguro, Akira, additional, Metspalu, Andres, additional, Middlebrooks, Candace, additional, Miyake, Masahiro, additional, Mizuki, Nobuhisa, additional, Musolf, Anthony, additional, Nickels, Stefan, additional, Oexle, Konrad, additional, Pang, Chi Pui, additional, Pärssinen, Olavi, additional, Paterson, Andrew D., additional, Pfeiffer, Norbert, additional, Polasek, Ozren, additional, Rahi, Jugnoo S., additional, Raitakari, Olli, additional, Rudan, Igor, additional, Sahebjada, Srujana, additional, Saw, Seang-Mei, additional, Simpson, Claire L., additional, Stambolian, Dwight, additional, Tai, E-Shyong, additional, Tedja, Milly S., additional, Tideman, J. Willem L., additional, Tsujikawa, Akitaka, additional, van Duijn, Cornelia M., additional, Verhoeven, Virginie J.M., additional, Vitart, Veronique, additional, Wang, Ningli, additional, Wang, Ya Xing, additional, Wedenoja, Juho, additional, Wei, Wen Bin, additional, Williams, Katie M., additional, Wilson, James F., additional, Wojciechowski, Robert, additional, Yam, Jason C.S., additional, Yamashiro, Kenji, additional, Yap, Maurice K.H., additional, Yazar, Seyhan, additional, Yip, Shea Ping, additional, Young, Terri L., additional, Zhou, Xiangtian, additional, Allen, Naomi, additional, Aslam, Tariq, additional, Atan, Denize, additional, Barman, Sarah, additional, Barrett, Jenny, additional, Bishop, Paul, additional, Black, Graeme, additional, Bunce, Catey, additional, Carare, Roxana, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chua, Sharon, additional, Cipriani, Valentina, additional, Day, Alexander, additional, Desai, Parul, additional, Dhillon, Bal, additional, Dick, Andrew, additional, Doney, Alexander, additional, Egan, Cathy, additional, Ennis, Sarah, additional, Foster, Paul, additional, Fruttiger, Marcus, additional, Gallacher, John, additional, Garway-Heath, David, additional, Gibson, Jane, additional, Gore, Dan, additional, Guggenheim, Jeremy, additional, Hammond, Chris, additional, Hardcastle, Alison, additional, Harding, Simon, additional, Hogg, Ruth, additional, Hysi, Pirro, additional, Keane, Pearse A., additional, Khaw, Peng Tee, additional, Khawaja, Anthony, additional, Lascaratos, Gerassimos, additional, Littlejohns, Thomas, additional, Lotery, Andrew, additional, Luthert, Phil, additional, MacGillivray, Tom, additional, Mackie, Sarah, additional, McGuinness, Bernadette, additional, McKay, Gareth, additional, McKibbin, Martin, additional, Mitry, Danny, additional, Moore, Tony, additional, Morgan, James, additional, Muthy, Zaynah, additional, O'Sullivan, Eoin, additional, Owen, Chris, additional, Patel, Praveen, additional, Paterson, Euan, additional, Peto, Tunde, additional, Petzold, Axel, additional, Pontikos, Nikolas, additional, Rahi, Jugnoo, additional, Rudnicka, Alicja, additional, Self, Jay, additional, Sergouniotis, Panagiotis, additional, Sivaprasad, Sobha, additional, Steel, David, additional, Stratton, Irene, additional, Strouthidis, Nicholas, additional, Sudlow, Cathie, additional, Tapp, Robyn, additional, Thaung, Caroline, additional, Thomas, Dhanes, additional, Trucco, Emanuele, additional, Tufail, Adnan, additional, Vernon, Stephen, additional, Viswanathan, Ananth, additional, Williams, Katie, additional, Woodside, Jayne, additional, Yates, Max, additional, Yip, Jennifer, additional, and Zheng, Yalin, additional
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- 2023
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21. Blue Light Exposure:Ocular Hazards and Prevention—A Narrative Review
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Cougnard-Gregoire, Audrey, Merle, Bénédicte M.J., Aslam, Tariq, Seddon, Johanna M., Aknin, Isabelle, Klaver, Caroline C.W., Garhöfer, Gerhard, Layana, Alfredo Garcia, Minnella, Angelo Maria, Silva, Rufino, Delcourt, Cécile, Cougnard-Gregoire, Audrey, Merle, Bénédicte M.J., Aslam, Tariq, Seddon, Johanna M., Aknin, Isabelle, Klaver, Caroline C.W., Garhöfer, Gerhard, Layana, Alfredo Garcia, Minnella, Angelo Maria, Silva, Rufino, and Delcourt, Cécile
- Abstract
Introduction: Exposure to blue light has seriously increased in our environment since the arrival of light emitting diodes (LEDs) and, in recent years, the proliferation of digital devices rich in blue light. This raises some questions about its potential deleterious effects on eye health. The aim of this narrative review is to provide an update on the ocular effects of blue light and to discuss the efficiency of methods of protection and prevention against potential blue light-induced ocular injury. Methods: The search of relevant English articles was conducted in PubMed, Medline, and Google Scholar databases until December 2022. Results: Blue light exposure provokes photochemical reactions in most eye tissues, in particular the cornea, the lens, and the retina. In vitro and in vivo studies have shown that certain exposures to blue light (depending on the wavelength or intensity) can cause temporary or permanent damage to some structures of the eye, especially the retina. However, currently, there is no evidence that screen use and LEDs in normal use are deleterious to the human retina. Regarding protection, there is currently no evidence of a beneficial effect of blue blocking lenses for the prevention of eye diseases, in particular age-related macular degeneration (AMD). In humans, macular pigments (composed of lutein and zeaxanthin) represent a natural protection by filtering blue light, and can be increased through increased intake from foods or food supplements. These nutrients are associated with lower risk for AMD and cataract. Antioxidants such as vitamins C, E, or zinc might also contribute to the prevention of photochemical ocular damage by preventing oxidative stress. Conclusion: Currently, there is no evidence that LEDs in normal use at domestic intensity levels or in screen devices are retinotoxic to the human eye. However, the potential toxicity of long-term cumulative exposure and the dose-response effect are currently unknown.
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- 2023
22. Rare variant analyses across multiethnic cohorts identify novel genes for refractive error
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Musolf, Anthony M., Haarman, Annechien E.G., Luben, Robert N., Ong, Jue Sheng, Patasova, Karina, Trapero, Rolando Hernandez, Marsh, Joseph, Jain, Ishika, Jain, Riya, Wang, Paul Zhiping, Lewis, Deyana D., Tedja, Milly S., Iglesias, Adriana I., Li, Hengtong, Cowan, Cameron S., Baird, Paul Nigel, Veluchamy, Amutha Barathi, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching Yu, Chew, Emily Y., Craig, Jamie E., Cumberland, Phillippa M., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Evans, David M., Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Han, Xikun, He, Mingguang, Hewitt, Alex W., Hoang, Quan V., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Klein, Barbara E., Lass, Jonathan H., Wang, Ya Xing, van Duijn, Cornelia M., Verhoeven, Virginie J.M., Klaver, Caroline C.W., Bailey-Wilson, Joan E., Musolf, Anthony M., Haarman, Annechien E.G., Luben, Robert N., Ong, Jue Sheng, Patasova, Karina, Trapero, Rolando Hernandez, Marsh, Joseph, Jain, Ishika, Jain, Riya, Wang, Paul Zhiping, Lewis, Deyana D., Tedja, Milly S., Iglesias, Adriana I., Li, Hengtong, Cowan, Cameron S., Baird, Paul Nigel, Veluchamy, Amutha Barathi, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching Yu, Chew, Emily Y., Craig, Jamie E., Cumberland, Phillippa M., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Evans, David M., Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Han, Xikun, He, Mingguang, Hewitt, Alex W., Hoang, Quan V., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Klein, Barbara E., Lass, Jonathan H., Wang, Ya Xing, van Duijn, Cornelia M., Verhoeven, Virginie J.M., Klaver, Caroline C.W., and Bailey-Wilson, Joan E.
- Abstract
Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles or other approaches for vision correction. Common genetic risk factors have been identified by genome-wide association studies (GWAS), but a great part of the refractive error heritability is still missing. Some of this heritability may be explained by rare variants (minor allele frequency [MAF] ≤ 0.01.). We performed multiple gene-based association tests of mean Spherical Equivalent with rare variants in exome array data from the Consortium for Refractive Error and Myopia (CREAM). The dataset consisted of over 27,000 total subjects from five cohorts of Indo-European and Eastern Asian ethnicity. We identified 129 unique genes associated with refractive error, many of which were replicated in multiple cohorts. Our best novel candidates included the retina expressed PDCD6IP, the circadian rhythm gene PER3, and P4HTM, which affects eye morphology. Future work will include functional studies and validation. Identification of genes contributing to refractive error and future understanding of their function may lead to better treatment and prevention of refractive errors, which themselves are important risk factors for various blinding conditions.
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- 2023
23. Real-World Outcomes of Ranibizumab Treatment in French Patients with Visual Impairment due to Macular Edema Secondary to Retinal Vein Occlusion: 24-Month Results from the BOREAL-RVO Study
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Glacet-Bernard, Agnès, primary, Girmens, Jean-François, additional, Kodjikian, Laurent, additional, Delcourt, Cécile, additional, Fajnkuchen, Franck, additional, Creuzot-Garcher, Catherine, additional, San Nicolas, Nathalie, additional, and Massin, Pascale, additional
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- 2023
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24. Using Artificial Intelligence to Analyse the Retinal Vascular Network: The Future of Cardiovascular Risk Assessment Based on Oculomics? A Narrative Review
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Arnould, Louis, primary, Meriaudeau, Fabrice, additional, Guenancia, Charles, additional, Germanese, Clément, additional, Delcourt, Cécile, additional, Kawasaki, Ryo, additional, Cheung, Carol Y., additional, Creuzot-Garcher, Catherine, additional, and Grzybowski, Andrzej, additional
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- 2022
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25. Plasma long‐chain omega‐3 polyunsaturated fatty acids and macular pigment in subjects with family history of age‐related macular degeneration: the Limpia Study
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Merle, Bénédicte M. J., Buaud, Benjamin, Korobelnik, Jean‐François, Bron, Alain, Delyfer, Marie‐Noëlle, Rougier, Marie‐Bénédicte, Savel, Hélène, Vaysse, Carole, Creuzot‐Garcher, Catherine, and Delcourt, Cécile
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- 2017
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26. The Phenotypic Course of Age-Related Macular Degeneration for ARMS2/HTRA1: The EYE-RISK Consortium
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Thee, Eric, Colijn, Johanna, Cougnard-Grégoire, Audrey, Meester-Smoor, Magda, Verzijden, Timo, Hoyng, Carel, Fauser, Sascha, Hense, Hans-Werner, Silva, Rufino, Creuzot-Garcher, Catherine, Ueffing, Marius, Delcourt, Cécile, den Hollander, Anneke, Klaver, Caroline C.W., Epidemiology, Ophthalmology, Julien, Sabine, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Bordeaux Population Health Research Center, Inserm, Bordeaux, Radboud University Medical Center [Nijmegen], University Hospital of Cologne [Cologne], F. Hoffmann-La Roche A.G., Switzerland, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Centro Hospitalar e Universitário [Coimbra], Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and University of Tübingen
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HTRA1 ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Genotype ,Age-related macular degeneration ,Proteins ,Retinal Drusen ,High-Temperature Requirement A Serine Peptidase 1 ,Polymorphism, Single Nucleotide ,Choroidal Neovascularization ,Europe ,Macular Degeneration ,Phenotype ,[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,Risk Factors ,Complement Factor H ,Humans ,genetics ,ARMS2 ,[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Purpose: Age-related maculopathy susceptibility 2 (ARMS2) is considered the most enigmatic of the genes for age-related macular degeneration (AMD). We investigated the phenotypic course and spectrum of AMD for the risk haplotype at the ARMS2 and high-temperature requirement A serine peptidase 1 (HTRA1) locus in a large European consortium. Design: Pooled analysis of 4 case-control and 6 cohort studies. Participants: Individuals (N = 17 204) aged 55 years or older participating in the European Eye Epidemiology consortium. Methods: Age-related macular degeneration features and macular thickness were determined on multimodal images; data on genetics and phenotype were harmonized. Risks of AMD features for rs3750486 genotypes at the ARMS2/HTRA1 locus were determined by logistic regression and were compared with a genetic risk score (GRS) of 19 variants at the complement pathway. Lifetime risks were estimated with Kaplan–Meier analyses in population-based cohorts. Main Outcome Measures: Age-related macular degeneration features and stage. Results: Of 2068 individuals with late AMD, 64.7% carried the ARMS2/HTRA1 risk allele. For homozygous carriers, the odds ratio (OR) of geographic atrophy was 8.6 (95% confidence interval [CI], 6.5–11.4), of choroidal neovascularization (CNV) was 11.2 (95% CI, 9.4–13.3), and of mixed late AMD was 12.2 (95% CI, 7.3–20.6). Cumulative lifetime risk of late AMD ranged from 4.4% for carriers of the nonrisk genotype to 9.4% and 26.8% for heterozygous and homozygous carriers. The latter received the diagnosis of late AMD 9.6 years (95% CI, 8.0–11.2) earlier than carriers of the nonrisk genotype. The risk haplotype was not associated with hard or soft drusen < 125 μm (OR, 1.2; 95% CI, 0.9–1.7), but risks increased significantly for soft drusen ≥ 125 μm (OR, 2.1; 95% CI, 1.5–3.0), up to an OR of 7.2 (95% CI, 3.8–13.8) for reticular pseudodrusen. Compared with persons with a high GRS for complement, homozygous carriers of ARMS2/HTRA1 showed a higher risk of CNV (OR, 4.1; 95% CI, 3.2–5.4); risks of other characteristics were not different. Conclusions: Carriers of the risk haplotype at ARMS2/HTRA1 have a particularly high risk of late AMD at a relatively early age. Data suggest that risk variants at ARMS2/HTRA1 act as a strong catalyst of progression once early signs are present. The phenotypic spectrum resembles that of complement genes, only with higher risks of CNV.
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- 2022
27. B Vitamins and Incidence of Advanced Age-Related Macular Degeneration: The Alienor Study
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Merle, Bénédicte M. J., primary, Barthes, Stéphanie, additional, Féart, Catherine, additional, Cougnard-Grégoire, Audrey, additional, Korobelnik, Jean-François, additional, Rougier, Marie-Bénédicte, additional, Delyfer, Marie-Noëlle, additional, and Delcourt, Cécile, additional
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- 2022
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28. Vision loss and 12-year risk of dementia in older adults: the 3C cohort study
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Naël, Virginie, Pérès, Karine, Dartigues, Jean-François, Letenneur, Luc, Amieva, Hélène, Arleo, Angelo, Scherlen, Anne-Catherine, Tzourio, Christophe, Berr, Claudine, Carrière, Isabelle, Helmer, Catherine, Sense-Cog consortium, Constantinidou, Fofi, Delcourt, Cécile, Constantinidou, Fofi [0000-0002-7928-8363], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU), Institut de la Vision, Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Essilor International, CMRR - Centres Mémoire de Ressources et de Recherche [CHU Bordeaux], CHU Bordeaux [Bordeaux], Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), The Three-City study is conducted under a partnership agreement between the Institut National de la Santé et de la Recherche Médicale (INSERM), the University Bordeaux 2 Victor Segalen and Sanofi-Aventis. The Fondation pour la Recherche Médicale funded the preparation and initiation of the study. The Three-City study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé, MGEN, Institut de la Longévité, Conseils Régionaux d’Aquitaine et Bourgogne, Fondation de France, Ministry of Research-INSERM Programme 'Cohortes et collections de données biologiques', Agence Nationale de la Recherche ANR PNRA 2006 and LongVie 2007, the 'Fondation Plan Alzheimer' (FCS 2009-2012) and the Caisse Nationale de Solidarité pour l’Autonomie (CNSA). None of the sponsors participated in the collection, management, statistical analysis and interpretation of the data, nor in the preparation, review or approval of the present manuscript. SENSE-Cog has received funding from the European Union’s Horizon 2020 research and innovation program under Grant agreement No. 668648., Sense-Cog consortium : Bertelsen G, Cosh S, Cougnard-Grégoire A, Dawes P, Delcourt C, Constantinidou F, Helmer C, Arfan Ikram M, Klaver CCW, Leroi I, Maharani A, Meester-Smor M, Mutlu U, Nael V, Pendleton N, Schirmer H, Tampubolon G, Tiemeier H, von Hanno T., European Project: 668648,H2020,H2020-PHC-2015-two-stage,SENSE-Cog(2016), Delcourt, Cécile, Ears, Eyes and Mind: The ‘SENSE-Cog Project’ to improve mental well-being for elderly Europeans with sensory impairment - SENSE-Cog - - H20202016-01-01 - 2020-12-31 - 668648 - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Epidemiology, Neurology, Radiology & Nuclear Medicine, Ophthalmology, and Psychiatry
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Male ,Pediatrics ,medicine.medical_specialty ,Time Factors ,Multivariate analysis ,Epidemiology ,[SDV]Life Sciences [q-bio] ,Population ,Visual impairment ,[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Vision Disorders ,030204 cardiovascular system & hematology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Vision loss ,Risk Factors ,medicine ,Humans ,Dementia ,030212 general & internal medicine ,[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,10. No inequality ,education ,ComputingMilieux_MISCELLANEOUS ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,education.field_of_study ,[SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology ,Depression ,business.industry ,[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology ,Cognition ,medicine.disease ,Increased risk ,[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Cohort ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,France ,Self Report ,medicine.symptom ,business ,Cohort study - Abstract
International audience; To analyze the longitudinal relationships between vision loss and the risk of dementia in the first 2 years, from 2 to 4 years and beyond 4 years after inclusion and to determine the roles of depressive symptomatology and engagement in cognitively stimulating activities in these associations. This study is based on the Three-City (3C) study, a population-based cohort of 7736 initially dementia-free participants aged 65 years and over with 12 years of follow-up. Near visual impairment (VI) was measured and distance visual function (VF) loss was self-reported. Dementia was diagnosed and screened over the 12-year period. At baseline, 8.7% had mild near VI, 4.2% had moderate to severe near VI, and 5.3% had distance VF loss. Among the 882 dementia cases diagnosed over the 12-year follow-up period, 140 cases occurred in the first 2 years, 149 from 2 to 4 years and 593 beyond 4 years after inclusion. In Cox multivariate analysis, moderate to severe near VI was associated with an increased risk of dementia in the first 2 years (HR 2.0, 95% CI 1.2-3.3) and from 2 to 4 years (HR 1.8, 95% CI 1.1-3.1) but the association was not significant beyond 4 years after inclusion even if pointing in similar direction (HR 1.3, 95% CI 0.95-1.9). Mild near VI was associated with an increased risk of dementia only in the first 2 years (HR 1.6, 95% CI 1.1-2.5). Moreover, self-reported distance VF loss was associated with an increased risk beyond 4 years after inclusion (HR 1.5, 95% CI 1.1-2.0) but the association was no longer significant after taking into account baseline cognitive performances. Further adjustment for engagement in cognitively stimulating activities only slightly decreased these associations. However, there was an interaction between vision loss and depressive symptomatology, with vision loss associated with dementia only among participants with depressive symptomatology. These results suggest that poor vision, in particular near vision loss, may represent an indicator of dementia risk at short and middle-term, mostly in depressed elderly people.
- Published
- 2019
29. Children’s Diet at 2 Years and Trajectories of Hyperactivity-Inattention Symptoms and Conduct Problems Between 3 and 8 Years: The EDEN Cohort
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Iv, Nicolas, primary, Herbein, Marie, additional, Heude, Barbara, additional, van der Waerden, Judith, additional, Melchior, Maria, additional, Feart, Catherine, additional, Delcourt, Cécile, additional, Côté, Sylvana, additional, De Lauzon-Guillain, Blandine, additional, Lioret, Sandrine, additional, and Galera, Cédric, additional
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- 2022
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30. Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study
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MAUSCHITZ, Matthias M., SCHMITZ, Marie Therese, Verzijden, Timo, Schmid, Matthias, THEE, Eric F., Colijn, Johanna M., Delcourt, Cécile, Cougnard-Gregoire, Audrey, MERLE, Benedicte M. J., KOROBELNIK, Jean Francois, Gopinath, Bamini, Mitchell, Paul, ELBAZ, Hisham, SCHUSTER, Alexander K., Wild, Philipp S., BRANDL, Caroline, STARK, Klaus J., Heid, Iris M., Gunther, Felix, Peters, Annette, KLAVER, Caroline C. W., FINGER, Robert P., EUROPEAN EYE EPIDEMIOLOGY, Consortium, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ophthalmology, and Epidemiology
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Adult ,medicine.medical_specialty ,genetic structures ,Population ,Physical activity ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,Cohort Studies ,03 medical and health sciences ,Macular Degeneration ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Risk Factors ,Internal medicine ,Age related ,medicine ,Humans ,Longitudinal Studies ,Risk factor ,education ,Exercise ,Aged ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Incidence ,Hazard ratio ,Macular degeneration ,Middle Aged ,medicine.disease ,eye diseases ,3. Good health ,Ophthalmology ,030221 ophthalmology & optometry ,Disease Progression ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,sense organs ,business ,030217 neurology & neurosurgery ,Cohort study ,Follow-Up Studies - Abstract
Contains fulltext : 249581.pdf (Publisher’s version ) (Closed access) PURPOSE: To investigate the impact of physical activity (PA) on the incidence or progression of age-related macular degeneration (AMD) in the general population. DESIGN: Meta-analysis of longitudinal cohort studies. METHODS: We included 14,630 adults with no or early AMD at baseline from 7 population-based studies and examined associations of PA with AMD incidence and progression using multistate models (MSM) per study and subsequent random effects meta-analysis. Age effects were assessed using meta-regression. The main outcome measure was the hazard ratio (HR) for incident early or progression to late AMD. RESULTS: At baseline, mean age was 60.7 ± 6.9 to 76.4 ± 4.3 years, and prevalence of early AMD was 7.7% (range, 3.6%-16.9%) between cohorts. During follow-up, 1461 and 189 events occurred for early and late AMD, respectively. In meta-analyses, no or low to moderate PA (high PA as reference) was associated with an increased risk for incident early AMD (HR, 1.19; 95% CI, 1.01-1.40; P = .04), but not for late AMD. In subsequent meta-regression, we found no association of age with the effect of PA on incident AMD. CONCLUSIONS: Our study suggests high levels of PA to be protective for the development of early AMD across several population-based cohort studies. Our results establish PA as a modifiable risk factor for AMD and inform further AMD prevention strategies to reduce its public health impact. 01 april 2022
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- 2022
31. Development of a Genotype Assay for Age-Related Macular Degeneration: The EYE-RISK Consortium
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de Breuk, Anita, Acar, Ilhan E., Kersten, Eveline, Schijvenaars, Mascha M.V.A.P., Colijn, Johanna M., Haer-Wigman, Lonneke, Bakker, Bjorn, de Jong, Sarah, Meester-Smoor, Magda, Verzijden, Timo, Missotten, Tom O.A.R., Monés, Jordi, Biarnés, Marc, Pauleikhoff, Daniel, Hense, Hans W., Silva, Rufino, Nunes, Sandrina, Melo, Joana B., Fauser, Sascha, Hoyng, Carel B., Ueffing, Marius, Coenen, Marieke J.H., Klaver, Caroline C.W., den Hollander, Anneke I., Ajana, Soufiane, Arango-Gonzalez, Blanca, Badura, Franz, De la Cerda, Berta, Borrell, Anna, Cougnard-Grégoire, Audrey, Dammeier, Sascha, de Jong, Eiko K., Delcourt, Cécile, Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Ikram, A., Kilger, Ellen, Langen, Hanno, Lengyel, Imre, Luthert, Phil, Merle, Bénédicte M.J., Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodríguez, Eduardo, Vingerling, Johannes, and Zumbansen, Markus
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genetic structures ,sense organs ,eye diseases - Abstract
PurposeTo develop a genotype assay to assess associations with common and rare age-related macular degeneration (AMD) risk variants, to calculate an overall genetic risk score (GRS), and to identify potential misdiagnoses with inherited macular dystrophies that mimic AMD.DesignCase-control study.ParticipantsIndividuals (n = 4740) from 5 European cohorts.MethodsWe designed single-molecule molecular inversion probes for target selection and used next generation sequencing to sequence 87 single nucleotide polymorphisms (SNPs), coding and splice-site regions of 10 AMD-(related) genes (ARMS2, C3, C9, CD46, CFB, CFH, CFI, HTRA1, TIMP3, and SLC16A8), and 3 genes that cause inherited macular dystrophies (ABCA4, CTNNA1, and PRPH2). Genetic risk scores for common AMD risk variants were calculated based on effect size and genotype of 52 AMD-associated variants. Frequency of rare variants was compared between late AMD patients and control individuals with logistic regression analysis.Main Outcome MeasuresGenetic risk score, association of genetic variants with AMD, and genotype–phenotype correlations.ResultsWe observed high concordance rates between our platform and other genotyping platforms for the 69 successfully genotyped SNPs (>96%) and for the rare variants (>99%). We observed a higher GRS for patients with late AMD compared with patients with early/intermediate AMD (P < 0.001) and individuals without AMD (P < 0.001). A higher proportion of pathogenic variants in the CFH (odds ratio [OR] = 2.88; P = 0.006), CFI (OR = 4.45; P = 0.005), and C3 (OR = 6.56; P = 0.0003) genes was observed in late AMD patients compared with control individuals. In 9 patients, we identified pathogenic variants in the PRPH2, ABCA4, and CTNNA1 genes, which allowed reclassification of these patients as having inherited macular dystrophy.ConclusionsThis study reports a genotype assay for common and rare AMD genetic variants, which can identify individuals at intermediate to high genetic risk of late AMD and enables differential diagnosis of AMD-mimicking dystrophies. Our study supports sequencing of CFH, CFI, and C3 genes because they harbor rare high-risk variants. Carriers of these variants could be amendable for new treatments for AMD that currently are under development.
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- 2021
32. Novel polyesteramide-based di- and triblock copolymers: From thermo-mechanical properties to hydrolytic degradation
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Deshayes, Gaëlle, Delcourt, Cécile, Verbruggen, Ingrid, Trouillet-Fonti, Lise, Touraud, Franck, Fleury, Etienne, Degée, Philippe, Destarac, Mathias, Willem, Rudolph, and Dubois, Philippe
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- 2011
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33. Exploring Consensus on Preventive Measures and Identification of Patients at Risk of Age-Related Macular Degeneration Using the Delphi Process
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García-Layana, Alfredo, primary, Garhöfer, Gerhard, additional, Aslam, Tariq M., additional, Silva, Rufino, additional, Delcourt, Cécile, additional, Klaver, Caroline C. W., additional, Seddon, Johanna M., additional, and Minnella, Angelo M., additional
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- 2021
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34. The Montrachet Study: study design, methodology and analysis of visual acuity and refractive errors in an elderly population
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Creuzot-Garcher, Catherine, Binquet, Christine, Daniel, Sandrine, Bretillon, Lionel, Acar, Nyiazi, de Lazzer, Aurélie, Arnould, Laurent, Tzourio, Christophe, Bron, Alain M., and Delcourt, Cécile
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- 2016
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35. Peroxydation lipidique et vieillissement cérébral : l’apport des études épidémiologiques
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Barberger-gateau Pascale, Delcourt Cécile, and Berr Claudine
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oxidative stress ,aging ,humans ,dementia ,Alzheimer disease ,omega-3 ,epidemiology ,Oils, fats, and waxes ,TP670-699 - Abstract
The brain is particularly vulnerable to oxidative stress. Epidemiological studies have provided nutritional and biological arguments for a role of anti-oxidants such as vitamins E and C, flavonoids, and carotenoids against brain aging. There are however discrepancies between studies regarding potentially effective doses, interactions with genetic characteristics or smoking, or efficacy of supplements. A single intervention trial showed a small effect of vitamin E in Alzheimer patients, whereas all primary or secondary prevention trials were negative. Part of these discrepancies may be explained by the absence of simultaneous consideration of the lipid status, whereas most epidemiologic studies have shown a protective effect of long-chain ω3 fatty acids against cognitive decline or dementia. However, there is no published clinical trial regarding their effect on this outcome. Additional studies are required to identify mechanisms of action and potentially effective doses before giving recommendations for a nutritional prevention of pathological brain aging.
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- 2006
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36. Vision Impairment and Adverse Health Conditions in Congolese Older People: A Population-Based Study
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Gbessemehlan, Antoine, Edjolo, Arlette, Helmer, Catherine, Delcourt, Cécile, Mbelesso, Pascal, Ndamba-Bandzouzi, Bébène, Samba, Harielle, Kehoua, Gilles, Dartigues, Jean François, Dartigues, Jean-François, Houinato, Dismand, Preux, Pierre-Marie, Guerchet, Maëlenn, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratory of Chronic and Neurological Diseases Epidemiology (LEMACEN), University of Abomey Calavi (UAC), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), and CHU Limoges
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Gerontology ,Quality of life ,Aging ,Visual acuity ,Cognitive disorders ,Population ,Visual Acuity ,Psychological intervention ,Vision impairment ,050105 experimental psychology ,Cohort Studies ,03 medical and health sciences ,030502 gerontology ,Surveys and Questionnaires ,Humans ,Medicine ,0501 psychology and cognitive sciences ,education ,Dependence ,Aged ,education.field_of_study ,business.industry ,African older people ,05 social sciences ,Confounding ,Cognition ,3. Good health ,Cross-Sectional Studies ,Residence ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Geriatrics and Gerontology ,medicine.symptom ,0305 other medical science ,business ,Cohort study - Abstract
Introduction: In sub-Saharan Africa, many older people experience vision impairment (VI) and its adverse health outcomes. In this study, we examined separately the association between VI and each adverse health conditions (cognitive disorders, vision-related quality of life [VRQoL], and daily functioning interference [DFI]) among Congolese older people. We also explored whether VI had a significant effect on VRQoL components in our population. Method: We performed cross-sectional analyses on data from 660 Congolese people aged ≥65 years who participated in the 2013 survey of the EPIDEMCA population-based cohort study. VI was defined as having a near visual acuity Results: VI was not associated with cognitive disorders after adjustment for residence area (adjusted odds ratio = 1.7; 95% confidence interval [CI]: 0.6; 4.7), but it was associated with a low VRQoL score (adjusted β = −12.4; 95% CI: −17.5; −7.3) even after controlling for several covariates. An interaction between VI and age (p = 0.007) was identified, and VI was associated with DFI only among people aged >73 years (adjusted β = 0.5; 95% CI: 0.2; 0.8). Our exploratory analysis showed that all components of VRQoL decreased with a decrease in visual acuity (corrected p ≤ 0.05). Conclusion: VI was associated with poor VRQoL and high DFI. Residence area seems to play a confounding role in the association between VI and cognitive disorders. Our findings suggest that targeting interventions on vision could reduce DFI among older people and improve their well-being.
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- 2021
37. The ALGOVUE Clinical Trial: Effects of the Daily Consumption of Eggs Enriched with Lutein and Docosahexaenoic Acid on Plasma Composition and Macular Pigment Optical Density
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Schnebelen-Berthier, Coralie, primary, Acar, Niyazi, additional, Simon, Emilie, additional, Thabuis, Clémentine, additional, Bourdillon, Anne, additional, Mathiaud, Adeline, additional, Dauchet, Luc, additional, Delcourt, Cécile, additional, Benlian, Pascale, additional, Crochet, Martine, additional, Defoort, Sabine, additional, Tailleux, Anne, additional, Staels, Bart, additional, Bretillon, Lionel, additional, and Lecerf, Jean-Michel, additional
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- 2021
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38. Mediterranean diet and prudent diet are both associated with low circulating esterified 3-hydroxy fatty acids, a proxy of LPS burden, among older adults
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André, Perrine, primary, Pais de Barros, Jean-Paul, additional, MJ Merle, Bénédicte, additional, Samieri, Cécilia, additional, Helmer, Catherine, additional, Delcourt, Cécile, additional, and Féart, Catherine, additional
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- 2021
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39. Retinal nerve fibre layer thickness measured with SD-OCT in a population-based study of French elderly subjects: the Alienor study
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Rougier, Marie-Bénédicte, Korobelnik, Jean-François, Malet, Florence, Schweitzer, Cédric, Delyfer, Marie-Noëlle, Dartigues, Jean-François, Delcourt, Cécile, and Helmer, Catherine
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- 2015
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40. Vitamin D Deficiency in Community-Dwelling Elderly Is Not Associated with Age-Related Macular Degeneration1-3
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Cougnard-Grégoire, Audrey, Merle, Bénédicte MJ, Korobelnik, Jean-Francois, Rougier, Marie-Bénédicte, Delyfer, Marie-Noëlle, Féart, Catherine, Le Goff, Mélanie, Dartigues, Jean-François, Barberger-Gateau, Pascale, and Delcourt, Cécile
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- 2015
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41. Visual acuity thresholds associated with activity limitations in the elderly. The Pathologies Oculaires Liées à lʼAge study
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Daien, Vincent, Peres, Karine, Villain, Max, Colvez, Alain, Carriere, Isabelle, and Delcourt, Cécile
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- 2014
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42. Plasma Lutein, a Nutritional Biomarker for Development of Advanced Age-Related Macular Degeneration: The Alienor Study
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Merle, Bénédicte M. J., primary, Cougnard-Grégoire, Audrey, additional, Korobelnik, Jean-François, additional, Schalch, Wolfgang, additional, Etheve, Stéphane, additional, Rougier, Marie-Bénédicte, additional, Féart, Catherine, additional, Samieri, Cécilia, additional, Delyfer, Marie-Noëlle, additional, and Delcourt, Cécile, additional
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- 2021
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43. Exploring the Concept of Customer-Perceived Intimacy in Healthscapes
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Martens, Carmen, Herssens, Jasmien, and Delcourt, Cécile
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Medisinske Fag: 700::Helsefag: 800 [VDP] ,Healthcare Services ,Customer-Perceived Intimacy ,Healthscape ,Servicescape - Abstract
Background —It is recognized that servicescapes (i.e., the manmade physical surroundings in which a service takes place) both affect customer and employee attitudes and behaviours. This is particularly the case in healthcare servicescapes (i.e., healthscapes) as studies demonstrated that an improvement in the servicescape can contribute to positive outcomes such as enhanced healing process. However, little is known about such a relationship can happen. Accordingly, we examine the concept of customer-perceived intimacy (CPI) as improving servicescapes can contribute to positive outcomes through the creation of CPI. Indeed, in healthcare, the intimacy of the customers (i.e., patients) is often under stress as they have to relinquish privacy by disclosing embarrassing personal information and/or intimate body parts. Objective – The purpose of this paper is to explore—based on an extended multidisciplinary literature review— the concept of CPI in healthscapes. The authors offer a conceptualization of customer-perceived intimacy in healthscapes together with a conceptual framework to highlight both the antecedents (i.e., the design and architectural components of the healthscape) and the short-term and long-term outcomes of CPI. Results – Customer-perceived intimacy defined as “the feeling that combines the dimensions of mutuality, discovery, emotions and kindness, from a customer's perspective” are caused by a holistic combination of intangible (i.e., interpersonal) and tangible factors (i.e., design of the physical healthcare environment) within the servicescape. This leads to higher levels of understanding of service systems and their fundamental role in human well-being. The authors argue that healthscape design focused on customer-perceived intimacy is necessary to make service systems more socially inclusive. Contribution – We provide architects with theoretical insights on how to foster customer-perceived intimacy in healthscapes. In doing so, we aim to help hospitals to adopt a more patient-centric strategy by improving the patient experience. The insights from our study can be generalized to public servicescapes so that the experience of users is improved by fostering customer-perceived intimacy.
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- 2021
44. Determination of initial soil moisture for a small highly erodible mountain basin with TELEMAC
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Delcourt, Cécile, Taccone, Florent, Delestre, Olivier, and TELEMAC-MASCARET Core Group
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Hydrodynamik (532.5) - Abstract
Hydrodynamics
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- 2021
45. Genetic risk, lifestyle, and AMD in Europe. The EYE-RISK consortium
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Colijn, Johanna Maria, Meester, Magda, Verzijden, T., de Breuk, A., SILVA, R., Merle, Bénédicte M. J., Cougnard-Grégoire, Audrey, Hoyng, Carel B., Fauser, Sascha, Coolen, T., Creuzot-Garcher, Catherine, Hense, H.W., UEFFING, M., Delcourt, Cécile, den Hollander, Anneke I., Klaver, Caroline C. W., EYE-RISK consortium, ., Erasmus University Medical Center [Rotterdam] (Erasmus MC), Radboud University Medical Center [Nijmegen], Coimbra Institute for Clinical and Biomedical Research [Coimbra, Portugal] (iCBR - Faculty of Medicine), University of Coimbra [Portugal] (UC), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospital of Cologne [Cologne], King‘s College London, Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Muenster, University of Tübingen, European Commission (grant number 634479) + Erasmus Medical Center + Rotterdam Eye Hospital through the CORR (Combined Ophthalmic Research Rotterdam) Foundation + Uitzicht (grant number 2015-36)., and Julien, Sabine
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Europe ,age-related macular degeneration (AMD) ,[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,pathways ,population ,genetics ,[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,eye diseases - Abstract
International audience; PURPOSE: Age-related macular degeneration(AMD) is a common multifactorial disease in elderly with a prominent genetic basis. Many risk variants have been identified, but the interpretation is still challenging. We investigated the genetic distribution of AMD-associated risk variants in a large European consortium, calculated attributable, and pathway-specific genetic risks, and assessed the influence of lifestyle on genetic outcomes. DESIGN: Pooled analysis of cross-sectional data from the E3 consortium. PARTICIPANTS: 17.174 individuals aged 45+ participating in 6 population-based cohort studies, 2 clinic based studies, 1 case-control study. METHODS: AMD was diagnosed and graded based on fundus photographs. Data on genetics, lifestyle, and diet were harmonized and completed where necessary. Minor allele frequencies and population attributable fraction (PAF) were calculated per single nucleotide polymorphism (SNP). A total genetic risk score (GRS) and pathway-specific risk scores (complement, lipid, extra-cellular matrix, other) were constructed based on the dosage of SNPs and conditional beta's; a lifestyle score was constructed based on smoking and dietary intake. RESULTS: The risk variants with the largest difference between late AMD cases and controls, and the highest PAFs were located in ARMS2 (rs3750846) and CHF (rs570618 and rs10922109). Both risk increasing and protective variants had the highest PAFs. Combining all genetic variants, the total genetic risk score ranged from -3.50 to 4.63, was normally distributed and increased with AMD severity. Of the late AMD cases, 1581/1777 (89%) had a positive total GRS. The complement pathway and ARMS2 were by far the most prominent genetic pathways contributing to late AMD (positive GRS 90% of late cases), but risk in three pathways was most frequent (35% of late cases). Lifestyle was a strong determinant of the outcome in each genetic risk category; unfavorable lifestyle increased the risk of late AMD at least twofold. CONCLUSIONS: Genetic risk variants contribute to late AMD in the majority of cases. However, lifestyle factors have a strong influence on the outcome of genetic risk, and should be a strong focus in patient management. Genetic risks in ARMS2 and the complement pathway are present in the majority of late AMD, but are mostly combined with risks in other pathways.
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- 2021
46. Predicting Progression to Advanced Age-Related Macular Degeneration from Clinical, Genetic, and Lifestyle Factors Using Machine Learning
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Ajana, Soufiane, Cougnard-Grégoire, Audrey, Colijn, Johanna M, Merle, Bénédicte M J, Verzijden, Timo, de Jong, Paulus T V M, Hofman, Albert, Vingerling, Johannes R, Hejblum, Boris P, Korobelnik, Jean-François, Meester-Smoor, Magda A, Ueffing, Marius, Jacqmin-Gadda, Hélène, Klaver, Caroline C W, Delcourt, Cécile, EYE-RISK consortium, Ajana, Soufiane, Cougnard-Grégoire, Audrey, Colijn, Johanna M, Merle, Bénédicte M J, Verzijden, Timo, de Jong, Paulus T V M, Hofman, Albert, Vingerling, Johannes R, Hejblum, Boris P, Korobelnik, Jean-François, Meester-Smoor, Magda A, Ueffing, Marius, Jacqmin-Gadda, Hélène, Klaver, Caroline C W, Delcourt, Cécile, and EYE-RISK consortium
- Abstract
PURPOSE: Current prediction models for advanced age-related macular degeneration (AMD) are based on a restrictive set of risk factors. The objective of this study was to develop a comprehensive prediction model applying a machine learning algorithm allowing selection of the most predictive risk factors automatically.DESIGN: Two population-based cohort studies.PARTICIPANTS: The Rotterdam Study I (RS-I; training set) included 3838 participants 55 years of age or older, with a median follow-up period of 10.8 years, and 108 incident cases of advanced AMD. The Antioxydants, Lipids Essentiels, Nutrition et Maladies Oculaires (ALIENOR) study (test set) included 362 participants 73 years of age or older, with a median follow-up period of 6.5 years, and 33 incident cases of advanced AMD.METHODS: The prediction model used the bootstrap least absolute shrinkage and selection operator (LASSO) method for survival analysis to select the best predictors of incident advanced AMD in the training set. Predictive performance of the model was assessed using the area under the receiver operating characteristic curve (AUC).MAIN OUTCOME MEASURES: Incident advanced AMD (atrophic, neovascular, or both), based on standardized interpretation of retinal photographs.RESULTS: The prediction model retained (1) age, (2) a combination of phenotypic predictors (based on the presence of intermediate drusen, hyperpigmentation in one or both eyes, and Age-Related Eye Disease Study simplified score), (3) a summary genetic risk score based on 49 single nucleotide polymorphisms, (4) smoking, (5) diet quality, (6) education, and (7) pulse pressure. The cross-validated AUC estimation in RS-I was 0.92 (95% confidence interval [CI], 0.88-0.97) at 5 years, 0.92 (95% CI, 0.90-0.95) at 10 years, and 0.91 (95% CI, 0.88-0.94) at 15 years. In ALIENOR, the AUC reached 0.92 at 5 years (95% CI, 0.87-0.98). In terms of calibration, the model tended to underestimate the cumulative i
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- 2021
47. Twenty-seven Years of Service Research: a Literature Review and Research Agenda
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Furrer, Olivier, Yu Kerguignas, Jie, Delcourt, Cécile, Gremler, Dwayne D., Furrer, Olivier, Yu Kerguignas, Jie, Delcourt, Cécile, and Gremler, Dwayne D.
- Abstract
Purpose – The growing service sector has experienced several revolutions that have transformed the way services are created and delivered. In parallel, services increasingly pique the interest of scholars, resulting in an expanding body of knowledge. Accordingly, it is time to reflect on extant service research, assess its boundaries, and think about its future. This paper aims to consider three research questions: How has service research evolved over the past 27 years? Which articles have most influenced the evolution of service research in the past 27 years? What are the most promising research themes for the future? Design/methodology/approach – To answer these questions, the authors analyze the contents of 3,177 service research articles published in ten major academic journals between 1993 and August 2019. Multiple correspondence analysis reveals the evolution of key service research themes and their underlying relationships. Findings – The research themes are organized in a growth–share matrix with four quadrants (stars, question marks, cash cows and pets) and also combine into four research clusters (human resource management, organizational behavior and strategy, technology, and operations and customer behavior and marketing). Together with a specified list of influential articles that have shaped the evolution of service research, these insights suggest an agenda for research. Originality/value – Acknowledging the vast growth of service research, this study presents an up-to-date picture of the discipline and an agenda to stimulate continued research
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- 2021
48. Exploring consensus on preventive measures and identification of patients at risk of age-related macular degeneration using the delphi process
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García-Layana, Alfredo, Garhöfer, Gerhard, Aslam, Tariq M., Silva, Rufino, Delcourt, Cécile, Klaver, Caroline C.W., Seddon, Johanna M., Minnella, Angelo M., García-Layana, Alfredo, Garhöfer, Gerhard, Aslam, Tariq M., Silva, Rufino, Delcourt, Cécile, Klaver, Caroline C.W., Seddon, Johanna M., and Minnella, Angelo M.
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Background: Early identification of AMD can lead to prompt and more effective treatment, better outcomes, and better final visual acuity; several risk scores have been devised to determine the individual level of risk for developing AMD. Herein, the Delphi method was used to provide recommendations for daily practice regarding preventive measures and follow-up required for subjects at low, moderate, and high risk of AMD evaluated with the Simplified Test AMD Risk-assessment Scale (STARS® ) questionnaire. Methods: A steering committee of three experts drafted and refined 25 statements on the approach to be recommended in different clinical situations [general recommendations (n = 2), use of evaluation tools (n = 4), general lifestyle advice (n = 3), and AREDS-based nutritional supplementation (n = 5)] with the help of a group of international experts, all co-authors of this paper. Thirty retinal specialists from Europe and the US were chosen based on relevant publications, clinical expertise, and experience in AMD, who then provided their level of agreement with the statements. Statements for which consensus was not reached were modified and voted upon again. Results: In the first round of voting, consensus was reached for 24 statements. After modification, consensus was then reached for the remaining statement. Conclusion: An interprofessional guideline to support preventive measures in patients at risk of AMD based on STARS® scoring has been developed to aid clinicians in daily practice, which will help to optimize preventive care of patients at risk of AMD.
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- 2021
49. Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk
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Samieri, Cécilia, Féart, Catherine, Letenneur, Luc, Dartigues, Jean-François, Pérès, Karine, Auriacombe, Sophie, Peuchant, Evelyne, Delcourt, Cécile, and Barberger-Gateau, Pascale
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- 2008
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50. Nutrition and age-related eye diseases: The Alienor (Antioxydants, lipides essentiels, nutrition et maladies oculaires) study
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Delcourt, Cécile, Korobelnik, J. -F., Barberger-Gateau, P., Delyfer, M. -N., Rougier, M. -B., Le Goff, M., Malet, F., Colin, J., and Dartigues, J. -F.
- Published
- 2010
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